CN103055090B - Pure Chinese medicinal composition for treating fowl cholera and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating fowl cholera and preparation method of pure Chinese medicinal composition Download PDFInfo
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- CN103055090B CN103055090B CN201210549115.7A CN201210549115A CN103055090B CN 103055090 B CN103055090 B CN 103055090B CN 201210549115 A CN201210549115 A CN 201210549115A CN 103055090 B CN103055090 B CN 103055090B
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Abstract
The invention relates to a pure Chinese medicinal composition for treating fowl cholera. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 15 to 35 parts of ovate leaf holly bark, 15 to 35 parts of folium eucalypti, 15 to 25 parts of Chinese brake herb, 15 to 35 parts of costus root, 15 to 25 parts of areca catechu, 15 to 45 parts of talc, 15 to 45 parts of mung bean, 15 to 25 parts of dioscorea bulbifera l, 15 to 35 parts of oriental stephania root and 15 to 35 parts of licorice root. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, pollution, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the fowl cholera.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of fowl cholera and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment fowl cholera and preparation method thereof.
Background technology
Fowl cholera claims again fowl pasteurellosis, fowl hueppe's disease, it is a kind of main contagious disease of encroaching on the birdss such as chicken, duck, goose, turkey being caused by pasteurella multocida, various age in days poultry and season all can infect, taking diarrhoea and septicemia as feature, mortality rate is very high, very harmful to poultry.
The pathogen of primary disease is pasteurella multocida, and this disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antibacterials, as colistine sulfate, florfenicol, kanamycin sulfate, ciprofloxacin etc.; Due to the prolonged and repeated use of antibacterials, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal body, its meat does not reach nuisanceless requirement, has affected the healthy of the outlet of poultry product and people.
Therefore researching and developing a kind of specific medicament for the treatment of fowl cholera is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment fowl cholera of toxic and side effects and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of fowl cholera, by following component by weight mixed preparing form: Cortex Ilicis Rotundae 15-35 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-35 part, Herba Pteridis Multifidae 15-25 part, Radix Aucklandiae 15-35 part, Semen Arecae 15-25 part, Talcum 15-45 part, Semen phaseoli radiati 15-45 part, Rhizoma Dioscoreae Bulbiferae 15-25 part, Radix Stephaniae Cepharanthae 15-35 part, Radix Glycyrrhizae 15-35 part.
Described various component optimum ratio amount is: 25 parts of Cortex Ilicis Rotundaes, 25 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 20 parts of Herba Pteridis Multifidaes, 25 parts of the Radix Aucklandiae, 20 parts of Semen Arecaes, 30 parts, Talcum, 30 parts, Semen phaseoli radiati, 20 parts of Rhizoma Dioscoreae Bulbiferaes, 25 parts of Radix Stephaniae Cepharanthaes, 25 parts, Radix Glycyrrhizae.
Treat a preparation method for the pure Chinese medicine composition of fowl cholera, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Cortex Ilicis Rotundae 15-35 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-35 part, Herba Pteridis Multifidae 15-25 part, Radix Aucklandiae 15-35 part, Semen Arecae 15-25 part, mix 5-10 minute to even;
(3) take by weight Talcum 15-45 part, Semen phaseoli radiati 15-45 part, Rhizoma Dioscoreae Bulbiferae 15-25 part, Radix Stephaniae Cepharanthae 15-35 part, Radix Glycyrrhizae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Cortex Ilicis Rotundae: bitter, cold, return lung, liver, large intestine channel, there is the function of heat-clearing and toxic substances removing, dampness removing, pain relieving; Cure mainly that cold, fever, laryngopharynx swelling and pain, stomachache, administration's diarrhea due to damp pathogen rush down, jaundice, dysentery, traumatic injury, rheumatic arthralgia, eczema, furuncle etc.
Folium eucalypti globueli (Eucalyptus globulus Labill.): pungent, bitter, cold, return lung, liver, spleen, stomach warp, there is the function of dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching; Cure mainly that flu, high dyspnea of heat type are coughed, abdominal distention, rheumatalgia, eczema, scabies etc.
Herba Pteridis Multifidae: bitter, cold, return lung, liver, large intestine, stomach, urinary bladder channel, there is the function of anticancer, the removing damp-heat of relieving internal heat, cooling blood for hemostasis; Cure mainly that damp and hot inflammation, heat in blood are hemorrhage, dysentery etc.
The Radix Aucklandiae: bitter, pungent, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, there is the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, stomach function regulating antidiarrheal; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe is swollen, weight, stomachache etc. after dysentery.
Semen Arecae: bitter, pungent, warm, return stomach, large intestine channel, there is the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, edema etc.
Talcum: bitter, sweet, cold, return lung, stomach, kidney channel, there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, yin asthenia generating intrinsic heat etc.
Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, removing toxic substances protect the liver, antiallergic etc.
Rhizoma Dioscoreae Bulbiferae: bitter, flat, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, the clear wart of removing heat from blood; Cure mainly laryngopharynx swelling and pain, dry cough without phlegm, carbuncle sore tumefacting virus, haematemesis, spitting of blood etc.
