CN106166206A - A kind of gynecological inflammation causes the rehabilitation medicine preparation method of frequent micturition - Google Patents
A kind of gynecological inflammation causes the rehabilitation medicine preparation method of frequent micturition Download PDFInfo
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Classifications
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Abstract
The invention discloses a kind of gynecological inflammation and cause the rehabilitation medicine preparation method of frequent micturition.(1) taking Herba Vaccinii Bracteati fruit and Radix et Rhizoma Iridis Sanguineae, boiling 2 times, collecting decoction after pulverizing, after filtration, filtrate is standby；(2) white tripe, Rhizoma Corydalis Decumbentis, orange ear, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Aster auriculatus Franch., Bao Xuecao, Herba Lysionoti Pauciflori, vinegar woods, chestnut are taken, clean, dry, pulverize, soak after mixing, add decoction 2 times, collecting decoction, stand, then toward the ethanol of addition 95% in decocting liquid, standing, centrifugal, supernatant obtains refined liquid after reclaiming ethanol；(3) gained refined liquid in gained filtrate in step (1) and step (2) is mixed, concentrate, be spray-dried, pulverized 300 mesh sieves, and be sub-packed in capsule after sterilizing.Drug prescription of the present invention is reasonable, and clear curative effect can effectively treat the frequent micturition that patient causes because of gynecological inflammation.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of oral drugs of enuresis frequency after pelvic inflammatory disease.
Background technology
When female pelvic cavity genitals and connective tissue about, pelvic peritoneum are inflamed, referred to as pelvic inflammatory disease, including
Acute pelvic inflammatory disease, chronic pelvic inflammatory disease, can fall ill at one or a few place simultaneously, be one of commonly encountered disease.Wherein chronic pelvic inflammatory disease is normal
Appropriate thoroughly treatment or patient's body constitution is poor, course of disease delay is caused is failed for acute pelvic inflammatory disease, according to statistics 22～60 years old married
In women, chronic pelvic inflammatory disease sickness rate is about 10%, easy recurrent exerbation, and the touching difficulty of the state of an illness is more.Cause the main disease of pelvic inflammation
Substance one is to be lodged in intravaginal flora, including aerobe and anaerobe from former；One comes from the pathogen in the external world such as
Diplococcus gonorrhoeae, chlamydia trachomatis, tubercule bacillus, bacillus pyocyaneus etc., as treated not in time, be easily caused infertile, dystopy is pregnant
Be pregnent, chronic pelvic pain, pelvic inflammatory disease recurrent exerbation etc., and have some patients can stimulate mucous membrane of urinary bladder and bladder muscle due to pelvic inflammatory
In meat, the teleneuron of distribution, causes detrusor the hyperfunction irritability of reflexive occur, and bladder is in the state of high stress, urinates
Frequently.
This " after pelvic inflammatory disease the enuresis frequency " is not cystitis, therefore antibacterial drug therapy be only capable of solving " pelvic inflammatory disease " this
Plant and catch, but its " frequency symptoms " brought can not be solved, therefore clinical pelvic inflammatory disease clinical cure patient has 15
～20% leave over frequent micturition, but routine urinalysis data are normal.
Chinese traditional treatment above-mentioned symptom frequent micturition, can only Symptomatic medicine, based on " clearing away heat-damp and promoting diuresis is treating stranguria ", medicinal Herba Dianthi, flat
Storage, Semen Plantaginis, Talcum, Bi, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Taraxaci, Herba Violae etc..But owing to above-mentioned frequent micturition does not exist urinary system
Infection index, the use of said medicine often effect is but and bad.
