CN102743657A - Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing piglet dysentery and a preparation method thereof. The traditional Chinese medicine composition, by weight, comprises 5-20 parts of bulk pharmaceutical chemicals hawthorn, 5-20 parts of malt, 5-25 parts of pericarpium citri reticulatae, 5-25 parts of medicated leaven, 10-30 parts of radix bupleuri, 10-30 parts of root of Chinese pulsatilla and 10-30 parts of root of common peony. Firstly needed bulk pharmaceutical chemicals are processed to be clean, then drying and smashing are carried out, various bulk pharmaceutical chemical powder are weighted to be sufficiently and evenly mixed, finally split charging is carried out. The traditional Chinese medicine composition can effectively prevent and treat various irritability diarrheas, trophism diarrheas and yellow and white dysentery caused by escherichia coli, has obvious effects on viral diarrheas, can protect and repair intestinal mucosa and recovers digestion capability of piglets.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition and method of making the same of preventing and treating piglet diarrhoea.
Background technology
Piglet diarrhea is a kind of typical ubiquitous multifactor property disease, is to threaten one of the most serious disease of piglet growth at present, also is the major reason that causes that piglet is dead.The Alimentary growth of ablactational baby pig is not perfect; Behind the weaned piglet owing to receive various influences that stress (daily ration changes, maternal antibody disappearance, change crowd and wean etc.); Intestinal villi is easy to receive the destruction of antibacterial and normal wean measure, thereby influences effective absorption of nutrient substance.When nutrient substance can not obtain fine digesting and assimilating; Dysbacteriosis and toxin poisoning that harmful colibacillary breeding is caused are extremely serious to the harm of ablactational baby pig; Then occurring with diarrhoea, edema is the ablactational baby pig series disease of cardinal symptom: like feed intake decline, gastric acid deficiency, poor growth, stagnation, negative growth, even the generation ablactational baby pig multisystemic wasting syndrome that has and death.
In recent years, account for 39.8% of the dead sum of piglet because of the dead piglet of suffering from diarrhoea.In China, because pig industry practitioner's technical merit, management level are lower, mostly aquaculture model is to raise scattered or cultures on a small scale, causes the sickness rate of piglet diarrhea higher.The annual sickness rate of piglet is 46.5%, and mortality rate is 10～15%, causes bigger economic loss to pig industry.
At present; Herding is produced, and control suckling pig diarrhoea mainly is through improving feeding and management condition, use measure such as antibiotics to reduce the generation of suckling pig diarrhoeal diseases, and piglet mainly is to make a living with breast milk; What oral administration difficulty, intramuscular administration strengthened piglet again stress.Antibiotic is invalid to viral disease, and antibacterials such as escherichia coli, Salmonella very easily produce drug resistance to antibiotic, and antibacterial drug therapy often effect is bad or invalid.Life-time service or abuse of antibiotics can cause the pathogen Drug resistance to increase gradually, cause the use amount of antibiotics increasing.And the long-term a large amount of antibacterials of using cause the archenteric flora imbalance easily, be diarrhoeal diseases more refractory more be prone to form cad pig.Residues of antibiotics has a strong impact on human beings'health and bio-safety etc. simultaneously, and livestock-raising production has been brought huge pressure.
Summary of the invention
The objective of the invention is weak point, a kind of Chinese medicine composition and method of making the same of preventing and treating piglet diarrhoea is provided to existing control piglet diarrhea medicine and method existence.Chinese medicine composition of the present invention prevents and treats the HUANGBAI(sic) dysentery that various irritability diarrhoea, trophism diarrhea and escherichia coli cause, and is comparatively obvious to the viral diarrhea effect; And can protect and repair intestinal mucosa, recover the digestion power of piglet.
In order to address the above problem, the technical scheme that the present invention takes is:
The present invention provides a kind of Chinese medicine compositions of preventing and treating piglet diarrhoea, representes with weight portion, and said Chinese medicine composition is by 5～20 parts of crude drug Fructus Crataegis; 5～20 parts in Fructus Hordei Germinatus, 5～25 parts of Pericarpium Citri Reticulataes, 5～25 parts of Massa Medicata Fermentata; 10～30 parts of Radix Bupleuri, 10～30 parts of the Radix Pulsatillaes and 10～30 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, said Chinese medicine composition is by 5～10 parts of crude drug Fructus Crataegis, 5～10 parts in Fructus Hordei Germinatus, 5～10 parts of Pericarpium Citri Reticulataes, 5～10 parts of Massa Medicata Fermentata, 10～15 parts of Radix Bupleuri, 10～15 parts of the Radix Pulsatillaes and 10～15 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, said Chinese medicine composition is by 10～15 parts of crude drug Fructus Crataegis, 10～15 parts in Fructus Hordei Germinatus; 10～20 parts of Pericarpium Citri Reticulataes; 10～20 parts of Massa Medicata Fermentata, 15～25 parts of Radix Bupleuri, 15～25 parts of the Radix Pulsatillaes and 15～25 parts of compositions of Radix Paeoniae Rubra.
