CN101637536B

CN101637536B - Medicine for treating chronic sinusitis and preparation method thereof

Info

Publication number: CN101637536B
Application number: CN2009100740151A
Authority: CN
Inventors: 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-23
Filing date: 2009-03-23
Publication date: 2011-09-14
Anticipated expiration: 2029-03-23
Also published as: CN101637536A

Abstract

The invention relates to a medicine for treating chronic sinusitis which is prepared by mixing leech, earthworm and plantain seed that are processed, flos magnoliae liliflorae, caulis akebiae, spica schizonepetae, honeysuckle, forsythia, radix scutellariae, golden cypress, anabaena, salvia miltiorrhiza, raw astragalus root, rehmanniae praeparatum, the root bark of the peony tree, ligusticum sinense oliver, bitter orange and liquorice; adding water into the mixture and decocting; merging decocted liquid; filtering and concentrating decocted liquid into clear paste, drying and grinding the clear paste, and putting into capsules. The medicine has the effects of clearing away heat and toxic material, replenishing qi and invigorating the spleen, dispelling wind and eliminating dampness, and dissipating phlegm and promoting the restoration consciousness, so as to be used for treating chronic sinusitis with the total effective rate of 95.0%. The medicine also has the advantages of treating the symptoms and the root causes, high cure rate and no toxic side effect.

Description

A kind of medicine for the treatment of chronic sinusitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of rhinitis, particularly relating to a kind of is the medicine of the treatment chronic sinusitis of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Nose has the natural whippy protecting film of one deck to play the effect that intercepts virus and antibacterial under normal condition.But when the person when weak, hypoimmunity (as flu), the function of this tunic will go down, follow the string, this moment, virus and bacteria was taken advantage of a weak point, a large amount of breedings cause the nose various diseases.

Chronic sinusitis is the suppurative inflammation of nasal sinuses mucosa, often is secondary to acute purulent nasosinusitis, is the able-bodied disease of a kind of serious harm human body.Its main pathogenic factor is acute purulent nasosinusitis malpractice or outbreak repeatedly, and changes chronic sinusitis into.

The Western medicine that many treatment chronic sinusitiss are arranged at present, the efficacy of a drug can reach diseased region fast, effectively reaches pain relieving, antiinflammatory effect, makes patient's ailing puzzlement of getting off quickly.But because its treatment principle is antiinflammatory, pain relieving, produce ailing basic reason and can not remove, pain easily recurs after the drug withdrawal, and cure rate is low, and side effect is bigger.Organic conception from the traditional Chinese medical science, from starting with of disease at all, adopt traditional Chinese medical herbal treatment can reach the effect that collateral dredging rushes down poison, blood circulation promoting and blood stasis dispelling, adjusting lung spleen, the strong kidney of positive liver, promoting the circulation of QI to relieve pain, make inflammation disappeared, have a headache gone down, olfactory sensation recovered, thereby reach the basic goal of treatment.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of chronic sinusitis, this medicine can be removed and produce ailing basic reason, cure rate height, instant effect, has no side effect, do not have recurrence.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Flos Magnoliae 5～15 Caulis Akebiaes 5～15

Herba Schizonepetae 5～10 Flos Loniceraes 15～30

Fructus Forsythiae 15～30 Radix Scutellariaes 5～15

Cortex Phellodendri 5～15 Herba Houttuyniae 10～20

Radix Salviae Miltiorrhizae 10～30 Radix Astragali 15～30

The Radix Rehmanniae 15～30 Cortex Moutans 5～15

Hirudo 2～6 Pheretimas 5～15

Rhizoma Ligustici 5～15 Fructus Aurantiis 5～15

Semen Plantaginis 15～30 Radix Glycyrrhizaes 2～5.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of medicine of the present invention being made capsule may further comprise the steps:

The water intaking trematodiasis is fried to golden yellow in the Pulvis Talci that scalds heat, soaks slightly with vinegar, pulls drying out; Pheretima is mixed thoroughly vexed with yellow wine, fry to little yellow; Semen Plantaginis is fried extremely will explosion.

