CN102078571A - Drug for treating early cirrhosis ascites - Google Patents
Drug for treating early cirrhosis ascites Download PDFInfo
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- CN102078571A CN102078571A CN2011100379902A CN201110037990A CN102078571A CN 102078571 A CN102078571 A CN 102078571A CN 2011100379902 A CN2011100379902 A CN 2011100379902A CN 201110037990 A CN201110037990 A CN 201110037990A CN 102078571 A CN102078571 A CN 102078571A
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Abstract
A drug for treating early cirrhosis ascites is prepared according to a routine preparation method by 18-30 parts of lanceolata, 20-40 parts of astragalus, 13-20 parts of deep-fried atractylodes, 13-20 parts of tangerine peel, 13-20 pars of Chinese yam, 12-18 parts of areca peel, 13-20 parts of wolfiporia cocos, 10-16 parts of sparganium, 10-16 parts of curcuma rhizome, 12-18 parts of citrus aurantium, 10-16 parts of magnolia cortex, 9-15 parts of rhubarb, 12-15 parts of eucommia, 15-20 parts of flos caryophyllata, 12-15 parts of costus root, 12-15 parts of curcuma tuber, 12-15 parts of coptis, 12-15 parts of scutellaria, 12-15 parts of phellodendron, 15-25 parts of artemisia capillaries, 12-15 parts of alpinia officinarum hance, 20-25 parts of each component of Jiaosanxian, 12-15 parts of faeces trogopterpri, 12-15 parts of rhizoma corydalis, 6-10 parts of licorice, 13-20 parts of plantain seed, 20-25 pars of fenugreek seed, and 15-20 parts of gardenia. The drug of the invention has the efficacy of invigorating energy and elevating yang, supplementing qi and generating body fluid, diuresis and detumence, drying moisture and alleviating water retention, relieving pain and expelling pus, and has a high cure rate when treating early cirrhosis ascites with few side effects on human body.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of medicine for the treatment of early stage liver cirrhosis ascites.
Background technology
Cirrhotic ascites is, carrying out property chronic in the liver that liver causes by one or more reason long terms, diffuse lesion, hepatocyte is extensively downright bad, remaining hepatocyte forms regenerated nodule, connective tissue proliferation and fibrosis, cause normal liver structural deterioration, pseudolobuli to form, occur clinical manifestation on this basis based on liver function injury and portal hypertension and ascites formation.Cirrhotic ascites is a kind of common frdquently encountered disease, and repeatability is strong, is difficult for treatment, and cirrhotic ascites causes that the abdominal cavity is poly-and stay hydrops that influence other system in the body, as untimely treatment, ascites stagnates for a long time and ties, and will cause function further to go down, and other system is got involved.Doctor trained in Western medicine to cirrhotic ascites research early generally adopts Therapeutic Method such as hepatoprotective, diuresis, abdominal paracentesis tapping art, operation at present, but does not still have the specific treatment scheme, still belongs to a difficult problem aspect treatment.
From twentieth century fifties, henceforth, the traditional Chinese medical herbal treatment of cirrhotic ascites draws attention modern TCM day by day to the research of cirrhotic ascites.By the accumulation repeatedly of clinical exploration and a large amount of clinical experiences, confirm that Chinese medicine eliminating ascites, improves liver function, all there is obvious effects aspects such as promotion liver quality deliquescing.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of therapeutic effect treatment early stage liver cirrhosis ascites good, that also can effect a permanent cure.
