CN102274326B - Pure Chinese medicinal combination for treating piglet yellow-white dysentery and preparation method thereof - Google Patents
Pure Chinese medicinal combination for treating piglet yellow-white dysentery and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 22
- 238000005303 weighing Methods 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims description 36
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 claims description 8
- 241000001522 Terminalia chebula Species 0.000 claims description 2
- 241001078983 Tetradium ruticarpum Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- KBDSLGBFQAGHBE-MSGMIQHVSA-N Limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 abstract 2
- 241000691155 Pteris multifida Species 0.000 abstract 2
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- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 210000000952 Spleen Anatomy 0.000 description 6
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- 201000010099 disease Diseases 0.000 description 5
- UCSJYZPVAKXKNQ-HZYVHMACSA-N 1-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
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- 206010059866 Drug resistance Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010018836 Haematochezia Diseases 0.000 description 2
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- 229960000625 Oxytetracycline Drugs 0.000 description 1
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Abstract
The invention relates to a pure Chinese medicinal combination for treating piglet yellow-white dysentery. The pure Chinese medicinal combination is prepared by mixing the following components in parts by weight: 10-35 parts of meadowrue root and rhizome, 10-25 parts of Chinese brake herb, 5-10 parts of dried alum, 10-15 parts of medicinal evodia fruit, 10-15 parts of medicine terminalia fruit and10-15 parts of liquoric root. A preparation method of the pure Chinese medicinal combination comprises the following steps of: (1) smashing the components in a formula respectively and screening witha screen of 24-80 meshes; (2) weighing 10-35 parts of meadowrue root and rhizome, 10-25 parts of Chinese brake herb and 5-10 parts of dried alum according to weights and mixing for 10-25 minutes to uniform state; (3) weighing 10-15 parts of medicinal evodia fruit, 10-15 parts of medicine terminalia fruit and 10-15 parts of liquoric root according to weights and mixing for 10-25 minutes to uniformstate; and (4) combining combinations obtained in the steps (2) and (3) and continually mixing for 10-25 minutes to uniform state. The pure Chinese medicinal combination has the advantages of reasonable formula, simple preparation, environmental friendliness and very remarkable curative effect. As proved by clinical application, the pure Chinese medicinal combination has a specially good effect on treating piglet yellow dysentery and piglet white dysentery.
Description
Technical field
The present invention relates to field of veterinary, particularly a kind of pure Chinese medicine composition that is specifically designed to the treatment yellow and white dysentery of piglet and preparation method thereof.
Background technology
Yellow scour of piglet, piglet pujos blancos are that a kind of common alimentary infection that is caused by escherichia coli is sick, clinically take diarrhoea, row's yellow or yellow-white feces as feature, or take ash discharge white, stench, paste shape loose stool as feature, very large to the harm of piglet.
The pathogen of primary disease is escherichia coli, and this disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antibacterials, such as oxytetracycline, chloromycetin, penicillin, streptomycin, quinolinones etc.; Because the prolonged and repeated use of antibacterials causes this pathogenic microorganism that medicine has been produced drug resistance, reduced curative effect, and drug residue in animal body, its meat does not reach nuisanceless requirement, has affected the outlet of livestock products and people's health.
Therefore researching and developing a kind of specific medicament for the treatment of yellow and white dysentery of piglet is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, effectively treat the pure Chinese medicine composition and preparation method thereof of yellow and white dysentery of piglet.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet, it is characterized in that by following component by weight mixed preparing form: Radix et Rhizoma Thalictri 10-35 part, Herba Pteridis Multifidae 10-25 part, dried Alumen 5-10 part, Fructus Evodiae 10-15 part, Fructus Chebulae 10-15 part, Radix Glycyrrhizae 10-15 part.