Clinic also it is believed that after this pelvic inflammatory disease the enuresis frequency to suffer from a deficiency of the kidney relevant, side's Pill for Decreasing Urination, take Rhizoma Dioscoreae tonifying the kidney to consolidate the essence；
Fructus Alpiniae Oxyphyllae warming and recuperating the kidney-YANG, restrains vital essence；Radix Linderae warming kidney for dispelling cold.But frequent micturition of actually suffering from a deficiency of the kidney mostly is nocturia to be increased, based on yang deficiency,
Therefore temperature compensation, after pelvic inflammatory disease, enuresis frequency is then that ember is clear, and pelvic inflammatory is distributed in stimulating mucous membrane of urinary bladder and bladder muscle
Teleneuron, causes detrusor the hyperfunction irritability of reflexive occur, and the two mechanism is contrary to.
It is thus desirable to a kind of safe and reliable, the oral drugs of the frequency of the enuresis after pelvic inflammatory disease having no side effect.
Summary of the invention
The technical assignment of the present invention is for above the deficiencies in the prior art, it is provided that a kind of curative effect is certainly and side effect is little
The oral drugs of enuresis frequency after pelvic inflammatory disease.
The present invention solves the technical scheme of its technical problem: a kind of oral drugs of enuresis frequency after pelvic inflammatory disease, its
Being characterised by, crude drug includes: Herba Vaccinii Bracteati fruit 10～15 parts, Radix et Rhizoma Iridis Sanguineae 10～15 parts, white tripe 5～15 parts, Rhizoma Corydalis Decumbentis 5～15
Part, orange ear 6～10 parts, Semen puerariae lobatae 3～10 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 6～12 parts, Aster auriculatus Franch. 3～10 parts, thin snow grass 6～12 parts, Herba Lysionoti Pauciflori 2
～5 parts, vinegar woods 1～3 parts, chestnut 1～3 parts..
In prescription:
Herba Vaccinii Bracteati fruit, for the fruit of ericad southwest Pericarpium Citri tangerinae.Nature and flavor acid, sweet, flat；Function cures mainly, bone and muscle strengthening, QI invigorating
Power.Main soreness of bones and muscles, myasthenia of limbs.
Radix et Rhizoma Iridis Sanguineae, for rhizome and the root of irides Radix et Rhizoma Iridis Sanguineae；Nature and flavor are pungent, flat, nontoxic；Function cures mainly, removing food stagnancy.
White tripe, for the Herb of vitaceae Vitis Labrusca L.Nature and flavor are pungent, flat；Function cures mainly, promoting blood circulation to remove obstruction in the collateral.Main rheumatalgia,
Treating swelling and pain by traumatic injury.
Rhizoma Corydalis Decumbentis, bloodroot lies prostrate the tuber of raw Herba corydalis edulis；Nature and flavor temperature, bitter, micro-pungent, return Liver Channel；Function cures mainly, invigorate blood circulation,
Dredging collateral, promoting the circulation of QI to relieve pain.
Orange ear, for the sporophore of Tremellaceae fungus orange ear；Nature and flavor are sweet, light, flat, return spleen, stomach warp；Function cures mainly, and nourishing the stomach is good for
Spleen antidiarrheal.Main inappetence；Insufficiency of the spleen chronic diarrhea.
Semen puerariae lobatae, for legume pueraria lobata, the seed of Radix Puerariae rattan；Nature and flavor are sweet, flat；GUIXIN, stomach, lung meridian；Function cures mainly, spleen invigorating
Antidiarrheal, relieves the effect of alcohol.Master has loose bowels；Dysentery；Insobriety.
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), for the herb of sedge rotation squama dried tuber；Nature and flavor are pungent, light, flat；Return liver, spleen channel；Function cures mainly, OK
Gas nourishes blood, regulating menstruation.Main menoxenia；Dysmenorrhea.
Aster auriculatus Franch., plants the root of Ke Erye Radix Asteris for Compositae；Nature and flavor are pungent, temperature；Function cures mainly, dispersing wind-cold, relieving cough and asthma.
Bao Xuecao, for the flower of feverfew thin snow Leontopodium leontopodioides (Willd.) Beauv..Nature and flavor are light, micro-sweet, flat；Function cures mainly, nourishing the lung to arrest cough.Main lung
Cough caused by dryness is coughed.
