CN105106692A - Traditional Chinese medicinal composition for gallstone postoperative recovery and preparation method of traditional Chinese medicinal composition - Google Patents

Traditional Chinese medicinal composition for gallstone postoperative recovery and preparation method of traditional Chinese medicinal composition Download PDF

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CN105106692A
CN105106692A CN201510554746.1A CN201510554746A CN105106692A CN 105106692 A CN105106692 A CN 105106692A CN 201510554746 A CN201510554746 A CN 201510554746A CN 105106692 A CN105106692 A CN 105106692A
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rhizoma
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不公告发明人
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Jiang Shufen
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Jiang Shufen
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Abstract

A traditional Chinese medicinal composition for gallstone postoperative recovery comprises active pharmaceutical ingredients such as giant knot weeds, dark plum fruits, capillary wormwood herbs, costustoot, pericarpium citri reticulatae viride, common nepenthes, dandelions, chicken's gizzard-membranes, scutellaria baicalensis, bittersweet herbs, desmodium, the root of Chinese thorowax, corn stigmas, eastern bracken fern rhizomes, selfheal, rhizoma corydalis, humifuse euphorbia herbs, setose thistles, pangolins, safflowers, the root of red-rooted salvia, Szechwan chinaberry fruits, white paeony roots, amur cork tree bark, schizonepeta, felwort, goldthread, jasmine flowers, spreading hedyotis herbs, the root of riparian homonoia and liquorice. The active pharmaceutical ingredients of the traditional Chinese medicinal composition are compatible with each other, calculus elimination, inflammation reduction and pain relief effects are achieved through compounding of the active pharmaceutical ingredients, microcirculation can be regulated, metabolism can be promoted, and the traditional Chinese medicinal composition has the advantages of quick result, high cure rate, nonexistence of toxic and side effects, safety, convenience and the like in terms of gallstone postoperative recovery, is low in cost and easy to prepare and can be widely applied to gallstone postoperative recovery.

Description

A kind of Chinese medicine composition for cholelithiasis post-operative recovery and preparation method thereof
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for cholelithiasis post-operative recovery and preparation method thereof.
Background technology
Cholelithiasis is mainly seen in adult, and women is more than male, and within 40 years old, sequela rate increases with the age and increases.Calculus is cholesterol calculus or the mixed calculus based on cholesterol and black bile pigment calculus.
The main clinical manifestation of cholelithiasis has biliary colic, upper abdomen dull pain and gallbladder hydrops.Patient be everlasting heavy meal, feed greasy food after or sleep in Body Position Change time, because gallbladder contraction or calculus displacement add vagal excitation, Incarcerated stone is at gallbladder ampulla or cervical region, and gall bladder emptying is obstructed, IBP power raises, and gallbladder brute force is shunk and causes angor.Pain is positioned at upper right abdomen or epigastrium, in paroxysmal, or the aggravation of constant pain paroxysmal, can radiate in scapular region and back to the right, can Nausea and vomiting be accompanied.Some patients accurately can not say painful area because pain is acute.After biliary colic occurs first, the patient of about 70% can be recurred in 1 year.Most patient only on the feed excessive, feel epigastrium or upper right abdomen dull pain when eating high lipid food, work strain or have a rest bad, or have glutted discomfort, belch, singultus etc., be easily misdiagnosed as " gastropathy ".The long-term incarceration of cholelithiasis or block cystic duct but non-concurrent infection time, gallbladder mucosa absorbs the bile pigments in bile.Secretion mucus material, forms gallbladder hydrops.Hydrops is transparent colourless, is also called white bile.
Cholelithiasis can stimulate mucous membrane of gallbladder after referring to that calculus is formed in gallbladder, not only can cause the chronic inflammatory disease of gallbladder, and when Incarcerated stone is after neck of gallbladder or cystic duct, can also cause secondary infection, causes the acute inflammation of gallbladder.Because calculus is to the chronic stimulation of mucous membrane of gallbladder, also may cause the generation of carcinoma of gallbladder, have the incidence rate of report this kind of carcinoma of gallbladder to reach 1-2%.
The method mainly operative treatment of current treatment cholelithiasis, cholelithiasis patient first post-operative day needs fasting, because the intestines and stomach is still in narcotism, patient can only drink rice water, within second day, can take food.The postoperative patient of calculus of bile duct then needs fasting three days, no matter 1 day or 3 days, concerning postoperative patient, is all need to stand hunger, must gives digestive function some time, allows its recovery recovery.Some patients also has the symptom of post-operation diarrhea, Nausea and vomiting, and health can be in very weak state.Even if spent 1 day to 3 days, can't stand too heavy burden because digestive system holds for the moment, also cannot at will take food.Along with the development of modern medicine, postoperative care is also paid attention to gradually, after nursing, carries out the recovery of correct nursing for disease by significant to patient affected part.
Summary of the invention
The present invention is directed to weak point of the prior art, a kind of Chinese medicine composition for cholelithiasis post-operative recovery is provided, this Chinese medicine composition for have for cholelithiasis post-operative recovery instant effect, cure rate high, have no side effect, the advantage such as safe ready, and low price, easy to prepare, cholelithiasis post-operative recovery can be widely used in.