Radix Stephaniae Cepharanthae: bitter, pungent, cool, return spleen, stomach, lung meridian, there is the function of heat-clearing and toxic substances removing, wind-expelling pain-stopping, cooling blood for hemostasis; Cure mainly laryngopharynx swelling and pain, pyretic toxicity carbuncle, rheumatic arthralgia, stomachache, dysentery, haematemesis, epistaxis etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and the clinical symptoms of fowl cholera, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment fowl cholera is had to specially good effect.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively ensured that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of fowl cholera and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Cortex Ilicis Rotundaes, 150 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 150 parts of Herba Pteridis Multifidaes, 150 parts of the Radix Aucklandiae, 150 parts of Semen Arecaes, mix 5-10 minute to even;
(3) take by weight 150 parts, Talcum, 150 parts, Semen phaseoli radiati, 150 parts of Rhizoma Dioscoreae Bulbiferaes, 150 parts of Radix Stephaniae Cepharanthaes, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of fowl cholera and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Cortex Ilicis Rotundaes, 250 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 200 parts of Herba Pteridis Multifidaes, 250 parts of the Radix Aucklandiae, 200 parts of Semen Arecaes, mix 5-10 minute to even;
(3) take by weight 300 parts, Talcum, 300 parts, Semen phaseoli radiati, 200 parts of Rhizoma Dioscoreae Bulbiferaes, 250 parts of Radix Stephaniae Cepharanthaes, 250 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of fowl cholera and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Cortex Ilicis Rotundaes, 350 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 250 parts of Herba Pteridis Multifidaes, 350 parts of the Radix Aucklandiae, 250 parts of Semen Arecaes, mix 5-10 minute to even;
(3) take by weight 450 parts, Talcum, 450 parts, Semen phaseoli radiati, 250 parts of Rhizoma Dioscoreae Bulbiferaes, 350 parts of Radix Stephaniae Cepharanthaes, 350 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-40 age in days, body weight at 1.0kg-1.5kg, the ill broiler that Laboratory Diagnosed is chicken cholera.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 220kg feeds, and the 410kg that drinks water, is used in conjunction 3-5 day at every day 2-3 time; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.
Table is the situation contrast of the present invention and other medicines treatment fowl cholera:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 12.0 | 62.0 | 26.0 |
| II | Florfenicol group | 8.0 | 80.0 | 12.0 |
| III | Kanamycin sulfate group | 8.0 | 83.0 | 9.0 |
| IV | Chinese medicine composition group of the present invention | 6.0 | 90.0 | 4.0 |
This clinical effectiveness statistical analysis, present composition treatment group is extremely significantly (P < 0.01) or remarkable (P < 0.05) of difference compared with florfenicol group, kanamycin sulfate group.
Safety testing:
Choose 60 of the healthy broiler of 150 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 1 or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that compound propolis pure Chinese medicinal composition to this treatment fowl cholera and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. treat a pure Chinese medicine composition for fowl cholera, it is characterized in that by following component by weight mixed preparing form: Cortex Ilicis Rotundae 15-35 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-35 part, Herba Pteridis Multifidae 15-25 part, Radix Aucklandiae 15-35 part, Semen Arecae 15-25 part, Talcum 15-45 part, Semen phaseoli radiati 15-45 part, Rhizoma Dioscoreae Bulbiferae 15-25 part, Radix Stephaniae Cepharanthae 15-35 part, Radix Glycyrrhizae 15-35 part; Concrete preparation method is carried out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Cortex Ilicis Rotundae 15-35 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-35 part, Herba Pteridis Multifidae 15-25 part, Radix Aucklandiae 15-35 part, Semen Arecae 15-25 part, mix 5-10 minute to even;
(3) take by weight Talcum 15-45 part, Semen phaseoli radiati 15-45 part, Rhizoma Dioscoreae Bulbiferae 15-25 part, Radix Stephaniae Cepharanthae 15-35 part, Radix Glycyrrhizae 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
2. the pure Chinese medicine composition for the treatment of fowl cholera according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Cortex Ilicis Rotundaes, 25 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 20 parts of Herba Pteridis Multifidaes, 25 parts of the Radix Aucklandiae, 20 parts of Semen Arecaes, 30 parts, Talcum, 30 parts, Semen phaseoli radiati, 20 parts of Rhizoma Dioscoreae Bulbiferaes, 25 parts of Radix Stephaniae Cepharanthaes, 25 parts, Radix Glycyrrhizae.
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| CN104436161A (en) * | 2014-11-12 | 2015-03-25 | 中国农业科学院哈尔滨兽医研究所 | Pteris multifida and colistin-containing compound drug for livestock and poultry |
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| CN101342351B (en) * | 2008-08-25 | 2010-10-06 | 河北农业大学 | Medicine for preventing and treating colibacillosis of poultry |
| CN101972419A (en) * | 2010-08-25 | 2011-02-16 | 天津生机集团股份有限公司 | Medicinal composition for preventing sunstroke and reducing temperature of milk cow and preparation method thereof |
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