CN102600305A - Compound propolis composition for treating swine pasteurellosis and preparation method for same - Google Patents
Compound propolis composition for treating swine pasteurellosis and preparation method for same Download PDFInfo
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- CN102600305A CN102600305A CN2011104342644A CN201110434264A CN102600305A CN 102600305 A CN102600305 A CN 102600305A CN 2011104342644 A CN2011104342644 A CN 2011104342644A CN 201110434264 A CN201110434264 A CN 201110434264A CN 102600305 A CN102600305 A CN 102600305A
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Abstract
The invention discloses a compound propolis composition for treating swine pasteurellosis and a preparation method for the same, and relates to the field of animal medicine. The preparation method disclosed by the invention comprises the following steps of: (1) superfinely grinding various ingredients in a prescription respectively, and then screening by a 700-mesh sieve; (2) weighing 15-35 parts of propolis, 15-35 parts of houttuynia cordata, 15-35 parts of honeysuckle, 15-35 parts of platycodon grandiflorum, and 15-45 parts of cape jasmine by weight, and mixing for 5-10 minutes to be uniform; (3) weighing 15-35 parts of folium isatidis, 15-40 parts of mother chrysanthemum, 15-45 parts of radix scutellariae, 15-45 parts of artemisia apiacea, and 15-45 parts of vervain by weight, and mixing for 5-10 minutes to be uniform; and (4) combining the compositions prepared in the steps (2) and (3), and continuing to mix for 10-15 minutes to be uniform. The compound propolis composition for treating swine pasteurellosis and the preparation method for the same disclosed by the invention have the advantages that the prescription is reasonable and preparation is simple; and the composition has no toxic or side effects, no pollution, no medicine residue and no tolerance, has high bioavailability and very remarkable curative effect due to superfine grinding, and has a specially good effect on treatment for swine pasteurellosis via clinical proof.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine pasteurellosis and preparation method thereof.
Background technology
Swine pasteurellosis is a kind of acute, the deteriorated blood property respiratory infectious disease that is caused by the pig pasteurella multocida, is characteristic with the hemorrhagic inflammation of septicemia and tissue, organ, can cause the infectious atrophic rhinitis of pig lung plague and pig.The pig of various ages and kind all can be taken place, and case fatality rate is all between 60%-70%.Primary disease all can take place throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug since life-time service drug residue is arranged and be prone to produce drug resistance, its clinical effectiveness worse and worse, and drug residue cause exporting limited healthy with the harm people, thereby make the use of antimicrobial drug receive very big restriction.
Therefore researching and developing a kind of specific medicament of treating the drug residue free of swine pasteurellosis, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment swine pasteurellosis of drug residue and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating swine pasteurellosis, by following component by weight mixed preparing form: propolis 15-35 part, Herba Houttuyniae 15-35 part, Flos Lonicerae 15-35 part, Radix Platycodonis 15-35 part, Fructus Gardeniae 15-45 part, Folium Isatidis 15-35 part, Flos Chrysanthemi Indici 15-40 part, Radix Scutellariae 15-45 part, Herba Artemisiae Annuae 15-45 part, Herba Verbenae 15-45 part.
On the basis of such scheme, said various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Herba Houttuyniae, 25 parts of Flos Loniceraes, 25 parts of Radix Platycodoniss, 30 parts of Fructus Gardeniaes, 25 parts of Folium Isatidiss, 25 parts of Flos Chrysanthemi Indicis, 30 parts of Radix Scutellariaes, 30 parts of Herba Artemisiae Annuaes, 30 parts of Herba Verbenae.
A kind of method for preparing of treating the compound bee-glue composition of swine pasteurellosis, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Herba Houttuyniae 15-35 part, Flos Lonicerae 15-35 part, Radix Platycodonis 15-35 part, Fructus Gardeniae 15-45 part by weight, mix 5-10 minute to even;
(3) take by weighing Folium Isatidis 15-35 part, Flos Chrysanthemi Indici 15-40 part, Radix Scutellariae 15-45 part, Herba Artemisiae Annuae 15-45 part, Herba Verbenae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, heat in blood epistaxis etc.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Platycodonis: bitter, hot, flat, return lung meridian, have lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Flos Chrysanthemi Indici: bitter, hot, be slightly cold, return liver, heart channel, have the function that heat-clearing and toxic substances removing, suppressing the hyperactive liver make eye bright; Cure mainly carbuncle sore tumefacting virus, conjunctival congestion and swelling pain etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, hyperpyrexia are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus etc.
Herba Artemisiae Annuae: bitter, hot, cold, return liver, gallbladder meridian, have heat-clearing and toxic substances removing, protozoacide function; Cure mainly coccidiosis, jaundice due to damp-heat etc.
