CN102836313B - Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets and preparation method thereof - Google Patents

Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets and preparation method thereof Download PDF

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CN102836313B
CN102836313B CN201110165490.7A CN201110165490A CN102836313B CN 102836313 B CN102836313 B CN 102836313B CN 201110165490 A CN201110165490 A CN 201110165490A CN 102836313 B CN102836313 B CN 102836313B
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CN102836313A (en
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周庆福
刘文利
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Qingdao Lvman Bioengineering Co Ltd
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Qingdao Lvman Bioengineering Co Ltd
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Abstract

The invention relates to a pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets, which is characterized by being prepared through mixing the following ingredients in parts by weight: 10-35 parts by weight of rhizoma atractylodis, 10-25 parts by weight of white peony root, 10-25 parts by weight of Chinese yam, 10-30 parts by weight of coptis, 10-35 parts by weight of banksia rose, 10-25 parts by weight of terminalia, 10-25 parts by weight of ricepaperplant pith medulla tetrapanacis, 10-30 parts by weight of akebia stem, 10-25 parts by weight of cowherb seed and 10-30 by weight of licorice. The preparation method comprises the following steps of: (1) crushing each of the ingredients of the composition separately, and screening through a sieve of 24-80 mesh; (2) weighing 10-35 parts by weight of the rhizoma atractylodis, 10-25 parts by weight of the white peony root, 10-25 parts by weight of the Chinese yam, 10-30 parts by weight of the coptis and 10-35 parts by weight of the banksia rose, and mixing evenly for 10-25 minutes; (3) weighing 10-25 parts by weight of the terminalia, 10-25 parts by weight of the ricepaperplant pith medulla tetrapanacis, 10-30 parts by weight of the akebia stem, 10-25 parts by weight of the cowherb seed and 10-30 by weight of the licorice, and mixing evenly for 10-25 minutes; (4) combining the compositions prepared in step (2) and step (3), and mixing evenly for another 15-20 minute to obtain the traditional Chinese medicine composition. The benefit effects of the invention are that the pure traditional Chinese medicine composition has reasonable formula, simple preparation method, no pollution because of being prepared by pure traditional Chinese herbs, and clinically proved special good treatment effect for yellow-white dysentery of piglets.

