CN103055003A - Pure Chinese medicinal composition for treating fin rot of fish and prawns and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating fin rot of fish and prawns and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the fin rot of fish and prawns. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 15 to 35 parts of red-knees herb, 15 to 35 parts of folium artemisiae argyi, 15 to 35 parts of sweet wormwood herb, 15 to 35 parts of propolis, 15 to 35 parts of tripterygium wilfordii, 15 to 35 parts of houttuynia cordata, 20 to 40 parts of astragalus, 20 to 40 parts of dried orange peel, 20 to 40 parts of bupleurum, 20 to 40 parts of szechuan lovage rhizome, 15 to 35 parts of Vietnamese sophora root and 20 to 40 parts of licorice root. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the fin rot of the fish and the prawns.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of the fish and shrimp gill rot and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment fish and shrimp gill rot and preparation method thereof.
Background technology
The fish and shrimp gill rot is a kind of common disease rapid, that the course of disease is long that infects in the fall.Gill rot mainly is divided into three kinds, is respectively parasitic gill rot, bacterial gill rot and fungoid gill rot.The parasitic gill rot is that the various gills that cause of parasite are sick, colonizes on the gill of fish and breeding, and a large amount of mucus is secreted by the gill section that stimulates fish, and gill filament enlargement, variable color have a strong impact on the breathing of fish; Bacterial gill rot disease is invaded by myxobacter and is caused, show as the gill filament and rot, with mud, gill cover inner surface is congested, and central epidermis often is etched into a duck eye that circle is transparent, is commonly called as blank; The fungoid gill rot is by the mould disease that causes of the gill, shows as disease fish gill section and is pale asphyxia, and point-like hyperemia or bleeding are arranged sometimes.
This disease very easily occurs, and spreads rapidly, and is wayward, often makes fishy fulminant ground dead, causes serious economic loss for the fish and shrimp aquaculture.
This disease almost spreads all over all fish and shrimp cultivation countries of the world, is widely distributed.The primary disease western medicine mainly uses antiparasitic and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of the fish and shrimp gill rot, micronizing, bioavailability height, the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, micronizing, high, the treating both the principal and secondary aspects of a disease of bioavailability, pure Chinese medicine composition of effective treatment fish and shrimp gill rot of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of the fish and shrimp gill rot, by following component by weight mixed preparing form: Herba polygoni hydropiperis 15-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Annuae 15-35 part, propolis 15-35 part, Radix Tripterygii Wilfordii 15-35 part, Herba Houttuyniae 15-35 part, Radix Astragali 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Radix Bupleuri 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Sophorae Tonkinensis 15-35 part, Radix Glycyrrhizae 20-40 part.
Described various component optimum ratio amount is: 25 parts of Herba polygoni hydropiperis, 25 parts of Folium Artemisiae Argyis, 25 parts of Herba Artemisiae Annuaes, 25 parts of propolis, 25 parts of Radix Tripterygii Wilfordiis, 25 parts of Herba Houttuyniae, 30 parts of the Radixs Astragali, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Radix Bupleuri, 30 parts of Rhizoma Chuanxiongs, 25 parts of Radix Sophorae Tonkinensiss, 30 parts in Radix Glycyrrhizae.
A kind of preparation method for the treatment of the pure Chinese medicine composition of fish and shrimp gill rot, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba polygoni hydropiperis 15-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Annuae 15-35 part, propolis 15-35 part, Radix Tripterygii Wilfordii 15-35 part, Herba Houttuyniae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Astragali 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Radix Bupleuri 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Sophorae Tonkinensis 15-35 part, Radix Glycyrrhizae 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Herba polygoni hydropiperis: hot, warm, return lung, liver, large intestine channel, have the function of detoxifcation, damp eliminating, dissipating blood stasis, hemostasis; Cure mainly dysentery, rheumatic arthralgia, carbuncle furuncle, eczema, traumatic hemorrhage etc.
