CN102670899B - Compound propolis composition for treating cattle and sheep fascioliasis and preparation method thereof - Google Patents
Compound propolis composition for treating cattle and sheep fascioliasis and preparation method thereof Download PDFInfo
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- 241000283898 Ovis Species 0.000 title claims abstract description 28
- 241000283690 Bos taurus Species 0.000 title claims abstract description 24
- 208000006275 Fascioliasis Diseases 0.000 title claims abstract description 24
- 150000001875 compounds Chemical class 0.000 title claims abstract description 18
- 229940069949 Propolis Drugs 0.000 title claims abstract description 16
- 241000241413 Propolis Species 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 12
- 239000011593 sulfur Substances 0.000 claims abstract description 12
- 240000005368 Areca catechu Species 0.000 claims abstract 2
- 241001385463 Hepatica <moth> Species 0.000 claims description 16
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- 239000003814 drug Substances 0.000 abstract description 14
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- 235000015162 Caesalpinia sappan Nutrition 0.000 abstract 1
- 241001660870 Cyrtomium Species 0.000 abstract 1
- 240000000233 Melia azedarach Species 0.000 abstract 1
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- 231100000486 side effect Toxicity 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 7
- 210000000952 Spleen Anatomy 0.000 description 6
- 210000004185 Liver Anatomy 0.000 description 5
- 210000002784 Stomach Anatomy 0.000 description 5
- 241000202755 Areca Species 0.000 description 4
- 210000004369 Blood Anatomy 0.000 description 4
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- 231100000614 Poison Toxicity 0.000 description 3
- 230000000507 anthelmentic Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 229940079593 drugs Drugs 0.000 description 3
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- 244000144972 livestock Species 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N Carbon tetrachloride Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000668709 Dipterocarpus costatus Species 0.000 description 2
- 210000003734 Kidney Anatomy 0.000 description 2
- 210000004072 Lung Anatomy 0.000 description 2
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- 230000002496 gastric Effects 0.000 description 2
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- 239000003440 toxic substance Substances 0.000 description 2
- 229940036592 ANTHELMINTICS Drugs 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 229960002669 Albendazole Drugs 0.000 description 1
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- 206010008909 Chronic hepatitis Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
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- 210000000232 Gallbladder Anatomy 0.000 description 1
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Abstract
The invention relates to a compound propolis composition for treating cattle and sheep fascioliasis and a preparation method thereof. The compound propolis composition is prepared by mixing the following components in parts by weight: 15-35 parts of propolis, 15-45 parts of areca nut, 15-35 parts of sappan wood, 10-25 parts of sulfur, 15-35 parts of lightyellow sophora root, 15-45 parts of cyrtomium rhizome, 15-35 parts of chinaberry bark and root-bark, 15-35 parts of oriental waterplantain rhizome and 15-40 parts of liquoric root. The compound propolis composition has the beneficial effects of reasonable formula, easiness for preparing, environment friendliness, freeness from toxic and side effects, avoidance of medicament tolerance, no medicament residues, and very remarkable curative effect; and as proved by clinic, the compound propolis composition has a special treatment effect on cattle and sheep fascioliasis.
Description
Technical field
The present invention relates to a kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment cattle and sheep fascioliasis hepatica and preparation method thereof.
Background technology
Cattle and sheep fascioliasis hepatica is that the distoma hepaticum by Fasciolidae Fasciola parasitizes caused a kind of comparatively serious parasitic disease in the liver bile ducts of cattle and sheep.Primary disease can cause that cattle and sheep are acute, chronic hepatitis and cholangitis, and the systemic toxicity that simultaneously occurs together and malnutrition, decline cattle and sheep fertility performance, and young stock can cause large quantities of death, to animal husbandry, produces and brings huge economic loss.
At present, this disease can only be treated with anthelmintics such as nitre chlorine powder, the two dichloro powder of sulfur, Albendazole, carbon tetrachloride, once produce drug resistance, this disease is difficult to cure; And also having drug residue, its livestock products affect health.This disease is to pig industry and people are healthy causes very large threat.
Therefore research and develop a kind of treat cattle and sheep fascioliasis hepatica and have no side effect, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, have no side effect, have no drug resistance generation, drug residue free, successful, effectively treat compound bee-glue composition of cattle and sheep fascioliasis hepatica and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica, by following component by weight mixed preparing form: propolis 15-35 part, Semen Arecae 15-45 part, Lignum Sappan 15-35 part, sulfur 10-25 part, Radix Sophorae Flavescentis 15-35 part, Rhizoma Osmundae 15-45 part, Cortex Meliae 15-35 part, Rhizoma Alismatis 15-35 part, Radix Glycyrrhizae 15-40 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts of Semen Arecaes, 25 parts of Lignum Sappans, 15 parts, sulfur, 25 parts of Radix Sophorae Flavescentiss, 30 parts of Rhizoma Osmundae, 25 parts of Cortex Meliaees, 25 parts of Rhizoma Alismatis, 30 parts, Radix Glycyrrhizae.
Treat a preparation method for the compound bee-glue composition of cattle and sheep fascioliasis hepatica, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Semen Arecae 15-45 part, Lignum Sappan 15-35 part, sulfur 10-25 part, Radix Sophorae Flavescentis 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Osmundae 15-45 part, Cortex Meliae 15-35 part, Rhizoma Alismatis 15-35 part, Radix Glycyrrhizae 15-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Lignum Sappan: sweet, salty, flat, GUIXIN, liver, spleen channel, have the function of promoting the circulation of blood removing blood stasis with potent drugs, reducing swelling and alleviating pain; Cure mainly blood stasis, carbuncle etc.
