CN103877544A - Traditional Chinese medicinal composition for treating ascites syndrome in broilers and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal composition for treating ascites syndrome in broilers. The composition is prepared by mixing the following components in parts by weight: 15-35 parts of peking euphorbia root, 10-30 parts of astragalus membranaceus, 15-35 parts of agastache rugosus, 15-45 parts of rattletop, 15-25 parts of prepared polygonum multiflorum, 15-35 parts of mint, 15-35 parts of bunge cherry seed, 15-45 parts of vinegar processed rhizoma cyperi, 15-35 parts of vinegar processed curcuma zedoary, 25-55 parts of pericarpium arecae, 15-45 parts of ginger peel, 15-35 parts of cinnamon, 15-25 parts of rhizoma arisaematis and 15-45 parts of liquorice. The traditional Chinese medicinal composition has the beneficial effects of reasonable formula, simple preparation, no pollution, no toxic or side effect, no drug residue and remarkable curative effect, and has a specific effect on the ascites syndrome in broilers by virtue of clinical verification.

Description

Chinese medicine composition for the treatment of broiler ascites syndrome and preparation method thereof

Technical field

The present invention relates to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment broiler ascites syndrome and preparation method thereof.

Background technology

Broiler ascites syndrome is a kind of common disease that mainly betides broiler chicken, and primary disease is distributed widely in all over the world, is gathered into too much ascites with serosity liquid, pulmonary venous pleonaemia edema, and cardiac dilatation, hypertrophy, hepatic lesions is feature.Fast large-scale broiler sickness rate with age in 2-3 week is the highest.This disease all can occur throughout the year, and mortality rate is between 1%-85%, very large to the harm of broiler chicken.Concrete predisposing factors it is generally acknowledged that pathogeny is relevant with its pulmonary hypertension with heredity, anoxia is relevant with feed factor.

At present, this disease does not also have good Therapeutic Method, and just in feedstuff, adding vitamin, aminoacid etc. prevents primary disease.Once poultry morbidity, medicine is not treated effectively, causes very large loss to broiler industry.

Therefore research and develop a kind of treat broiler ascites syndrome and have no side effect, the specific medicament of drug residue free is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, have no side effect, drug residue free, successful, effectively treat Chinese medicine composition of broiler ascites syndrome and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of broiler ascites syndrome, by following component by weight mixed preparing form: Radix Euphorbiae Pekinensis 15-35 part, Radix Astragali 10-30 part, Herba Pogostemonis 15-35 part, Rhizoma Cimicifugae 15-45 part, Radix Polygoni Multiflori Preparata 15-25 part, Herba Menthae 15-35 part, Semen Pruni 15-35 part, Rhizoma Cyperi (processed with vinegar) 15-45 part, stir-baked RHIIZOMA CURCUMAE with vinegar 15-35 part, Pericarpium Arecae 25-55 part, Cortex Zingiberis 15-45 part, Cortex Cinnamomi 15-35 part, Rhizoma Arisaematis 15-25 part, Radix Glycyrrhizae 15-45 part.

Described various component optimum ratio amount is: 25 parts of Radix Euphorbiae Pekinensiss, 20 parts of the Radixs Astragali, 25 parts of Herba Pogostemoniss, 30 parts of Rhizoma Cimicifugaes, 20 parts of Radix Polygoni Multiflori Preparatas, 25 parts of Herba Menthaes, 25 parts of Semen Prunis, 30 parts of Rhizoma Cyperi (processed with vinegar), 25 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 40 parts of Pericarpium Arecae, 30 parts of Cortex Zingiberiss, 25 parts of Cortex Cinnamomis, 20 parts of Rhizoma Arisaematiss, 30 parts, Radix Glycyrrhizae.

Treat a preparation method for the Chinese medicine composition of broiler ascites syndrome, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Radix Euphorbiae Pekinensis 15-35 part, Radix Astragali 10-30 part, Herba Pogostemonis 15-35 part, Rhizoma Cimicifugae 15-45 part, Radix Polygoni Multiflori Preparata 15-25 part, Herba Menthae 15-35 part, Semen Pruni 15-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Cyperi (processed with vinegar) 15-45 part, stir-baked RHIIZOMA CURCUMAE with vinegar 15-35 part, Pericarpium Arecae 25-55 part, Cortex Zingiberis 15-45 part, Cortex Cinnamomi 15-35 part, Rhizoma Arisaematis 15-25 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Radix Euphorbiae Pekinensis: bitter, cold, return lung, kidney, large intestine channel, have that removing water retention by purgation is drunk then, the function of dispersing swelling and dissipating binds; Cure mainly that edema dyspnea with fullness of the chest, breast abdomen hydrops, phlegm retention knot are poly-, carbuncle sore tumefacting virus, the expectorant nuclei of condensation etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Herba Pogostemonis: pungent, warm, return lung, spleen, stomach warp, there is the function of dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach; Cure mainly the headache of flu, cold and heat, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels etc.