Described various component optimum ratio amount is: 30 parts of Radix et Rhizoma Thalictri, 20 parts of Herba Pteridis Multifidaes, 10 parts of dried Alumens, 10 parts of Fructus Evodiaes, 15 parts of Fructus Chebulaes, 15 parts in Radix Glycyrrhizae.
A kind of preparation method for the treatment of the pure Chinese medicine composition of yellow and white dysentery of piglet is characterized in that carrying out as follows:
(1) the various compositions in the prescription is pulverized respectively the rear 24-80 of mistake mesh sieve;
(2) take by weighing by weight Radix et Rhizoma Thalictri 10-35 part, Herba Pteridis Multifidae 10-25 part, dried Alumen 5-10 part, mix 10-25 minute to even;
(3) take by weighing by weight Fructus Evodiae 10-15 part, Fructus Chebulae 10-15 part, Radix Glycyrrhizae 10-15 part, mix 10-25 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
The medicinal property of each component is as follows:
Radix et Rhizoma Thalictri: cold, bitter, GUIXIN, liver, gallbladder, large intestine channel have heat clearing and damp drying, a function of the removing heat from blood that dispels the wind, anti-inflammtory anti-dysentery; Cure mainly the damp and hot dysentery of letting out.
Herba Pteridis Multifidae: little hardship, cold, return liver, kidney, large intestine channel, have the function of clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating; Cure mainly damp-heat diarrhea, jaundice etc.
Dried Alumen: cold, acid, puckery, return lung, spleen, large intestine, Liver Channel, have the function of heat clearing away expectorant, hemostasis antidiarrheal, dampness removing to stop itchin, detoxifcation parasite killing; Cure mainly incessant chronic diarrhea, heavily wait after having blood in stool, let out dysentery.
Fructus Evodiae: hot, bitter, hot, return spleen, liver, stomach, kidney channel, have warming middle-JIAO to relieve pain, a function of the preventing or arresting vomiting of regulating the flow of vital energy; Cure mainly that Deficiency and coldness of spleen and stomach, cold intestinal are had loose bowels, the cold salivation of stomach.
The Fructus Chebulae: bitter, sour, puckery, flat, return lung, large intestine channel, the function of have astringing intestine to stop diarrhea, astringing the lung; Cure mainly the chronic diarrhea chronic dysentery, have blood in stool, proctoptosis, cough and asthma due to lung deficiency etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Above all flavor Chinese medicine for pathogenic microorganism and the clinical symptoms of yellow and white dysentery of piglet, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the tcm theory compatible combination.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and the generation that has no drug resistance, cost is low, draws materials wide the curative effect highly significant.Adopt molecular pharmacology and the Chinese veterinarian of motherland determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs method, optimize this six kinds of medicines, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves that treatment yellow scour of piglet, piglet pujos blancos are had specially good effect.And make the livestock products meat reach nuisanceless requirement, satisfy the export standard of livestock products, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in the prescription is pulverized respectively the rear 24-80 of mistake mesh sieve;
(2) take by weighing by weight Radix et Rhizoma Thalictri 350g, Herba Pteridis Multifidae 150g, dried Alumen 100g, mix 10-25 minute to even;
(3) take by weighing by weight Fructus Evodiae 100g, Fructus Chebulae 150g, Radix Glycyrrhizae 150g, mix 10-25 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in the prescription is pulverized respectively the rear 24-80 of mistake mesh sieve;
(2) take by weighing by weight Radix et Rhizoma Thalictri 200g, Herba Pteridis Multifidae 100g, dried Alumen 100g, mix 10-25 minute to even;
(3) take by weighing by weight Fructus Evodiae 100g, Fructus Chebulae 100g, Radix Glycyrrhizae 100g, mix 10-25 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in the prescription is pulverized respectively the rear 24-80 of mistake mesh sieve;
(2) take by weighing by weight gulfweed 350g, Herba Pteridis Multifidae 250g, dried Alumen 100g, mix 10-25 minute to even;
(3) take by weighing by weight Fructus Evodiae 150g, Fructus Chebulae 150g, Radix Glycyrrhizae 150g, mix 10-25 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Clinical trial:
With the ill domestic animal of product feeding of the present invention etc., a day dose is: pig is by per kilogram of body weight 2g, and spice is fed, and every day 3 times, is used in conjunction 3-5 day; Absorb the purpose that reaches the treatment disease by gastrointestinal after oral.
