CN102784243B - Pure Chinese medicine composition for treating cattle flu and preparation method of same - Google Patents

Abstract

The invention relates to a pure Chinese medicine composition for treating cattle flu and a preparation method of the pure Chinese medicine composition. The composition is prepared by fixing the following components in part by weight: 15-35 parts of sweet wormwood, 15-35 parts of Chinese thorowax, 15-35 parts of radix isatidis, 15-35 parts of isatis leaves, 15-45 parts of trichosanthes, 15-35 parts of coptis, 15-45 parts of licorice, 15-45 parts of dried orange peel, 15-35 parts of platycodon root, and 15-45 parts of milk vetch. The pure Chinese medicine composition has the benefits of reasonable formula, simplicity in preparation, no toxic or side effect, no pollution, no medicinal residue, no drug tolerance, ultrafine particles, high bioavailability and very remarkable curative effect, and has a specially good effect on treating bovine ephemeral fever, which is proved clinically.

Description

Pure Chinese medicine composition for the treatment of cattle influenza and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition for the treatment of cattle influenza and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment cattle influenza and preparation method thereof.

Background technology

Bovine ephemeral flu is called for short influenza, is the infectious disease of the acute respiratory infection that caused by influenza virus.Clinical manifestation is that heating, cough, asthenia universalis are unable, presents the respiratory inflammation of different characteristics.Pathological change is mainly manifested in respiratory apparatus.As the mucous hyperemia of trachea and bronchus, swelling, thoracic cavity, pericardial cavity are accumulated the serosity that is mixed with in a large number cellulose sample.The color of lungs, subsided to purple by red, solid etc.This disease occurs suddenly, propagates rapidly fiercely, presents popularity, and M & M is all higher, without age, sex and kind difference.All send out throughout the year, but common with the season of early spring, late fall and the cold that there was an abrupt change in weather, be one of principal disease of serious harm cattle-raising.

This disease almost spreads all over all cowboying country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral agents and antipyretic analgesic medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antiviral agents is due to serious toxic and side effects and drug residue, and the Ministry of Agriculture bans use of; Antipyretic analgesic medicine is owing to having drug residue and easily producing drug resistance, and worse and worse, and drug residue causes exporting limited and harm people are healthy for its clinical effectiveness, thereby the use of antipyretic analgesic medicine is very restricted.

Therefore research and develop a kind of drug residue free for the treatment of cattle influenza, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment cattle influenza of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of cattle influenza, by following component by weight mixed preparing form: Herba Artemisiae Annuae 15-35 part, Radix Bupleuri 15-35 part, Radix Isatidis 15-35 part, Folium Isatidis 15-35 part, Fructus Trichosanthis 15-45 part, Rhizoma Coptidis 15-35 part, Radix Glycyrrhizae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Radix Platycodonis 15-35 part, Radix Astragali 15-45 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of Herba Artemisiae Annuaes, 25 parts of Radix Bupleuri, 25 parts of Radix Isatidis, 25 parts of Folium Isatidiss, 30 parts of Fructus Trichosanthis, 25 parts of Rhizoma Coptidis, 30 parts, Radix Glycyrrhizae, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Platycodoniss, 30 parts of the Radixs Astragali.

Treat a preparation method for the pure Chinese medicine composition of cattle influenza, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively,

(2) take by weight Herba Artemisiae Annuae 15-35 part, Radix Bupleuri 15-35 part, Radix Isatidis 15-35 part, Folium Isatidis 15-35 part, Fructus Trichosanthis 15-45 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Coptidis 15-35 part, Radix Glycyrrhizae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Radix Platycodonis 15-35 part, Radix Astragali 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Herba Artemisiae Annuae: bitter, acrid, cold, return liver, gallbladder meridian, there is the function of heat-clearing and toxic substances removing, protozoacide; Cure mainly coccidiosis, jaundice due to damp-heat etc.

Radix Bupleuri: pungent, bitter, be slightly cold, return liver, gallbladder, lung meridian, there is the function of delivering with inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea, proctoptosis etc.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Fructus Trichosanthis: sweet, bitter, cold, return lung, stomach, large intestine channel, there is the function of removing heat-phlegm, promoting the circulation of QI eliminating stagnation, moistening dryness for relaxing bowels; Cure mainly cough due to lung-heat, chest and diaphragm pain, acute mastitis, feces dry etc.

Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.

Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, because larynx swells and ache, lung abscess etc.

Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.

Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for clinical symptoms and the pathological change of cattle influenza, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment cattle influenza is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensured that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of pure Chinese medicine composition for the treatment of cattle influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of Herba Artemisiae Annuaes, 150 parts of Radix Bupleuri, 150 parts of Radix Isatidis, 150 parts of Folium Isatidiss, 150 parts of Fructus Trichosanthis, mix 5-10 minute to even;

(3) take by weight 150 parts of Rhizoma Coptidis, 150 parts, Radix Glycyrrhizae, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Radix Platycodoniss, 150 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of cattle influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of Herba Artemisiae Annuaes, 250 parts of Radix Bupleuri, 250 parts of Radix Isatidis, 250 parts of Folium Isatidiss, 300 parts of Fructus Trichosanthis, mix 5-10 minute to even;

(3) take by weight 250 parts of Rhizoma Coptidis, 300 parts, Radix Glycyrrhizae, 300 parts of Pericarpium Citri Reticulataes, 250 parts of Radix Platycodoniss, 300 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of cattle influenza and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of Herba Artemisiae Annuaes, 350 parts of Radix Bupleuri, 350 parts of Radix Isatidis, 350 parts of Folium Isatidiss, 450 parts of Fructus Trichosanthis, mix 5-10 minute to even;

(3) take by weight 350 parts of Rhizoma Coptidis, 450 parts, Radix Glycyrrhizae, 450 parts of Pericarpium Citri Reticulataes, 350 parts of Radix Platycodoniss, 450 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal is selected 200-250 age in days, and Laboratory Diagnosed is the beef cattle of cattle influenza, and isolated separately and raised, the complete feed of feeding, and be divided at random 3 groups, and 20 every group, 3 groups of feeding environments are identical, and test period is 5 days; Blank group is left intact, and medicine matched group uses treatment with " cattle GANKANG is loose " by specification; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill cattle of feeding etc., and a day dose is: boiled water soaks, and waits temperature to gavage, and by the each 200g of product of the present invention, every day 1 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.

Table is the situation contrast of the present invention and other medicines treatment cattle influenza:

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	30.0	30.0	40.0
II	The cattle GANKANG group of faling apart	10.0	80.0	10.0
					III	Present composition group	5.0	90.0	5.0

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and cattle GANKANG extremely significantly (P < 0.01) of difference compared with aspect cure rate.

Safety testing:

Choose 10 of the healthy beef cattles of 150 ages in days, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 5 days, during medication, healthy beef cattle is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

The above-mentioned detailed description that pure Chinese medicine composition to this treatment cattle influenza and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for cattle influenza, it is characterized in that by following component by weight mixed preparing form: Herba Artemisiae Annuae 15-35 part, Radix Bupleuri 15-35 part, Radix Isatidis 15-35 part, Folium Isatidis 15-35 part, Fructus Trichosanthis 15-45 part, Rhizoma Coptidis 15-35 part, Radix Glycyrrhizae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Radix Platycodonis 15-35 part, Radix Astragali 15-45 part.

2. the Chinese medicine composition for the treatment of according to claim 1 cattle influenza, it is characterized in that by following component by weight mixed preparing form: 25 parts of Herba Artemisiae Annuaes, 25 parts of Radix Bupleuri, 25 parts of Radix Isatidis, 25 parts of Folium Isatidiss, 30 parts of Fructus Trichosanthis, 25 parts of Rhizoma Coptidis, 30 parts, Radix Glycyrrhizae, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Platycodoniss, 30 parts of the Radixs Astragali.

3. a preparation method for the Chinese medicine composition for the treatment of cattle influenza according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Herba Artemisiae Annuae 15-35 part, Radix Bupleuri 15-35 part, Radix Isatidis 15-35 part, Folium Isatidis 15-35 part, Fructus Trichosanthis 15-45 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Coptidis 15-35 part, Radix Glycyrrhizae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Radix Platycodonis 15-35 part, Radix Astragali 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.