CN102743669A - Compound propolis composition for treating swine enzootic pneumonia - Google Patents
Compound propolis composition for treating swine enzootic pneumonia Download PDFInfo
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Abstract
The invention relates to a compound propolis composition for treating swine enzootic pneumonia. The compound propolis composition for treating swine enzootic pneumonia is prepared by mixing 15 to 35 parts by weight of propolis, 15 to 35 parts by weight of rhizoma anemarrhenae, 15 to 35 parts by weight of almonds, 15 to 35 parts by weight of sessile stemona root, 15 to 45 parts by weight of platycodon grandiflorum, 15 to 35 parts by weight of bitter orange, 15 to 40 parts by weight of liquorice, 15 to 45 parts by weight of heartleaf houttuynia herb, 15 to 45 parts by weight of pericarpium citri reticulatae and 15 to 45 parts by weight of mung beans. The compound propolis composition has a reasonable formula, can be prepared by simple processes, has no toxic or side effects, does not produce pollution and drug residues, does not cause drug resistance, is crushed into superfine powder, and has high bioavailability and obvious treatment effects. In clinical, the compound propolis composition has special effects of treatment on swine enzootic pneumonia.
Description
Technical field
The present invention relates to compound bee-glue composition of treating swine enzootic pneumonia and preparation method thereof, belong to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine enzootic pneumonia and preparation method thereof.
Background technology
Swine enzootic pneumonia is a kind of contact respiratory infectious disease that is caused by mycoplasma hyopneumoniae, is characteristic with cough, asthma, and in a single day infect on the pig farm, is difficult to thoroughly eliminate.The pig of various ages and kind all can be taken place, and M & M is all between 5%-20%.Primary disease all can take place throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug since life-time service drug residue is arranged and be prone to produce drug resistance, its clinical effectiveness worse and worse, and drug residue cause exporting limited healthy with the harm people, thereby make the use of antimicrobial drug receive very big restriction.
Therefore researching and developing a kind of specific medicament of treating the drug residue free of swine enzootic pneumonia, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment swine enzootic pneumonia of drug residue and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating swine enzootic pneumonia, by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Anemarrhenae 15-35 part, Semen Armeniacae Amarum 15-35 part, Radix Stemonae 15-35 part, Radix Platycodonis 15-45 part, Fructus Aurantii 15-35 part, Radix Glycyrrhizae 15-40 part, Herba Houttuyniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Semen phaseoli radiati 15-45 part.
Said various component optimum ratio amount is: 25 parts of propolis, 25 parts of the Rhizoma Anemarrhenaes, 25 parts in Semen Armeniacae Amarum, 25 parts of the Radixs Stemonae, 30 parts of Radix Platycodoniss, 25 parts of Fructus Aurantiis, 30 parts in Radix Glycyrrhizae, 30 parts of Herba Houttuyniae, 30 parts of Pericarpium Citri Reticulataes, 30 parts in Semen phaseoli radiati.
A kind of method for preparing of treating the compound bee-glue composition of swine enzootic pneumonia, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Rhizoma Anemarrhenae 15-35 part, Semen Armeniacae Amarum 15-35 part, Radix Stemonae 15-35 part, Radix Platycodonis 15-45 part by weight, mix 5-10 minute to even;
(3) take by weighing Fructus Aurantii 15-35 part, Radix Glycyrrhizae 15-40 part, Herba Houttuyniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Semen phaseoli radiati 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, have clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, interior-heat caused by deficiency of YIN etc.
Semen Armeniacae Amarum: bitter, tepor, return lung, large intestine channel, have the function of relieving cough and asthma, loosening bowel to relieve constipation; Cure mainly cough and asthma, dryness of the intestine constipation etc.
The Radix Stemonae: bitter, sweet, warm, return lung meridian, have nourishing the lung to arrest cough, parasiticidal function; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.
Radix Platycodonis: bitter, hot, flat, return lung meridian, have lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Fructus Aurantii: bitter, hot, acid, warm, return stomach, spleen channel, the function that have promoting the circulation of QI to alleviate the stagnation in middle-JIAO, reduce phlegm, helps digestion; Cure mainly that dyspepsia does not disappear, tripe expands, feces is dry, hang down and take off disease, the expectorant vapour lock etc. that stagnates.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly that appetite minimizing, stomachache, tripe are expanded, had loose bowels, productive cough due to phlegm-damp etc.
Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, the function that has heat-clearing and toxic substances removing, relieves summer heat and be good for the stomach; Cure mainly that diarrhea due to damp-heat, detoxifcation protect the liver, antiallergic etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of swine enzootic pneumonia, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this ten flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment swine enzootic pneumonia there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition of treating swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, 150 parts of the Rhizoma Anemarrhenaes, 150 parts in Semen Armeniacae Amarum, 150 parts of the Radixs Stemonae, 150 parts of Radix Platycodoniss by weight, mix 5-10 minute to even;
(3) take by weighing 150 parts of Fructus Aurantiis, 150 parts in Radix Glycyrrhizae, 150 parts of Herba Houttuyniae, 150 parts of Pericarpium Citri Reticulataes, 150 parts in Semen phaseoli radiati by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition of treating swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, 250 parts of the Rhizoma Anemarrhenaes, 250 parts in Semen Armeniacae Amarum, 250 parts of the Radixs Stemonae, 300 parts of Radix Platycodoniss by weight, mix 5-10 minute to even;
(3) take by weighing 250 parts of Fructus Aurantiis, 250 parts in Radix Glycyrrhizae, 300 parts of Herba Houttuyniae, 300 parts of Pericarpium Citri Reticulataes, 300 parts in Semen phaseoli radiati by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition of treating swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 350 parts of propolis, 350 parts of the Rhizoma Anemarrhenaes, 350 parts in Semen Armeniacae Amarum, 350 parts of the Radixs Stemonae, 450 parts of Radix Platycodoniss by weight, mix 5-10 minute to even;
(3) take by weighing 350 parts of Fructus Aurantiis, 400 parts in Radix Glycyrrhizae, 450 parts of Herba Houttuyniae, 450 parts of Pericarpium Citri Reticulataes, 450 parts in Semen phaseoli radiati by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects for use 80-90 age in days, body weight at 35kg-50kg, and laboratory is diagnosed as the ill pig of swine enzootic pneumonia.Ill pig is isolated raising separately, the complete feed of feeding, and be divided into 3 groups at random, and 30 every group, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " pig asthma health is loose " by specification; Chinese medicine composition group of the present invention can be with the ill pig of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment swine enzootic pneumonia:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 16.7 | 56.6 | 26.7 |
| II | Pig asthma health is loose and is organized | 10.0 | 78.4 | 10.0 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with pig asthma health and compared difference extremely significantly (P＜0.01) aspect the cure rate.
Safety testing:
Choose 10 of 70 age in days health pig; 5 times of spices according to the embodiment of the invention 1 made compositions RD were fed 10 days; During the medication; Health pig has no bad or Deviant Behavior performance, and the drinking-water of searching for food is normal, and it is not remarkable that weight increase and blank group (being not administration of health group) are compared difference.
Above-mentioned detailed description of compound bee-glue composition of this treatment swine enzootic pneumonia and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition of treating swine enzootic pneumonia, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Rhizoma Anemarrhenae 15-35 part, Semen Armeniacae Amarum 15-35 part, Radix Stemonae 15-35 part, Radix Platycodonis 15-45 part, Fructus Aurantii 15-35 part, Radix Glycyrrhizae 15-40 part, Herba Houttuyniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Semen phaseoli radiati 15-45 part.
2. the compound bee-glue composition of treatment swine enzootic pneumonia according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of the Rhizoma Anemarrhenaes, 25 parts in Semen Armeniacae Amarum, 25 parts of the Radixs Stemonae, 30 parts of Radix Platycodoniss, 25 parts of Fructus Aurantiis, 30 parts in Radix Glycyrrhizae, 30 parts of Herba Houttuyniae, 30 parts of Pericarpium Citri Reticulataes, 30 parts in Semen phaseoli radiati.
3. the method for preparing of the compound bee-glue composition of a treatment swine enzootic pneumonia according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Rhizoma Anemarrhenae 15-35 part, Semen Armeniacae Amarum 15-35 part, Radix Stemonae 15-35 part, Radix Platycodonis 15-45 part by weight, mix 5-10 minute to even;
(3) take by weighing Fructus Aurantii 15-35 part, Radix Glycyrrhizae 15-40 part, Herba Houttuyniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Semen phaseoli radiati 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102117909A CN102743669B (en) | 2012-06-26 | 2012-06-26 | Compound propolis composition for treating swine enzootic pneumonia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102117909A CN102743669B (en) | 2012-06-26 | 2012-06-26 | Compound propolis composition for treating swine enzootic pneumonia |
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| CN102743669A true CN102743669A (en) | 2012-10-24 |
| CN102743669B CN102743669B (en) | 2013-11-13 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947887A (en) * | 2014-05-09 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed for preventing and treating mycoplasmal pneumonia of swine and traditional Chinese medicine composition as well as preparation method |
| CN103623313B (en) * | 2013-12-03 | 2015-10-21 | 金陵科技学院 | Traditional Chinese medicine composition for preventing and treating swine mycoplasmal pneumonia and preparation method and application thereof |
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| CN1586552A (en) * | 2004-07-19 | 2005-03-02 | 左耀武 | External plaster for treating baby heat cough and preparing method |
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Patent Citations (3)
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| CN1586552A (en) * | 2004-07-19 | 2005-03-02 | 左耀武 | External plaster for treating baby heat cough and preparing method |
| CN1781547A (en) * | 2005-05-26 | 2006-06-07 | 钟健琳 | Plaster for clearing lung, relieving asthma and stopping cough |
| CN102319385A (en) * | 2011-09-08 | 2012-01-18 | 闫振国 | Medicament for treating emphysema and preparation method thereof |
Non-Patent Citations (1)
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| 林志川 等: "中药治牛劳伤咳嗽与气喘症", 《福建畜牧兽医》, vol. 24, no. 4, 31 December 2002 (2002-12-31), pages 16 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623313B (en) * | 2013-12-03 | 2015-10-21 | 金陵科技学院 | Traditional Chinese medicine composition for preventing and treating swine mycoplasmal pneumonia and preparation method and application thereof |
| CN103947887A (en) * | 2014-05-09 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed for preventing and treating mycoplasmal pneumonia of swine and traditional Chinese medicine composition as well as preparation method |
| CN103947887B (en) * | 2014-05-09 | 2015-08-12 | 山东新希望六和集团有限公司 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating swine enzootic pneumonia |
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