According to the Chinese medicine compositions of above-mentioned control piglet diarrhoea, said Chinese medicine composition is by 15～20 parts of crude drug Fructus Crataegis, 15～20 parts in Fructus Hordei Germinatus; 20～25 parts of Pericarpium Citri Reticulataes; 20～25 parts of Massa Medicata Fermentata, 25～30 parts of Radix Bupleuri, 25～30 parts of the Radix Pulsatillaes and 25～30 parts of compositions of Radix Paeoniae Rubra.
Chinese medicine compositions according to above-mentioned control piglet diarrhoea; Said Chinese medicine preparation of compositions method is: prepare various raw materials according to the required crude drug of above-mentioned control piglet diarrhoea Chinese medicine compositions; At first handle required various crude drug clean; Carry out drying, pulverizing then successively, pulverize the back and cross 80 mesh sieves, obtain the medicated powder of various crude drug after the pulverizing; Take by weighing the crude drug medicated powder after the various pulverizing according to the proportioning ratio of above-mentioned control piglet diarrhoea Chinese medicine compositions, the various crude drug medicated powder that will take by weighing then mix, and fully mix homogeneously carries out packing at last and gets final product.
The pharmacological action of the used various crude drug of the present invention:
Fructus Crataegi: these article sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.Effect cures mainly: these article have appetite-stimulating indigestion-relieving, change the removing food stagnancy that stagnates, promoting blood circulation to remove blood stasis, the effects such as circulation of qi promoting of reducing phlegm.Be usually used in carnivorous stagnating and amass, lump in the abdomen, the abdominal distention feeling of fullness, stasis of blood resistance stomachache, phlegm retention is had loose bowels, cards such as discharging fresh blood stool.
Modern medicine study: these article contain materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum, have effects such as blood fat reducing, blood pressure lowering, heart tonifying and arrhythmia.Flavone compound vitexin in the Fructus Crataegi is the stronger medicine of a kind of antitumaous effect, and Fructus Crataegi extract all has certain inhibitory action to growth in the cancerous cell body, propagation and infiltration metastasis.Fructus Crataegi can prevent and treat cardiovascular disease, has blood vessel dilating, heart tonifying, coronary blood flow increasing, improves the heart vigor, the stimulating central nervous system system, brings high blood pressure down and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, and is also helpful to senile heart disease.
Fructus Hordei Germinatus: these article sweet in the mouth, property is flat; Return spleen, stomach warp.Effect cures mainly: these article have promote qi circulation digestion promoting, and spleen benefiting and stimulating the appetite moves back effects such as newborn relieving distension.Be usually used in food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, women's ablactation, Fructus Hordei Germinatus invigorating the spleen and regulating the stomach lactogenesis.
Modern medicine study: the main starch-containing enzyme of these article, conversion carbohydrase, vitamin B, fat, phospholipid, dextrin, maltose, glucose etc.Have effects such as digestion-aid effect, hypoglycemic activity, antifungic action, inhibition prolactin antagonist are released into, also have radioactive protective action.
Pericarpium Citri Reticulatae: these article acrid in the mouth, hardship, warm in nature; Go into spleen, stomach, lung meridian.Effect cures mainly: these article have regulating qi-flowing for strengthening spleen, in the accent, and dampness, effect such as reduce phlegm; The distension and fullness in the abdomen of controlling stagnation of QI in spleen and stomach commonly used or pain, dyspepsia, abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance, phlegm-damp is stopped up the cards such as cough and asthma of lung.
Modern medicine study: mainly contain volatile oil in these article, other contains flavones ingredient, hesperidin, compositions such as Nobiletin and Neosynephrine.
Contained volatile oil in the Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal tract, but pneumatosis in the intestinal tube is got rid of in the secretion of facilitating digestion liquid, has shown that fragrance is good for the stomach and the effectiveness of the therapeutic method to keep the adverse QI flowing downwards of dispeling the wind; The arteriosclerosis that pectin in the Pericarpium Citri Reticulatae causes high fat diet has certain preventive effect; Contained volatile oil has the passive phlegm-dispelling functions of zest in the Pericarpium Citri Reticulatae, makes sputum be prone to expectoration; The Pericarpium Citri Reticulatae decoct has faint dilating effect to bronchus, and it is higher that the relievining asthma of its ethanol extract tired; The Pericarpium Citri Reticulatae decoct can make the kidney vasoconstriction, makes hypourocrinia; Pericarpium Citri Reticulatae has effects such as antiinflammatory.
