CN102657808B - Compound propolis combination for treating cattle and sheep hepatic fascioliasis and preparation method thereof - Google Patents

Abstract

The invention relates to a compound propolis combination for treating cattle and sheep hepatic fascioliasis and a preparation method of the compound propolis combination. The combination is formed by mixing the following components in parts by weight: 15-35 parts of propolis, 15-45 parts of gentian, 15-35 parts of three medicines (i.e. coke malt, coke hawthorn and coke medicated leaven), 15-35 parts of red peony root, 15-45 parts of akebiaquinata, 15-35 parts of rhizoma alismatis, 15-35 parts of cortex magnoliae officinalis, 15-35 parts of cardamom and 15-45 parts of radix glycyrrhizae. The compound propolis combination disclosed by the invention is a pure traditional Chinese medicine combination and has the beneficial effects of reasonable composing prescription, simpleness in preparation, no pollution, no toxic or side effect, no drug resistance and no drug residue and very significant curative effect. Proved by clinic, the compound propolis combination has special effect on treating the cattle and sheep hepatic fascioliasis.

Description

A kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof

Technical field

The present invention relates to a kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment cattle and sheep fascioliasis hepatica and preparation method thereof.

Background technology

Cattle and sheep fascioliasis hepatica is to parasitize caused a kind of comparatively serious parasitic disease in the liver bile ducts of cattle and sheep by the distoma hepaticum of Fasciolidae Fasciola.Primary disease can cause that cattle and sheep are acute, chronic hepatitis and cholangitis, and the systemic toxicity that simultaneously occurs together and malnutrition, decline cattle and sheep fertility performance, and young stock can cause large quantities of death, produces and brings huge economic loss to animal husbandry.

At present, this disease can only be treated with anthelmintics such as nitre chlorine powder, the two dichloro powder of sulfur, Albendazole, carbon tetrachloride, once produce drug resistance, this disease is difficult to cure; And also having drug residue, its livestock products affect health.This disease is to pig industry and people are healthy causes very large threat.

Therefore research and develop a kind of treat cattle and sheep fascioliasis hepatica and have no side effect, drug residue free, have no drug resistance produce specific medicament be one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, have no side effect, have no drug resistance generation, drug residue free, successful, effectively treat compound bee-glue composition of cattle and sheep fascioliasis hepatica and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica, by following component by weight mixed preparing form: propolis 15-35 part, Radix Gentianae 15-45 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15-35 part, Radix Paeoniae Rubra 15-35 part, Caulis Akebiae 15-45 part, Rhizoma Alismatis 15-35 part, Mangnolia officinalis 15-35 part, Fructus Amomi Rotundus 15-35 part, Radix Glycyrrhizae 15-45 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts of Radix Gentianaes, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 25 parts of Radix Paeoniae Rubra, 30 parts of Caulis Akebiaes, 25 parts of Rhizoma Alismatis, 25 parts of Mangnolia officinalis, 25 parts, Fructus Amomi Rotundus, 30 parts, Radix Glycyrrhizae.

Treat a preparation method for the compound bee-glue composition of cattle and sheep fascioliasis hepatica, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, Radix Gentianae 15-45 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15-35 part, Radix Paeoniae Rubra 15-35 part, Caulis Akebiae 15-45 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Alismatis 15-35 part, Mangnolia officinalis 15-35 part, Fructus Amomi Rotundus 15-35 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.

Radix Gentianae: bitter, cold, return liver, gallbladder meridian, there is eliminating pathogen in the liver gallbladder excess-fire, function except damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): sweet, flat, warm, GUIXIN, liver, kidney, large intestine channel, have invigorating the spleen and regulating the stomach, the stagnant function of soothing the liverization; Curing mainly food stagnation does not disappear, vomits and have loose bowels etc.

Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, there is the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, carbuncle skin infection etc.

Caulis Akebiae: bitter, be slightly cold, GUIXIN, small intestinal, urinary bladder channel, have clearing away heat-fire, diuresis, a function of the stimulating milk secretion of stimulating the menstrual flow; Cure mainly aphtha of the mouth and tongue, dark coloured urine, five types of stranguria, edema, damp-heat vaginal discharge, galactostasis etc.