Above-mentioned purpose of the present invention is realized by following technical proposals:
For a Chinese medicine composition for cholelithiasis post-operative recovery, the crude drug of described Chinese medicine composition is made up of crude drug such as Rhizoma Polygoni Cuspidati, Fructus Mume, Herba Artemisiae Scopariae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Herba nepenthis, Herba Taraxaci, Endothelium Corneum Gigeriae Galli, Radix Scutellariae, Herba Solani Lyrati, Herba Lysimachiae, Radix Bupleuri, Stigma Maydis, Rhizoma pteridii latiusculi, Spica Prunellae, Rhizoma Corydalis, Herba Euphorbiae Humifusae, Radix Cirsii Japonici, Squama Manis, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Toosendan, the Radix Paeoniae Alba, Cortex Phellodendri, Herba Schizonepetae, Radix Gentianae, Rhizoma Coptidis, Fructus Gardeniae, Herba Hedyotidis Diffusae, Radix Homonoiae Ripariae, Radix Glycyrrhizaes.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 3-6 part, Fructus Mume 8-13 part, Herba Artemisiae Scopariae 3-5 part, Radix Aucklandiae 11-15 part, Pericarpium Citri Reticulatae Viride 5-10 part, Herba nepenthis 2-5 part, Herba Taraxaci 4-9 part, Endothelium Corneum Gigeriae Galli 12-20 part, Radix Scutellariae 10-16 part, Herba Solani Lyrati 3-8 part, Herba Lysimachiae 5-12 part, Radix Bupleuri 12-17 part, Stigma Maydis 7-12 part, Rhizoma pteridii latiusculi 4-9 part, Spica Prunellae 15-20 part, Rhizoma Corydalis 10-15 part, Herba Euphorbiae Humifusae 8-12 part, Radix Cirsii Japonici 2-5 part, Squama Manis 3-7 part, Flos Carthami 11-14 part, Radix Salviae Miltiorrhizae 9-15 part, Fructus Toosendan 3-6 part, Radix Paeoniae Alba 8-13 part, Cortex Phellodendri 3-5 part, Herba Schizonepetae 1-3 part, Radix Gentianae 5-10 part, Rhizoma Coptidis 5-10 part, Fructus Gardeniae 13-16 part, Herba Hedyotidis Diffusae 3-10 part, Radix Homonoiae Ripariae 8-13 part, Radix Glycyrrhizae 3-5 part.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 6 parts, Fructus Mume 8 parts, Herba Artemisiae Scopariae 3 parts, the Radix Aucklandiae 15 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 parts, Herba Taraxaci 5 parts, Endothelium Corneum Gigeriae Galli 12 parts, Radix Scutellariae 16 parts, Herba Solani Lyrati 3 parts, Herba Lysimachiae 12 parts, Radix Bupleuri 12 parts, Stigma Maydis 10 parts, Rhizoma pteridii latiusculi 9 parts, Spica Prunellae 15 parts, Rhizoma Corydalis 15 parts, Herba Euphorbiae Humifusae 8 parts, Radix Cirsii Japonici 5 parts, Squama Manis 3 parts, 14 parts, Flos Carthami, Radix Salviae Miltiorrhizae 9 parts, Fructus Toosendan 6 parts, the Radix Paeoniae Alba 8 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 1 part, Radix Gentianae 10 parts, Rhizoma Coptidis 5 parts, Fructus Gardeniae 16 parts, Herba Hedyotidis Diffusae 10 parts, Radix Homonoiae Ripariae 8 parts, 5 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 4 parts, Fructus Mume 10 parts, Herba Artemisiae Scopariae 4 parts, the Radix Aucklandiae 13 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 parts, Herba Taraxaci 8 parts, Endothelium Corneum Gigeriae Galli 20 parts, Radix Scutellariae 10 parts, Herba Solani Lyrati 8 parts, Herba Lysimachiae 5 parts, Radix Bupleuri 17 parts, Stigma Maydis 12 parts, Rhizoma pteridii latiusculi 4 parts, Spica Prunellae 20 parts, Rhizoma Corydalis 10 parts, Herba Euphorbiae Humifusae 12 parts, Radix Cirsii Japonici 2 parts, Squama Manis 7 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 15 parts, Fructus Toosendan 3 parts, the Radix Paeoniae Alba 13 parts, Cortex Phellodendri 3 parts, Herba Schizonepetae 3 parts, Radix Gentianae 5 parts, Rhizoma Coptidis 10 parts, Fructus Gardeniae 13 parts, Herba Hedyotidis Diffusae 3 parts, Radix Homonoiae Ripariae 13 parts, 3 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 5 parts, Fructus Mume 12 parts, Herba Artemisiae Scopariae 3 parts, the Radix Aucklandiae 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 parts, Herba Taraxaci 7 parts, Endothelium Corneum Gigeriae Galli 13 parts, Radix Scutellariae 11 parts, Herba Solani Lyrati 4 parts, Herba Lysimachiae 6 parts, Radix Bupleuri 13 parts, Stigma Maydis 7 parts, Rhizoma pteridii latiusculi 5 parts, Spica Prunellae 18 parts, Rhizoma Corydalis 11 parts, Herba Euphorbiae Humifusae 9 parts, Radix Cirsii Japonici 4 parts, Squama Manis 6 parts, 12 parts, Flos Carthami, Radix Salviae Miltiorrhizae 13 parts, Fructus Toosendan 4 parts, the Radix Paeoniae Alba 9 parts, Cortex Phellodendri 4 parts, Herba Schizonepetae 2 parts, Radix Gentianae 6 parts, Rhizoma Coptidis 6 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 5 parts, Radix Homonoiae Ripariae 10 parts, 4 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 4 parts, Fructus Mume 11 parts, Herba Artemisiae Scopariae 4 parts, the Radix Aucklandiae 14 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 parts, Herba Taraxaci 6 parts, Endothelium Corneum Gigeriae Galli 17 parts, Radix Scutellariae 15 parts, Herba Solani Lyrati 7 parts, Herba Lysimachiae 11 parts, Radix Bupleuri 16 parts, Stigma Maydis 8 parts, Rhizoma pteridii latiusculi 8 parts, Spica Prunellae 16 parts, Rhizoma Corydalis 14 parts, Herba Euphorbiae Humifusae 11 parts, Radix Cirsii Japonici 3 parts, Squama Manis 5 parts, 13 parts, Flos Carthami, Radix Salviae Miltiorrhizae 14 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 12 parts, Cortex Phellodendri 3 parts, Herba Schizonepetae 1 part, Radix Gentianae 10 parts, Rhizoma Coptidis 9 parts, Fructus Gardeniae 13 parts, Herba Hedyotidis Diffusae 7 parts, Radix Homonoiae Ripariae 11 parts, 3 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 6 parts, Fructus Mume 9 parts, Herba Artemisiae Scopariae 5 parts, the Radix Aucklandiae 12 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 5 parts, Herba Taraxaci 9 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Scutellariae 12 parts, Herba Solani Lyrati 5 parts, Herba Lysimachiae 9 parts, Radix Bupleuri 15 parts, Stigma Maydis 9 parts, Rhizoma pteridii latiusculi 7 parts, Spica Prunellae 19 parts, Rhizoma Corydalis 13 parts, Herba Euphorbiae Humifusae 10 parts, Radix Cirsii Japonici 4 parts, Squama Manis 4 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 11 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 10 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 3 parts, Radix Gentianae 8 parts, Rhizoma Coptidis 8 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 9 parts, Radix Homonoiae Ripariae 12 parts, 5 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 3 parts, Fructus Mume 8 parts, Herba Artemisiae Scopariae 5 parts, the Radix Aucklandiae 15 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 2 parts, Herba Taraxaci 4 parts, Endothelium Corneum Gigeriae Galli 19 parts, Radix Scutellariae 14 parts, Herba Solani Lyrati 6 parts, Herba Lysimachiae 7 parts, Radix Bupleuri 14 parts, Stigma Maydis 9 parts, Rhizoma pteridii latiusculi 6 parts, Spica Prunellae 17 parts, Rhizoma Corydalis 13 parts, Herba Euphorbiae Humifusae 10 parts, Radix Cirsii Japonici 4 parts, Squama Manis 4 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 11 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 10 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 3 parts, Radix Gentianae 8 parts, Rhizoma Coptidis 8 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 4 parts, Radix Homonoiae Ripariae 9 parts, 5 parts, Radix Glycyrrhizae.