With the Hirudo, Pheretima, Semen Plantaginis and the Flos Magnoliae that cook, Caulis Akebiae, Herba Schizonepetae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Cortex Phellodendri, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Radix Astragali, the Radix Rehmanniae, Cortex Moutan, Rhizoma Ligustici, Fructus Aurantii, Radix Glycyrrhizae by described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction, filter, being condensed into relative density is the clear paste of 1.0～1.2 (65 ℃), after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization is made the capsule product.

Chronic sinusitis belongs to the category of traditional Chinese medical science nasal sinusitis, and main pathogenesis is an insufficiency of lung-QI, instability of surface, being invaded by exogenous pathogen, deficiency-weakness of spleen-QI in addition, the fortuneization mistake is strong, the damp-phlegm cohesion, and evil poison is detained, and turbid damp is gathered in the nose key fall ill, the yellow turbid pus tears of normal wake, it is obstructed to have a stuffy nose, hyposmia, symptoms such as dizzy headache.Its pathogenesis is a deficiency in origin and excess in superficiality, so should adopt heat-clearing and toxic substances removing, replenishing QI to invigorate the spleen, expelling wind and removing dampness, the sensible method of reducing phlegm.In the prescription of the present invention, the hot temperature of loosing of Flos Magnoliae is logical, and fragrance is walked to scurry, up women's head-ornaments, a surname's clearing the nasal passage; Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae heat-clearing and toxic substances removing, the evil poison of evacuation; The Radix Astragali expelling pus and toxin by strengthening QI; Caulis Akebiae pathogenic fire purging row water, promoting blood circulation; The Herba Schizonepetae relieving the exterior syndrome by diaphoresis dispels the wind; Radix Scutellariae, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication; The Radix Rehmanniae, Cortex Moutan heat clearing away, promote the production of body fluid, YIN nourishing, nourish blood; The Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire; The detumescence of Hirudo removing blood stasis with potent drugs; Pheretima clearing heat for calming endogenous wind, current meridians; Rhizoma Ligustici diaphoresis cold expelling, wind-expelling pain-stopping; The capable expectorant of Fructus Aurantii dispelling the stagnated QI; The Semen Plantaginis clearing away heat and promoting diuresis; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is held concurrently with detoxifcation.All medicines share, treating both the principal and the secondary aspects of a disease at the same time, and collateral dredging rushes down the strong kidney of poison, blood circulation promoting and blood stasis dispelling, adjusting lung spleen, positive liver, promoting the circulation of QI to relieve pain, inflammation is disappeared, headache is gone down, olfactory sensation recovers.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 200 routine chronic sinusitis patients that the curative effect of Drug therapy chronic sinusitis of the present invention is carried out clinical observation.

200 routine cases are divided into two groups at random, every group 100 example.Matched group man 62 examples, women 38 examples; 6～53 years old age; The course of disease is the shortest 15 months, and is the longest 5 years.Male 58 examples are organized in treatment, women 42 examples; 5～54 years old age; The course of disease is the shortest 12 months, and is the longest 5 years.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse not statistically significant (P＞0.05), have comparability.All cases are all diagnosed with reference to the diagnostic criteria of chronic sinusitis in " practical otolaryngology ".

Matched group oral antibiotic medicine is treated, and unites based on broad-spectrum antibiotic drug and metronidazole and takes, and the fraction case adopts muscle or intravenous route administration, 7 days is a course of treatment, drug withdrawal 3 days improves degree according to the state of an illness afterwards and adjusts medication in good time, carries out the treatment of the next course of treatment again.The treatment group adopts drug oral treatment of the present invention, and 4 weeks were a course of treatment, took 3 courses of treatment altogether.

Criterion of therapeutical effect: cure: clinical symptom disappearance, two nasal cavities do not have purulent secretion, and check Wa Shi bit slice shows that sinusitis disappears, and follows up a case by regular visits to and does not have recurrence in 6～9 months.Produce effects: clinical symptoms disappears substantially, two concha nasalis silght enlargements, and check Wa Shi bit slice shows the nasal mucosa light inflammation, follows up a case by regular visits to 6～9 months stable disease.Effectively: clinical symptom relief, check Wa Shi bit slice show that the nasal mucosa inflammation takes a turn for the better, and follow up a case by regular visits to not see in 6～9 months and increase the weight of.Invalid: clinical symptoms does not have improvement, and check Wa Shi bit slice shows that sinusitis sign do not have change.

