CN103055206B - Pure Chinese medicinal composition for treating chicken colibacillosis and pullorum disease and preparation method thereof - Google Patents
Pure Chinese medicinal composition for treating chicken colibacillosis and pullorum disease and preparation method thereof Download PDFInfo
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- CN103055206B CN103055206B CN201210549178.2A CN201210549178A CN103055206B CN 103055206 B CN103055206 B CN 103055206B CN 201210549178 A CN201210549178 A CN 201210549178A CN 103055206 B CN103055206 B CN 103055206B
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Abstract
The invention relates to a pure Chinese medicinal composition for treating chicken colibacillosis and pullorum disease. The composition is prepared by mixing the following components in part by weight: 15 to 25 parts of dangshen, 15 to 35 parts of astragalus, 15 to 25 parts of coptis root, 15 to 25 parts of weeping forsythia, 15 to 25 parts of red-rooted salvia root, 15 to 25 parts of common anemarrhena, 10 to 30 parts of red paeony root, 15 to 25 parts of giant knotweed, 15 to 35 parts of garden burnet root, 15 to 35 parts of malt, 15 to 40 parts of tuckahoe and 15 to 25 parts of liquorice root. The pure Chinese medicinal composition is reasonable in formula, is easy to prepare, does not have any toxic or side effect, is subjected to superfine grinding, is high in bioavailability, has a very obvious curative effect and is clinically proven to have a special effect of treating chicken colibacillosis and pullorum disease, and pollution, medicine residue and medicine resistance are avoided.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of chickling colibacillosis and Pullorum Disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment chickling colibacillosis and Pullorum Disease and preparation method thereof.
Background technology
In the stage of brooding, the modal disease of chickling is exactly colibacillosis and Pullorum Disease.Chicken colibacillosis is the acute or chronic bacterial sexually transmitted disease of the one that caused by Escherichia coli, and the chicken at different cultivars and each age all can infection morbidity, and young bird and growing chickens, to the susceptible of primary disease, all can occur throughout the year, but with comparatively common at the beginning of last month of spring in winter.Chickling colibacillosis is clinically take acute septic, yolk peritonitis, omphalitis, airsacculitis, panophthalmitis, articular synovitis etc. as principal character, and mortality rate is very high, very harmful to chickling.
Pullorum Disease is by the salmonellal infectious disease of Pullorum Disease, all has generation all over the world, is one of disease that harm poultry husbandry is the most serious, main infection chickling.Chickling cardinal symptom and pathological changes show as and do not eat feedstuff, are afraid of cold, spirit is depressed or lethargy, row's white thickness or yellowish, light green loose stool, dyspnea.Cut open the visible hepatomegaly of inspection, hyperemia, have the little downright bad point of many yellow-whites.Absorption of yolk at its is bad, the necrosis region that has yellow-white to differ in size in lung, and caecum expands, and enteral has cheese sample concretion.When the course of disease is longer, at the white Hakuri tuberosity of the visible protuberance to position such as cardiac muscle, muscular stomach, intestinal tube.Primary disease mortality rate is very high, very harmful to chickling.
These two kinds of diseases spread all over more than 100 countries of five continents, are widely distributed.At present, treat this disease the most frequently used be various antibacterials, as colistine sulfate, florfenicol, kanamycin sulfate, ciprofloxacin etc.; Due to the prolonged and repeated use of antibacterials, cause pathogenic microorganism to produce drug resistance to medicine, reduce curative effect; Due to the toxic and side effects of antibacterials, the growth promoter of chickling has been caused to serious injury, affect the healthy growth of chickling; And drug residue in animal body, its poultry product does not reach nuisanceless requirement, has affected the healthy of the outlet of poultry product and people.
Therefore researching and developing a kind of specific medicament for the treatment of chickling colibacillosis and Pullorum Disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, have no drug resistance and effective treatment chickling colibacillosis of toxic and side effects and pure Chinese medicine composition of Pullorum Disease and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of chickling colibacillosis and Pullorum Disease, by following component by weight mixed preparing form: Radix Codonopsis 15-25 part, Radix Astragali 15-35 part, Rhizoma Coptidis 15-25 part, Fructus Forsythiae 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Anemarrhenae 15-25 part, Radix Paeoniae Rubra 10-30 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Sanguisorbae 15-35 part, Fructus Hordei Germinatus 15-35 part, Poria 15-40 part, Radix Glycyrrhizae 15-25 part.
Described various component optimum ratio amount is: 20 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 20 parts of Rhizoma Coptidis, 20 parts of Fructus Forsythiaes, 20 parts of Radix Salviae Miltiorrhizaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Rhizoma Polygoni Cuspidati, 25 parts of Radix Sanguisorbaes, 25 parts, Fructus Hordei Germinatus, 25 parts, Poria, 20 parts, Radix Glycyrrhizae.
