CN101642532A - Traditional Chinese medicine composition for treating apoplexy and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating apoplexy and preparation method thereof Download PDFInfo
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- CN101642532A CN101642532A CN200910092917A CN200910092917A CN101642532A CN 101642532 A CN101642532 A CN 101642532A CN 200910092917 A CN200910092917 A CN 200910092917A CN 200910092917 A CN200910092917 A CN 200910092917A CN 101642532 A CN101642532 A CN 101642532A
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Abstract
The invention provides a traditional Chinese medicine composition for treating apoplexy and a preparation method thereof. The composition is prepared from astragalus root, angelica, cassia twig, wideearthworm, licorice, tuber fleeceflower, white peony root, peach kernel, rhizoma ligustici wallichii, chrysanthemum, tall gastrodia tuber and hawthorn. The traditional Chinese medicine composition fortreating apoplexy has the effects of promoting blood circulation, relieving the stasis of blood, promoting the circulation of qi, alleviating pain, reducing fever, relieving wind, lowering fat and resisting coagulation, is used for treating apoplexy and also can be used for treating diseases, such as cerebral concussion sequelae, cerebral arteriosclerosis and the like.
Description
Technical field
The invention belongs to the Chinese medicine composition field, specifically, relate to a kind of Chinese medicinal composition capsules for the treatment of apoplexy and preparation method thereof.
Background technology
Apoplexy is the brain function loss of being obstructed and developing rapidly owing to brain blood supply liquid, this may be the ischemia (shortage blood supply) that causes because of thrombosis or thromboembolism, or causes because of hemorrhage.Apoplexy belongs to emergency case, can cause permanent nervous lesion, if untimely diagnosis and treatment can cause complication and death.
Apoplexy has sickness rate height, mortality rate height, disability rate height, characteristics that relapse rate is high, is frequently-occurring disease, the commonly encountered diseases of middle-aged and elderly people.In the U.S., apoplexy is the third-largest cause of the death, at US and European it be cause being grown up disabled head because of.Apoplexy is the second largest cause of the death all over the world, and may become dead first cause very soon.
CN1406609 discloses " a kind of Chinese medicinal capsule agent and method for making thereof that can be used for treating the apoplexy and the thoracic obstruction " and has been made up of 15 flavor Chinese medicines such as Chinese medicine astragalus, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis; The red capsule for freeing collateral vessels of selling on the market in sky is used for acute period of cerebral infarction, recovers early stage; belong to traditional Chinese medical science apoplex involving the channels and collaterals wind-phlegm blood stasis numbness resistance venation person; disease is seen hemiplegia, crooked mouth and tongue, hemianesthesia, the not smoothgoing plug of language etc., is made up of Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Siegesbeckiae, Hirudo, Rhizoma Gastrodiae, Flos Sophorae, Rhizoma Acori Graminei, artificial Calculus Bovis, the Radix Astragali, Radix Achyranthis Bidentatae Chinese medicine.
At present, clinical most common therapeutic method is a thrombolytic therapy.Aggrenox mostly is thrombolytic medicine and antithrombotic greatly in recent years more than ten of drugs approved by FDA, but being it, the defective of such thrombolytic drug therapy maximum only is applicable to that apoplexy takes place in back 3-6 hour, as surpassing 3 hours, can cause intracerebral hemorrhage and cerebral edema behind the thrombolytic, increase the weight of the state of an illness on the contrary.Chang Yong thrombolytic medicine has further limited acute paralytic's early treatment thus for how also can increase the hemorrhage probability in treatment back for treatments such as general enzyme, urokinase, streptokinase, defibrase, tissue-type plasminogen activator (tPA), r-ProUK in the market.Though some antithrombotic, as aspirin, warfarin, clopidogrel etc. are widely used in prophylactic treatment, and the Therapeutic Method that can be used for the apoplexy early treatment safely and effectively is very crucial.Chinese medicine has a multi-angle collaboratively prevents and treats characteristics and arteriosclerosis forms, and antithrombotic multiple therapeutical effect can more thoroughly be treated apoplexy all sidedly.
Summary of the invention
For overcoming above-mentioned defective, the inventor is through research for many years, obtained the Chinese medicine composition and preparation method thereof of the application's treatment apoplexy.
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of apoplexy.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
The present invention treats the Chinese medicine composition of apoplexy, and it is to be made by following raw materials by weight proportions: the Radix Astragali 27～33, Radix Angelicae Sinensis 9～11, Ramulus Cinnamomi 9～11, LUMBRICUS 10.5～13.44, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 9～11.5, the Radix Paeoniae Alba 9.2～11, Semen Persicae 9.2～11.2, Rhizoma Chuanxiong 10.5～13.5, Flos Chrysanthemi 13.05～16.95, Rhizoma Gastrodiae 9～11, Fructus Crataegi 10.5～13.5.