Rhizoma Cimicifugae: pungent, sweet, cold, return lung, spleen, stomach, large intestine channel, there is the function of the rash delivered, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy; Curing mainly varioliform exanthema thoroughly sends out smooth, laryngopharynx swelling and pain, chronic diarrhea, proctoptosis, uterus and hangs down de-etc.

Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, tepor, return liver, kidney, large intestine channel, there is the function of invigorating the liver and kidney, benefiting essence-blood, bone and muscle strengthening; Cure mainly blood deficiency and yellow complexion, vertigo and tinnitus, soreness of the waist and knees, numb limbs and tense tendons, chronic malaria body void etc.

Herba Menthae: pungent, cool, return lung, Liver Channel, there is the function of wind-dispelling heat-dissipating, the cleaning head, Li Yin, rash; Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, rubella etc.

Semen Pruni: sweet, pungent, bitter, return lung, the heart, spleen, kidney channel, there is the function of moisturizing laxation, relieving constipation, diuretic; Cure mainly combined symptoms, flatulence stomachache, edema of the limbs, dysuria etc.

Rhizoma Cyperi (processed with vinegar): sweet, pungent, bitter, return liver, tri-jiao channel, there is the function of the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; Cure mainly stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia etc.

Stir-baked RHIIZOMA CURCUMAE with vinegar: warm, pungent, bitter, return liver, spleen channel, there is the function of circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving; Zhu Zhi mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain etc.

Pericarpium Arecae: pungent, warm, return spleen, stomach, large intestine, small intestine meridian, there is the function of promoting the circulation of QI to alleviate the stagnation in middle-JIAO, line water detumescence; Cure mainly retention of damp leading to blockage of QI, edema distension, retained water and stop umbilicus, dysuria etc.

Cortex Zingiberis: pungent, tepor, return lung, spleen channel, there is the function of row water, detumescence; Cure mainly edema distension, dysuria etc.

Cortex Cinnamomi: sweet, pungent, hot, return liver,kidney,spleen, heart channel, there is the function of warming spleen and stomach for dispelling cold, warming the kidney to invigorate YANG, row water; Cure mainly that insufficiency of kidney-YANG, taste are cold, cold type of pain, edema, have loose bowels, anemofrigid-damp arthralgia, enterospasm etc.

Rhizoma Arisaematis: acrid, bitter, warm, return lung, liver, spleen channel, there is the function of drying dampness to eliminate phlegm, expelling wind to relieve convulsion, mass dissipating and swelling eliminating; Cure mainly persistent ailment cough, wind-phlegm cough, convulsions, cold-phlegm condensation, tetanus, skin ulcer Huang toxic swelling etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

All taste Chinese medicine, according to tcm theory compatible combination, for paathogenic factor and the pathological change of broiler ascites syndrome, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.According to the tradition Chinese veterinarian of motherland, theoretical and modern Chinese medicine pharmacology theory, optimizes this 14 kinds of medicines, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment broiler ascites syndrome is had specially good effect and had no side effect and drug resistance.And make poultry product reach nuisanceless requirement, meet the export standard of poultry product, effectively ensured that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of Chinese medicine composition for the treatment of broiler ascites syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of Radix Euphorbiae Pekinensiss, 100 parts of the Radixs Astragali, 150 parts of Herba Pogostemoniss, 150 parts of Rhizoma Cimicifugaes, 150 parts of Radix Polygoni Multiflori Preparatas, 150 parts of Herba Menthaes, 150 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 150 parts of Rhizoma Cyperi (processed with vinegar), 150 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 250 parts of Pericarpium Arecae, 150 parts of Cortex Zingiberiss, 150 parts of Cortex Cinnamomis, 150 parts of Rhizoma Arisaematiss, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of Chinese medicine composition for the treatment of broiler ascites syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of Radix Euphorbiae Pekinensiss, 200 parts of the Radixs Astragali, 250 parts of Herba Pogostemoniss, 300 parts of Rhizoma Cimicifugaes, 200 parts of Radix Polygoni Multiflori Preparatas, 250 parts of Herba Menthaes, 250 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 300 parts of Rhizoma Cyperi (processed with vinegar), 250 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 400 parts of Pericarpium Arecae, 300 parts of Cortex Zingiberiss, 250 parts of Cortex Cinnamomis, 005 part of Rhizoma Arisaematis, 300 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of Chinese medicine composition for the treatment of broiler ascites syndrome: carry out as follows (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of Radix Euphorbiae Pekinensiss, 300 parts of the Radixs Astragali, 350 parts of Herba Pogostemoniss, 450 parts of Rhizoma Cimicifugaes, 250 parts of Radix Polygoni Multiflori Preparatas, 350 parts of Herba Menthaes, 350 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 450 parts of Rhizoma Cyperi (processed with vinegar), 350 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 550 parts of Pericarpium Arecae, 450 parts of Cortex Zingiberiss, 350 parts of Cortex Cinnamomis, 250 parts of Rhizoma Arisaematiss, 450 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 25 ages in days, body weight at 1.2kg-1.3kg, and Laboratory Diagnosed is that the ill chicken of broiler chicken Ascites is tested.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Present composition group is product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill chicken of feeding, and a day dose is: 300 kilograms are fed or drunk water to 200 kilograms of every 100 grams of present composition spices, every day 1-2 time; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 7th day) when following table is experiment end.