Massa Medicata Fermentata: these article bitter in the mouth, warm in nature, go into spleen, stomach, large intestine channel.Effect cures mainly: these article have strengthening the spleen to promote digestion, regulating QI to expel dampness, effect such as induce sweat; The food feeling of stuffiness in chest of controlling commonly used, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, children's hinders hungry full grade for the card that loses.
Modern medicine study: contain yeast in the Massa Medicata Fermentata, its composition has volatile oil, glycoside, fatty oil and vitamin B etc.These article have the effect of vitamin B group appearance, like appetite stimulator, keep normal stool function etc.
Radix Bupleuri: these article bitter in the mouth, suffering, cold nature; Go into Liver Channel, gallbladder meridian.Effect cures mainly: these article have expelling pathogenic factors from the exterior and expel the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, cards such as elevate a turnable ladder yang-energy; The heating that cures cold commonly used, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, cards such as menoxenia.
Modern medicine study: its composition of Radix Bupleuri mainly contains saikoside, sterol, volatile oil (bupleurumol, eugenol etc.), fatty acid (oleic acid, linoleic acid, Palmic acid, stearic acid etc.) and polysaccharide etc.These article have analgesic, and antiinflammatory promotes immunologic function, anti-liver injury, effects such as Antiradiation injury.
The Radix Pulsatillae: these article bitter in the mouth, cold in nature; Go into stomach, large intestine channel.Effect cures mainly: these article have heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effects such as removing dampness and killing parasites; Use always and control pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, cards such as scrofula.
Modern medicine study: Radix Pulsatillae root master contains anemoside.These article have anti-ameba effect, anti-trichomonas vaginitis effect, antibacterial action, effects such as antiviral.
Radix Paeoniae Rubra: these article contain peoniflorin, lactone glucoside of Radix Paeoniae, oxypaeoniflorin, benzoylpaeoniflorin, the lucky ketone of Radix Paeoniae, lacdtlorin, gallotannin, benzoic acid, volatile oil, fatty oil, resin etc.These article ability coronary artery dilator, coronary blood flow increasing; Radix Paeoniae Rubra water extract, Radix Paeoniae Rubra glycosides, Radix Paeoniae Rubra composition and derivant thereof have the anticoagulant effect; The outer TFT of its water decoction ability extension body alleviates the thrombosis dry weight; Contained peoniflorin has calmness, anti-inflammatory analgesic effect; Radix Paeoniae fluid extract, peoniflorin have anticonvulsant action; Radix Paeoniae Rubra, peoniflorin have spasmolysis; Radix Paeoniae Rubra has tangible potentiation to hepatocyte DNA synthetic, and multiple source of disease microorganism is had stronger inhibitory action.
The compatibility mechanism of medicament composing prescription of the present invention: reuse Radix Bupleuri in the prescription of the present invention, can be analgesic, antiinflammatory, promotion immunity, anti-liver injury, functions such as Antiradiation injury are monarch drug; Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, Radix Paeoniae Rubra has stronger inhibitory action to the several diseases pathogenic microorganism, is ministerial drug; The Fructus Crataegi appetite-stimulating indigestion-relieving is changed the removing food stagnancy that stagnates, promoting blood circulation to remove blood stasis, and the circulation of qi promoting of reducing phlegm, the Fructus Hordei Germinatus promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back effects such as newborn relieving distension, is adjuvant drug; Pericarpium Citri Reticulatae, Massa Medicata Fermentata have regulating qi-flowing for strengthening spleen, transfer medium effect, but coordinating the actions of various ingredients in a prescription is messenger drug.All medicines share, but antipyretic and anti-inflammatory promotes immunity.
Various crude drug compatibilities are reasonable in the medicine of the present invention, all medicines share have dampness, spleen invigorating, protect the liver, function such as intestine moistening, mix the back to take to piglet; Diarrhoeal diseases therapeutic effect to piglet is better, need not use other all antibacterials, is particularly useful for the pathology of antibiotic therapy DeGrain; Can demonstrate fully the organic conception and the advantage of Chinese medicine, make drug effect and function reach treating both the principal and secondary aspects of a disease more comprehensively, practical; Evident in efficacy, the scope of application is wide.
Positive beneficial effect of the present invention:
1, Chinese medicine composition of the present invention prevents and treats the HUANGBAI(sic) dysentery that various irritability diarrhoea, trophism diarrhea and escherichia coli cause, and is comparatively obvious to the viral diarrhea effect; And can protect and repair intestinal mucosa, recover the digestion power of piglet.
