CN102961636B - Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure traditional Chinese medicine composition for treating poultry infectious bursal disease and a preparation method thereof. The pure traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of dandelion, 15-25 parts of Chinese violet, 15-35 parts of rhizoma phragmitis, 15-25 parts of cortex moutan, 15-35 parts of codonopsis pilosula, 15-35 parts of liquorice, 15-25 parts of poria, 15-45 parts of tangerine peel, 15-45 parts of astragalus and 15-45 parts of isatis root. The pure traditional Chinese medicine composition has the beneficial effects that the formula is reasonable, preparation is simple, and the pure traditional Chinese medicine composition does not have any toxic or side effect, is free of pollution, drug residue and drug resistance, is high in bioavailability due to superfine grinding, and obvious in curative effect, and has a special effect of treating the poultry infectious bursal disease due to clinical verification.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of man poultry infectious bursal disease and preparation method thereof, belong to field of animal, be particularly a kind ofly specifically designed to pure Chinese medicine composition for the treatment of man poultry infectious bursal disease and preparation method thereof.
Background technology
Family's poultry infectious bursal disease is that a kind of common transmittable caused by poultry infectious bursal disease virus is sick, main infection 3-6 poultry in age in week, clinically with diarrhoea, row thick white or water sample loose stool for feature, pathological change main manifestations is the congested enlargement of immune organ fabricius bursa or atrophy, and immunity of poultry reduces.This mortality rate is very high, very harmful to poultry.
The pathogen of primary disease is poultry infectious bursal disease virus, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine, but because its prescription is unreasonable or just simply pulverize, particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability to reduce, clinical effectiveness is not fine; And various antiviral Western medicine is as ribavirin, amantadine etc., the Ministry of Agriculture prohibits the use.
Therefore researching and developing a kind of specific medicament for the treatment of a poultry infectious bursal disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and pure Chinese medicine composition and preparation method thereof of effective treatment man poultry infectious bursal disease of toxic and side effects.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease, by following component by weight mixed preparing form: Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Rhizoma Phragmitis 15-35 part, Cortex Moutan 15-25 part, Radix Codonopsis 15-35 part, Radix Glycyrrhizae 15-35 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-45 part, Radix Astragali 15-45 part, Radix Isatidis 15-45 part.
Described various component optimum ratio amount is: Herba Taraxaci 20 parts, Herba Violae 20 parts, Rhizoma Phragmitis 25 parts, Cortex Moutan 20 parts, Radix Codonopsis 25 parts, 25 parts, Radix Glycyrrhizae, 20 parts, Poria, Pericarpium Citri Reticulatae 30 parts, the Radix Astragali 30 parts, Radix Isatidis 30 parts.
Treat a preparation method for the pure Chinese medicine composition of a poultry infectious bursal disease, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Rhizoma Phragmitis 15-35 part, Cortex Moutan 15-25 part, Radix Codonopsis 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Glycyrrhizae 15-35 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-45 part, Radix Astragali 15-45 part, Radix Isatidis 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Herba Taraxaci: bitter, sweet, cold, returns liver, stomach warp, has the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Cure mainly sore, lung abscess, pharyngalgia, jaundice due to damp-heat, pyretic stranguria etc.
Herba Violae: bitter, acrid, cold, Gui Xin, Liver Channel, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly skin ulcer yellow furunculosis, conjunctival congestion and swelling pain etc.
Rhizoma Phragmitis: sweet, cold, attaches to the lung and stomach meridians, has the function of clearing away heat and promoting production of body fluid, preventing or arresting vomiting, diuresis; Cure mainly that interior-heat is thirsty, lung abscess, gastropyretic vomiting, the puckery pain of pyretic stranguria etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Cortex Moutan: bitter, pungent, be slightly cold, returns liver, the heart, kidney channel, has the function of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Cure mainly maculae caused by violent heat pathogen, epistaxis, have blood in stool, hematuria, traumatic injury, carbuncle sore tumefacting virus etc.
Radix Codonopsis: sweet, flat, returns spleen, lung meridian, has the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea less, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy hang down de-etc.
Poria: sweet, light, flat, returns lung, the heart, spleen, kidney channel, has the function of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming; Cure mainly edema oliguria, have loose bowels in insufficiency of the spleen lack of appetite, loose stool, malaise etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.
