CN101637548B

CN101637548B - Medicine for treating kidney stone and preparation method thereof

Info

Publication number: CN101637548B
Application number: CN2009100740166A
Authority: CN
Inventors: 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-23
Filing date: 2009-03-23
Publication date: 2011-06-15
Anticipated expiration: 2029-03-23
Also published as: CN101637548A

Abstract

The invention relates to a medicine for treating kidney stone which is prepared by mixing leech, talcum powder, pangolin scales, corydalis humosa, rhizoma corydalis, plantain seed and turtle shell that are processed, medicinal cyathula root, polygonum aviculare, alisma orientale, pyrrosia lingua, caulis akebiae, longhairy antenoron herb, salvia miltiorrhiza, immature bitter orange, umbellate porefungus and liquorice; decocting the mixture for three times; merging decocted liquid; filtering and concentrating decocted liquid into clear paste, drying and grinding the clear paste, and putting into capsules; after sterilization, preparing capsules of the medicine. The medicine has the effects of clearing away heat evil and promoting diuresis, relieving stranguria and discharging calculus as well as tonifying qi and kidney, so as to be used for treating kidney stone, lead the stone to become smaller and smaller and then be discharged out of the human body; furthermore, the medicine is easily taken by the patients, overcomes the defects of large wound in western medicine treatment and small application scope, and is suitable for the old and the weak people who do not adapt to the operation. By clinical observation, the total effective rate is 95.0%.

Description

A kind of medicine for the treatment of renal calculus and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of calculus, particularly relating to a kind of is the medicine of the treatment renal calculus of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Renal calculus is a kind of multiple, stubborn disease, mainly is because environmental pollution, psychentonia, eating and drinking without temperance, drinking-water less at ordinary times, physical function is impaired etc. former thereby cause bile or urine unusual, concentrates and forms crystallization, and adhesive aggregation changes and forms.The method of treatment lithiasis mainly is a Drug therapy both at home and abroad at present, comprises thiazide diuretic, sodium phosphate fibre resin, orthophosphate etc., and very little to the curative effect of lithiasis, the curative effect scope only is to limit calculus increase aspect, can not eradicate at all.The shortcoming of extracorporeal shock-wave lithotomy is that the physical action of shock wave makes hydrone generation chemical change, generates H ₂O ₂With multiple free radical, can make calculus surrounding tissue cell injury, hemorrhage, and treatment back rubble can not very fast discharge, influences renal tubules, glomerule function.Non-open operation is got stone by uretero-renoscope, big, painful big, the weak curative effect of limitation; Open operation is got the limitation of the protected renal function of stone, and indication is few, easily recurrence.In a word, the method for the treatment of lithiasis at present all has limitation and deficiency separately, is difficult to eradicate renal calculus.

Chinese medicine renal calculus not only toxic and side effects is little, and drug effect is remarkable.The advantage and the characteristic of performance Chinese medicine, Iithiasic Chinese medicine medicine is treated in further investigation and exploitation, can improve patient's quality of life, for extensive patients brings glad tidings, has the wide development prospect.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of renal calculus, this medicine has the effect of vital energy benefiting and the kidney invigorating, inducing diuresis for treating stranguria syndrome, calculus dissolving and excreting, is used for the treatment of renal calculus, can make maximum sizeization little, and progressively excrete.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Radix Cyathulae 15～25 Herba Polygoni Avicularis 10～25

Rhizoma Alismatis 8～13 Folium Pyrrosiaes 18～40

Rhizoma Corydalis 8～18 Pulvis Talci 13～20

Caulis Akebiae 8～13 Hirudos 2～5

Eupolyphaga 2～6 Squama Maniss 3～8

Herba Lysimachiae 20～50 Radix Salviae Miltiorrhizaes 8～25

Fructus Aurantii Immaturus 8～18 Semen Plantaginiss 13～30

Polyporus 8～13 Carapax Trionycis 8～25

Radix Glycyrrhizae 4～6.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of medicine of the present invention being made capsule is:

Hirudo is fried to golden yellow in the Pulvis Talci that scalds heat, soaked drying with vinegar slightly; Squama Manis is fried to golden yellow in the sand that scalds heat, soaked drying with vinegar slightly; Eupolyphaga is fried to little Huang, dried after the spray vinegar; Rhizoma Corydalis is fried to little yellow, dried after the spray vinegar; Semen Plantaginis is fried to explosion; Carapax Trionycis is fried to golden yellow in the sand that scalds heat, soaked airing with vinegar slightly.