Herba Lysionoti Pauciflori, the dry aerial parts of Gesneriaceae Lysionotus carnosus Hemsl. (Lysionotus pauciflorus Maxim.)；Nature and flavor temperature, bitter, return lung meridian；Merit only can be reduced phlegm
Cough, hard masses softening and resolving.With controlling cough with copious phlegm, scrofula sucutaneous nodule.
Vinegar woods, for the fruit of rosaceous plant Photinia.Nature and flavor acid, temperature；Function cures mainly, parasite killing, hemostasis, astringing intestine to stop diarrhea,
Promote the production of body fluid, relieve the effect of alcohol.Main ascarid is suffered from abdominal pain, anal fistula hematochezia, chronic dysentery.
Chestnut, for Fagaceae chestnut endocarp；Nature and flavor are sweet, puckery, flat；Function cures mainly, the eliminating stagnation therapeutic method to keep the adverse QI flowing downwards, skin care.Main
A fishbone or other bone caught in the throat；Scrofula；Regurgitation；There is wrinkle in face.
Composition principle: " enuresis frequency after pelvic inflammatory disease " is not cystitis, and therefore antibacterial drug therapy is only capable of solving " pelvic cavity
Scorching " this catch, but its " frequency symptoms " brought can not be solved, therefore in clinical pelvic inflammatory disease clinical cure patient
Have 15～20% to leave over frequent micturition, but routine urinalysis data are normal.Chinese traditional treatment above-mentioned symptom frequent micturition, can only Symptomatic medicine, with
" clearing away heat-damp and promoting diuresis is treating stranguria " is main, medicinal Herba Dianthi, Herba Polygoni Avicularis, Semen Plantaginis, Talcum, Bi, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Taraxaci, Herba Violae
Deng.But owing to above-mentioned frequent micturition does not exist urinary system infection index, the use of said medicine often effect is but and bad.Clinic is also
It is believed that after this pelvic inflammatory disease the enuresis frequency to suffer from a deficiency of the kidney relevant, side's Pill for Decreasing Urination, take Rhizoma Dioscoreae tonifying the kidney to consolidate the essence；Fructus Alpiniae Oxyphyllae temperature compensation kidney
Sun, restrains vital essence；Radix Linderae warming kidney for dispelling cold.But frequent micturition of actually suffering from a deficiency of the kidney mostly is nocturia to be increased, based on yang deficiency, therefore temperature compensation, and
After pelvic inflammatory disease, enuresis frequency is then that ember is clear, and the teleneuron that pelvic inflammatory is distributed in stimulating mucous membrane of urinary bladder and bladder muscle is led
Causing detrusor and the hyperfunction irritability of reflexive occur, the two mechanism is contrary to.It practice, the pathomechanism of frequent micturition is pelvic inflammatory disease period of disease
Between, owing to inflammatory stimulus bladder mucosa causes bladder muscle nervus motorius and sympathetic nerve disorderly, detrusor occurs that reflexive is hyperfunction,
Bladder muscle is in the state of high stress, is easily caused bladder muscle nervous by excitation, produces uriesthesia, uses diuresis or the kidney invigorating
Therapeutic effect is the most inconspicuous.