The medicine that the present invention treats early stage liver cirrhosis ascites is that the Chinese medicine by following portions by weight is that crude drug is made:
Radix Codonopsis 18-30 Radixs Astragali 20-40
Rhizoma Atractylodis Macrocephalae preparata 13-20 Pericarpium Citri Reticulataes 13-20
Rhizoma Dioscoreae 13-20 Pericarpium Arecae 12-18
Poria 13-20 rhizoma sparganic 10-16
Rhizoma Curcumae 10-16 Fructus Aurantii Immaturuss 12-18
Cortex Magnoliae Officinalis 10-16 Radix Et Rhizoma Rhei 9-15
The Cortex Eucommiae 12-15 Flos Caryophyllis 15-20
Radix Aucklandiae (Radix Vladimiriae) 12-15 Radix Curcumaes 12-15
Rhizoma Coptidis 12-15 Radix Scutellariaes 12-15
Cortex Phellodendri 12-15 Herba Artemisiae Scopariaes 15-25
Rhizoma Alpiniae Officinarum 12-15 Fructus Crataegi (parched to brown)s 20-25
Fructus Hordei Germinatus (parched to brown) 20-25 Massa Medicata Fermentata (parched to brown) 20-25
Oletum Trogopterori 12-15 Rhizoma Corydalis 12-15
Radix Glycyrrhizae 6-10 Semen Plantaginiss 13-20
Semen Trigonellae 20-25 Fructus Gardeniaes 15-20.
The preferred raw material medicines in portions by weight number of medicine that the present invention treats early stage liver cirrhosis ascites is:
Radix Codonopsis 20-25 Radixs Astragali 30-35
Rhizoma Atractylodis Macrocephalae preparata 16-18 Pericarpium Citri Reticulataes 16-18
Rhizoma Dioscoreae 16-18 Pericarpium Arecae 16-18
Poria 16-18 rhizoma sparganic 12-15
Rhizoma Curcumae 12-15 Fructus Aurantii Immaturuss 12-15
Cortex Magnoliae Officinalis 12-15 Radix Et Rhizoma Rhei 9-12
The Cortex Eucommiae 12-15 Flos Caryophyllis 16-18
Radix Aucklandiae (Radix Vladimiriae) 12-15 Radix Curcumaes 12-15
Rhizoma Coptidis 12-15 Radix Scutellariaes 12-15
Cortex Phellodendri 12-15 Herba Artemisiae Scopariaes 20-25
Rhizoma Alpiniae Officinarum 12-15 Fructus Crataegi (parched to brown)s 20-25
Fructus Hordei Germinatus (parched to brown) 20-25 Massa Medicata Fermentata (parched to brown) 20-25
Oletum Trogopterori 12-15 Rhizoma Corydalis 12-15
Radix Glycyrrhizae 6-8 Semen Plantaginiss 16-18
Semen Trigonellae 20-25 Fructus Gardeniaes 16-18.
Above-mentioned each crude drug is made medicinal preparation for oral administration according to conventional method, i.e. the above tablet, pill, powder, capsule etc. of pharmaceutics, the preferred dosage form of the present invention is a capsule.
The concrete preparation method of medicine capsule of the present invention is as follows:
Take by weighing each crude drug of above-mentioned parts by weight, rinse well with water purification, decoct with water 3 times, each water that adds 2 times of crude drug gross weights that decocts, decocted 20 minutes, and merged 3 times decocting liquid, be condensed into relative density 1.20～1.24(50 ℃ after the filtration) thick paste, dry, be ground into fine powder, make capsule in incapsulating.
Above-mentioned all crude drug are the conventional Chinese medicine material, all are documented in Chinese Pharmacopoeia.
The present invention is based on the traditional Chinese medical science to pathogenetic research of hepatic ascites and Therapeutic Principle, screen rational prescription according to theory of Chinese medical science, meticulous compatibility, make drug effect complementation between each component, have the effect of tonifying Qi and lifting yang, supplementing QI for promoting the production of body fluid, inducing diuresis to remove edema, dampness diuretic and pain relieving evacuation of pus, can increase the urine flow, reduce ascites, prevent the hepatocyte fibrosis, accelerate liver cell regeneration, promote cirrhotic ascites patient recovery from illness.
The mode of taking of medicine of the present invention is oral, and be 4 months 1 course of treatment, takes 6 at every turn, 2 times on the one, sooner or later services once.
Drug therapy early stage liver cirrhosis ascites of the present invention, though treatment cycle is long, after the treatment through a course of treatment, effective percentage and cure rate are higher, and be little to the human body side effect, medical expense is also lower.