Preferably, the weight proportion of crude drug is: the Radix Astragali 28～32, Radix Angelicae Sinensis 9.5～10.5, Ramulus Cinnamomi 9.5～10.5, LUMBRICUS 11～13, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 10～11, the Radix Paeoniae Alba 10～11, Semen Persicae 9.5～11, Rhizoma Chuanxiong 11～13, Flos Chrysanthemi 13.5～16.5, Rhizoma Gastrodiae 9.5～10.5, Fructus Crataegi 11～13.
Most preferred, the weight proportion of crude drug is: the Radix Astragali 30, Radix Angelicae Sinensis 10, Ramulus Cinnamomi 10, LUMBRICUS 12, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 10, the Radix Paeoniae Alba 10, Semen Persicae 10, Rhizoma Chuanxiong 12, Flos Chrysanthemi 15, Rhizoma Gastrodiae 10, Fructus Crataegi 12.
The Chinese medicine composition of treatment apoplexy of the present invention can be preferably capsule for decoction, granule, capsule, tablet or the like.
The preparation method of the Chinese medicine composition of treatment apoplexy of the present invention comprises the steps:
(1) according to described weight proportion weighting raw materials: the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, LUMBRICUS, Radix Glycyrrhizae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Semen Persicae, Rhizoma Chuanxiong, Flos Chrysanthemi, Rhizoma Gastrodiae, Fructus Crataegi;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) add water (10 times of volumes) in fine powder, in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) filtrate being concentrated into relative density is 1.34～1.40, adds 1.6 parts of Icing Sugar, 1.4 parts of white dextrins, mix homogeneously, oven dry;
(5) (4) are pulverized, dried, operate, granulate, incapsulate, promptly according to capsular preparation technology.
Treat in the preparation method of apoplexy Chinese medicine composition in the present invention, it preferably includes step:
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: the Radix Astragali 27～33, Radix Angelicae Sinensis 9～11, Ramulus Cinnamomi 9～11, LUMBRICUS 10.5～13.44, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 9～11.5, the Radix Paeoniae Alba 9.2～11, Semen Persicae 9.2～11.2, Rhizoma Chuanxiong 10.5～13.5, Flos Chrysanthemi 13.05～16.95, Rhizoma Gastrodiae 9～11, Fructus Crataegi 10.5～13.5;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) to wherein adding water (10 times of volumes), in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) will collect filtrate simmer down to thick paste, being concentrated into relative density is 1.34～1.40, adds 1.6 parts of Icing Sugar, 1.4 parts of white dextrins, mix homogeneously, oven dry;
(5) (4) are pulverized, dried, operate, granulate, incapsulate, promptly according to capsular preparation technology.
The present invention treats the Chinese medicine composition of apoplexy, has the following advantages and effect:
(1) raw material of pharmaceutical composition of the present invention is formed: reuse the Radix Astragali in the side, tonifying Qi and lifting yang, capable stagnant, the strongly invigorating primordial QI of hemopoietic.Make vigour fill Sheng by QI invigorating and reach the capable merit of the capable then blood of gas; The Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and is coughed lung moistening, the emergency detoxifcation.The Radix Astragali and Radix Glycyrrhizae can stagnate by the QI invigorating row, the effect that blood stasis dispelling stimulates the menstrual flow, and the two share, and is monarch drug, and the merit of benefiting QI for activating blood circulation, eliminating blood stasis and smoothing collaterals is arranged.Radix Angelicae Sinensis can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving; Radix Polygoni Multiflori energy enrich and benefit essence and blood, detoxifcation; The Radix Paeoniae Alba yin fluid astringing that can nourish blood, easing the affected liver to relieve pain; Rhizoma Chuanxiong can blood-activating and qi-promoting, wind-expelling pain-stopping, and the same usefulness of Rhizoma Chuanxiong that Radix Angelicae Sinensis, Radix Polygoni Multiflori and the Radix Paeoniae Alba can be enriched blood and be invigorated blood circulation and can blood-activating and qi-promoting can reach the capable effect of gas, and blood circulation promoting and blood stasis dispelling, auxiliary monarch drug reach the capable merit of the capable then blood of gas, are ministerial drug altogether.Semen Persicae energy blood circulation promoting and blood stasis dispelling; Fructus Crataegi have activating blood circulation to dissipate blood stasis effect assistant principal drug assistance ministerial drug performance blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain.Rhizoma Gastrodiae has endogenous wind stopping and ends warp, wind-damp dispelling, stopping numbness pain effect; LUMBRICUS energy clearing heat for calming endogenous wind, current meridians; Ramulus Cinnamomi, Flos Chrysanthemi have dispelling wind and heat pathogens, effects such as heat-clearing and toxic substances removing, the meridian dredging.