Compared with prior art, the invention have the characteristics that:
1, prescription is with " Herba Vaccinii Bracteati fruit, Radix et Rhizoma Iridis Sanguineae " medicine to as monarch, and the acid of Herba Vaccinii Bracteati fruity, Radix et Rhizoma Iridis Sanguineae acrid in the mouth, octanoic acidization the moon directly rushes down faints
The moon, bladder muscle nervus motorius and sympathetic nerve disorder are that liver channel of foot-Jueyin ember is the most clear actually.Experimentation shows: Herba Vaccinii Bracteati
Really, Radix et Rhizoma Iridis Sanguineae mixed in equal amounts water decoction is for cyclophosphamide inducing chronic overactive bladder rat model, treatment group rat
Average maximum bladder capacity increases (0.70 ± 0.38mL)；Phase of urinating is obviously prolonged (17.32 ± 0.28min)；Basis bladder
Press significantly raised (52.19 ± 3.5cmH2O)；(0.32 ± 0.21mL is compared with blank group；12.87±0.35min；
42.03±4.3cmH2O), difference is respectively provided with statistical significance (P < 0.05)；Result above may be with suppression Bladder afferent
Irritability and the release of Afferent Mediator relevant with synthesis；
2, white tripe dredging collateral, Rhizoma Corydalis Decumbentis, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), the gas of orange ear row taste liver and gall, all medicine cooperations, few sun is let out in acid, sweet rushing down is lacked
The moon, burnt water route in the people having the same aspiration and interest, but the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels will not be had an impact, there is no the merit of diuretic, kidney burden will not be strengthened.Control with the power of middle Jiao
The sufferer of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, is the central characteristics of this prescription, and its reason is Liver Channel gas in the factor that originates of this part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels sufferer (frequent micturition) in fact
Machine is unfavorable, stagnation of QI due to depression of the liver, even if therefore pelvic inflammation has controlled, still can remain frequency symptoms；
3, Aster auriculatus Franch., thin snow grass enter lung meridian, the lung being the upper source of fluids, and the meaning adding Aster auriculatus Franch. and Bao Xuecao is priming water channel gas
Machine.Steam is solidifying and does not turn to it " insubstantial phlegm " and produces the performance of bladder irritability, and Bao Xuecao, Herba Lysionoti Pauciflori, merit can be reduced phlegm
Knot, slows down this excitation symptom；
4, vinegar woods are warm in nature, chestnut eliminating stagnation, contribute to lower-jiao Qi dysfunction, and have emergency effect.Meanwhile, chestnut is puckery flat, dissipate and not
Consumption.
Detailed description of the invention
Below in conjunction with practical situation, the detailed description of the invention of the present invention is elaborated.
Embodiment 1, crude drug part by weight is: Herba Vaccinii Bracteati fruit 10g, Radix et Rhizoma Iridis Sanguineae 10g, white tripe 10g, Rhizoma Corydalis Decumbentis 10g, orange ear
8g, Semen puerariae lobatae 6g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8g, Aster auriculatus Franch. 7g, thin snow grass 10g, Herba Lysionoti Pauciflori 3g, vinegar woods 1g, chestnut 2g.
The preparation method of embodiment 1 is: Herba Vaccinii Bracteati fruit, Radix et Rhizoma Iridis Sanguineae, white tripe, Rhizoma Corydalis Decumbentis, orange ear, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), straw rain cape
Lotus, Bao Xuecao, Herba Lysionoti Pauciflori, vinegar woods, chestnut, clean roguing, put into Traditional Chinese medicine decocting earthen pot.Add cold water and cover powder, soak
60min, intense fire decocts to boiling, after change slow fire and decoct 30min slowly, decoct 2 times altogether, filtered through gauze collecting decoction, oral every day one
Agent.
Embodiment 2, crude drug part by weight is: Herba Vaccinii Bracteati fruit 10 parts, Radix et Rhizoma Iridis Sanguineae 10 parts, 5 parts of white tripe, Rhizoma Corydalis Decumbentis 15 parts,
6 parts of ear of orange, Semen puerariae lobatae 3 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, 10 parts of Aster auriculatus Franch., thin snow grass 6 parts, Herba Lysionoti Pauciflori 2 parts, vinegar woods 3 parts, chestnut 1 part.
Embodiment 3, crude drug part by weight is: Herba Vaccinii Bracteati fruit 15 parts, Radix et Rhizoma Iridis Sanguineae 15 parts, 10 parts of white tripe, Rhizoma Corydalis Decumbentis 10 parts,
8 parts of ear of orange, Semen puerariae lobatae 6 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8 parts, 7 parts of Aster auriculatus Franch., thin snow grass 10 parts, Herba Lysionoti Pauciflori 3 parts, vinegar woods 1 part, chestnut 2 parts.