Propolis: bitter, hot, cold, return spleen, stomach warp, have anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve the function of immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa etc.
Rhizoma Chuanxiong: hot, warm, return gallbladder, liver, pericardium channel, have the function of blood-activating and qi-promoting, wind-expelling pain-stopping; Cure mainly traumatic injury, stagnation of QI-blood, puerperal blood stasis, rheumatic arthralgia etc.
Herba Artemisiae Annuae: bitter, hot, cold, return liver, gallbladder meridian, have the function of heat-clearing and toxic substances removing, protozoacide; Cure mainly coccidiosis, jaundice due to damp-heat etc.
Radix Tripterygii Wilfordii: hot, bitter, cool, return liver, kidney channel, have the function of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, reducing swelling and alleviating pain, detoxifcation parasite killing; Cure mainly that skin is itched, rheumatic arthralgia, the yellow furunculosis of skin ulcer etc.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly that poor appetite, stomachache, tripe expand, have loose bowels, productive cough due to phlegm-damp etc.
Radix Bupleuri: hot, bitter, be slightly cold, return liver, gallbladder, lung meridian, have the function of delivering with inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea, proctoptosis etc.
Folium Artemisiae Argyi: hot, bitter, warm, return the liver,kidney,spleen warp, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
Radix Sophorae Tonkinensis: cold, bitter, attach to the lung and stomach meridians, have the function of heat-clearing and toxic substances removing, detumescence sore-throat relieving, expelling phlegm for arresting cough; Cure mainly laryngopharynx swelling and pain, lung-heat cough with asthma, the yellow furunculosis of skin ulcer etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
More than all herbal medicines according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of fish and shrimp gill rot, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, and it is wide to draw materials, micronizing, bioavailability height, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this 12 herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment fish and shrimp gill rot is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of the fish and shrimp gill rot and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of Herba polygoni hydropiperis, 150 parts of Folium Artemisiae Argyis, 150 parts of Herba Artemisiae Annuaes, 150 parts of propolis, 150 parts of Radix Tripterygii Wilfordiis, 150 parts of Herba Houttuyniae, mix 5-10 minute to even;
(3) take by weighing by weight 200 parts of the Radixs Astragali, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Radix Bupleuri, 200 parts of Rhizoma Chuanxiongs, 150 parts of Radix Sophorae Tonkinensiss, 200 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of the fish and shrimp gill rot and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Herba polygoni hydropiperis, 250 parts of Folium Artemisiae Argyis, 250 parts of Herba Artemisiae Annuaes, 250 parts of propolis, 250 parts of Radix Tripterygii Wilfordiis, 250 parts of Herba Houttuyniae, mix 5-10 minute to even;
(3) take by weighing by weight 300 parts of the Radixs Astragali, 300 parts of Pericarpium Citri Reticulataes, 300 parts of Radix Bupleuri, 300 parts of Rhizoma Chuanxiongs, 250 parts of Radix Sophorae Tonkinensiss, 300 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of the fish and shrimp gill rot and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Herba polygoni hydropiperis, 350 parts of Folium Artemisiae Argyis, 350 parts of Herba Artemisiae Annuaes, 350 parts of propolis, 350 parts of Radix Tripterygii Wilfordiis, 350 parts of Herba Houttuyniae, mix 5-10 minute to even;
(3) take by weighing by weight 400 parts of the Radixs Astragali, 400 parts of Pericarpium Citri Reticulataes, 400 parts of Radix Bupleuri, 400 parts of Rhizoma Chuanxiongs, 350 parts of Radix Sophorae Tonkinensiss, 400 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 150 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus gill rot.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 30 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the fish and shrimp rotten cheek is loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 1 is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus gill rot:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 43.3 | 36.7 | 20.0 |
| II | The loose group of fish and shrimp rotten cheek | 10.0 | 76.7 | 13.3 |
| III | Present composition group | 3.3 | 86.7 | 10.0 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of fish and shrimp rotten cheek aspect the cure rate.