2, medicine of the present invention effectively solves new escherichia coli that breed and the toxin further destruction to small intestinal through effect of sticking and package action, and solving ablactational baby pig is master's serial disease with diarrhoea, edema; Recover the pH value and the nutrition that replenishes generation antibody of intestinal, intestinal is effectively protected, make impaired intestinal villi obtain repairing and unfolding; Thereby improve the ability of digesting and assimilating; The generation of enhancing antibody suppresses pathogen, particularly suppresses harmful colibacillary breeding.
3, Chinese medicine composition compatibility of the present invention is reasonable, and all medicines share, and have anti-inflammation, protection and reparation intestinal mucosa, recover digestion power, the relieving diarrhea with astringents of piglet, supplements the nutrients and disappearance sodium potassium ion the effect of control dehydration.
4, utilize Chinese medicine composition of the present invention can effectively prevent and treat the diarrhoeal diseases that the piglet a variety of causes causes, prevention effect is remarkable, has remarkable economic efficiency (seeing concrete clinical test results for details).
Utilize the clinical trial data of Chinese medicine composition control piglet diarrhoea of the present invention:
The present invention prevents and treats the method for using of the Chinese medicine composition of piglet diarrhoea: in feedstuff, add Chinese medicine composition of the present invention and eat; According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Be prone to take place the syndromic pig farm of diarrhea of weaned piglets: before the suckling pig wean, progressively increase the forage volume of supplementary feeding, adopt the method that weans gradually; The sucking number of times that reduces every day and the amount of sucking, with wean in 3-5 days, the wean beginning was not reloaded; Wean after 5 days, begin to change feedstuff, adopt and mix the method for reloading gradually; With 5-7 days replacing feedstuffs, in the feedstuff of changing, add Chinese medicine composition of the present invention simultaneously and finish back 3 days to reloading; Be direct wean like what adopt, change feedstuff simultaneously,, in feedstuff, add Chinese medicine composition of the present invention and use continuously from changing feedstuff to reloading back 10 days.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out the clinical practice test at large-scale pig farm, and test specific embodiments result sees following test report.
First group of clinical trial data:
The proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
Represent with weight portion, by 15 parts of crude drug Fructus Crataegis, 18 parts in Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 18 parts of Radix Bupleuri, 18 parts of the Radix Pulsatillaes and 22 parts of compositions of Radix Paeoniae Rubra.
The experiment situation: ablactational baby pig is added Chinese medicine composition of the present invention and un-added comparative effectiveness:
1, test material:
1.1 supplying the examination pig selects: about 500 of large scale of pig farm field, Nanyang sow livestock on hand, delivery room piglet are prone to suffer from diarrhoea.Random choose is 400 of ablactational baby pig not, are divided into two groups at random, 1 group 200 of random experiments, 2 groups 200 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2 medicated premix amount: test 1 group of prevention diarrhea of weaned piglets and add Chinese medicine composition of the present invention, Chinese medicine composition of the present invention inserts in the feedstuff for 250 kilograms according to every 1000g spice and feeds; Testing 2 groups is the blank group.
2, test method:
2.1, supply the examination pig to handle: test 1 group and remove and add Chinese medicine composition beyond the region of objective existence of the present invention, 2 groups of matched groups of other and test are all undertaken by conventional feeding and management.Test finished to weaning after 5 days from weaned piglet in 15 days, carried out altogether 10 days.
2.2 test data statistical disposition:
Test is in charge of by the special messenger, observes spirit, body temperature and feces situation with the record piglet at any time; During off-test, supply the examination piglet to weigh, and, calculate average weight gain, the incidence and mortality of adding up piglet simultaneously according to the conventional statistical method of Animal Science to all.
3, result of the test:
Through 10 days test, and through the sorting-out in statistics of test data, this test obtained result preferably.Existing result of the test is tabulated 1 following:
Table 1 utilizes the therapeutic effect of medical treatment piglet diarrhoea of the present invention
Can be known by table 1 result of the test data: add the Chinese medicine composition of the present invention group of feeding in the pig starter feed, its average weight gain promptly improves 24.9% than 1.24 kilograms of matched group raisings; The piglet sickness rate is lower by 11.5% than matched group, mortality rate low 9%.
4, conclusion:
Add the Chinese medicine composition that the present invention prevents and treats piglet diarrhoea in the ablactational baby pig feedstuff, can obviously reduce the sickness rate of diarrhea of weaned piglets, reduce mortality rate, improve the weight gain of piglets amount, increase economic efficiency.
Second group of clinical trial data:
The proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
Represent with weight portion, by 13 parts of crude drug Fructus Crataegis, 14 parts in Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 20 parts of Radix Bupleuri, 20 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Method for using: to plant's 1/3 of original feed intake of feeding after 10 hours, later every day, dosage recovered former scale of feeding after 3-5 days, in feedstuff, added Chinese medicine composition of the present invention, logotype 10 days simultaneously.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out the clinical practice test at large-scale pig farm, and test specific embodiments result sees following test report.