Description

Pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment yellow and white dysentery of piglet and preparation method thereof.
Background technology
Yellow scour of piglet, piglet pujos blancos are that a kind of common alimentary infection being caused by escherichia coli is sick, and take clinically diarrhoea, row's yellow or yellow-white feces is feature, or take ash discharge white, smell as of rotten fish, paste shape loose stool is feature, very large to the harm of piglet.
The pathogen of primary disease is escherichia coli, and this disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antibacterials, as oxytetracycline, chloromycetin, penicillin, streptomycin, quinolinones etc.; Due to the prolonged and repeated use of antibacterials, cause this pathogenic microorganism to produce drug resistance to medicine, reduced curative effect, and drug residue is in animal body, its meat does not reach nuisanceless requirement, has affected the outlet of livestock products and people's health.
Yellow scour of piglet, piglet pujos blancos are the frequently-occurring disease of piglet when 7 age in days left and right, be injection or gavage to piglet stress be all very large, affect the normal growth of piglet.
Therefore research and develop a kind of treat yellow and white dysentery of piglet not only easy to use and to piglet stress not but also have no side effect, the specific medicament of drug residue free is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, effectively treat pure Chinese medicine composition of yellow and white dysentery of piglet and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet, it is characterized in that by following component by weight mixed preparing form: Rhizoma Atractylodis 10-35 part, Radix Paeoniae Alba 10-25 part, Rhizoma Dioscoreae 10-25 part, Rhizoma Coptidis 10-30 part, Radix Aucklandiae 10-35 part, Fructus Chebulae 10-25 part, Medulla Tetrapanacis 10-25 part, Caulis Akebiae 10-30 part, Semen Vaccariae 10-25 part, Radix Glycyrrhizae 10-30 part.
Described various component optimum ratio amount is: 25 parts of Rhizoma Atractylodis, 15 parts of the Radix Paeoniae Albas, 15 parts of Rhizoma Dioscoreaes, 20 parts of Rhizoma Coptidis, 20 parts of the Radix Aucklandiae, 15 parts of Fructus Chebulaes, 15 parts of Medulla Tetrapanaciss, 20 parts of Caulis Akebiaes, 15 parts of Semen Vaccariae, 20 parts, Radix Glycyrrhizae.
Treat a preparation method for the pure Chinese medicine composition of yellow and white dysentery of piglet, it is characterized in that carrying out as follows:
(1) the various compositions in prescription are pulverized respectively to the rear 24-80 of mistake mesh sieve;
(2) take by weight Rhizoma Atractylodis 10-35 part, Radix Paeoniae Alba 10-25 part, Rhizoma Dioscoreae 10-25 part, Rhizoma Coptidis 10-30 part, Radix Aucklandiae 10-35 part, mix 10-15 minute to even;
(3) take by weight Fructus Chebulae 10-25 part, Medulla Tetrapanacis 10-25 part, Caulis Akebiae 10-30 part, Semen Vaccariae 10-25 part, Radix Glycyrrhizae 10-30 part, mix 10-15 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
The medicinal property of each component is as follows:
The Radix Aucklandiae: acrid, bitter, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, there is the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe is swollen, weight, stomachache etc. after dysentery.
Semen Vaccariae: bitter, flat, return liver, stomach warp, the function that there is dredging collateral for promoting lactation, invigorates blood circulation and disappear and become silted up; Cure mainly galactostasis, acute mastitis, furuncle.
The Radix Paeoniae Alba: bitter, acid, be slightly cold, return spleen, Liver Channel, there is suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Rhizoma Atractylodis: bitter, pungent, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia etc.
Caulis Akebiae: bitter, be slightly cold, GUIXIN, small intestinal, urinary bladder channel, have clearing away heat-fire, diuresis, a function of the stimulating milk secretion of stimulating the menstrual flow; Cure mainly aphtha of the mouth and tongue, dark coloured urine, five types of stranguria, damp-heat vaginal discharge, galactostasis etc.
Medulla Tetrapanacis: sweet, light, be slightly cold, return stomach, lung meridian, there is the function of clearing away heat and promoting diuresis, ventilation stimulating milk secretion; Cure mainly that damp and hot urine drenches, short urination is red, edema, agalactia etc.
Fructus Chebulae: bitter, sour, puckery, flat, return lung, large intestine channel, the function of there is astringing intestine to stop diarrhea, astringing the lung; Cure mainly chronic diarrhea chronic dysentery, have blood in stool, proctoptosis, cough and asthma due to lung deficiency etc.
Rhizoma Dioscoreae: sweet, flat, return lung, spleen, kidney channel, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen etc.
Rhizoma Coptidis: bitter, cold, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, fire-toxin carbuncle sore etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
All taste Chinese medicine, according to tcm theory compatible combination, for pathogenic microorganism and the clinical symptoms of yellow and white dysentery of piglet, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.Theoretical according to the tradition Chinese veterinarian of motherland, optimize this ten kinds of medicines, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves that treatment yellow scour of piglet, piglet pujos blancos are had to specially good effect.This medicine is by gavaging or the spice sow of feeding, piglet sucks the object that breast milk reaches treatment, not only easy to use but also to piglet without stress, and make livestock products meat reach nuisanceless requirement, meet the export standard of livestock products, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to the rear 24-80 of mistake mesh sieve;
(2) take by weight 100 parts of Rhizoma Atractylodis, 100 parts of the Radix Paeoniae Albas, 100 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Coptidis, 100 parts of the Radix Aucklandiae, mix 10-15 minute to even;
(3) take by weight 100 parts of Fructus Chebulaes, 100 parts of Medulla Tetrapanaciss, 100 parts of Caulis Akebiaes, 100 parts of Semen Vaccariae, 100 parts, Radix Glycyrrhizae, mix 10-15 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to the rear 24-80 of mistake mesh sieve;
(2) take by weight 250 parts of Rhizoma Atractylodis, 150 parts of the Radix Paeoniae Albas, 150 parts of Rhizoma Dioscoreaes, 200 parts of Rhizoma Coptidis, 200 parts of the Radix Aucklandiae, mix 10-15 minute to even;
(3) take by weight 150 parts of Fructus Chebulaes, 150 parts of Medulla Tetrapanaciss, 200 parts of Caulis Akebiaes, 150 parts of Semen Vaccariae, 200 parts, Radix Glycyrrhizae, mix 10-15 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet and preparation method thereof: it is characterized in that carrying out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to the rear 24-80 of mistake mesh sieve;
(2) take by weight 350 parts of Rhizoma Atractylodis, 250 parts of the Radix Paeoniae Albas, 250 parts of Rhizoma Dioscoreaes, 300 parts of Rhizoma Coptidis, 350 parts of the Radix Aucklandiae, mix 10-15 minute to even;
(3) take by weight 250 parts of Fructus Chebulaes, 250 parts of Medulla Tetrapanaciss, 300 parts of Caulis Akebiaes, 250 parts of Semen Vaccariae, 300 parts, Radix Glycyrrhizae, mix 10-15 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
Clinical trial:
Product of the present invention is fed or reconstitute after medicine is waited temperature and gavage lactating sow with boiled water, piglet is controlled dysentery by sucking breast milk, and a day dose is: gavage, by per kilogram of body weight 2g; Spice is fed, and by every Kg body weight 3g, every day 1-2 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table 1 is the field applicable cases contrast of the present invention and other medicines treatment yellow scour of piglet:
Numbering Group Mortality rate % Cure rate % During end, there is symptom rate %
ZHUSHEYONG LIUSUAN LIANMEISU group 10.6 66.0 23.4
YANSUAN TUMEISU ZHUSHEYE group 7.5 74.4 18.1
Chinese medicine composition of the present invention 3.5 89.0 7.5
Clinical effectiveness statistical analysis, present composition treatment group is compared difference extremely significantly (P < 0.01) with YANSUAN TUMEISU ZHUSHEYE treatment group, streptomycin sulfate treatment group.
Table 2 is field applicable cases contrasts of the present invention and other medicines treatment piglet pujos blancos:
Numbering Group Mortality rate % Cure rate % During end, there is symptom rate %
ZHUSHEYONG LIUSUAN LIANMEISU group 7.5 82.0 10.5
YANSUAN TUMEISU ZHUSHEYE group 11.5 73.7 14.8
Chinese medicine composition of the present invention 5.9 89.9 6.0
This clinical effectiveness statistical analysis, present composition treatment group is compared difference extremely significantly (P < 0.01) with YANSUAN TUMEISU ZHUSHEYE treatment group, compare significant difference (P < 0.05) with streptomycin sulfate treatment group.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment yellow and white dysentery of piglet and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a pure Chinese medicine composition for yellow and white dysentery of piglet, it is characterized in that by following component by weight mixed preparing form: Rhizoma Atractylodis 10-35 part, Radix Paeoniae Alba 10-25 part, Rhizoma Dioscoreae 10-25 part, Rhizoma Coptidis 10-30 part, Radix Aucklandiae 10-35 part, Fructus Chebulae 10-25 part, Medulla Tetrapanacis 10-25 part, Caulis Akebiae 10-30 part, Semen Vaccariae 10-25 part, Radix Glycyrrhizae 10-30 part.
2. the pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet according to claim 1, is characterized in that described various component proportion amount is: 25 parts of Rhizoma Atractylodis, 15 parts of the Radix Paeoniae Albas, 15 parts of Rhizoma Dioscoreaes, 20 parts of Rhizoma Coptidis, 20 parts of the Radix Aucklandiae, 15 parts of Fructus Chebulaes, 15 parts of Medulla Tetrapanaciss, 20 parts of Caulis Akebiaes, 15 parts of Semen Vaccariae, 20 parts, Radix Glycyrrhizae.
3. a preparation method for the pure Chinese medicine composition for the treatment of yellow and white dysentery of piglet according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are pulverized respectively to the rear 24-80 of mistake mesh sieve;
(2) take by weight Rhizoma Atractylodis 10-35 part, Radix Paeoniae Alba 10-25 part, Rhizoma Dioscoreae 10-25 part, Rhizoma Coptidis 10-30 part, Radix Aucklandiae 10-35 part, mix 10-15 minute to even;
(3) take by weight Fructus Chebulae 10-25 part, Medulla Tetrapanacis 10-25 part, Caulis Akebiae 10-30 part, Semen Vaccariae 10-25 part, Radix Glycyrrhizae 10-30 part, mix 10-15 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-25 minute to even.
CN201110165490.7A 2011-06-20 2011-06-20 Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets and preparation method thereof Expired - Fee Related CN102836313B (en)