Herba Verbenae: bitter, cool, return liver, spleen channel, have the function of promoting blood circulation to remove blood stasis, inducing diuresis to remove edema, heat-clearing and toxic substances removing; Cure mainly dysentery, jaundice, edema, abdominal distention, carbuncle sore tumefacting virus etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of swine pasteurellosis, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this ten flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment swine pasteurellosis there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition of treating swine pasteurellosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, 150 parts of Herba Houttuyniae, 150 parts of Flos Loniceraes, 150 parts of Radix Platycodoniss, 150 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;
(3) take by weighing 150 parts of Folium Isatidiss, 150 parts of Flos Chrysanthemi Indicis, 150 parts of Radix Scutellariaes, 150 parts of Herba Artemisiae Annuaes, 150 parts of Herba Verbenae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition of treating swine pasteurellosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, 250 parts of Herba Houttuyniae, 250 parts of Flos Loniceraes, 250 parts of Radix Platycodoniss, 300 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;
(3) take by weighing 250 parts of Folium Isatidiss, 250 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Scutellariaes, 300 parts of Herba Artemisiae Annuaes, 300 parts of Herba Verbenae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition of treating swine pasteurellosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 350 parts of propolis, 350 parts of Herba Houttuyniae, 350 parts of Flos Loniceraes, 350 parts of Radix Platycodoniss, 450 parts of Fructus Gardeniaes by weight, mix 5-10 minute to even;
(3) take by weighing 350 parts of Folium Isatidiss, 400 parts of Flos Chrysanthemi Indicis, 450 parts of Radix Scutellariaes, 450 parts of Herba Artemisiae Annuaes, 450 parts of Herba Verbenae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 200kg feeds, drinking-water 400kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment swine pasteurellosis:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 62.5 | 19.6 | 17.9 |
| II | Pig bacillus health is loose and is organized | 10.5 | 79.7 | 9.8 |
| III | Present composition group | 5.5 | 88.9 | 5.6 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with pig bacillus health and compared difference extremely significantly (P＜0.01) aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment swine pasteurellosis and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition of treating swine pasteurellosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Herba Houttuyniae 15-35 part, Flos Lonicerae 15-35 part, Radix Platycodonis 15-35 part, Fructus Gardeniae 15-45 part, Folium Isatidis 15-35 part, Flos Chrysanthemi Indici 15-40 part, Radix Scutellariae 15-45 part, Herba Artemisiae Annuae 15-45 part, Herba Verbenae 15-45 part.
2. a kind of compound bee-glue composition of treating swine pasteurellosis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Herba Houttuyniae, 25 parts of Flos Loniceraes, 25 parts of Radix Platycodoniss, 30 parts of Fructus Gardeniaes, 25 parts of Folium Isatidiss, 25 parts of Flos Chrysanthemi Indicis, 30 parts of Radix Scutellariaes, 30 parts of Herba Artemisiae Annuaes, 30 parts of Herba Verbenae.
3. the method for preparing of the compound bee-glue composition of a treatment swine pasteurellosis according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Herba Houttuyniae 15-35 part, Flos Lonicerae 15-35 part, Radix Platycodonis 15-35 part, Fructus Gardeniae 15-45 part by weight, mix 5-10 minute to even;
(3) take by weighing Folium Isatidis 15-35 part, Flos Chrysanthemi Indici 15-40 part, Radix Scutellariae 15-45 part, Herba Artemisiae Annuae 15-45 part, Herba Verbenae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (6)
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| CN103432215A (en) * | 2013-07-26 | 2013-12-11 | 清远容大生物工程有限公司 | Medicine used for preventing and treating high swine fever and preparation method thereof |
| CN103599350A (en) * | 2013-10-18 | 2014-02-26 | 赵刚 | Traditional Chinese medicine for treating swine plague |
| CN103599267A (en) * | 2013-10-18 | 2014-02-26 | 赵刚 | Traditional Chinese medicine for treating swine plague |
| CN103877505A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating swine pasteurellosis and preparation method thereof |
| CN104042868A (en) * | 2014-06-19 | 2014-09-17 | 南京麦思德餐饮管理有限公司 | Traditional Chinese medicine for preventing hemorrhagic septicemia of rex rabbits |
| CN106074880A (en) * | 2016-08-24 | 2016-11-09 | 贵州台江老里原生态农业特色有限公司 | A kind of prevent and treat swine flue, the Chinese medicine composition of pig lung plague and preparation method |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432215A (en) * | 2013-07-26 | 2013-12-11 | 清远容大生物工程有限公司 | Medicine used for preventing and treating high swine fever and preparation method thereof |
| CN103432215B (en) * | 2013-07-26 | 2016-03-02 | 广东容大生物股份有限公司 | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof |
| CN103599350A (en) * | 2013-10-18 | 2014-02-26 | 赵刚 | Traditional Chinese medicine for treating swine plague |
| CN103599267A (en) * | 2013-10-18 | 2014-02-26 | 赵刚 | Traditional Chinese medicine for treating swine plague |
| CN103599267B (en) * | 2013-10-18 | 2016-03-02 | 赵刚 | A kind of Chinese medicine for the treatment of swine pasteurellosis |
| CN103877505A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating swine pasteurellosis and preparation method thereof |
| CN104042868A (en) * | 2014-06-19 | 2014-09-17 | 南京麦思德餐饮管理有限公司 | Traditional Chinese medicine for preventing hemorrhagic septicemia of rex rabbits |
| CN106074880A (en) * | 2016-08-24 | 2016-11-09 | 贵州台江老里原生态农业特色有限公司 | A kind of prevent and treat swine flue, the Chinese medicine composition of pig lung plague and preparation method |
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Application publication date: 20120725 |