Experiment situation: newly purchase piglet and add Chinese medicine composition of the present invention and un-added comparative effectiveness:
1, test material:
1.1 supplying the examination pig selects: about 600 of large scale of pig farm field, Shandong sow livestock on hand, newly purchase piglet and be prone to suffer from diarrhoea.Random choose is newly purchased 200 of piglets, is divided into two groups at random, 1 group 100 of random experiments, 2 groups 100 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2 medicated premix amount: test 1 group of prevention and newly purchase piglet diarrhea interpolation Chinese medicine composition of the present invention, insert in the feedstuff for 250 kilograms according to every 1000g Chinese medicine composition spice of the present invention and feed, testing 2 groups is the blank group.
2, test method:
2.1, supply the examination pig to handle: test 1 group and remove and add Chinese medicine composition beyond the region of objective existence of the present invention, 2 groups of matched groups of other and test are all undertaken by conventional feeding and management.Test was carried out 10 days from newly purchasing piglet day end on the same day to 10 altogether.
2.2 test data statistical disposition: test is in charge of by the special messenger, observes spirit, body temperature and feces situation with the record piglet at any time; During off-test, supply the examination piglet to weigh, and, calculate average weight gain, the incidence and mortality of adding up piglet simultaneously according to the conventional statistical method of Animal Science to all.
3, result of the test: through 10 days test, and through the sorting-out in statistics of test data, this test obtained result preferably.Existing result of the test is tabulated 2 following:
Second group of clinical experiment statistical result of table 2
Can be known by last table 2 result of the test data: newly purchase in the pig starter feed and to add the Chinese medicine composition of the present invention group of feeding, its average weight gain improves 0.86 kilogram than matched group, promptly improves 16.4%, and the piglet sickness rate is lower by 9% than matched group, and mortality rate hangs down 5%.
4, conclusion: newly purchase and add Chinese medicine composition of the present invention in the pig starter feed, can obviously reduce the sickness rate of newly purchasing piglet diarrhea, reduce mortality rate, improve the weight gain of piglets amount, increase economic efficiency.
The 3rd group of clinical trial data:
The proportioning that the present invention prevents and treats the crude drug of piglet diarrhoea Chinese medicine composition is:
Represent with weight portion, by 13 parts of crude drug Fructus Crataegis, 14 parts in Fructus Hordei Germinatus, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 23 parts of Radix Bupleuri, 24 parts of the Radix Pulsatillaes and 23 parts of compositions of Radix Paeoniae Rubra.
Method for using: slight diarrheal, adopt Chinese medicine composition spice logotype of the present invention 3-5 days; For cacatory, adopt Chinese medicine composition spice of the present invention to use continuously 7-15 days.According to 250 kilograms of uses of every 1000g Chinese medicine composition spice of the present invention.
Chinese medicine composition of the present invention has carried out the clinical practice test at large-scale pig farm, and test specific embodiments result sees following test report.
Experiment situation: newly purchase piglet and ablactational baby pig and add Chinese medicine composition of the present invention and the comparative effectiveness of adding other medicine.
1, test material:
1.1, supply the examination pig to select: about 450 of large scale of pig farm field, Hebei sow livestock on hand, newly purchase piglet and ablactational baby pig is all suffered from diarrhoea.Draw yellow water sample loose stool, the course of disease is longer, the piglet death of dewatering at last.35 of random choose morbidity piglets are divided into two groups at random, 1 group 17 of random experiments, 2 groups 18 of tests, and all piglets all carry out feeding and management under identical trophic level and management condition.
1.2, the medicated premix amount: test 1 group of morbidity piglet diarrhea and add Chinese medicine composition of the present invention, insert in the feedstuff for 250 kilograms according to every 1000g Chinese medicine composition spice of the present invention and feed; Testing 2 groups of morbidity piglet diarrhea oxytetracyclines inserts in the feedstuff for 250 kilograms according to every 1000g oxytetracycline spice and feeds.
2, test method:
2.1, supply the examination pig to handle: test 1 group and all undertaken by conventional feeding and management with 2 groups of matched groups of test.Tested continuous 15 days.
2.2, the test data statistical disposition: test is in charge of by the special messenger, observes spirit, body temperature and feces situation with the record piglet at any time; During off-test, according to the conventional statistical method of Animal Science, cure rate and the mortality rate of statistics piglet.
3, result of the test: through 15 days test, and through the sorting-out in statistics of test data, this test obtained result preferably.Existing result of the test is tabulated 3 following:
The 3rd group of clinical test results of table 3
Can be known by last table 3 result of the test data: add the Chinese medicine composition of the present invention group of feeding in the morbidity pig starter feed, its average cure rate improves 21.3% than the oxytetracycline matched group, and the piglet mortality rate of falling ill is than oxytetracycline matched group low 5.2%.