The invention still further relates to a kind of preparation method of the described Chinese medicine composition for cholelithiasis post-operative recovery, comprise the steps:
(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of claim 3-8 is got, be ground into coarse powder, add in the ethanol of the 8-12 times amount of coarse powder gross weight and soak 1.5-2.5 hour, heating extraction three times, each return time is 3-5h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3), after the micropowders that step (2) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the micropowders that step (2) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or the micropowders that step (2) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.
The invention still further relates to the application of a kind of described Chinese medicine composition before the treatment in row gland anti-proliferative agent.
Chinese medicine composition for cholelithiasis post-operative recovery provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:
The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea , WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.
Fructus Mume: sour in the mouth, micro-puckery, property is put down.Return liver, spleen, lung, stomach, large intestine channel.Matter profit is held back puckery.Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.
The Radix Aucklandiae, pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature, enter liver, gallbladder, stomach warp, there is the effect that easypro gallbladder dispelling the stagnated QI, removing food stagnancyization are stagnant, for stagnation of QI due to dyspepsia, abdominal distention, infantile malnutrition, old man stops eating abdominal distention, gentle stimulation is had to gastrointestinal tract, can facilitating digestion liquid secretion and get rid of gas in body, again can diastole gastrointestinal smooth muscle, main manifestations is the effect of adjustment gastrointestinal function.
Herba nepenthis: sweet in the mouth, light, cool in nature; Return lung, gallbladder, stomach warp.Nourishing the lung to arrest cough, clearing away heat-damp and promoting diuresis calculus, removing toxic substances and promoting subsidence of swelling.Main dryness of the lung hemoptysis, cold cough, pertussis, jaundice, dysentery, lithangiuria, also can be used for gastric and duodenal ulcers, hypertension, diabetes, skin infection carbuncle.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing.Control icterohepatitis, gastric and duodenal ulcers pain, lithangiuria, hypertension, cold cough, pertussis.”
Herba Taraxaci: be feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Endothelium Corneum Gigeriae Galli: property is sweet puts down, be slightly cold, nontoxic, returns spleen, stomach, kidney, urinary bladder channel.Cure mainly: can promoting digestion and invigorating the stomach, arresting seminal emission, fossil.Removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.Radix Scutellariae has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by Radix Scutellariae and baicalin can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, and most test proves, the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.
Herba Solani Lyrati: sweet in the mouth, hardship, cold in nature; Return liver, gallbladder, kidney channel.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat, cholecystitis, cholelithiasis, oedema due to nephritis, rheumatic arthritis, women's damp-heat vaginal discharge, infantile hyperpyrexia is frightened jerks, carbuncle scrofula, eczema pruritus, herpes zoster.Modern medicine study confirms, Herba Solani Lyrati and Fructus Jujubae are mixed and made into decoct with 1:1, syrup has inhibitory action to the solid type of the empty ehrlich ascites carcinoma of white mice Ai Li and spindle cell sarcoma and ascitic type.
Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature; Return liver, gallbladder, kidney, urinary bladder channel.Relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Main liver and gall and urinary system calculus, pyretic stranguria, oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.Modern medicine study confirms, Herba Lysimachiae has effect mouth of cholagogic and lithagogue and diuresis and expelling stone.
Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Application: 1. for the disease such as alternate attack of chill and fever, cold, fever.Treatment is evil in few sun, alternate attack of chill and fever, and normal being equal to Radix Scutellariae, the Rhizoma Pinelliae is used; Cure cold heating, with Radix Puerariae, Gypsum Fibrosum, Radix Scutellariae compatibility.2. for depression of liver-QI, the pain over the hypochondriac region, menoxenia etc.With the medicine such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae with using.3. for diseases such as collapse of QI, chronic diarrhea proctoptosis, uterine prolapses.Join Radix Codonopsis, the Radix Astragali, Rhizoma Cimicifugae etc.
Stigma Maydis: sweet in the mouth, light, property is put down.Return kidney, stomach, liver, gallbladder meridian.Inducing diuresis to remove edema, liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis." modern Practical Chinese medicinal " carries: " be diuretic, effective to nephropathy, edema illness, diabetes etc.It is again the active drug of cholecystitis, cholelithiasis, hepatic inflammatory jaundice etc." modern medicine study confirmation, corn stigma can promote bile excretion, reduces its viscosity, reduces its bile pigments content, thus can be used as the cholangitis patient of choleretic for uncomplicated chronic cholecystitis, bile discharge obstacle.
Rhizoma pteridii latiusculi: sweet in the mouth, cold in nature; Return lung, liver, spleen, large intestine channel.Heat clearing away, dampness removing, suppressing the hyperactive liver is calmed the nerves, removing toxic substances and promoting subsidence of swelling.Main heating, laryngopharynx swelling and pain, diarrhoea, dysentery, jaundice, leucorrhea, hypertension, dizzy insomnia, rheumatic arthralgia, hemorrhoid, proctoptosis, eczema, scalds, snake bite and insect sting." Jilin Chinese herbal medicine " carries: " antipyretic, diuresis, QI invigorating, yin nourishing.Control unconsciousness due to high fever, deficient five internal organs, stagnation of QI meridians, bones and muscles pain.”
Spica Prunellae: bitter in the mouth; Pungent; Cold in nature.Return liver; Gallbladder meridian.Liver heat removing and eyesight improving; Powder detoxifcation.Cure mainly corneal nebula photophobia; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute, chronic hepatitis; Hypertension." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " liver-wind of dispelling, network of passing through.Control facial hemiparalysis, row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, loose scrofula, whole body tuberculosis." modern medicine study confirmation, Spica Prunellae has significant blood pressure lowering and antibacterial action.
Rhizoma Corydalis, bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp; Benefaction is wandered away, and can rise and can fall, have promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.Cure mainly obstruction of qi in the chest and cardialgia, the side of body rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal, the stasis of blood was suffered from abdominal pain, traumatic injury.
Herba Euphorbiae Humifusae, pungent, flat.Return liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.
