CN102397383B - Compound propolis pure Chinese medicinal composition for treating avian spirochaetosis and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating the avian spirochaetosis and a preparation method thereof, relating to the field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components in a formula respectively, and sieving with a 700-mesh sieve; (2) weighing 15-40 parts by weight of propolis, 15-35 parts by weight of Chinese pulsatilla root and 15-35 parts by weight of coptis root, and mixing for 5-10 minutes to uniform state; (3) weighing 10-45 parts by weight of sweet wormwood herb, 15-35 parts by weight of heartleaf houttuynia herb, 10-30 parts by weight of yerbadetajo herb and 10-40 parts by weight of mung bean, and mixing for 5-10 minutes to uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the pure Chinese medicinal composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and remarkable curative effect; and as proved by clinical application, the pure Chinese medicinal composition has a special treatment effect on the avian spirochaetosis.

Description

A kind of compound bee-glue Chinese medicine composition for the treatment of avian spirochaetosis and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of compound propolis pure Chinese medicinal composition for the treatment of avian spirochaetosis and preparation method thereof.

Background technology

Avian spirochaetosis is that various age in days poultry and season all can infect by a kind of birds septic infectious disease due to the goose Bollinger body spirillum, and take diarrhoea, heating, anorexia and head cyanosis as feature, mortality rate is very high, very harmful to poultry.

The pathogen of primary disease is goose Bollinger body spirillum, and this disease is widely distributed.At present, treat this disease the most frequently used be various antibacterials, such as penicillin, florfenicol, kanamycin sulfate, ciprofloxacin etc.; Because the prolonged and repeated use of antibacterials causes this pathogenic microorganism that medicine has been produced drug resistance, reduced curative effect, and drug residue in animal body, its meat does not reach nuisanceless requirement, has affected the healthy of the outlet of poultry product and people.

Therefore researching and developing a kind of specific medicament for the treatment of avian spirochaetosis is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, have no drug resistance and the compound propolis pure Chinese medicinal composition of effective treatment avian spirochaetosis of toxic and side effects and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound propolis pure Chinese medicinal composition for the treatment of avian spirochaetosis, by following component by weight mixed preparing form: propolis 15-40 part, Radix Pulsatillae 15-35 part, Rhizoma Coptidis 15-35 part, Herba Artemisiae Annuae 15-45 part, Herba Houttuyniae 15-35 part, Herba Ecliptae 10-30 part, Semen phaseoli radiati 10-40 part.

Described various component optimum ratio amount is: 25 parts of propolis, 25 parts of the Radix Pulsatillaes, 25 parts of Rhizoma Coptidis, 30 parts of Herba Artemisiae Annuaes, 25 parts of Herba Houttuyniae, 20 parts of Herba Ecliptaes, 30 parts in Semen phaseoli radiati.

A kind of preparation method for the treatment of the compound propolis pure Chinese medicinal composition of avian spirochaetosis, carry out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight propolis 15-40 part, Radix Pulsatillae 15-35 part, Rhizoma Coptidis 15-35 part, mix 5-10 minute to even;

(3) take by weighing by weight Herba Artemisiae Annuae 15-45 part, Herba Houttuyniae 15-35 part, Herba Ecliptae 10-30 part, Semen phaseoli radiati 10-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis protozoacide, protection gastrointestinal mucosa.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.

Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.

Herba Artemisiae Annuae: bitter, hot, cold, return liver, gallbladder meridian, have the function of clearing away summer-heat, reducing the asthenic fever, protozoacide; Cure mainly diseases caused by exogenous pathogenic factor summer-heat, fever due to yin deficiency, jaundice due to damp-heat, babesiasis, coccidiosis etc.

Herba Houttuyniae: hot, be slightly cold, return lung meridian, have the function of heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome; Cure mainly lung abscess, intestinal Huang, dysentery, stranguria with turbid discharge etc.

Herba Ecliptae: sweet, sour, cold, return kidney, Liver Channel, have the function of cooling blood for hemostasis, nourishing the liver and kidney; It is unable etc. to cure mainly YinXuXueRe, epistaxis, hematuria, dysentery, waist hip.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, detoxifcation protect the liver, antiallergic etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for avian spirochaetosis pathogenic microorganism and clinical symptoms, the performance treating both the principal and secondary aspects of a disease effect.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention optimizes this seven flavors Chinese medicine, and makes them form pure Chinese powder medicine according to optimum ratio according to Chinese veterinarian's traditional theory, and clinical practice proves that the treatment avian spirochaetosis is had specially good effect.And make the poultry product meat reach nuisanceless requirement, satisfy the export standard of poultry product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound propolis pure Chinese medicinal composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 150 parts of propolis, 150 parts of the Radix Pulsatillaes, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 150 parts of Herba Artemisiae Annuaes, 150 parts of Herba Houttuyniae, 100 parts of Herba Ecliptaes, 100 parts in Semen phaseoli radiati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound propolis pure Chinese medicinal composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 250 parts of propolis, 250 parts of the Radix Pulsatillaes, 250 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 300 parts of Herba Artemisiae Annuaes, 250 parts of Herba Houttuyniae, 200 parts of Herba Ecliptaes, 250 parts in Semen phaseoli radiati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound propolis pure Chinese medicinal composition for the treatment of avian spirochaetosis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 400 parts of propolis, 350 parts of the Radix Pulsatillaes, 350 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing by weight 450 parts of Herba Artemisiae Annuaes, 350 parts of Herba Houttuyniae, 300 parts of Herba Ecliptaes, 400 parts in Semen phaseoli radiati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 210kg feeds, and drinking-water 420kg, is used in conjunction 3-5 day at every day 2-3 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment avian spirochaetosis:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	11.2	73.1	15.7
II	The florfenicol group	7.2	83.9	8.9
					III	The penicillin group	6.2	85.2	8.6
IV	The ciprofloxacin group	6.8	85.4	7.8
					V	Chinese medicine composition group of the present invention	4.2	92.3	3.5

This clinical effectiveness statistical analysis, present composition treatment group are compared difference all remarkable (P＜0.05) with florfenicol group, penicillin group, ciprofloxacin group.

Above-mentioned detailed description of compound propolis pure Chinese medicinal composition of this treatment avian spirochaetosis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound bee-glue Chinese medicine composition for the treatment of avian spirochaetosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-40 part, Radix Pulsatillae 15-35 part, Rhizoma Coptidis 15-35 part, Herba Artemisiae Annuae 15-45 part, Herba Houttuyniae 15-35 part, Herba Ecliptae 10-30 part, Semen phaseoli radiati 10-40 part.

2. the compound bee-glue Chinese medicine composition for the treatment of avian spirochaetosis according to claim 1 is characterized in that described various component optimum ratio amount is: 25 parts of propolis, 25 parts of the Radix Pulsatillaes, 25 parts of Rhizoma Coptidis, 30 parts of Herba Artemisiae Annuaes, 25 parts of Herba Houttuyniae, 20 parts of Herba Ecliptaes, 30 parts in Semen phaseoli radiati.

3. the preparation method of the compound bee-glue Chinese medicine composition of a treatment avian spirochaetosis according to claim 1 and 2 is characterized in that carrying out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight propolis 15-40 part, Radix Pulsatillae 15-35 part, Rhizoma Coptidis 15-35 part, mix 5-10 minute to even;

(3) take by weighing by weight Herba Artemisiae Annuae 15-45 part, Herba Houttuyniae 15-35 part, Herba Ecliptae 10-30 part, Semen phaseoli radiati 10-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.