4, conclusion: add Chinese medicine composition of the present invention in the morbidity pig starter feed, can obviously cure the morbidity piglet diarrhea and reduce mortality rate.
Five, the specific embodiment:
Further set forth the present invention below in conjunction with embodiment, but do not limit content of the present invention.
Embodiment 1:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 13 parts of crude drug Fructus Crataegis, 14 parts in Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 20 parts of Radix Bupleuri, 20 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Embodiment 2:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 15 parts of crude drug Fructus Crataegis, 18 parts in Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 18 parts of Radix Bupleuri, 18 parts of the Radix Pulsatillaes and 22 parts of compositions of Radix Paeoniae Rubra.
Embodiment 3:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 20 parts of crude drug Fructus Crataegis, 20 parts in Fructus Hordei Germinatus, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Massa Medicata Fermentata, 30 parts of Radix Bupleuri, 30 parts of the Radix Pulsatillaes and 30 parts of compositions of Radix Paeoniae Rubra.
Embodiment 4:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 10 parts of crude drug Fructus Crataegis, 10 parts in Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 13 parts of Massa Medicata Fermentata, 12 parts of Radix Bupleuri, 14 parts of the Radix Pulsatillaes and 13 parts of compositions of Radix Paeoniae Rubra.
Embodiment 5:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 5 parts of crude drug Fructus Crataegis, 5 parts in Fructus Hordei Germinatus, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Massa Medicata Fermentata, 10 parts of Radix Bupleuri, 10 parts of the Radix Pulsatillaes and 10 parts of compositions of Radix Paeoniae Rubra.
Embodiment 6:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 8 parts of crude drug Fructus Crataegis, 16 parts in Fructus Hordei Germinatus, 8 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 7:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 18 parts of crude drug Fructus Crataegis, 7 parts in Fructus Hordei Germinatus, 22 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 22 parts of the Radix Pulsatillaes and 26 parts of compositions of Radix Paeoniae Rubra.
Embodiment 8:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 16 parts of crude drug Fructus Crataegis, 17 parts in Fructus Hordei Germinatus, 24 parts of Pericarpium Citri Reticulataes, 28 parts of Massa Medicata Fermentata, 27 parts of Radix Bupleuri, 26 parts of the Radix Pulsatillaes and 28 parts of compositions of Radix Paeoniae Rubra.
Embodiment 9:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 5 parts of crude drug Fructus Crataegis, 5 parts in Fructus Hordei Germinatus, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Massa Medicata Fermentata, 11 parts of Radix Bupleuri, 10 parts of the Radix Pulsatillaes and 10 parts of compositions of Radix Paeoniae Rubra.
Embodiment 10:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 10 parts of crude drug Fructus Crataegis, 10 parts in Fructus Hordei Germinatus, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 11:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 8 parts of crude drug Fructus Crataegis, 7 parts in Fructus Hordei Germinatus, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Massa Medicata Fermentata, 12 parts of Radix Bupleuri, 13 parts of the Radix Pulsatillaes and 12 parts of compositions of Radix Paeoniae Rubra.
Embodiment 12:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 6 parts of crude drug Fructus Crataegis, 8 parts in Fructus Hordei Germinatus, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Massa Medicata Fermentata, 10 parts of Radix Bupleuri, 12 parts of the Radix Pulsatillaes and 14 parts of compositions of Radix Paeoniae Rubra.
Embodiment 13:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 12 parts of crude drug Fructus Crataegis, 13 parts in Fructus Hordei Germinatus, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Massa Medicata Fermentata, 21 parts of Radix Bupleuri, 19 parts of the Radix Pulsatillaes and 20 parts of compositions of Radix Paeoniae Rubra.
Embodiment 14:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 10 parts of crude drug Fructus Crataegis, 11 parts in Fructus Hordei Germinatus, 12 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 15 parts of Radix Bupleuri, 16 parts of the Radix Pulsatillaes and 15 parts of compositions of Radix Paeoniae Rubra.
Embodiment 15:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 13 parts of crude drug Fructus Crataegis, 14 parts in Fructus Hordei Germinatus, 18 parts of Pericarpium Citri Reticulataes, 18 parts of Massa Medicata Fermentata, 23 parts of Radix Bupleuri, 24 parts of the Radix Pulsatillaes and 23 parts of compositions of Radix Paeoniae Rubra.
Embodiment 16:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 15 parts of crude drug Fructus Crataegis, 15 parts in Fructus Hordei Germinatus, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 25 parts of the Radix Pulsatillaes and 25 parts of compositions of Radix Paeoniae Rubra.
Embodiment 17:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 13 parts of crude drug Fructus Crataegis, 10 parts in Fructus Hordei Germinatus, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Massa Medicata Fermentata, 17 parts of Radix Bupleuri, 15 parts of the Radix Pulsatillaes and 16 parts of compositions of Radix Paeoniae Rubra.