The clinical experiment animal selects 300 ages in days, body weight at 0.04kg-0.06kg, and Laboratory Diagnosed is the ill shrimp of Macrobrachium rosenbergii gill rot.Ill shrimp isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 100 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the fish and shrimp rotten cheek is loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2.5% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 2 is field applicable cases contrasts of the present invention and other medicines treatment shrimp gill rot:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 53 | 27 | 20 |
| II | The loose group of fish and shrimp rotten cheek | 13 | 77 | 10 |
| III | Present composition group | 8 | 85 | 7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared significant difference (P＜0.05) with the loose group of fish and shrimp rotten cheek aspect the cure rate.
Safety testing:
Choose 80 age in days healthy grass carp, 30 tails, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Choose healthy Macrobrachium rosenbergii 30 tails of 100 ages in days, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy shrimp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment fish and shrimp gill rot and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of the fish and shrimp gill rot, it is characterized in that by following component by weight mixed preparing form: Herba polygoni hydropiperis 15-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Annuae 15-35 part, propolis 15-35 part, Radix Tripterygii Wilfordii 15-35 part, Herba Houttuyniae 15-35 part, Radix Astragali 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Radix Bupleuri 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Sophorae Tonkinensis 15-35 part, Radix Glycyrrhizae 20-40 part.
2. the pure Chinese medicine composition for the treatment of fish and shrimp gill rot according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Herba polygoni hydropiperis, 25 parts of Folium Artemisiae Argyis, 25 parts of Herba Artemisiae Annuaes, 25 parts of propolis, 25 parts of Radix Tripterygii Wilfordiis, 25 parts of Herba Houttuyniae, 30 parts of the Radixs Astragali, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Radix Bupleuri, 30 parts of Rhizoma Chuanxiongs, 25 parts of Radix Sophorae Tonkinensiss, 30 parts in Radix Glycyrrhizae.
3. the preparation method of the pure Chinese medicine composition of a treatment fish and shrimp gill rot according to claim 1 and 2 is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba polygoni hydropiperis 15-35 part, Folium Artemisiae Argyi 15-35 part, Herba Artemisiae Annuae 15-35 part, propolis 15-35 part, Radix Tripterygii Wilfordii 15-35 part, Herba Houttuyniae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Astragali 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Radix Bupleuri 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Sophorae Tonkinensis 15-35 part, Radix Glycyrrhizae 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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Cited By (3)
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| CN104257812A (en) * | 2014-09-29 | 2015-01-07 | 浙江海洋学院 | Fish medicine for treating branchiomycosis |
| CN105918644A (en) * | 2015-10-16 | 2016-09-07 | 湖北文理学院 | Feed additive for control of goldfish fin rot disease and preparation method thereof |
| CN106509486A (en) * | 2016-10-24 | 2017-03-22 | 广西智宝科技有限公司 | Crucian carp feed capable of preventing and treating branchia hyperemia disease and preparation method of crucian carp feed |
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Patent Citations (3)
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| CN1895419A (en) * | 2006-06-16 | 2007-01-17 | 天津生机集团有限公司 | Multiple Chinese-medicinal prescription for aquatic cultivation |
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| CN102138994A (en) * | 2010-10-31 | 2011-08-03 | 仙桃市魏氏生物工程有限责任公司 | Pharmaceutical composition for preventing and treating black gill disease of aquatic animals |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257812A (en) * | 2014-09-29 | 2015-01-07 | 浙江海洋学院 | Fish medicine for treating branchiomycosis |
| CN105918644A (en) * | 2015-10-16 | 2016-09-07 | 湖北文理学院 | Feed additive for control of goldfish fin rot disease and preparation method thereof |
| CN106509486A (en) * | 2016-10-24 | 2017-03-22 | 广西智宝科技有限公司 | Crucian carp feed capable of preventing and treating branchia hyperemia disease and preparation method of crucian carp feed |
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| CN103055003B (en) | 2014-08-20 |
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