The specific embodiment
Embodiment 1
Get Radix Codonopsis 2.8Kg, Radix Astragali 3.5Kg, Rhizoma Atractylodis Macrocephalae preparata 1.8Kg, Pericarpium Citri Reticulatae 1.8Kg, Rhizoma Dioscoreae 1.8Kg, Pericarpium Arecae 1.6Kg, Poria 1.8Kg, rhizoma sparganic 1.5Kg, Rhizoma Curcumae 1.5Kg, Fructus Aurantii Immaturus 1.5Kg, Cortex Magnoliae Officinalis 1.5Kg, Radix Et Rhizoma Rhei 1.3Kg, Cortex Eucommiae 1.4Kg, Flos Caryophylli 1.8Kg, Radix Aucklandiae (Radix Vladimiriae) 1.4Kg, Radix Curcumae 1.4Kg, Rhizoma Coptidis 1.4Kg, Radix Scutellariae 1.4Kg, Cortex Phellodendri 1.4Kg, Herba Artemisiae Scopariae 2.3Kg, Rhizoma Alpiniae Officinarum 1.4Kg, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown)) each 2.5Kg, Oletum Trogopterori 1.4Kg, Rhizoma Corydalis 1.4Kg, Radix Glycyrrhizae 0.8Kg, Semen Plantaginis 1.8Kg, Semen Trigonellae 2.4Kg, Fructus Gardeniae 2Kg, rinse well with water purification, pack in the extraction pot, add 107.2Kg water, heat to boiling point, decocted 20 minutes, solid-liquid separation, add 107.2Kg water in the medicinal residues again, heat to boiling point, decocted 20 minutes, solid-liquid separation, add 107.2Kg water in the medicinal residues once more, heat to boiling point, decocted 20 minutes, solid-liquid separation, merge 3 times decocting liquid, be condensed into relative density 1.20～1.24(50 ℃ after the filtration) thick paste, dry, be ground into fine powder, make the capsule product in incapsulating, every heavy 0.5g, every gram contains raw material of Chinese medicine medicine 7.8g.
Use the clinical observation of present embodiment Drug therapy early stage liver cirrhosis ascites relatively to be reported as follows.
The Western medicine diagnose standard: B ultrasonic and CT detectable ascitic fluid, can make a definite diagnosis.
Differential diagnosis in tcm standard cardinal symptom: distention and fullness in the abdomen, puffiness of the face and limbs, tongue are greasy in vain, stringy pulse, and oliguria, body of the tongue is fat and pale purple, and deep and stringy pulse is unable.
Test case standard: (1) includes the case standard in: the patient who meets early stage liver cirrhosis ascites disease and Chinese medical discrimination standard.(2) get rid of the case standard: A trimester of pregnancy or women breast-feeding their children, to this medicine allergy sufferers; B is associated with serious primary disease such as cardiovascular, kidney and hemopoietic system, psychotic; The all standards of including in that do not meet of C, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
Curative effect determinate standard: carry out efficacy evaluation with reference to " disease of tcm diagnosis criterion of therapeutical effect ".(1) cure: ascites and General Symptoms are alleviated or are disappeared, and it is normal that liver function is recovered substantially; (2) take a turn for the better: ascites and symptom thereof are clearly better, and lab testing makes moderate progress; (3) do not heal: ascites does not see and alleviates that other symptom and liver function do not have improvement, or during treating massive hemorrhage of gastrointestinal tract take place, and cause state of an illness rapid deterioration person.
Determine that according to clinical experience medicament instructions of taking and dosage are: 1 course of treatment of oral capsule, 4 totally months, 2 times on the one, each 6, sooner or later service once.
The early stage liver cirrhosis patients with ascites of Pass Test case standard is totally 117 examples, wherein male 76 examples, women 41 examples, 56.23 ± 6.25 one full year of life of mean age, average medical history 3.71 ± 1.26 years.After treatment, cure 73 examples, account for 62.39%, 38 examples that take a turn for the better account for 32.48%, and 6 examples that do not heal account for 5.13%.
Though the treatment cycle of medicine of the present invention is longer than general Chinese medicine, after the treatment through four months course of treatment, present embodiment reaches 94.87% to the treatment total effective rate (healing adds improvement) of early stage liver cirrhosis ascites, and cure rate reaches 62.39%, and side effect is less.