Treat a preparation method for the pure Chinese medicine composition of chickling colibacillosis and Pullorum Disease, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Codonopsis 15-25 part, Radix Astragali 15-35 part, Rhizoma Coptidis 15-25 part, Fructus Forsythiae 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Anemarrhenae 15-25 part, mix 5-10 minute to even;
(3) take by weight Radix Paeoniae Rubra 10-30 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Sanguisorbae 15-35 part, Fructus Hordei Germinatus 15-35 part, Poria 15-40 part, Radix Glycyrrhizae 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Radix Codonopsis: sweet, flat, return spleen, lung meridian, there is the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down de-etc.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Radix Salviae Miltiorrhizae: bitter, be slightly cold, GUIXIN, Liver Channel, have the function of blood circulation promoting and blood stasis dispelling, pain relieving, nourishing blood to tranquillize the mind, removing heat from blood eliminating carbuncle; Cure mainly stagnation of QI-blood, the yellow furunculosis of skin ulcer, lochiorrhea etc.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, yin asthenia generating intrinsic heat etc.
Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, there is the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, carbuncle skin infection etc.
Rhizoma Polygoni Cuspidati: bitter, cold, return liver, gallbladder, lung meridian, there is the function of heat-clearing and toxic substances removing, dampness removing jaundice eliminating, the analgesic therapy of invigorating blood circulation, relieving cough and resolving phlegm; Cure mainly jaundice due to damp-heat, puerperal blood stasis, stranguria with turbid discharge, rheumatic arthralgia, carbuncle sore tumefacting virus, cough due to lung-heat etc.
Radix Sanguisorbae: bitter, sour, puckery, be slightly cold, return liver, large intestine channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, epistaxis, the yellow furunculosis of skin ulcer etc.
Fructus Hordei Germinatus: sweet, flat, return spleen, stomach warp, there is the function of spleen benefiting and stimulating the appetite, promote qi circulation digestion promoting; Cure mainly that food stagnation does not disappear, tripe is swollen etc.
Poria: sweet, light, flat, return kidney, urinary bladder channel, there is the function of inducing diuresis to remove edema; Cure mainly edema, dysuria etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine, according to the theoretical compatible combination of Chinese veterinarian, for pathogenic microorganism and clinical symptoms and the pathological change of chickling colibacillosis and Pullorum Disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition has no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this 12 taste Chinese medicine, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment chickling colibacillosis and Pullorum Disease are had to specially good effect.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of chickling colibacillosis and Pullorum Disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Radix Codonopsis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Coptidis, 150 parts of Fructus Forsythiaes, 150 parts of Radix Salviae Miltiorrhizaes, 150 parts of the Rhizoma Anemarrhenaes, mix 5-10 minute to even;
(3) take by weight 100 parts of Radix Paeoniae Rubra, 150 parts of Rhizoma Polygoni Cuspidati, 150 parts of Radix Sanguisorbaes, 150 parts, Fructus Hordei Germinatus, 150 parts, Poria, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of chickling colibacillosis and Pullorum Disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 200 parts of Radix Codonopsis, 250 parts of the Radixs Astragali, 200 parts of Rhizoma Coptidis, 200 parts of Fructus Forsythiaes, 200 parts of Radix Salviae Miltiorrhizaes, 200 parts of the Rhizoma Anemarrhenaes, mix 5-10 minute to even;
(3) take by weight 200 parts of Radix Paeoniae Rubra, 200 parts of Rhizoma Polygoni Cuspidati, 250 parts of Radix Sanguisorbaes, 250 parts, Fructus Hordei Germinatus, 250 parts, Poria, 200 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of chickling colibacillosis and Pullorum Disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Radix Codonopsis, 350 parts of the Radixs Astragali, 250 parts of Rhizoma Coptidis, 250 parts of Fructus Forsythiaes, 250 parts of Radix Salviae Miltiorrhizaes, 250 parts of the Rhizoma Anemarrhenaes, mix 5-10 minute to even;
(3) take by weight 300 parts of Radix Paeoniae Rubra, 250 parts of Rhizoma Polygoni Cuspidati, 350 parts of Radix Sanguisorbaes, 350 parts, Fructus Hordei Germinatus, 400 parts, Poria, 250 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 12-15 age in days, body weight at 0.4kg-0.5kg, the ill broiler that Laboratory Diagnosed is chicken colibacillosis.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill poultry of feeding etc., and a day dose is: feed or the 150kg that drinks water by the every 100g spice of the present invention 100kg, every day 2-3 time, be used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Result (testing the 5th day) when following table is experiment end.