(2) pharmaceutical composition of the present invention is used for the treatment of apoplexy, also can be used for cerebral concussion sequela, the treatment of diseases such as cerebral arteriosclerosis.
(3), has blood circulation promoting and blood stasis dispelling, the organic compatibility of medical material of blood fat reducing anticoagulant economic benefits and social benefits class effect for stroke patient, period of use, resist short of money and synergism, reach from blood and vascular treatment and start with simultaneously, comprehensively improve impaired blood and vascular lesion, and prevent the therapeutic purposes of its recurrence.
Embodiment 1 Chinese medicinal composition capsules of the present invention
(1) according to following weight proportioning weighting raw materials: Radix Astragali 30g, Radix Angelicae Sinensis 10g, Ramulus Cinnamomi 10g, LUMBRICUS 12g, Radix Glycyrrhizae 15g, Radix Polygoni Multiflori 10g, Radix Paeoniae Alba 10g, Semen Persicae 10g, Rhizoma Chuanxiong 12g, Flos Chrysanthemi 15g, Rhizoma Gastrodiae 10g, Fructus Crataegi 12g;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) to wherein adding water (10 times of volumes), in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) will collect filtrate simmer down to thick paste, being concentrated into relative density is 1.34～1.40, adds 1.6 parts of Icing Sugar, 1.4 parts of white dextrins, mix homogeneously, oven dry;
(5) (4) are pulverized, dried, operate, granulate, incapsulate, promptly according to capsular preparation technology.
Embodiment 2 Chinese medicine composition decoctions of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Radix Astragali 28g, Radix Angelicae Sinensis 9.5g, Ramulus Cinnamomi 9.5g, LUMBRICUS 11g, Radix Glycyrrhizae 15g, Radix Polygoni Multiflori 10g, Radix Paeoniae Alba 10g, Semen Persicae 9.5g, Rhizoma Chuanxiong 11g, Flos Chrysanthemi 13.5g, Rhizoma Gastrodiae 9.5g, Fructus Crataegi 11g;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) to wherein adding water (10 times of volumes), in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) with filtrate simmer down to 800ml, divide to be filled in the bottle, promptly get decoction.
Embodiment 3 Chinese medicine composition mixture of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Radix Astragali 29g, Radix Angelicae Sinensis 9.8g, Ramulus Cinnamomi 9.8g, LUMBRICUS 12g, Radix Glycyrrhizae 15g, Radix Polygoni Multiflori 10.5g, Radix Paeoniae Alba 10.5g, Semen Persicae 10g, Rhizoma Chuanxiong 10.5g, Flos Chrysanthemi 145g, Rhizoma Gastrodiae 10g, Fructus Crataegi 11.5g;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) to wherein adding water (10 times of volumes), in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) with filtrate simmer down to 800ml, add sodium benzoate 0.25g branch and be filled in the bottle, promptly get mixture.
Embodiment 4 Chinese medicinal composition granules of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Radix Astragali 32g, Radix Angelicae Sinensis 10.5g, Ramulus Cinnamomi 10.5g, LUMBRICUS 13, Radix Glycyrrhizae 15g, Radix Polygoni Multiflori 11g, Radix Paeoniae Alba 11g, Semen Persicae 11g, Rhizoma Chuanxiong 13g, Flos Chrysanthemi 16.5g, Rhizoma Gastrodiae 10.5g, Fructus Crataegi 13g;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) to wherein adding water (10 times of volumes), in 80 ℃ of decoctions three times, filter and remove filtering residue, collection filtrate is stand-by;
(4) will collect filtrate simmer down to thick paste, being concentrated into relative density is 1.34～1.40, adds 1.6 parts of Icing Sugar, 1.4 parts of white dextrins, mix homogeneously, oven dry;
(5) (4) are added sucrose, dextrin 700g, stevioside 8g, fully mixing is made the about 1000g of granule, divides to be filled in the bag, promptly gets granule.