Radix Cirsii Japonici main component is containing alkaloid, volatile oil, taraxasterylacetate, stigmasterol, a mono-Amyrin, B-Ji Amyrin, B-sitosterol, Herba Linariae Vulgaris flower glycoside 2-1%, sweet in the mouth, bitter, cool in nature, nontoxic, GUIXIN, Liver Channel, the effect having removing heat from blood, stop blooding, disappear bitterly, detoxify, controls the diseases such as haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle.
Squama Manis, part of being used as medicine, the scute of Squama Manis, effect and effect: blood circulation promoting and dispersing pathogen accumulation; To stimulate the menstrual flow stimulating milk secretion; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle; Scrofula.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.
Radix Salviae Miltiorrhizae, bitter, be slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Fructus Toosendan: Chinese crude drug is the mature fruit of Meliaceae deciduous tree toosendanin, cold in nature, and bitter in the mouth is the one of qi-activating drug.There are soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.But also be make efficiently without the important source material of the free of contamination novel plant pesticide of residual hazard.The sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, catharsis liver-heat, and promoting the circulation of QI to relieve pain, control the stagnation of QI and have the card of heat especially suitable.
The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, is classified as middle product, and note has " main pathogen, the Radix Paeoniae Alba is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.Modern pharmacology research display, paeoniflorin is to the intestine in vitro of Cavia porcellus, rat with in stomach motion, and rat uterus smooth muscle all shows suppression, and the contraction of energy caused by antagonize oxytocin; With acetic acid injection in mouse peritoneal, using writhing response as the index of pain, paeoniflorin has significant analgesic effect; The convulsions caused by extractum energy antagonism strychnine of Radix Paeoniae; Radix Paeoniae Alba decoct has bacteriostasis to dysentery bacterium in vitro, and preserved material also has inhibitory action to some pathogenic fungus.Paeoniflorin has cooling effect to white mice normal body temperature, also has refrigeration function to the mice of artificial fever.Antiinflammatory action is had to Rat Experimental metapedes sole of the foot edema; Paeoniflorin in vitro or intravenous injection time to adenosine diphosphate (ADP) induction rat platelet aggregation have inhibitory action; Paeoniflorin has obvious inhibitory action to the digestive tract in rats ulcer of bringing out because anxiety irritates.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee PhellodendronchinenseSchneid..Bitter in the mouth, cold in nature, energy heat clearing and damp drying, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-edema." medication heart method " records Cortex Phellodendri: " control the unbearably painful person of skin ulcer." Cortex Phellodendri contains large number of biological alkali components, has the antibacterial action of wide spectrum, can block nerves joint, nervus centralis is had to the effect of suppression.
Herba Schizonepetae: acrid in the mouth, slightly warm in nature, returns lung, Liver Channel; Have and deliver, dispel the wind, treating blood disorders, broken knot gather qi together, lower blood stasis, except arthralgia chiefly caused by damp pathogen, loose wind heat, refresh oneself, throat, the effects such as the skin ulcer that disappears is swollen; Cure mainly cold, fever, headache, laryngopharynx swelling and pain, apoplexy locked mouth, spit blood, epistaxis, the disease such as to have blood in stool.
Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Be used as medicine part for gentianaceae plant Radix Gentianae, Gentiana manshurica, G. triflora and Yunnan Radix Gentianae, root welding technology.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms." detailed outline ": treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross clothes and probably to injure one's stomach the gas of middle hair growth promoting, instead help pathogenic fire, also take Rhizoma Coptidis for a long time instead from the justice of cremate." book on Chinese herbal medicine is newly organized ": Radix Gentianae, its merit, specially in diuretic, disappears wet, and except jaundice, all the other are controlled order, dysentery relieving, detumescent, bring down a fever, and the speech of all popularizations also.But this kind too divides profit, rather consume gas deteriorated blood, water goes and blood also goes, wet disappearing and gas also disappears, from the beginning of water to wet jaundice, have to urgently with it, the water of prolonged illness wets jaundice, with must delay, just cannot not entirely rely on for diuretic god red, disappearing the wet miraculous cure removing illness also.Or meaning Radix Gentianae is controlled damp and hot, the most sharp illness is sick, just damp and hot disease also, so with Radix Gentianae with subcutaneous ulcer of harnessing the Yellow River, have not effect person, how also more? the real incessantly damp and hot one of jaundice also, have not hot and also become jaundice person, can control also by non-Radix Gentianae.Outstanding Radix Gentianae rushes down the heat in wetting, and can not rush down not hot wetting also.
Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Energy heat clearing and damp drying, eliminating fire and detoxication, the liver benefiting gallbladder, thick the intestines and stomach; For damp and hot feeling of fullness, jaundice, dysentery, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, quenches one's thirst.
Its cold in nature, bitter in the mouth of Fructus Gardeniae, function with cure mainly: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Shennong's Herbal: " cure mainly pathogen in five, tuberculoid leprosy, red leprosy, skin infection ....”
Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance, often utilize Herba Hedyotidis Diffusae anticancer, and it has certain radiation resistance.
Radix Homonoiae Ripariae: bitter in the mouth, cold in nature; Return liver, gallbladder, urinary bladder channel.Heat clearing away, function of gallbladder promoting, diuresis, removing toxic substances.Main acute, chronic hepatitis, cholecystitis, cholelithiasis, vesical calculus, gonorrhea, syphilis, hemorrhoid, traumatic injury, scalds." register planted by Guangxi medicine " carries: " diuresis.Control traumatic injury, ulcer, hemorrhoid, gonorrhea, syphilis, vesical calculus, cholelithiasis.”
Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong.
In side of the present invention with Herba nepenthis, Herba Solani Lyrati, Herba Lysimachiae, Stigma Maydis, Radix Homonoiae Ripariae, Radix Gentianae, Endothelium Corneum Gigeriae Galli for monarch drug, clearing away heat-damp and promoting diuresis, eliminating pathogen in the liver excess-heat of the gallbladder, holding concurrently can calculus; Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Herba Taraxaci, Radix Scutellariae, Radix Bupleuri, Herba Artemisiae Scopariae, Rhizoma pteridii latiusculi, Spica Prunellae, Herba Euphorbiae Humifusae, Fructus Toosendan, Cortex Phellodendri, Herba Hedyotidis Diffusae are ministerial drug, liver-smoothing, qi-regulating, resolving depression heat clearing away, inducing diuresis for treating stranguria syndrome; Squama Manis, Flos Carthami, the Radix Paeoniae Alba, Radix Glycyrrhizae etc. make for assistant, and smoothening secretion, makes heresy have outlet, and activating blood circulation and dissipating blood stasis, along the property of six internal organs tonneau.Full side's monarch emphasizes particularly on different fields, and plays the merit of liver-smoothing, qi-regulating, clearing heat secreting bile altogether.
Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, all medicines are harmonious the effect having and melt calculus, anti-inflammatory analgetic, microcirculation can be regulated, enhance metabolism, for have for cholelithiasis post-operative recovery instant effect, cure rate high, have no side effect, the advantage such as safe ready, and low price, easily prepare, cholelithiasis post-operative recovery can be widely used in.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 6 grams, Fructus Mume 8 grams, Herba Artemisiae Scopariae 3 grams, the Radix Aucklandiae 15 grams, 5 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 grams, Herba Taraxaci 5 grams, Endothelium Corneum Gigeriae Galli 12 grams, Radix Scutellariae 16 grams, Herba Solani Lyrati 3 grams, Herba Lysimachiae 12 grams, Radix Bupleuri 12 grams, Stigma Maydis 10 grams, Rhizoma pteridii latiusculi 9 grams, Spica Prunellae 15 grams, Rhizoma Corydalis 15 grams, Herba Euphorbiae Humifusae 8 grams, Radix Cirsii Japonici 5 grams, Squama Manis 3 grams, 14 grams, Flos Carthami, Radix Salviae Miltiorrhizae 9 grams, Fructus Toosendan 6 grams, the Radix Paeoniae Alba 8 grams, Cortex Phellodendri 5 grams, Herba Schizonepetae 1 gram, Radix Gentianae 10 grams, Rhizoma Coptidis 5 grams, Fructus Gardeniae 16 grams, Herba Hedyotidis Diffusae 10 grams, Radix Homonoiae Ripariae 8 grams, 5 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 12 times amount of coarse powder gross weight and soak 1.5 hours, heating extraction three times, each return time is 3h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3) micropowders that step (2) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.
Embodiment 2:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 4 grams, Fructus Mume 10 grams, Herba Artemisiae Scopariae 4 grams, the Radix Aucklandiae 13 grams, 6 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 grams, Herba Taraxaci 8 grams, Endothelium Corneum Gigeriae Galli 20 grams, Radix Scutellariae 10 grams, Herba Solani Lyrati 8 grams, Herba Lysimachiae 5 grams, Radix Bupleuri 17 grams, Stigma Maydis 12 grams, Rhizoma pteridii latiusculi 4 grams, Spica Prunellae 20 grams, Rhizoma Corydalis 10 grams, Herba Euphorbiae Humifusae 12 grams, Radix Cirsii Japonici 2 grams, Squama Manis 7 grams, 11 grams, Flos Carthami, Radix Salviae Miltiorrhizae 15 grams, Fructus Toosendan 3 grams, the Radix Paeoniae Alba 13 grams, Cortex Phellodendri 3 grams, Herba Schizonepetae 3 grams, Radix Gentianae 5 grams, Rhizoma Coptidis 10 grams, Fructus Gardeniae 13 grams, Herba Hedyotidis Diffusae 3 grams, Radix Homonoiae Ripariae 13 grams, 3 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 8 times amount of coarse powder gross weight and soak 1.5 hours, heating extraction three times, each return time is 4h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3), after the micropowders that step (2) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.
Embodiment 3:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 5 grams, Fructus Mume 12 grams, Herba Artemisiae Scopariae 3 grams, the Radix Aucklandiae 12 grams, 9 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 grams, Herba Taraxaci 7 grams, Endothelium Corneum Gigeriae Galli 13 grams, Radix Scutellariae 11 grams, Herba Solani Lyrati 4 grams, Herba Lysimachiae 6 grams, Radix Bupleuri 13 grams, Stigma Maydis 7 grams, Rhizoma pteridii latiusculi 5 grams, Spica Prunellae 18 grams, Rhizoma Corydalis 11 grams, Herba Euphorbiae Humifusae 9 grams, Radix Cirsii Japonici 4 grams, Squama Manis 6 grams, 12 grams, Flos Carthami, Radix Salviae Miltiorrhizae 13 grams, Fructus Toosendan 4 grams, the Radix Paeoniae Alba 9 grams, Cortex Phellodendri 4 grams, Herba Schizonepetae 2 grams, Radix Gentianae 6 grams, Rhizoma Coptidis 6 grams, Fructus Gardeniae 14 grams, Herba Hedyotidis Diffusae 5 grams, Radix Homonoiae Ripariae 10 grams, 4 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 10 times amount of coarse powder gross weight and soak 2 hours, heating extraction three times, each return time is 3h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3) micropowders that step (2) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.
Embodiment 4:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 4 grams, Fructus Mume 11 grams, Herba Artemisiae Scopariae 4 grams, the Radix Aucklandiae 14 grams, 8 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 grams, Herba Taraxaci 6 grams, Endothelium Corneum Gigeriae Galli 17 grams, Radix Scutellariae 15 grams, Herba Solani Lyrati 7 grams, Herba Lysimachiae 11 grams, Radix Bupleuri 16 grams, Stigma Maydis 8 grams, Rhizoma pteridii latiusculi 8 grams, Spica Prunellae 16 grams, Rhizoma Corydalis 14 grams, Herba Euphorbiae Humifusae 11 grams, Radix Cirsii Japonici 3 grams, Squama Manis 5 grams, 13 grams, Flos Carthami, Radix Salviae Miltiorrhizae 14 grams, Fructus Toosendan 5 grams, the Radix Paeoniae Alba 12 grams, Cortex Phellodendri 3 grams, Herba Schizonepetae 1 gram, Radix Gentianae 10 grams, Rhizoma Coptidis 9 grams, Fructus Gardeniae 13 grams, Herba Hedyotidis Diffusae 7 grams, Radix Homonoiae Ripariae 11 grams, 3 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 11 times amount of coarse powder gross weight and soak 1.5 hours, heating extraction three times, each return time is 5h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3), after the micropowders that step (2) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.
Embodiment 5:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 6 grams, Fructus Mume 9 grams, Herba Artemisiae Scopariae 5 grams, the Radix Aucklandiae 12 grams, 7 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 5 grams, Herba Taraxaci 9 grams, Endothelium Corneum Gigeriae Galli 15 grams, Radix Scutellariae 12 grams, Herba Solani Lyrati 5 grams, Herba Lysimachiae 9 grams, Radix Bupleuri 15 grams, Stigma Maydis 9 grams, Rhizoma pteridii latiusculi 7 grams, Spica Prunellae 19 grams, Rhizoma Corydalis 13 grams, Herba Euphorbiae Humifusae 10 grams, Radix Cirsii Japonici 4 grams, Squama Manis 4 grams, 11 grams, Flos Carthami, Radix Salviae Miltiorrhizae 11 grams, Fructus Toosendan 5 grams, the Radix Paeoniae Alba 10 grams, Cortex Phellodendri 5 grams, Herba Schizonepetae 3 grams, Radix Gentianae 8 grams, Rhizoma Coptidis 8 grams, Fructus Gardeniae 14 grams, Herba Hedyotidis Diffusae 9 grams, Radix Homonoiae Ripariae 12 grams, 5 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 9 times amount of coarse powder gross weight and soak 1.5 hours, heating extraction three times, each return time is 3-5h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3) micropowders that step (2) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.