Embodiment 18:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 16 parts of crude drug Fructus Crataegis, 16 parts in Fructus Hordei Germinatus, 20 parts of Pericarpium Citri Reticulataes, 22 parts of Massa Medicata Fermentata, 25 parts of Radix Bupleuri, 26 parts of the Radix Pulsatillaes and 25 parts of compositions of Radix Paeoniae Rubra.
Embodiment 19:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 18 parts of crude drug Fructus Crataegis, 18 parts in Fructus Hordei Germinatus, 22 parts of Pericarpium Citri Reticulataes, 23 parts of Massa Medicata Fermentata, 28 parts of Radix Bupleuri, 27 parts of the Radix Pulsatillaes and 28 parts of compositions of Radix Paeoniae Rubra.
Embodiment 20:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 20 parts of crude drug Fructus Crataegis, 20 parts in Fructus Hordei Germinatus, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Massa Medicata Fermentata, 30 parts of Radix Bupleuri, 30 parts of the Radix Pulsatillaes and 30 parts of compositions of Radix Paeoniae Rubra.
Embodiment 21:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 15 parts of crude drug Fructus Crataegis, 19 parts in Fructus Hordei Germinatus, 24 parts of Pericarpium Citri Reticulataes, 20 parts of Massa Medicata Fermentata, 26 parts of Radix Bupleuri, 25 parts of the Radix Pulsatillaes and 27 parts of compositions of Radix Paeoniae Rubra.
Embodiment 22:
The present invention prevents and treats the Chinese medicine compositions of piglet diarrhoea, representes with weight portion, and by 19 parts of crude drug Fructus Crataegis, 15 parts in Fructus Hordei Germinatus, 23 parts of Pericarpium Citri Reticulataes, 21 parts of Massa Medicata Fermentata, 27 parts of Radix Bupleuri, 28 parts of the Radix Pulsatillaes and 26 parts of compositions of Radix Paeoniae Rubra.
The method for preparing that the foregoing description 1-22 the present invention prevents and treats the Chinese medicine composition of piglet diarrhoea is: prepare various crude drug according to the required crude drug of control piglet diarrhoea Chinese medicine compositions described in the foregoing description; At first handle required various crude drug clean; Carry out drying, pulverizing then successively; Pulverize the back and cross 80 mesh sieves, obtain the medicated powder of various crude drug after the pulverizing; Take by weighing the crude drug medicated powder after the various pulverizing according to the proportioning ratio of control piglet diarrhoea Chinese medicine compositions among each embodiment then, the various crude drug medicated powder that will take by weighing then mix, and fully mix homogeneously carries out packing at last and gets final product.
Claims (5)
1. a Chinese medicine compositions of preventing and treating piglet diarrhoea is characterized in that: represent that with weight portion said Chinese medicine composition is by 5～20 parts of crude drug Fructus Crataegis; 5～20 parts in Fructus Hordei Germinatus, 5～25 parts of Pericarpium Citri Reticulataes, 5～25 parts of Massa Medicata Fermentata; 10～30 parts of Radix Bupleuri, 10～30 parts of the Radix Pulsatillaes and 10～30 parts of compositions of Radix Paeoniae Rubra.
2. the Chinese medicine compositions of control piglet diarrhoea according to claim 1 is characterized in that: said Chinese medicine composition is by 5～10 parts of crude drug Fructus Crataegis, 5～10 parts in Fructus Hordei Germinatus; 5～10 parts of Pericarpium Citri Reticulataes; 5～10 parts of Massa Medicata Fermentata, 10～15 parts of Radix Bupleuri, 10～15 parts of the Radix Pulsatillaes and 10～15 parts of compositions of Radix Paeoniae Rubra.
3. the Chinese medicine compositions of control piglet diarrhoea according to claim 1; It is characterized in that: said Chinese medicine composition is by 10～15 parts of crude drug Fructus Crataegis; 10～15 parts in Fructus Hordei Germinatus, 10～20 parts of Pericarpium Citri Reticulataes, 10～20 parts of Massa Medicata Fermentata; 15～25 parts of Radix Bupleuri, 15～25 parts of the Radix Pulsatillaes and 15～25 parts of compositions of Radix Paeoniae Rubra.
4. the Chinese medicine compositions of control piglet diarrhoea according to claim 1; It is characterized in that: said Chinese medicine composition is by 15～20 parts of crude drug Fructus Crataegis; 15～20 parts in Fructus Hordei Germinatus, 20～25 parts of Pericarpium Citri Reticulataes, 20～25 parts of Massa Medicata Fermentata; 25～30 parts of Radix Bupleuri, 25～30 parts of the Radix Pulsatillaes and 25～30 parts of compositions of Radix Paeoniae Rubra.