Curative effect comparative result after two groups of cases are treated sees Table 1.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Hirudo 50g is put into the Pulvis Talci that marmite has scalded heat, and stir-fry is sent out shortcake to fully expanding, and takes out when being golden yellow, drops in the vinegar while hot and soaks slightly, pulls drying for standby out; Get Pheretima 100g and mix thoroughly vexedly with yellow wine, put into marmite, fry to little yellow with slow fire, taking-up cools; Semen Plantaginis 300g is fried to taking out during explosion with marmite.

With above-mentioned Chinese medicine that cooks and Flos Magnoliae 150g, Caulis Akebiae 150g, Herba Schizonepetae 100g, Flos Lonicerae 300g, Fructus Forsythiae 300g, Radix Scutellariae 150g, Cortex Phellodendri 150g, Herba Houttuyniae 200g, Radix Salviae Miltiorrhizae 300g, Radix Astragali 300g, Radix Rehmanniae 300g, Cortex Moutan 150g, Rhizoma Ligustici 150g, Fructus Aurantii 150g, Radix Glycyrrhizae 50g is evenly mixed, decocts with water 3 times, each 2 hours, collecting decoction filters, and being condensed into relative density is the clear paste of 1.2 (65 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization is made the capsule product.

Embodiment 2

Hirudo 60g is put into the Pulvis Talci that marmite has scalded heat, and stir-fry is sent out shortcake to fully expanding, and takes out when being golden yellow, drops in the vinegar while hot and soaks slightly, pulls drying for standby out; Get Pheretima 150g and mix thoroughly vexedly with yellow wine, put into marmite, fry to little yellow with slow fire, taking-up cools; Semen Plantaginis 300g is fried to taking out during explosion with marmite.

With above-mentioned Chinese medicine that cooks and Flos Magnoliae 130g, Caulis Akebiae 130g, Herba Schizonepetae 80g, Flos Lonicerae 250g, Fructus Forsythiae 250g, Radix Scutellariae 130g, Cortex Phellodendri 130g, Herba Houttuyniae 150g, Radix Salviae Miltiorrhizae 250g, Radix Astragali 250g, Radix Rehmanniae 250g, Cortex Moutan 130g, Rhizoma Ligustici 130g, Fructus Aurantii 130g, Radix Glycyrrhizae 40g is evenly mixed, decocts with water 3 times, each 1 hour, collecting decoction filters, and being condensed into relative density is the clear paste of 1.1 (65 ℃), after 60 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization is made the capsule product.

Claims

1. medicine for the treatment of chronic sinusitis is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:

Flos Magnoliae 5～15 Caulis Akebiaes 5～15

Herba Schizonepetae 5～10 Flos Loniceraes 15～30

Fructus Forsythiae 15～30 Radix Scutellariaes 5～15

Cortex Phellodendri 5～15 Herba Houttuyniae 10～20

Radix Salviae Miltiorrhizae 10～30 Radix Astragali 15～30

The Radix Rehmanniae 15～30 Cortex Moutans 5～15

Hirudo 2～6 Pheretimas 5～15

Rhizoma Ligustici 5～15 Fructus Aurantiis 5～15

Semen Plantaginis 15～30 Radix Glycyrrhizaes 2～5.

2. the medicine of treatment chronic sinusitis according to claim 1 is characterized in that described medicine is made capsule.

3. the preparation method of the medicine of the described treatment chronic sinusitis of claim 2 may further comprise the steps:

The water intaking trematodiasis is fried to golden yellow in the Pulvis Talci that scalds heat, soaks slightly with vinegar, pulls drying out; Pheretima is mixed thoroughly vexed with yellow wine, fry to little yellow; Semen Plantaginis is fried to will explosion;

With the Hirudo, Pheretima, Semen Plantaginis and the Flos Magnoliae that cook, Caulis Akebiae, Herba Schizonepetae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Cortex Phellodendri, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Radix Astragali, the Radix Rehmanniae, Cortex Moutan, Rhizoma Ligustici, Fructus Aurantii, Radix Glycyrrhizae by described parts by weight mix homogeneously, decoct with water 2～4 times, each 1～2 hour, collecting decoction, filter, be condensed into 65 ℃ of relative densities and be 1.0～1.2 clear paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization is made the capsule product.