Embodiment 2
Get Radix Codonopsis 1.8Kg, Radix Astragali 2Kg, Rhizoma Atractylodis Macrocephalae preparata 1.3Kg, Pericarpium Citri Reticulatae 1.3Kg, Rhizoma Dioscoreae 1.3Kg, Pericarpium Arecae 1.2Kg, Poria 1.3Kg, rhizoma sparganic 1.2Kg, Rhizoma Curcumae 1.2Kg, Fructus Aurantii Immaturus 1.2Kg, Cortex Magnoliae Officinalis 1.2Kg, Radix Et Rhizoma Rhei 0.9Kg, Cortex Eucommiae 1.2Kg, Flos Caryophylli 1.5Kg, Radix Aucklandiae (Radix Vladimiriae) 1.2Kg, Radix Curcumae 1.2Kg, Rhizoma Coptidis 1.2Kg, Radix Scutellariae 1.2Kg, Cortex Phellodendri 1.2Kg, Herba Artemisiae Scopariae 1.5Kg, Rhizoma Alpiniae Officinarum 1.2Kg, each 2Kg of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Oletum Trogopterori 1.2Kg, Rhizoma Corydalis 1.2Kg, Radix Glycyrrhizae 0.6Kg, Semen Plantaginis 1.3Kg, Semen Trigonellae 2Kg, Fructus Gardeniae 1.5Kg, preparation method is with embodiment 1.
Embodiment 3
Get Radix Codonopsis 3Kg, Radix Astragali 4Kg, Rhizoma Atractylodis Macrocephalae preparata 2Kg, Pericarpium Citri Reticulatae 2Kg, Rhizoma Dioscoreae 2Kg, Pericarpium Arecae 1.8Kg, Poria 2Kg, rhizoma sparganic 1.6Kg, Rhizoma Curcumae 1.6Kg, Fructus Aurantii Immaturus 1.8Kg, Cortex Magnoliae Officinalis 1.6Kg, Radix Et Rhizoma Rhei 1.5Kg, Cortex Eucommiae 1.5Kg, Flos Caryophylli 2Kg, Radix Aucklandiae (Radix Vladimiriae) 1.5Kg, Radix Curcumae 1.5Kg, Rhizoma Coptidis 1.5Kg, Radix Scutellariae 1.5Kg, Cortex Phellodendri 1.5Kg, Herba Artemisiae Scopariae 2.5Kg, Rhizoma Alpiniae Officinarum 1.5Kg, each 2.5Kg of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Oletum Trogopterori 1.5Kg, Rhizoma Corydalis 1.5Kg, Radix Glycyrrhizae 1Kg, Semen Plantaginis 2Kg, Semen Trigonellae 2.5Kg, Fructus Gardeniae 2Kg, preparation method is with embodiment 1.
Claims (2)
1. medicine for the treatment of early stage liver cirrhosis ascites is characterized in that it being that Chinese medicine by following portions by weight is the crude drug medicament of formulation method preparation routinely:
Radix Codonopsis 18-30 Radixs Astragali 20-40
Rhizoma Atractylodis Macrocephalae preparata 13-20 Pericarpium Citri Reticulataes 13-20
Rhizoma Dioscoreae 13-20 Pericarpium Arecae 12-18
Poria 13-20 rhizoma sparganic 10-16
Rhizoma Curcumae 10-16 Fructus Aurantii Immaturuss 12-18
Cortex Magnoliae Officinalis 10-16 Radix Et Rhizoma Rhei 9-15
The Cortex Eucommiae 12-15 Flos Caryophyllis 15-20
Radix Aucklandiae (Radix Vladimiriae) 12-15 Radix Curcumaes 12-15
Rhizoma Coptidis 12-15 Radix Scutellariaes 12-15
Cortex Phellodendri 12-15 Herba Artemisiae Scopariaes 15-25
Rhizoma Alpiniae Officinarum 12-15 Fructus Crataegi (parched to brown)s 20-25
Fructus Hordei Germinatus (parched to brown) 20-25 Massa Medicata Fermentata (parched to brown) 20-25
Oletum Trogopterori 12-15 Rhizoma Corydalis 12-15
Radix Glycyrrhizae 6-10 Semen Plantaginiss 13-20
Semen Trigonellae 20-25 Fructus Gardeniaes 15-20.