Efficacy assessment standard:

Cure: spirit is normal, the drinking-water of searching for food is normal, and bouncing cuts open the histoorgans such as inspection liver, heart normal.

When end, there is symptom: clinical symptoms is not improved even and increased the weight of.

Table is the field applicable cases contrast of the present invention and other medicines treatment broiler chicken Ascites:

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	30	3	67
II	Ascites dissipation group	10	70	20
					III	Chinese medicine composition group of the present invention	6	80	14

This clinical effectiveness statistical analysis, present composition group and ascites dissipation group extremely significantly (P<0.01) of difference compared with aspect cure rate.

Safety testing:

Choose 60 of 20 age in days healthy chickens, according to 10 times of spices of the made Chinese medicine composition recommended dose of the embodiment of the present invention 2 or drinking-water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

The above-mentioned detailed description that Chinese medicine composition to this treatment broiler ascites syndrome and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for broiler ascites syndrome, it is characterized in that by following component by weight mixed preparing form: Radix Euphorbiae Pekinensis 15-35 part, Radix Astragali 10-30 part, Herba Pogostemonis 15-35 part, Rhizoma Cimicifugae 15-45 part, Radix Polygoni Multiflori Preparata 15-25 part, Herba Menthae 15-35 part, Semen Pruni 15-35 part, Rhizoma Cyperi (processed with vinegar) 15-45 part, stir-baked RHIIZOMA CURCUMAE with vinegar 15-35 part, Pericarpium Arecae 25-55 part, Cortex Zingiberis 15-45 part, Cortex Cinnamomi 15-35 part, Rhizoma Arisaematis 15-25 part, Radix Glycyrrhizae 15-45 part form.

2. the Chinese medicine composition for the treatment of broiler ascites syndrome according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of Radix Euphorbiae Pekinensiss, 20 parts of the Radixs Astragali, 25 parts of Herba Pogostemoniss, 30 parts of Rhizoma Cimicifugaes, 20 parts of Radix Polygoni Multiflori Preparatas, 25 parts of Herba Menthaes, 25 parts of Semen Prunis, 30 parts of Rhizoma Cyperi (processed with vinegar), 25 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 40 parts of Pericarpium Arecae, 30 parts of Cortex Zingiberiss, 25 parts of Cortex Cinnamomis, 20 parts of Rhizoma Arisaematiss, 30 parts of compositions of Radix Glycyrrhizae.

3. a preparation method for the Chinese medicine composition for the treatment of broiler ascites syndrome according to claim 1 and 2, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Radix Euphorbiae Pekinensis 15-35 part, Radix Astragali 10-30 part, Herba Pogostemonis 15-35 part, Rhizoma Cimicifugae 15-45 part, Radix Polygoni Multiflori Preparata 15-25 part, Herba Menthae 15-35 part, Semen Pruni 15-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Cyperi (processed with vinegar) 15-45 part, stir-baked RHIIZOMA CURCUMAE with vinegar 15-35 part, Pericarpium Arecae 25-55 part, Cortex Zingiberis 15-45 part, Cortex Cinnamomi 15-35 part, Rhizoma Arisaematis 15-25 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.