Investigate the effect of traditional Chinese medicine composition for treating apoplexy of the present invention
Medicine of the present invention is adjusted repeatedly through clinical practice for many years, has improved the effective percentage of apoplexy treatment.After the treatment of 150 stroke patients, obtain: clinical cure 32 examples account for 21%; Produce effects 40 examples account for 27%; 36 examples that take a turn for the better account for 24%; Invalid 42 examples account for 28%, and total effective rate reaches 72%.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (6)
1, a kind of Chinese medicine composition for the treatment of apoplexy, it is characterized in that, make: the Radix Astragali 27～33, Radix Angelicae Sinensis 9～11, Ramulus Cinnamomi 9～11, LUMBRICUS 10.5～13.44, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 9～11.5, the Radix Paeoniae Alba 9.2～11, Semen Persicae 9.2～11.2, Rhizoma Chuanxiong 10.5～13.5, Flos Chrysanthemi 13.05～16.95, Rhizoma Gastrodiae 9～11, Fructus Crataegi 10.5～13.5 by following raw materials by weight proportions.
2, treat the Chinese medicine composition of apoplexy according to claim 1, it is characterized in that, make: the Radix Astragali 28～32, Radix Angelicae Sinensis 9.5～10.5, Ramulus Cinnamomi 9.5～10.5, LUMBRICUS 11～13, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 10～11, the Radix Paeoniae Alba 10～11, Semen Persicae 9.5～11, Rhizoma Chuanxiong 11～13, Flos Chrysanthemi 13.5～16.5, Rhizoma Gastrodiae 9.5～10.5, Fructus Crataegi 11～13 by following raw materials by weight proportions.
3, treat the Chinese medicine composition of apoplexy as claimed in claim 1 or 2, it is characterized in that, make: the Radix Astragali 30, Radix Angelicae Sinensis 10, Ramulus Cinnamomi 10, LUMBRICUS 12, Radix Glycyrrhizae 15, Radix Polygoni Multiflori 10, the Radix Paeoniae Alba 10, Semen Persicae 10, Rhizoma Chuanxiong 12, Flos Chrysanthemi 15, Rhizoma Gastrodiae 10, Fructus Crataegi 12 by following raw materials by weight proportions.
4, Chinese medicine composition as claimed in claim 1 or 2, it is decoction, granule, capsule or tablet.
5, Chinese medicine composition as claimed in claim 4, it is a capsule.
6, a kind of preparation is characterized in that as the method for claim 1-5 Chinese medicine composition as described in each, comprises the steps:
(1) according to described weight proportion weighting raw materials: the Radix Astragali, Radix Angelicae Sinensis, Ramulus Cinnamomi, LUMBRICUS, Radix Glycyrrhizae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Semen Persicae, Rhizoma Chuanxiong, Flos Chrysanthemi, Rhizoma Gastrodiae, Fructus Crataegi;
(2) crude drug that (1) is taken by weighing is ground into fine powder;
(3) add an amount of decoction of water three times in fine powder, filter and remove filtering residue, collection filtrate is stand-by;
(4) with filtrate simmer down to thick paste, add Icing Sugar, white dextrin is an amount of, mix homogeneously, oven dry gets final product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846741A (en) * | 2012-08-28 | 2013-01-02 | 赵爱良 | Navel-applied plaster for treating sequelae of hemiplegia and preparation method thereof |
| CN104547973A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Health traditional Chinese medicine for treating chest obstruction and preparation method thereof |
| CN104547951A (en) * | 2015-01-29 | 2015-04-29 | 王东宝 | Traditional Chinese medicine preparation for treating cerebral apoplexy and preparation method of traditional Chinese medicine preparation |
| CN105816698A (en) * | 2016-06-08 | 2016-08-03 | 江苏天晟药业股份有限公司 | Traditional Chinese medicine composition preventing stroke, preparation method, traditional Chinese medicine preparation and application |
-
2009
- 2009-09-11 CN CN200910092917A patent/CN101642532A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846741A (en) * | 2012-08-28 | 2013-01-02 | 赵爱良 | Navel-applied plaster for treating sequelae of hemiplegia and preparation method thereof |
| CN102846741B (en) * | 2012-08-28 | 2014-04-09 | 赵爱良 | Navel-applied plaster for treating sequelae of hemiplegia and preparation method thereof |
| CN104547973A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Health traditional Chinese medicine for treating chest obstruction and preparation method thereof |
| CN104547951A (en) * | 2015-01-29 | 2015-04-29 | 王东宝 | Traditional Chinese medicine preparation for treating cerebral apoplexy and preparation method of traditional Chinese medicine preparation |
| CN105816698A (en) * | 2016-06-08 | 2016-08-03 | 江苏天晟药业股份有限公司 | Traditional Chinese medicine composition preventing stroke, preparation method, traditional Chinese medicine preparation and application |
| CN105816698B (en) * | 2016-06-08 | 2020-01-17 | 江苏天晟药业股份有限公司 | Traditional Chinese medicine composition for preventing and treating stroke, preparation method, traditional Chinese medicine preparation and application |
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Open date: 20100210 |