Table 1 is the field applicable cases contrast of the present invention and other medicines treatment yellow scour of piglet:
Clinical effectiveness statistical analysis, present composition treatment group are compared difference extremely significantly (P＜0.01) with YANSUAN TUMEISU ZHUSHEYE treatment group, streptomycin sulfate treatment group.
Table 2 is field applicable cases contrasts of the present invention and other medicines treatment piglet pujos blancos:
This clinical effectiveness statistical analysis, present composition treatment group are compared difference extremely significantly (P＜0.01) with the YANSUAN TUMEISU ZHUSHEYE treatment group, compare significant difference (P＜0.05) with the streptomycin sulfate treatment group.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment yellow and white dysentery of piglet and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet, it is characterized in that by following component by weight mixed preparing form: Radix et Rhizoma Thalictri 10-35 part, Herba Pteridis Multifidae 10-25 part, dried Alumen 5-10 part, Fructus Evodiae 10-15 part, Fructus Chebulae 10-15 part, Radix Glycyrrhizae 10-15 part.
2. the pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet according to claim 1 is characterized in that described various component optimum ratio amount is: 30 parts of Radix et Rhizoma Thalictri, 20 parts of Herba Pteridis Multifidaes, 10 parts of dried Alumens, 10 parts of Fructus Evodiaes, 15 parts of Fructus Chebulaes, 15 parts in Radix Glycyrrhizae.
3. the preparation method of the pure Chinese medicine composition of a treatment yellow and white dysentery of piglet according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is pulverized respectively the rear 24-80 of mistake mesh sieve;
(2) take by weighing by weight Radix et Rhizoma Thalictri 10-35 part, Herba Pteridis Multifidae 10-25 part, dried Alumen 5-10 part, mix 10-25 minute to even;
(3) take by weighing by weight Fructus Evodiae 10-15 part, Fructus Chebulae 10-15 part, Radix Glycyrrhizae 10-15 part, mix 10-25 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
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| CN102512651B (en) * | 2012-01-06 | 2014-05-28 | 张树森 | Traditional Chinese medicament for treating yellow-white dysentery of baby pigs |
| CN112618692B (en) * | 2021-01-12 | 2022-03-25 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating yellow and white scour of piglets as well as preparation method and application thereof |
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| CN1223121C (en) * | 2002-09-23 | 2005-10-12 | 华为技术有限公司 | Multimedia broadcast/multicast service method |
| CN101417016A (en) * | 2008-10-31 | 2009-04-29 | 天津必佳药业集团有限公司 | Traditional Chinese medicine composition for treating Escherichia coli |
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| CN1223121C (en) * | 2002-09-23 | 2005-10-12 | 华为技术有限公司 | Multimedia broadcast/multicast service method |
| CN101417016A (en) * | 2008-10-31 | 2009-04-29 | 天津必佳药业集团有限公司 | Traditional Chinese medicine composition for treating Escherichia coli |
Non-Patent Citations (4)
| Title |
|---|
| 中医药治疗慢性非特异性溃疡性结肠炎的近况;田凤鸣等;《北京中医》;19840825(第04期);38-40 * |
| 中草药防治猪传染病的研究概况;马玉芳等;《中兽医学杂志》;20001125(第04期);33-35 * |
| 田凤鸣等.中医药治疗慢性非特异性溃疡性结肠炎的近况.《北京中医》.1984,(第04期), |
| 马玉芳等.中草药防治猪传染病的研究概况.《中兽医学杂志》.2000,(第04期), |
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