Embodiment 6:
A kind of Chinese medicine composition for cholelithiasis post-operative recovery of the present invention, get following traditional Chinese medicine raw medicine: Rhizoma Polygoni Cuspidati 3 grams, Fructus Mume 8 grams, Herba Artemisiae Scopariae 5 grams, the Radix Aucklandiae 15 grams, 7 grams, Pericarpium Citri Reticulatae Viride, Herba nepenthis 2 grams, Herba Taraxaci 4 grams, Endothelium Corneum Gigeriae Galli 19 grams, Radix Scutellariae 14 grams, Herba Solani Lyrati 6 grams, Herba Lysimachiae 7 grams, Radix Bupleuri 14 grams, Stigma Maydis 9 grams, Rhizoma pteridii latiusculi 6 grams, Spica Prunellae 17 grams, Rhizoma Corydalis 13 grams, Herba Euphorbiae Humifusae 10 grams, Radix Cirsii Japonici 4 grams, Squama Manis 4 grams, 11 grams, Flos Carthami, Radix Salviae Miltiorrhizae 11 grams, Fructus Toosendan 5 grams, the Radix Paeoniae Alba 10 grams, Cortex Phellodendri 5 grams, Herba Schizonepetae 3 grams, Radix Gentianae 8 grams, Rhizoma Coptidis 8 grams, Fructus Gardeniae 14 grams, Herba Hedyotidis Diffusae 4 grams, Radix Homonoiae Ripariae 9 grams, 5 grams, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition is prepared according to following method:
(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, add in the ethanol of 10 times amount of coarse powder gross weight and soak 1.5-2.5 hour, heating extraction three times, each return time is 3-5h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3) micropowders that step (2) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.
Acute toxicity test:
Get Kunming mouse 60, body weight 20-23 gram, be divided into 2 groups at random by body weight, treatment group and matched group: treatment group takes granule prepared by the embodiment of the present invention 4, and 0.443ml/10g body weight gastric infusion is pressed in fasting after 12 hours, dose 0.45g/ml, matched group took distilled water, three times on the one, to observation post administration 14 days, mice is without death, and behavior is active, and food ration is as usual, hair color light is without loose dirty, without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe of docking.Select 10 execution, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows that this drug particles is all without acute toxicity.
Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, all there is not toxic reaction in result mice.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, gained medicine of the present invention shows without chronic toxicity animal.
Clinical reasoning:
In order to verify the effect of Chinese medicine composition of the present invention, in January ,-2015 in July, 2014, the routine clinical observation of Patients with Cholelithiasis 180 is randomly drawed in outpatient service place, patient is divided into two groups at random, treatment group 90 example, wherein male 45 example, women 45 example, age 18-70 year, 40 years old mean age, the course of disease 2 months-26 years; Matched group 90 example, wherein male 44 example, women 46 example, age 25-70 year, 35 years old mean age, the course of disease 2 months-20 years.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
Therapeutic Method:
Take the tablet of the oral embodiment of the present invention 1 preparation after treatment group operation in patients, one time three, sooner or later each once.Warm water delivery service in half an hour after meal 7 days is a course for the treatment of, and taking 2 to 4 courses for the treatment of continuously can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes XIAOYAN LIDAN PIAN, by specification use, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Efficacy determination:
(1) cure: gallbladder wall is thinning, children's's upper right abdomen paroxysmal colic, have an intense pain, gallbladder volume-diminished, gallbladder increase, the allergy of bad, the gallbladder of gallbladder contraction function, biliary colic, calcium bilirubinate calculus, the transference cure such as rubble or trichobezoar formation in digestive tract, physical recovery is normal.
(2) effective: above-mentioned symptom is alleviated to some extent.
(3) invalid: disease is unchanged.
Result of the test:
Through the treatment of 3 months, and the return visit to healing person, Clinical efficacy comparison, the results are shown in Table 1.
Table 1 liang group patient effective percentage relative analysis
Group Number of cases Cure Effectively Invalid Effectively total
Treatment group 90 78(86.7%) 9(10%) 3(3.3%) 87(96.7%)
Matched group 90 35(38.9%) 18(20%) 37(41.1%) 53(58.9%)
Wherein, total effective rate=cure rate+obvious effective rate.
Table 1 result shows: the pharmaceutical preparation total effective rate 96.7% taking the embodiment of the present invention 1, and the total effective rate of matched group only has 58.9%; As can be seen from cure rate also, the cure rate of the pharmaceutical preparation of the embodiment of the present invention 1 is much larger than matched group.Thus pharmaceutical preparation of the present invention compared with prior art has very significant advantage.
Model case:
Case 1
Zhao, female, 62 years old, Qingdao City Laoshan District people, patient's gallbladder volume is normal, and cyst wall owes smooth, neck of gallbladder is looked into and is seen that size is about the strong echo group accompanying sound shadow of 2.5cm, and stones in intrahepatic bile duct right anterior branch, right rami posterior superior, left outside arm intracavity are looked into and seen the strong echo of casting shape, and stones in intrahepatic bile duct is shown in obvious expansion.After anti-inflammatory analgetic, carry out operative treatment.Carry out cholelithiasis Post operation, take tablet of the present invention one day three times, each three, one after each meal, 7 days is a course for the treatment of, after 1 course for the treatment of, picks body sooner or later; Continue to take 2 courses for the treatment of of medicine of the present invention, health is fully recovered, and follows up a case by regular visits to and does not recur, thoroughly cure.
Case 2
Money, female, 55 years old, Qingdao Jimo people.Patient suffers from more than 10 years of cholelithiasis medical history, often has epigastric discomfort, but without serious attack, is interrupted and takes calculus medicine and antibiotic medicine.Go hospital doctor all to advise he excises gallbladder at every turn, but he is because fearing that operation be can not make a decision in tow always.Over nearly 1 year, pain increases the weight of duration extension, occasionally has fever, has xanthochromia bimester of near, fever, and stomachache obviously increases the weight of, and B ultrasonic shows: gallbladder 4*5cm calculus, gallbladder wall thickness, stones in intrahepatic bile duct is broadening.Carry out my surgical treatment, carry out Post operation and take capsule of the present invention one day three times, each three, sooner or later one after each meal, within 7 days, be a course for the treatment of, after 1 course for the treatment of, above-mentioned symptom alleviates; Continue to take 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom all disappears, and follows up a case by regular visits to and does not recur, and thoroughly cures.