Mangnolia officinalis: bitter, pungent, warm, return spleen, stomach, lung, large intestine channel, there is the function of therapeutic method to keep the adverse QI flowing downwards relieving distension, dampness expectorant; Cure mainly that dyspepsia does not disappear, stagnation of QI due to dyspepsia, tripe is swollen constipation, phlegm retention cough with asthma etc.

Fructus Amomi Rotundus: pungent, warm, return spleen, stomach, lung meridian, there is the function of the removing dampness of being amusing, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving; Curing mainly spleen-cold syndrome dyspepsia, abdominal distention, inappetence, cold type of pain, vomiting, deficiency and coldness has loose bowels etc.

Rhizoma Alismatis: sweet, light, cold, return kidney, urinary bladder channel, there is the function of diuresis, clearing away damp-heat; Cure mainly dysuria, edema distension, diarrhea due to damp-heat etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

All taste Chinese medicine, according to tcm theory compatible combination, for paathogenic factor and the pathological change of cattle and sheep fascioliasis hepatica, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.According to the tradition Chinese veterinarian of motherland, theoretical and modern Chinese medicine pharmacology theory, optimizes this nine kinds of medicines, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment cattle and sheep fascioliasis hepatica is had specially good effect and had no side effect and drug resistance.And make livestock products reach nuisanceless requirement, meet the export standard of livestock products, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of cattle and sheep distoma hepaticum and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 150 parts of Radix Gentianaes, 150 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 150 parts of Radix Paeoniae Rubra, 150 parts of Caulis Akebiaes, mix 5-10 minute to even;

(3) take by weight 150 parts of Rhizoma Alismatis, 150 parts of Mangnolia officinalis, 150 parts, Fructus Amomi Rotundus, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 300 parts of Radix Gentianaes, 250 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 250 parts of Radix Paeoniae Rubra, 300 parts of Caulis Akebiaes, mix 5-10 minute to even;

(3) take by weight 250 parts of Rhizoma Alismatis, 250 parts of Mangnolia officinalis, 250 parts, Fructus Amomi Rotundus, 300 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of propolis, 450 parts of Radix Gentianaes, 350 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 350 parts of Radix Paeoniae Rubra, 450 parts of Caulis Akebiaes, mix 5-10 minute to even;

(3) take by weight 350 parts of Rhizoma Alismatis, 350 parts of Mangnolia officinalis, 350 parts, Fructus Amomi Rotundus, 450 parts, Radix Glycyrrhizae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 80-150 age in days, body weight at 20kg-45kg, and Laboratory Diagnosed is the ill sheep of Hepar Caprae seu ovis fascioliasis.Ill sheep isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 20 every group, 3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and medicine matched group uses treatment with " liver fluke is loose " by specification; Chinese medicine composition group of the present invention can gavage ill cattle and sheep by product of the present invention, and a day dose is the 100-200 gram of present composition, every day 1 time, is used in conjunction 3-5 days; After oral, reach the object for the treatment of disease by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment Hepar Caprae seu ovis fascioliasis:

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	10.1	62.0	27.9
II	The liver fluke group of faling apart	6.2	84.1	9.7
					III	Chinese medicine composition group of the present invention	4.5	91.2	5.3

This clinical effectiveness statistical analysis, the loose group of present composition group and liver fluke significant difference (P < 0.05) compared with aspect cure rate.

The above-mentioned detailed description that compound bee-glue composition to this treatment cattle and sheep fascioliasis hepatica and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for cattle and sheep fascioliasis hepatica, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Gentianae 15-45 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15-35 part, Radix Paeoniae Rubra 15-35 part, Caulis Akebiae 15-45 part, Rhizoma Alismatis 15-35 part, Mangnolia officinalis 15-35 part, Fructus Amomi Rotundus 15-35 part, Radix Glycyrrhizae 15-45 part.

2. the compound bee-glue composition for the treatment of according to claim 1 cattle and sheep fascioliasis hepatica, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Radix Gentianaes, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 25 parts of Radix Paeoniae Rubra, 30 parts of Caulis Akebiaes, 25 parts of Rhizoma Alismatis, 25 parts of Mangnolia officinalis, 25 parts, Fructus Amomi Rotundus, 30 parts, Radix Glycyrrhizae.

3. a preparation method for the compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, Radix Gentianae 15-45 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15-35 part, Radix Paeoniae Rubra 15-35 part, Caulis Akebiae 15-45 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Alismatis 15-35 part, Mangnolia officinalis 15-35 part, Fructus Amomi Rotundus 15-35 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.