CN102600259B - Complex propolis composition for treating eperythrozoon suis and preparation method thereof - Google Patents
Complex propolis composition for treating eperythrozoon suis and preparation method thereof Download PDFInfo
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- CN102600259B CN102600259B CN2011104342682A CN201110434268A CN102600259B CN 102600259 B CN102600259 B CN 102600259B CN 2011104342682 A CN2011104342682 A CN 2011104342682A CN 201110434268 A CN201110434268 A CN 201110434268A CN 102600259 B CN102600259 B CN 102600259B
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Abstract
The invention relates to a complex propolis composition for treating eperythrozoon suis and a preparation method thereof, and relates to the animal medicine field. The preparation method comprises the following steps that (1) each ingredient in the prescription is respectively micro-smashed to pass through a 700-mesh sieve; (2) 15 to 30 parts of propolis, 15 to 35 parts of rhizoma coptidis, 15 to 45 parts of Chinese bulbul and 15 to 35 parts of rhubarb are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; (3) 15 to 45 parts of kuh-seng, 15 to 35 parts of cortex meliae, 15 to 40 parts of radix codonopsitis, 15 to 45 parts of radix dichroae and 15 to 45 parts of southernwood are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; and (4) compositions respectively prepared in steps (2) and (3) are mixed to be continuously blended for 10 to 15 minutes until being uniformly blended. The complex propolis composition has beneficial effects that the prescription is reasonable, simplicity in preparation is realized, and the composition is toxic-free, has no side effect and is free from pollution, medicinal residue and drug resistance. Being micro-smashed, the biological availability is high, the curative effect is very remarkable, and a specially good effect on treating eperythrozoon suis is clinically proved.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine eperythrozoonosis and preparation method thereof.
Background technology
Swine eperythrozoonosis is the boar infectious disease that anemia, jaundice, heating be feature of take caused by eperythrozoon suis.The pig of various ages and kind all can occur, and sick temperature of pig body raises, skin rubefaction, and constipation or diarrhoea, visual mucosa swelling flushing, packed cell volume reduces, organa parenchymatosum's enlargement, xanthochromia or hyperemia; Case fatality rate is between 30%-80%.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.
This disease almost spreads all over all countries of raising pigs in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug has drug residue and easily produces drug resistance due to life-time service, and worse and worse, and drug residue causes exporting limited and the harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop and a kind ofly treat the drug residue free of swine eperythrozoonosis, the specific medicament produced that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment swine eperythrozoonosis of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of swine eperythrozoonosis, by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Sophorae Flavescentiss, 25 parts of Cortex Meliaees, 25 parts of Radix Codonopsis, 30 parts of Radix Dichroaes, 30 parts of Herba Artemisiae Annuaes.
A kind of preparation method for the treatment of the compound bee-glue composition of swine eperythrozoonosis, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, stomach, large intestine, the heart, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery, jaundice, edema, scabies etc.
Cortex Meliae: hot, cold, return stomach, spleen, Liver Channel, there is the function of parasite killing, treatment tinea; Cure mainly abdominal pain due to worm stagnation, scabies etc.
Radix Codonopsis: sweet, flat, return spleen, lung meridian, there is the functions such as invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down de-etc.
Radix Dichroae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of parasite killing, expectorant removing food stagnancy; Curing mainly protozoacide, the impaction of rumen, phlegm retention gathers etc.
Herba Artemisiae Annuae: bitter, acrid, cold, return liver, gallbladder meridian, there is the function of clearing away summer-heat, reducing the asthenic fever, protozoacide; Cure mainly protozoacide, babesiasis, jaundice due to damp-heat etc.
Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of swine eperythrozoonosis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this nine flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, the treatment swine eperythrozoonosis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Rhizoma Coptidis, 150 parts of the Radix Pulsatillaes, 150 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Sophorae Flavescentiss, 150 parts of Cortex Meliaees, 150 parts of Radix Codonopsis, 150 parts of Radix Dichroaes, 150 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of Rhizoma Coptidis, 300 parts of the Radix Pulsatillaes, 250 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 300 parts of Radix Sophorae Flavescentiss, 250 parts of Cortex Meliaees, 250 parts of Radix Codonopsis, 300 parts of Radix Dichroaes, 300 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 300 parts of propolis, 350 parts of Rhizoma Coptidis, 450 parts of the Radix Pulsatillaes, 350 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 450 parts of Radix Sophorae Flavescentiss, 350 parts of Cortex Meliaees, 400 parts of Radix Codonopsis, 450 parts of Radix Dichroaes, 450 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 210kg feeds, and drinking-water 400kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment swine eperythrozoonosis:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 35.9 | 54.5 | 18.6 |
| II | Attached red dissipation group | 11.7 | 79.0 | 9.3 |
| III | Present composition group | 5.4 | 90.5 | 4.1 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P<0.01) with the attached red dissipation group of pig aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment swine eperythrozoonosis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. a compound bee-glue composition for the treatment of swine eperythrozoonosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part; Concrete preparation method following steps are carried out:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
2. a kind of compound bee-glue composition for the treatment of swine eperythrozoonosis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Sophorae Flavescentiss, 25 parts of Cortex Meliaees, 25 parts of Radix Codonopsis, 30 parts of Radix Dichroaes, 30 parts of Herba Artemisiae Annuaes.
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| CN2011104342682A CN102600259B (en) | 2011-12-22 | 2011-12-22 | Complex propolis composition for treating eperythrozoon suis and preparation method thereof |
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| CN2011104342682A CN102600259B (en) | 2011-12-22 | 2011-12-22 | Complex propolis composition for treating eperythrozoon suis and preparation method thereof |
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| CN103652449B (en) * | 2013-12-09 | 2015-01-07 | 山东新希望六和集团有限公司 | Feed for treating Eperythrozoon suis, and preparation method thereof |
| CN105769988A (en) * | 2014-12-26 | 2016-07-20 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for treating swine eperythrozoonosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879201A (en) * | 2010-07-02 | 2010-11-10 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for preventing and curing eperythrozoonosis of pigs, sheep and cows and preparation method thereof |
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| US7889334B2 (en) * | 2005-03-15 | 2011-02-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof |
| US20090068218A1 (en) * | 2005-09-09 | 2009-03-12 | Universitat Zurich | Antigens for Vaccination Against and Detection of Mycoplasma Suis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879201A (en) * | 2010-07-02 | 2010-11-10 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for preventing and curing eperythrozoonosis of pigs, sheep and cows and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘家国等.第八章 近年来猪出现的新病及疑难杂症.《土法良方治猪病》.化学工业出版社,2010,(第1版),第289-290页，尤其是第290页方2、4、5. * |
| 程玮等.苦楝皮乙醇提取物驱除猪蛔虫效果研究及对猪主要免疫指标的影响.《中兽医医药杂志》.2009,(第1期),第15-17页，尤其是第17页右栏第1段. |
| 苦楝皮乙醇提取物驱除猪蛔虫效果研究及对猪主要免疫指标的影响;程玮等;《中兽医医药杂志》;20091231(第1期);第15-17页，尤其是第17页右栏第1段 * |
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