2. the medicine of treatment early stage liver cirrhosis ascites according to claim 1 is characterized in that it being that Chinese medicine by following portions by weight is the crude drug medicament of formulation method preparation routinely:
Radix Codonopsis 20-25 Radixs Astragali 30-35
Rhizoma Atractylodis Macrocephalae preparata 16-18 Pericarpium Citri Reticulataes 16-18
Rhizoma Dioscoreae 16-18 Pericarpium Arecae 16-18
Poria 16-18 rhizoma sparganic 12-15
Rhizoma Curcumae 12-15 Fructus Aurantii Immaturuss 12-15
Cortex Magnoliae Officinalis 12-15 Radix Et Rhizoma Rhei 9-12
The Cortex Eucommiae 12-15 Flos Caryophyllis 16-18
Radix Aucklandiae (Radix Vladimiriae) 12-15 Radix Curcumaes 12-15
Rhizoma Coptidis 12-15 Radix Scutellariaes 12-15
Cortex Phellodendri 12-15 Herba Artemisiae Scopariaes 20-25
Rhizoma Alpiniae Officinarum 12-15 Fructus Crataegi (parched to brown)s 20-25
Fructus Hordei Germinatus (parched to brown) 20-25 Massa Medicata Fermentata (parched to brown) 20-25
Oletum Trogopterori 12-15 Rhizoma Corydalis 12-15
Radix Glycyrrhizae 6-8 Semen Plantaginiss 16-18
Semen Trigonellae 20-25 Fructus Gardeniaes 16-18.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100379902A CN102078571B (en) | 2011-02-15 | 2011-02-15 | Drug for treating early cirrhosis ascites |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100379902A CN102078571B (en) | 2011-02-15 | 2011-02-15 | Drug for treating early cirrhosis ascites |
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| Publication Number | Publication Date |
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| CN102078571A true CN102078571A (en) | 2011-06-01 |
| CN102078571B CN102078571B (en) | 2012-06-06 |
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| CN2011100379902A Expired - Fee Related CN102078571B (en) | 2011-02-15 | 2011-02-15 | Drug for treating early cirrhosis ascites |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877544A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicinal composition for treating ascites syndrome in broilers and preparation method thereof |
| CN104127821A (en) * | 2014-08-01 | 2014-11-05 | 孙苗苗 | Liver cirrhosis ascites treating medicine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163776A (en) * | 1997-05-16 | 1997-11-05 | 张庆群 | Medicine for treating hepatic disease |
| CN101785819A (en) * | 2010-02-26 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for hydrothorax treatment |
| CN101869686A (en) * | 2009-11-05 | 2010-10-27 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cirrhosis and preparation method thereof |
-
2011
- 2011-02-15 CN CN2011100379902A patent/CN102078571B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163776A (en) * | 1997-05-16 | 1997-11-05 | 张庆群 | Medicine for treating hepatic disease |
| CN101869686A (en) * | 2009-11-05 | 2010-10-27 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cirrhosis and preparation method thereof |
| CN101785819A (en) * | 2010-02-26 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for hydrothorax treatment |
Non-Patent Citations (2)
| Title |
|---|
| 《医学文选》 19931231 长虹 治疗肝硬化新方 , 第03期 2 * |
| 《江苏中医药》 19930330 蔡新 小温中汤治疗肝硬化腹水45例 , 第03期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877544A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicinal composition for treating ascites syndrome in broilers and preparation method thereof |
| CN103877544B (en) * | 2014-03-15 | 2016-08-17 | 青岛众志合才智能科技有限公司 | Chinese medicine composition for the treatment of broiler ascites syndrome and preparation method thereof |
| CN104127821A (en) * | 2014-08-01 | 2014-11-05 | 孙苗苗 | Liver cirrhosis ascites treating medicine |
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| CN102078571B (en) | 2012-06-06 |
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