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Publication number Priority date Publication date Assignee Title
CN103432340B (en) * 2013-09-16 2015-02-25 河北科技师范学院 Chinese herbal medicine oral liquid for treating yellow scours of piglets
CN106937972A (en) * 2016-01-04 2017-07-11 天津中敖生物科技有限公司 Treat Chinese medicine composition of piglet yellow-white dysentery and preparation method thereof
CN106334075A (en) * 2016-11-07 2017-01-18 四会市恒星智能科技有限公司 Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1919330A (en) * 2006-08-22 2007-02-28 夏金陵 Traditional medicine composition for treating chronic colitis and its preparing process
CN101238858A (en) * 2008-01-28 2008-08-13 吴忠尚 Chinese medicinal composition for preventing and controlling yellow and white scour of piglets
CN101259171A (en) * 2008-04-11 2008-09-10 福建农林大学 Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1919330A (en) * 2006-08-22 2007-02-28 夏金陵 Traditional medicine composition for treating chronic colitis and its preparing process
CN101238858A (en) * 2008-01-28 2008-08-13 吴忠尚 Chinese medicinal composition for preventing and controlling yellow and white scour of piglets
CN101259171A (en) * 2008-04-11 2008-09-10 福建农林大学 Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
中草药防治仔猪黄白痢的研究进展;王新等;《兽药与饲料添加剂》;20031231;第8卷;第22-24页 *
中西医结合防制猪黄白痢;黄守琼等;《四川畜牧兽医》;20091231(第10期);第54,56页 *
王新等.中草药防治仔猪黄白痢的研究进展.《兽药与饲料添加剂》.2003,第8卷第22-24页.
黄守琼等.中西医结合防制猪黄白痢.《四川畜牧兽医》.2009,(第10期),第54,56页.

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