Semen Arecae: bitter, pungent, warm, return stomach, large intestine channel, there is the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Sulfur: acid, temperature, poisonous, return kidney, large intestine channel, have and mend function fiery supporing yang, relieving constipation; Cure mainly yang deficiency constipation, deficiency and coldness asthma, scabies, carbuncle of yin nature malignant boil etc.
Radix Sophorae Flavescentis: bitter, puckery, cold, return liver, gallbladder, large intestine channel, there is the function of heat clearing and damp drying, astringent therapy dysentery relieving, improving eyesight; Cure mainly damp-heat diarrhea, conjunctival congestion and swelling pain, nebula etc.
Rhizoma Osmundae: bitter, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Cortex Meliae: bitter, cold, return stomach, liver, spleen channel, there is the function of parasite killing, treatment tinea; Cure mainly abdominal pain due to worm stagnation, scabies etc.
Rhizoma Alismatis: sweet, light, cold, return kidney, urinary bladder channel, there is the function of diuresis, clearing away damp-heat; Cure mainly dysuria, edema distension, diarrhea due to damp-heat etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All taste Chinese medicine, according to tcm theory compatible combination, for paathogenic factor and the pathological change of cattle and sheep fascioliasis hepatica, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.According to the tradition Chinese veterinarian of motherland, theoretical and modern Chinese medicine pharmacology theory, optimizes this nine kinds of medicines, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment cattle and sheep fascioliasis hepatica is had specially good effect and had no side effect and drug resistance.And make livestock products reach nuisanceless requirement, meet the export standard of livestock products, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of cattle and sheep distoma hepaticum and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Semen Arecaes, 150 parts of Lignum Sappans, 100 parts, sulfur, 150 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(3) take by weight 150 parts of Rhizoma Osmundae, 150 parts of Cortex Meliaees, 150 parts of Rhizoma Alismatis, 150 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 300 parts of Semen Arecaes, 250 parts of Lignum Sappans, 150 parts, sulfur, 250 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(3) take by weight 300 parts of Rhizoma Osmundae, 250 parts of Cortex Meliaees, 250 parts of Rhizoma Alismatis, 300 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 450 parts of Semen Arecaes, 350 parts of Lignum Sappans, 250 parts, sulfur, 350 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(3) take by weight 450 parts of Rhizoma Osmundae, 350 parts of Cortex Meliaees, 350 parts of Rhizoma Alismatis, 400 parts, Radix Glycyrrhizae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 80-150 age in days, body weight at 20kg-40kg, and Laboratory Diagnosed is the ill sheep of Hepar Caprae seu ovis fascioliasis.Ill sheep isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 20 every group, 3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and medicine matched group is used treatment with " liver fluke is loose " by specification; Chinese medicine composition group of the present invention can gavage ill cattle and sheep by product of the present invention, and a day dose is the 50-100 gram of present composition, every day 1 time, is used in conjunction 3-5 days; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment Hepar Caprae seu ovis fascioliasis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 10.1 | 62.0 | 27.9 |
| II | The liver fluke group of faling apart | 6.2 | 84.1 | 9.7 |
| III | Chinese medicine composition group of the present invention | 3.4 | 92.0 | 4.6 |
This clinical effectiveness statistical analysis, present composition group is being compared significant difference (P < 0.05) with the loose group of liver fluke aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment cattle and sheep fascioliasis hepatica and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for cattle and sheep fascioliasis hepatica, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Semen Arecae 15-45 part, Lignum Sappan 15-35 part, sulfur 10-25 part, Radix Sophorae Flavescentis 15-35 part, Rhizoma Osmundae 15-45 part, Cortex Meliae 15-35 part, Rhizoma Alismatis 15-35 part, Radix Glycyrrhizae 15-40 part.
2. the compound bee-glue composition for the treatment of according to claim 1 cattle and sheep fascioliasis hepatica, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Semen Arecaes, 25 parts of Lignum Sappans, 15 parts, sulfur, 25 parts of Radix Sophorae Flavescentiss, 30 parts of Rhizoma Osmundae, 25 parts of Cortex Meliaees, 25 parts of Rhizoma Alismatis, 30 parts, Radix Glycyrrhizae.
3. a preparation method for the compound bee-glue composition for the treatment of according to claim 1 cattle and sheep fascioliasis hepatica, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Semen Arecae 15-45 part, Lignum Sappan 15-35 part, sulfur 10-25 part, Radix Sophorae Flavescentis 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Osmundae 15-45 part, Cortex Meliae 15-35 part, Rhizoma Alismatis 15-35 part, Radix Glycyrrhizae 15-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN201210144956.XA CN102670899B (en) | 2012-05-11 | 2012-05-11 | Compound propolis composition for treating cattle and sheep fascioliasis and preparation method thereof |
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| CN201210144956.XA CN102670899B (en) | 2012-05-11 | 2012-05-11 | Compound propolis composition for treating cattle and sheep fascioliasis and preparation method thereof |
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| CN106039162A (en) * | 2016-07-03 | 2016-10-26 | 张俊清 | Mongolian medicine composition for treating bovine theileriosis |
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| CN112691153A (en) * | 2021-01-26 | 2021-04-23 | 辽宁农业职业技术学院 | Traditional Chinese medicine composition for treating sheep liver leech and preparation method thereof |
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| CN100471517C (en) * | 2006-06-12 | 2009-03-25 | 杨兴喜 | Domestic Chinese-herb insect-repellent growth |
| CN101690767B (en) * | 2009-09-29 | 2012-08-08 | 北京大北农动物保健科技有限责任公司 | Compound pesticide for fishing and preparation method and application thereof |
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| CN106039162A (en) * | 2016-07-03 | 2016-10-26 | 张俊清 | Mongolian medicine composition for treating bovine theileriosis |
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