Embodiment 4, crude drug part by weight is: Herba Vaccinii Bracteati fruit 12 parts, Radix et Rhizoma Iridis Sanguineae 12 parts, 15 parts of white tripe, Rhizoma Corydalis Decumbentis 5 parts,
10 parts of ear of orange, Semen puerariae lobatae 10 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 6 parts, 3 parts of Aster auriculatus Franch., thin snow grass 12 parts, Herba Lysionoti Pauciflori 5 parts, vinegar woods 1 part, chestnut 3 parts.
The preparation method of embodiment 2～4 oral drugs is:
(1) take Herba Vaccinii Bracteati fruit and Radix et Rhizoma Iridis Sanguineae, boiling 2 times after pulverizing, each 1h, the collecting decoction of recipe quantity, stand, filter
Rear filtrate is standby；
(2) the white tripe of recipe quantity, Rhizoma Corydalis Decumbentis, orange ear, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Aster auriculatus Franch., Bao Xuecao, Herba Lysionoti Pauciflori, vinegar woods, chestnut are taken
, clean roguing, dry, be ground into granule, after mixing, add water to cover powder 2cm, after soaking 0.5～1h, add up medical material 10
The water of times weight, decocts 2 times, each 1h, collecting decoction, stands, then toward the second of add 3～4 times of medicinal liquids in decocting liquid 95%
Alcohol, stands 15 minutes, is then centrifuged for, and takes after supernatant reclaims ethanol and obtains refined liquid；
(3) gained refined liquid in gained filtrate in step (1) and step (2) is mixed, concentrate, be spray-dried, pulverized 300 mesh
Sieve, after sterilizing, fill is in capsule.
During use, oral daily dosage is equivalent to crude drug amount 95g.
Said medicine efficient combination, coordinates mutually, effectively reaches to treat enuresis purpose frequently after pelvic inflammatory disease, and side effect is relatively
Few.The above results is that clinical data fully proves, relevant information is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in October, 2014～in April, 2016 leave over frequent micturition patient after acute pelvic inflammatory disease clinical cure
205 examples, wherein 2 weeks patient 78 examples of frequent micturition course of disease ＞；Age 23～56 years old, average 41.34 years old, equal sexual intercourse history.Patient daytime
Nocturia number of times ＞ 10 times, gets rid of drug-induced bladder maximum and holds reduction, and getting rid of the cause of disease such as calculus, tumor stimulates the urine caused
Frequently, the patient in terms of heart, kidney, spirit.
1.1.2 packet: be randomly divided into three groups, wherein matched group 68 example, decoction group 69 example, Capsules group 68 example.Three groups of patients
Age, the state of an illness, course of disease distribution are compared, no significant difference (P > 0.05), there is comparability.
1.1.3 group standard is entered: pelvic inflammatory disease lab index is normal, and ametria or adnexa tenderness；Patient urinates number of times round the clock
＞ 10 times, routine urinalysis index is normal, anuria pain shape.
1.2 method.
1.2.1 Therapeutic Method: matched group uses " Pill for Decreasing Urination " (Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, the Radix Linderae)；Decoction group uses embodiment 1
The decoction oral prepared；Capsules group uses the capsule oral that embodiment 3 prepares.Every day 1 dose point is administered orally for 2 times, three groups of patients all with
It within 15 days, it is a course for the treatment of.
1.2.2 observation item: observe three groups of patient's total urination time round the clock and medication related reactions.
1.2.3 curative effect determinate standard: cure: symptom is wholly absent；Effective: frequent micturition number of times reduces to treatment the first half；Invalid:
Symptom is without improving.
1.2.4 statistical analysis: SPSS 18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ2
Inspection.
2 results.