Table 1 is the applicable cases contrast of the present invention and other medicines treatment poultry colibacillosis:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 17 | 48 | 35 |
| II | The Radix Pulsatillae group of faling apart | 7 | 81 | 12 |
| III | Chinese medicine composition group of the present invention | 5 | 89 | 6 |
This clinical experiment result statistical analysis, present composition treatment group is significant difference (P < 0.05) compared with the loose group of the Radix Pulsatillae.
Clinical experiment animal selects 15-17 age in days, body weight at 0.5kg-0.6kg, the ill broiler that Laboratory Diagnosed is Pullorum Disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill poultry of feeding etc., and a day dose is: feed or the 150kg that drinks water by the every 100g spice of the present invention 100kg, every day 2-3 time, be used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Result (testing the 5th day) when following table is experiment end.
Table 2 is applicable cases contrasts of the present invention and other medicines treatment Pullorum Disease:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 15 | 55 | 30 |
| II | The Radix Pulsatillae group of faling apart | 8 | 80 | 12 |
| III | Chinese medicine composition group of the present invention | 4 | 90 | 6 |
This clinical experiment result statistical analysis, present composition treatment group is extremely significantly (P < 0.01) of difference compared with the loose group of the Radix Pulsatillae.
Safety testing:
Choose 60 of the healthy broiler of 10 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 1 or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that pure Chinese medicine composition to this treatment chickling colibacillosis and Pullorum Disease and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for chickling colibacillosis and Pullorum Disease, it is characterized in that by following component by weight mixed preparing form: Radix Codonopsis 15-25 part, Radix Astragali 15-35 part, Rhizoma Coptidis 15-25 part, Fructus Forsythiae 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Anemarrhenae 15-25 part, Radix Paeoniae Rubra 10-30 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Sanguisorbae 15-35 part, Fructus Hordei Germinatus 15-35 part, Poria 15-40 part, Radix Glycyrrhizae 15-25 part.
2. the pure Chinese medicine composition for the treatment of according to claim 1 chickling colibacillosis and Pullorum Disease, it is characterized in that by following component by weight mixed preparing form: 20 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 20 parts of Rhizoma Coptidis, 20 parts of Fructus Forsythiaes, 20 parts of Radix Salviae Miltiorrhizaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Rhizoma Polygoni Cuspidati, 25 parts of Radix Sanguisorbaes, 25 parts, Fructus Hordei Germinatus, 25 parts, Poria, 20 parts, Radix Glycyrrhizae.
3. a preparation method for the pure Chinese medicine composition for the treatment of chickling colibacillosis according to claim 1 and Pullorum Disease, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Codonopsis 15-25 part, Radix Astragali 15-35 part, Rhizoma Coptidis 15-25 part, Fructus Forsythiae 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Anemarrhenae 15-25 part, mix 5-10 minute to even;
(3) take by weight Radix Paeoniae Rubra 10-30 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Sanguisorbae 15-35 part, Fructus Hordei Germinatus 15-35 part, Poria 15-40 part, Radix Glycyrrhizae 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN201210549178.2A CN103055206B (en) | 2012-12-05 | 2012-12-05 | Pure Chinese medicinal composition for treating chicken colibacillosis and pullorum disease and preparation method thereof |
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| CN201210549178.2A CN103055206B (en) | 2012-12-05 | 2012-12-05 | Pure Chinese medicinal composition for treating chicken colibacillosis and pullorum disease and preparation method thereof |
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| CN103520582A (en) * | 2013-09-27 | 2014-01-22 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of colibacillosis of poultry and preparation method thereof |
| CN105617017A (en) * | 2014-11-03 | 2016-06-01 | 王巧丽 | Composition used for preventing and treating dysentery of free range chicks |
| CN112451589B (en) * | 2020-12-18 | 2022-05-27 | 河南科技大学 | Pharmaceutical composition for treating pullorum disease and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101543262A (en) * | 2009-04-20 | 2009-09-30 | 邹振可 | Chinese medicinal herb additive for egg chickens and application |
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| CN101543262A (en) * | 2009-04-20 | 2009-09-30 | 邹振可 | Chinese medicinal herb additive for egg chickens and application |
Non-Patent Citations (2)
| Title |
|---|
| 《中草药防治鸡病的饲养模式探讨》;雷红等;《中兽医学杂志》;20021231(第2期);36-39 * |
| 雷红等.《中草药防治鸡病的饲养模式探讨》.《中兽医学杂志》.2002,(第2期),36-39. |
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