Case 3:
Grandson, man, 40 years old, people from Laiyang, Yantai.Patient's epigastric discomfort 3 months, health check-up B ultrasonic finds that gallbladder has microlith, and my institute that came in 2 years requires to do laparoscopic cholecystectomy.See at my institute's check B ultrasonic: have more muddy stone in gallbladder, move with displacement body, gallbladder wall is not thick.Postoperatively take tablet of the present invention one day three times, each three for after treatment, one after each meal, 7 days is a course for the treatment of sooner or later, and after 2 courses for the treatment of, health starts to take a turn for the better; Continue to take 2 courses for the treatment of of medicine of the present invention, health is fully recovered, and follows up a case by regular visits to and does not recur, thoroughly cure.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. for a Chinese medicine composition for cholelithiasis post-operative recovery, it is characterized in that: the crude drug of described Chinese medicine composition is made up of crude drug such as Rhizoma Polygoni Cuspidati, Fructus Mume, Herba Artemisiae Scopariae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Herba nepenthis, Herba Taraxaci, Endothelium Corneum Gigeriae Galli, Radix Scutellariae, Herba Solani Lyrati, Herba Lysimachiae, Radix Bupleuri, Stigma Maydis, Rhizoma pteridii latiusculi, Spica Prunellae, Rhizoma Corydalis, Herba Euphorbiae Humifusae, Radix Cirsii Japonici, Squama Manis, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Toosendan, the Radix Paeoniae Alba, Cortex Phellodendri, Herba Schizonepetae, Radix Gentianae, Rhizoma Coptidis, Fructus Gardeniae, Herba Hedyotidis Diffusae, Radix Homonoiae Ripariae, Radix Glycyrrhizaes.
2. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 3-6 part, Fructus Mume 8-13 part, Herba Artemisiae Scopariae 3-5 part, Radix Aucklandiae 11-15 part, Pericarpium Citri Reticulatae Viride 5-10 part, Herba nepenthis 2-5 part, Herba Taraxaci 4-9 part, Endothelium Corneum Gigeriae Galli 12-20 part, Radix Scutellariae 10-16 part, Herba Solani Lyrati 3-8 part, Herba Lysimachiae 5-12 part, Radix Bupleuri 12-17 part, Stigma Maydis 7-12 part, Rhizoma pteridii latiusculi 4-9 part, Spica Prunellae 15-20 part, Rhizoma Corydalis 10-15 part, Herba Euphorbiae Humifusae 8-12 part, Radix Cirsii Japonici 2-5 part, Squama Manis 3-7 part, Flos Carthami 11-14 part, Radix Salviae Miltiorrhizae 9-15 part, Fructus Toosendan 3-6 part, Radix Paeoniae Alba 8-13 part, Cortex Phellodendri 3-5 part, Herba Schizonepetae 1-3 part, Radix Gentianae 5-10 part, Rhizoma Coptidis 5-10 part, Fructus Gardeniae 13-16 part, Herba Hedyotidis Diffusae 3-10 part, Radix Homonoiae Ripariae 8-13 part, Radix Glycyrrhizae 3-5 part.
3. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 6 parts, Fructus Mume 8 parts, Herba Artemisiae Scopariae 3 parts, the Radix Aucklandiae 15 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 parts, Herba Taraxaci 5 parts, Endothelium Corneum Gigeriae Galli 12 parts, Radix Scutellariae 16 parts, Herba Solani Lyrati 3 parts, Herba Lysimachiae 12 parts, Radix Bupleuri 12 parts, Stigma Maydis 10 parts, Rhizoma pteridii latiusculi 9 parts, Spica Prunellae 15 parts, Rhizoma Corydalis 15 parts, Herba Euphorbiae Humifusae 8 parts, Radix Cirsii Japonici 5 parts, Squama Manis 3 parts, 14 parts, Flos Carthami, Radix Salviae Miltiorrhizae 9 parts, Fructus Toosendan 6 parts, the Radix Paeoniae Alba 8 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 1 part, Radix Gentianae 10 parts, Rhizoma Coptidis 5 parts, Fructus Gardeniae 16 parts, Herba Hedyotidis Diffusae 10 parts, Radix Homonoiae Ripariae 8 parts, 5 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 4 parts, Fructus Mume 10 parts, Herba Artemisiae Scopariae 4 parts, the Radix Aucklandiae 13 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 parts, Herba Taraxaci 8 parts, Endothelium Corneum Gigeriae Galli 20 parts, Radix Scutellariae 10 parts, Herba Solani Lyrati 8 parts, Herba Lysimachiae 5 parts, Radix Bupleuri 17 parts, Stigma Maydis 12 parts, Rhizoma pteridii latiusculi 4 parts, Spica Prunellae 20 parts, Rhizoma Corydalis 10 parts, Herba Euphorbiae Humifusae 12 parts, Radix Cirsii Japonici 2 parts, Squama Manis 7 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 15 parts, Fructus Toosendan 3 parts, the Radix Paeoniae Alba 13 parts, Cortex Phellodendri 3 parts, Herba Schizonepetae 3 parts, Radix Gentianae 5 parts, Rhizoma Coptidis 10 parts, Fructus Gardeniae 13 parts, Herba Hedyotidis Diffusae 3 parts, Radix Homonoiae Ripariae 13 parts, 3 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 5 parts, Fructus Mume 12 parts, Herba Artemisiae Scopariae 3 parts, the Radix Aucklandiae 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 4 parts, Herba Taraxaci 7 parts, Endothelium Corneum Gigeriae Galli 13 parts, Radix Scutellariae 11 parts, Herba Solani Lyrati 4 parts, Herba Lysimachiae 6 parts, Radix Bupleuri 13 parts, Stigma Maydis 7 parts, Rhizoma pteridii latiusculi 5 parts, Spica Prunellae 18 parts, Rhizoma Corydalis 11 parts, Herba Euphorbiae Humifusae 9 parts, Radix Cirsii Japonici 4 parts, Squama Manis 6 parts, 12 parts, Flos Carthami, Radix Salviae Miltiorrhizae 13 parts, Fructus Toosendan 4 parts, the Radix Paeoniae Alba 9 parts, Cortex Phellodendri 4 parts, Herba Schizonepetae 2 parts, Radix Gentianae 6 parts, Rhizoma Coptidis 6 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 5 parts, Radix Homonoiae Ripariae 10 parts, 4 parts, Radix Glycyrrhizae.
6. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 4 parts, Fructus Mume 11 parts, Herba Artemisiae Scopariae 4 parts, the Radix Aucklandiae 14 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 3 parts, Herba Taraxaci 6 parts, Endothelium Corneum Gigeriae Galli 17 parts, Radix Scutellariae 15 parts, Herba Solani Lyrati 7 parts, Herba Lysimachiae 11 parts, Radix Bupleuri 16 parts, Stigma Maydis 8 parts, Rhizoma pteridii latiusculi 8 parts, Spica Prunellae 16 parts, Rhizoma Corydalis 14 parts, Herba Euphorbiae Humifusae 11 parts, Radix Cirsii Japonici 3 parts, Squama Manis 5 parts, 13 parts, Flos Carthami, Radix Salviae Miltiorrhizae 14 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 12 parts, Cortex Phellodendri 3 parts, Herba Schizonepetae 1 part, Radix Gentianae 10 parts, Rhizoma Coptidis 9 parts, Fructus Gardeniae 13 parts, Herba Hedyotidis Diffusae 7 parts, Radix Homonoiae Ripariae 11 parts, 3 parts, Radix Glycyrrhizae.
7. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 6 parts, Fructus Mume 9 parts, Herba Artemisiae Scopariae 5 parts, the Radix Aucklandiae 12 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 5 parts, Herba Taraxaci 9 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Scutellariae 12 parts, Herba Solani Lyrati 5 parts, Herba Lysimachiae 9 parts, Radix Bupleuri 15 parts, Stigma Maydis 9 parts, Rhizoma pteridii latiusculi 7 parts, Spica Prunellae 19 parts, Rhizoma Corydalis 13 parts, Herba Euphorbiae Humifusae 10 parts, Radix Cirsii Japonici 4 parts, Squama Manis 4 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 11 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 10 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 3 parts, Radix Gentianae 8 parts, Rhizoma Coptidis 8 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 9 parts, Radix Homonoiae Ripariae 12 parts, 5 parts, Radix Glycyrrhizae.
8. the Chinese medicine composition for cholelithiasis post-operative recovery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Rhizoma Polygoni Cuspidati 3 parts, Fructus Mume 8 parts, Herba Artemisiae Scopariae 5 parts, the Radix Aucklandiae 15 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Herba nepenthis 2 parts, Herba Taraxaci 4 parts, Endothelium Corneum Gigeriae Galli 19 parts, Radix Scutellariae 14 parts, Herba Solani Lyrati 6 parts, Herba Lysimachiae 7 parts, Radix Bupleuri 14 parts, Stigma Maydis 9 parts, Rhizoma pteridii latiusculi 6 parts, Spica Prunellae 17 parts, Rhizoma Corydalis 13 parts, Herba Euphorbiae Humifusae 10 parts, Radix Cirsii Japonici 4 parts, Squama Manis 4 parts, 11 parts, Flos Carthami, Radix Salviae Miltiorrhizae 11 parts, Fructus Toosendan 5 parts, the Radix Paeoniae Alba 10 parts, Cortex Phellodendri 5 parts, Herba Schizonepetae 3 parts, Radix Gentianae 8 parts, Rhizoma Coptidis 8 parts, Fructus Gardeniae 14 parts, Herba Hedyotidis Diffusae 4 parts, Radix Homonoiae Ripariae 9 parts, 5 parts, Radix Glycyrrhizae.
9. the preparation method of the arbitrary described Chinese medicine composition for cholelithiasis post-operative recovery of claim 3-8, is characterized in that, comprise the steps:
(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of claim 3-8 is got, be ground into coarse powder, add in the ethanol of the 8-12 times amount of coarse powder gross weight and soak 1.5-2.5 hour, heating extraction three times, each return time is 3-5h, get supernatant, merge extractive liquid, 120 orders filter, be the ultrafiltration post ultrafiltration of 8000-12000 again through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, 60 DEG C of concentrating under reduced pressure removing alcohol solvents, obtain concentrated solution;
(2) by the concentrated solution spraying dry that step (1) is obtained, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 65 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s; Sieve, obtain 120-150 object micropowders;
(3), after the micropowders that step (2) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the micropowders that step (2) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or the micropowders that step (2) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.
10. the Chinese medicine composition for cholelithiasis post-operative recovery as described in as arbitrary in claim 1-8 is for the application in cholelithiasis post-operative recovery medicine.
CN201510554746.1A 2015-09-02 2015-09-02 Traditional Chinese medicinal composition for gallstone postoperative recovery and preparation method of traditional Chinese medicinal composition Pending CN105106692A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106107036A (en) * 2016-06-28 2016-11-16 宿松飞翔生态养殖有限公司 A kind of livestock fodder additives with epidemic prevention function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1127128A (en) * 1995-09-14 1996-07-24 隋嫣玲 Traditional Chinese medicine for cholelithiasis and preparing method
CN104162107A (en) * 2014-08-13 2014-11-26 王金枝 Traditional Chinese medicine formula benefiting gallstone postoperative recovery
CN104225493A (en) * 2014-09-29 2014-12-24 唐武 Traditional Chinese medicine for treating gallstone
CN104306780A (en) * 2014-11-05 2015-01-28 杨恒艳 Medicine for postoperative recovery of cholelithiasis and preparation method
CN104758701A (en) * 2015-04-22 2015-07-08 张桂芳 Medicament for nursing treatment of stomach stones after lithotripsy and preparation method of medicament

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1127128A (en) * 1995-09-14 1996-07-24 隋嫣玲 Traditional Chinese medicine for cholelithiasis and preparing method
CN104162107A (en) * 2014-08-13 2014-11-26 王金枝 Traditional Chinese medicine formula benefiting gallstone postoperative recovery
CN104225493A (en) * 2014-09-29 2014-12-24 唐武 Traditional Chinese medicine for treating gallstone
CN104306780A (en) * 2014-11-05 2015-01-28 杨恒艳 Medicine for postoperative recovery of cholelithiasis and preparation method
CN104758701A (en) * 2015-04-22 2015-07-08 张桂芳 Medicament for nursing treatment of stomach stones after lithotripsy and preparation method of medicament

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
吴震宇: ""利胆排石汤治疗肝内胆管结石取石术后胆结石残留及胆管狭窄疗效观察"", 《中华中医药学刊》 *
唐乾利: ""胆石症术后残留及复发的中医治疗近况"", 《河北中西医结合杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106107036A (en) * 2016-06-28 2016-11-16 宿松飞翔生态养殖有限公司 A kind of livestock fodder additives with epidemic prevention function

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