With the Hirudo, Pulvis Talci, Squama Manis, eupolyphaga, Rhizoma Corydalis, Semen Plantaginis, Carapax Trionycis and the Radix Cyathulae, Herba Polygoni Avicularis that cook, Rhizoma Alismatis, Folium Pyrrosiae, Caulis Akebiae, Herba Lysimachiae, Radix Salviae Miltiorrhizae, Fructus Aurantii Immaturus, Polyporus, Radix Glycyrrhizae by above-mentioned parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and being condensed into relative density is the clear paste of 1.0～1.2 (50 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.

The category that renal calculus belongs to the traditional Chinese medical science " stranguria caused by urinary stone ", " sand Stranguria " and part " stranguria with blood ", " qi stranguria " how because of damp invasion of lower energizer, pents up the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, turning into fire and then burning YIN, decoct urine, impurity solidifies and becomes sandstone in the urine, and treatment should be based on clearing away heat and promoting diuresis, Tonglin Paishi, vital energy benefiting and the kidney invigorating.In the prescription of the present invention, the merit of Herba Lysimachiae, Semen Plantaginis, Folium Pyrrosiae, Herba Polygoni Avicularis tool clearing away heat and promoting diuresis, Tonglin Paishi; Pulvis Talci diuresis and non-impairment of YIN can the promoting defecation and urination roads, to help calculus; Radix Cyathulae can the kidney invigorating, again can dissipating blood stasis, and the vim and vigour circulation is stagnated to loose, can also the descending through sick institute of priming; Hirudo, Squama Manis, the detumescence of eupolyphaga removing blood stasis with potent drugs, the dissipating blood stasis of assaulting fortified position, change silt hemostasis, reducing swelling and alleviating pain, removing obstruction in the collateral to relieve pain; Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving; Carapax Trionycis nourishing kidney YANG hyperactivity suppressing, hard masses softening and resolving; Rhizoma Alismatis, Polyporus, Caulis Akebiae promoting diuresis to eliminate damp pathogen, clearing away heat and promoting diuresis; Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow; The Fructus Aurantii Immaturus diffusing painful abdominal mass of reducing phlegm, the dispelling the stagnated QI removing food stagnancy; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and clearing away heat-damp and promoting diuresis, Tonglin Paishi, vital energy benefiting and the kidney invigorating are used for the treatment of renal calculus, can make calculus little by bigization, get rid of external.

Pharmaceutical dosage form of the present invention is a capsule, and the patient is easy to take, and takes safety, has overcome the shortcoming that traditional western medical treatment wound is big, subject range is little, has reduced the patient suffering, is more suitable for using in old, incompatibility operator.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 120 routine renal calculus patients that the curative effect of Drug therapy renal calculus of the present invention has been carried out clinical observation.

120 routine cases are divided into two groups at random, every group 60 example.Male 32 examples in the matched group, women 28 examples; Wherein left renal calculus 13 examples, right renal calculus 17 examples, two renal calculus 30 examples, calculus diameter 0.8～1.0cm.Male 34 examples in the treatment group, women 26 examples; Wherein left renal calculus 15 examples, right renal calculus 12 examples, two renal calculus 33 examples, calculus diameter 0.7～1.2cm.All cases are all diagnosed with reference to the diagnostic criteria of renal calculus in " practical internal medicine ".

The oral Semen daturae tablet 16mg of matched group, has the infected to add and uses lomefloxacin tablet 0.2g, every day 2 times every day 3 times.The treatment group adopts medicine of the present invention to treat.2 weeks were 1 course of treatment, treated 4 courses of treatment altogether.

Criterion of therapeutical effect is drafted with reference to " clinical disease diagnosis standard ".Recovery from illness: after medication 1～2 course of treatment, clinical symptoms, sign all disappear, and the ultrasound diagnosis calculus disappears.Produce effects: after medication 1～2 course of treatment, clinical symptoms, sign obviously alleviate, and the ultrasound diagnosis calculus reduces more than 50%.Effectively: after medication 1～2 course of treatment, clinical symptoms, sign alleviate, and the ultrasound diagnosis calculus reduces below 50%.Invalid: after medication 1～2 course of treatment, clinical symptoms, sign do not have obvious improvement, and the ultrasound diagnosis calculus does not have significant change.The results are shown in Table 1 after two groups of treatments.