5. according to the Chinese medicine compositions of each described control piglet diarrhoea of claim 1～4; It is characterized in that; Said Chinese medicine preparation of compositions method is: prepare various raw materials according to the required crude drug of each said control piglet diarrhoea Chinese medicine compositions of claim 1～4, at first required various crude drug are handled totally, carry out drying, pulverizing then successively; Pulverize the back and cross 80 mesh sieves, obtain the medicated powder of various crude drug after the pulverizing; Take by weighing the crude drug medicated powder after the various pulverizing according to the proportioning ratio of each said control piglet diarrhoea Chinese medicine compositions of claim 1～4, the various crude drug medicated powder that will take by weighing then mix, and fully mix homogeneously carries out packing at last and gets final product.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432228A (en) * | 2013-09-09 | 2013-12-11 | 刘水石 | Porcine antidiarrheal traditional Chinese medicine and preparation method thereof |
| CN104351514A (en) * | 2014-10-23 | 2015-02-18 | 吴咏梅 | Piglet low-residue green feed additive and manufacturing method thereof |
| CN105796715A (en) * | 2016-05-19 | 2016-07-27 | 丽水市农业科学研究院 | Formula of Chinese herbal medicinal composition for treating porcine gastroenteritis diseases and preparation method of Chinese herbal medicinal composition |
| CN106692917A (en) * | 2016-11-18 | 2017-05-24 | 钱峰 | Traditional Chinese medicine feed additive for preventing and treating piglet diarrhea and preparation method thereof |
| CN108541809A (en) * | 2018-04-11 | 2018-09-18 | 浙江博信药业股份有限公司 | A kind of livestock and poultry Chinese herb feed additive and its preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN101874883A (en) * | 2009-04-28 | 2010-11-03 | 姜国银 | Traditional Chinese medicine for preventing and treating high fever diseases of pigs |
| CN102406888A (en) * | 2010-09-25 | 2012-04-11 | 张恒 | Medicament for treating liver-stomach disharmony |
-
2012
- 2012-07-31 CN CN201210267014.0A patent/CN102743657B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874883A (en) * | 2009-04-28 | 2010-11-03 | 姜国银 | Traditional Chinese medicine for preventing and treating high fever diseases of pigs |
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN102406888A (en) * | 2010-09-25 | 2012-04-11 | 张恒 | Medicament for treating liver-stomach disharmony |
Non-Patent Citations (5)
| Title |
|---|
| 刘树阳: "鸡、猪用复方中草药饲料添加剂配方举例", 《养殖技术顾问》 * |
| 张锐等: "柴胡抗炎及免疫药理学研究进展", 《中国兽药杂志》 * |
| 王红宁: "仔猪腹泻成因及综合防治技术措施", 《中国畜牧杂志市场版》 * |
| 由昭红: "断奶仔猪腹泻防治药物的研究进展", 《畜牧与饲料科学》 * |
| 高启贤等: "仔猪腹泻的应对措施", 《国外畜牧学（猪与禽）》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432228A (en) * | 2013-09-09 | 2013-12-11 | 刘水石 | Porcine antidiarrheal traditional Chinese medicine and preparation method thereof |
| CN104351514A (en) * | 2014-10-23 | 2015-02-18 | 吴咏梅 | Piglet low-residue green feed additive and manufacturing method thereof |
| CN105796715A (en) * | 2016-05-19 | 2016-07-27 | 丽水市农业科学研究院 | Formula of Chinese herbal medicinal composition for treating porcine gastroenteritis diseases and preparation method of Chinese herbal medicinal composition |
| CN105796715B (en) * | 2016-05-19 | 2019-11-22 | 丽水市农业科学研究院 | A kind of Chinese herbal medicine formula and preparation method thereof for treating pig stomach enteritis disease |
| CN106692917A (en) * | 2016-11-18 | 2017-05-24 | 钱峰 | Traditional Chinese medicine feed additive for preventing and treating piglet diarrhea and preparation method thereof |
| CN108541809A (en) * | 2018-04-11 | 2018-09-18 | 浙江博信药业股份有限公司 | A kind of livestock and poultry Chinese herb feed additive and its preparation method and application |
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|---|---|
| CN102743657B (en) | 2014-05-07 |
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Effective date of registration: 20161128 Address after: 450000 eighteen Mile River, Guan Cheng District, Henan, Zhengzhou Patentee after: HENAN ZHONGYA SHENPENG MEDICAL TECHNOLOGY CO., LTD. Address before: 451164 Henan province Zhengzhou city Xinzheng Port Development Zone, Taiwan investment Patentee before: Henan Guangtai Animal Pharmaceutical Co., Ltd. |
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