The Radix Astragali: sweet, tepor, returns spleen, lung meridian, has the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Cure mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficulty burst, burst for a long time and do not hold back.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the pathogenic microorganism of family's poultry infectious bursal disease, clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves, has specially good effect to treatment man poultry infectious bursal disease.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Taraxaci 150 parts, Herba Violae 150 parts, Rhizoma Phragmitis 150 parts, Cortex Moutan 150 parts, Radix Codonopsis 150 parts by weight, mix 5-10 minute to even;
(3) take 150 parts, Radix Glycyrrhizae, 150 parts, Poria, Pericarpium Citri Reticulatae 150 parts, the Radix Astragali 150 parts, Radix Isatidis 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Taraxaci 200 parts, Herba Violae 200 parts, Rhizoma Phragmitis 250 parts, Cortex Moutan 200 parts, Radix Codonopsis 250 parts by weight, mix 5-10 minute to even;
(3) take 250 parts, Radix Glycyrrhizae, 200 parts, Poria, Pericarpium Citri Reticulatae 300 parts, the Radix Astragali 300 parts, Radix Isatidis 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Taraxaci 250 parts, Herba Violae 250 parts, Rhizoma Phragmitis 350 parts, Cortex Moutan 250 parts, Radix Codonopsis 350 parts by weight, mix 5-10 minute to even;
(3) take 350 parts, Radix Glycyrrhizae, 250 parts, Poria, Pericarpium Citri Reticulatae 450 parts, the Radix Astragali 450 parts, Radix Isatidis 450 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-30 age in days, body weight at 0.8kg-1.5kg, and Laboratory Diagnosed is the ill broiler of infectious bursal disease.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 60,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention by product of the present invention (compositions obtained by the embodiment of the present invention 1) the ill poultry of feeding etc., day dose be: by the every 100g of the present invention, spice 260kg feeds or the 500kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the situation that the present invention and other medicines treat family's poultry infectious bursal disease contrasts:
Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
I | Blank group | 21.7 | 51.7 | 26.6 |
II | Fuzheng Jiedu powder group | 10.0 | 78.3 | 11.7 |
III | Chinese medicine composition of the present invention | 6.7 | 86.6 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is significant difference (P < 0.05) compared with Fuzheng Jiedu powder group.
Safety testing:
Choose the healthy broiler 60 of 20 ages in days, according to the made compositions recommended dose of the embodiment of the present invention 15 times of spices or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment man poultry infectious bursal disease and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for a poultry infectious bursal disease, it is characterized in that by following component by weight mixed preparing form: Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Rhizoma Phragmitis 15-35 part, Cortex Moutan 15-25 part, Radix Codonopsis 15-35 part, Radix Glycyrrhizae 15-35 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-45 part, Radix Astragali 15-45 part, Radix Isatidis 15-45 part.
2. the pure Chinese medicine composition for the treatment of man poultry infectious bursal disease according to claim 1, it is characterized in that by following component by weight mixed preparing form: Herba Taraxaci 20 parts, Herba Violae 20 parts, Rhizoma Phragmitis 25 parts, Cortex Moutan 20 parts, Radix Codonopsis 25 parts, 25 parts, Radix Glycyrrhizae, 20 parts, Poria, Pericarpium Citri Reticulatae 30 parts, the Radix Astragali 30 parts, Radix Isatidis 30 parts.
3. a preparation method for the pure Chinese medicine composition for the treatment of man according to claim 1 poultry infectious bursal disease, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Herba Taraxaci 15-25 part, Herba Violae 15-25 part, Rhizoma Phragmitis 15-35 part, Cortex Moutan 15-25 part, Radix Codonopsis 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Glycyrrhizae 15-35 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-45 part, Radix Astragali 15-45 part, Radix Isatidis 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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CN103463318A (en) * | 2013-08-10 | 2013-12-25 | 安徽快康生物科技有限公司 | Traditional Chinese medicinal composition for clearing away heat and toxic materials from livestock |
CN104857174A (en) * | 2015-05-26 | 2015-08-26 | 郭庆 | Preparation method of traditional Chinese medicine micro-ecological oral preparation for preventing and treating staphylococcosis in chickens |
CN105495036A (en) * | 2015-12-07 | 2016-04-20 | 杨成胜 | Chinese herbal medicine additive of feed for Viviparidae |
CN106728135A (en) * | 2017-01-19 | 2017-05-31 | 天津市中升挑战生物科技有限公司 | A kind of medicine for preventing and treating chicken bursal disease |
CN107668379A (en) * | 2017-09-30 | 2018-02-09 | 安徽麒麟正大饲料有限公司 | 4% premix for preventing and treating Bursal Disease and preparation method thereof |
CN111135251B (en) * | 2020-01-09 | 2021-11-26 | 太原市恩禾动物药业有限公司 | Veterinary drug for preventing and treating chicken bursal disease as well as preparation method and application thereof |
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CN101390995A (en) * | 2008-10-23 | 2009-03-25 | 田明军 | Medicine for preventing and treating swine influenza |
CN102370813A (en) * | 2011-11-26 | 2012-03-14 | 王少云 | Chinese medicinal composition for treating pyaemia septica of foals |
CN102406070A (en) * | 2011-10-25 | 2012-04-11 | 上海交通大学 | Chinese herbal medicine feed additive and pig feed for reducing respiratory disease of piglets |
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CN101390995A (en) * | 2008-10-23 | 2009-03-25 | 田明军 | Medicine for preventing and treating swine influenza |
CN102406070A (en) * | 2011-10-25 | 2012-04-11 | 上海交通大学 | Chinese herbal medicine feed additive and pig feed for reducing respiratory disease of piglets |
CN102370813A (en) * | 2011-11-26 | 2012-03-14 | 王少云 | Chinese medicinal composition for treating pyaemia septica of foals |
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