Curative effect after the table 1 liang group case treatment relatively

The specific embodiment

Embodiment 1

Water intaking trematodiasis 60g adding is scalded among the Pulvis Talci 300g of heat, fries to abundant expanded shortcake, takes out when being golden yellow, soaks slightly with vinegar while hot, pulls drying out; Squama Manis 100g is put into sand that marmite scalds heat fry when fully expanded shortcake is golden yellow, drop in the vinegar and soak slightly, pull drying out; Eupolyphaga 80g is put into marmite fry to little Huang, sprayed airing with vinegar; Rhizoma Corydalis 200g is put into marmite fry, sprayed, dry with vinegar to little yellow; Semen Plantaginis 400g is fried to explosion airing; Carapax Trionycis 300g is put into the sand of the boiling hot heat of pot and fry, take out when being golden yellow, drop in the vinegar and soak slightly, pull airing out to fully expanded extremely crisp.

With above-mentioned Chinese medicine that cooks and Radix Cyathulae 300g ， Herba Polygoni Avicularis 300g, Rhizoma Alismatis 200g, Folium Pyrrosiae 500g, Caulis Akebiae 200g, Herba Lysimachiae 500g, Radix Salviae Miltiorrhizae 300g, Fructus Aurantii Immaturus 200g, Polyporus 200g, Radix Glycyrrhizae 80g mix homogeneously decocts with water 3 times, each 1 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.15 (50 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Embodiment 2

Water intaking trematodiasis 50g adding is scalded among the Pulvis Talci 200g of heat, fries to abundant expanded shortcake, takes out when being golden yellow, soaks slightly with vinegar while hot, pulls drying out; Squama Manis 80g is put into sand that marmite scalds heat fry when fully expanded shortcake is golden yellow, drop in the vinegar and soak slightly, pull drying out; Eupolyphaga 60g is put into marmite fry to little Huang, sprayed airing with vinegar; Rhizoma Corydalis 180g is put into marmite fry, sprayed, dry with vinegar to little yellow; Semen Plantaginis 300g is fried to explosion airing; Carapax Trionycis 250g is put into the sand of the boiling hot heat of pot and fry, take out when being golden yellow, drop in the vinegar and soak slightly, pull airing out to fully expanded extremely crisp.

With above-mentioned Chinese medicine that cooks and Radix Cyathulae 250g ， Herba Polygoni Avicularis 250g, Rhizoma Alismatis 130g, Folium Pyrrosiae 400g, Caulis Akebiae 130g, Herba Lysimachiae 400g, Radix Salviae Miltiorrhizae 250g, Fructus Aurantii Immaturus 180g, Polyporus 130g, Radix Glycyrrhizae 60g mix homogeneously decocts with water 3 times, each 2 hours, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.18 (50 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Claims

1. medicine for the treatment of renal calculus is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:

Radix Cyathulae 15～25 Herba Polygoni Avicularis 10～25

Rhizoma Alismatis 8～13 Folium Pyrrosiaes 18～40

Rhizoma Corydalis 8～18 Pulvis Talci 13～20

Caulis Akebiae 8～13 Hirudos 2～5

Eupolyphaga 2～6 Squama Maniss 3～8

Herba Lysimachiae 20～50 Radix Salviae Miltiorrhizaes 8～25

Fructus Aurantii Immaturus 8～18 Semen Plantaginiss 13～30

Polyporus 8～13 Carapax Trionycis 8～25

Radix Glycyrrhizae 4～6.

2. the medicine of treatment renal calculus according to claim 1 is characterized in that described medicine is made capsule.

3. the preparation method of the medicine of the described treatment renal calculus of claim 2 may further comprise the steps:

Hirudo is fried to golden yellow in the Pulvis Talci that scalds heat, soaked drying with vinegar slightly; Squama Manis is fried to golden yellow in the sand that scalds heat, soaked drying with vinegar slightly; Eupolyphaga is fried to little Huang, dried after the spray vinegar; Rhizoma Corydalis is fried to little yellow, dried after the spray vinegar; Semen Plantaginis is fried to explosion; Carapax Trionycis is fried to golden yellow in the sand that scalds heat, soaked airing with vinegar slightly;

With the Hirudo, Pulvis Talci, Squama Manis, eupolyphaga, Rhizoma Corydalis, Semen Plantaginis, Carapax Trionycis and the Radix Cyathulae, Herba Polygoni Avicularis that cook, Rhizoma Alismatis, Folium Pyrrosiae, Caulis Akebiae, Herba Lysimachiae, Radix Salviae Miltiorrhizae, Fructus Aurantii Immaturus, Polyporus, Radix Glycyrrhizae by above-mentioned parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction filters, and is condensed into 50 ℃ of relative densities and is 1.0～1.2 clear paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.