2.1 3 groups treated for 1 course for the treatment of after compare:
After treating 1 course for the treatment of, decoction group compares with Capsules group total effective rate and matched group, has notable statistics difference (χ2
=4.93, P ＜ 0.05；χ2=7.29, P ＜ 0.05), decoction group, Capsules group cure rate compare with matched group, have significance
Significant difference (χ2=6.15, P ＜ 0.05；χ2=9.74, P ＜ 0.01), it was demonstrated that the medicine that the embodiment of the present invention prepares can be bright
Aobvious reduction after pelvic inflammatory disease is cured leaves over frequent micturition controlled micturition number of times.
2.2 untoward reaction and toleration: during drug treatment, three groups all do not occur without the obvious heart, liver, kidney untoward reaction
And symptom.
3. conclusion.
This result of study shows, uses the decoction group of drug regimen of the present invention and Capsules group total effective rate apparently higher than comparison
Group and having no adverse reaction, illustrates that medicine prepared by the inventive method has in terms of leaving over frequent micturition after treatment pelvic inflammatory disease is cured
The advantage that curative effect is affirmed, safety is higher.
Claims (2)
1. a gynecological inflammation causes the rehabilitation medicine preparation method of frequent micturition, it is characterised in that be made up of following crude drug: full meal
Flowers and fruits, Radix et Rhizoma Iridis Sanguineae, white tripe, Rhizoma Corydalis Decumbentis, orange ear, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Aster auriculatus Franch., Bao Xuecao, Herba Lysionoti Pauciflori, vinegar woods, chestnut, its
Preparation method is:
(1) take Herba Vaccinii Bracteati fruit and Radix et Rhizoma Iridis Sanguineae, boiling 2 times after pulverizing, each 1h, the collecting decoction of recipe quantity, stand, filter
Rear filtrate is standby；
(2) the white tripe of recipe quantity, Rhizoma Corydalis Decumbentis, orange ear, Semen puerariae lobatae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Aster auriculatus Franch., Bao Xuecao, Herba Lysionoti Pauciflori, vinegar woods, chestnut are taken
, clean roguing, dry, pulverize, after soaking after mixing, add up the water of 10 times of weight of medical material, decoct 2 times, each 1h, close
And decocting liquid, stand, then toward the ethanol of the 95% of 3 ~ 4 times of medicinal liquids of addition in decocting liquid, stand 15 minutes, be then centrifuged for, take supernatant
Refined liquid is obtained after reclaiming ethanol；
(3) gained refined liquid in gained filtrate in step (1) and step (2) is mixed, concentrate, be spray-dried, pulverized 300 mesh
Sieve, is sub-packed in capsule after sterilizing.
A kind of gynecological inflammation the most according to claim 1 causes the rehabilitation medicine preparation method of frequent micturition, it is characterized by, by with
Lower raw material medicine is made: Herba Vaccinii Bracteati fruit 10 parts, Radix et Rhizoma Iridis Sanguineae 10 parts, 10 parts of white tripe, Rhizoma Corydalis Decumbentis 10 parts, orange 8 parts of ear, Semen puerariae lobatae 6
Part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8 parts, 7 parts of Aster auriculatus Franch., thin snow grass 10 parts, Herba Lysionoti Pauciflori 3 parts, vinegar woods 1 part, chestnut 2 parts.
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| CN111671850A (en) * | 2020-07-22 | 2020-09-18 | 管柳军 | Uterus warming and pregnancy promoting pill |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658644A (en) * | 2009-09-16 | 2010-03-03 | 蒋保珍 | Internal administration medicament for treating urolithiasis disease |
| CN103055072A (en) * | 2012-11-23 | 2013-04-24 | 邹洪胜 | Traditional Chinese medicine composition for treating stranguria |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658644A (en) * | 2009-09-16 | 2010-03-03 | 蒋保珍 | Internal administration medicament for treating urolithiasis disease |
| CN103055072A (en) * | 2012-11-23 | 2013-04-24 | 邹洪胜 | Traditional Chinese medicine composition for treating stranguria |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111671850A (en) * | 2020-07-22 | 2020-09-18 | 管柳军 | Uterus warming and pregnancy promoting pill |
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Application publication date: 20161130 |