CN102397473B - Composite propolis composition for treating gosling plague and preparation method thereof - Google Patents

Abstract

The invention relates to a composite propolis composition for treating gosling plague and a preparation method thereof, which relate to the field of animal medicines. The preparation method of the composition comprises the steps that: (1) each ingredient in the formulation is respectively carried out supermicro pulverization and then is filtered by a 700-mesh sieve; (2) 15 to 35 parts by weight of propolis, 10 to 25 parts by weight of angelica, 10 to 35 parts by weight of cassia twig and 15 to 35 parts by weight of radix isatidis are uniformly mixed for 5 to 10 minutes; (3) 10 to 30 parts by weight of charred radix sanguisorbae, 10 to 30 parts by weight of radix bupleuri, 15 to 45 parts by weight of dyers woad leaves, 10 to 35 parts by weight of green beans and 10 to 35 parts by weight of bletilla are weighed and uniformly mixed for 5 to 10 minutes; (4) and the compositions obtained in the step (2) and the step (3) are continuously mixed for 10 to 15 minutes until being uniformly mixed. The composite propolis composition for treating the gosling pest has beneficial effects that: the formulation is reasonable, the composition is simple to prepare, the composition has no side effect and no toxicity, is free from pollution, has no medicinal residue and no drug resistance, the composition is obtained through supermicro pulverization, the availability is high, the treatment effect is very remarkable, and a specific effect on treating the gosling pest is clinically proved.

Description

A kind of compound bee-glue composition for the treatment of gosling plague and preparation method thereof

Technical field

Animal field of medicaments of the present invention, particularly a kind of compound bee-glue composition for the treatment of gosling plague and preparation method thereof.

Background technology

Gosling plague is a kind of acute or subacute septic infectious disease caused by Goose Parvovirus, mainly encroaches on 3-20 age in days gosling, take infect fast, sickness rate is high, mortality rate is high, serious dysentery and exudative enteritis are feature.The goose of the various length of time and kind all can infect, and mortality rate generally, between 20%-50%, can affect growth and the egg laying performance of goose.This disease all can occur throughout the year, is one of principal disease of the foster goose industry of harm.

The pathogen of primary disease is Goose Parvovirus, and virus resistance to external world is very strong.This disease almost spreads all over the world all poultry country, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.

Therefore research and develop that a kind of gosling plague's for the treatment of drug residue free, the generation that has no drug resistance, bioavailability are high, the significant specific medicament of clinical effectiveness is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and effective treatment gosling plague's of drug residue compound bee-glue composition and preparation method thereof.

For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of gosling plague, by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Sinensis 10-25 part, Ramulus Cinnamomi 10-35 part, Radix Isatidis 15-35 part, charred Radix Sanguisorbae 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Semen phaseoli radiati 10-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-35 part.

Described various component optimum ratio amount is: 30 parts of propolis, 15 parts of Radix Angelicae Sinensis, 25 parts of Ramulus Cinnamomi, 25 parts of Radix Isatidis, 20 parts of charred Radix Sanguisorbae, 20 parts of Radix Bupleuri, 35 parts of Folium Isatidiss, 25 parts, Semen phaseoli radiati, 25 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).

A kind of preparation method for the treatment of gosling plague's compound bee-glue composition, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, Radix Angelicae Sinensis 10-25 part, Ramulus Cinnamomi 10-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;

(3) take by weight charred Radix Sanguisorbae 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Semen phaseoli radiati 10-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Radix Angelicae Sinensis: sweet, hot, warm, return liver, the heart, spleen channel, there is the function of blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, moistening dryness for relaxing bowels; Cure mainly blood deficiency impairment caused by overstrain, blood stasis pain, traumatic injury, carbuncle skin infection, dryness of the intestine constipation etc.

Ramulus Cinnamomi: sweet, hot, warm, return lung, the heart, urinary bladder channel, there is the function of diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI; Cure mainly wind and cold sign, arthralgia, retention of water-damp etc.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Charred Radix Sanguisorbae: bitter, sour, puckery, be slightly cold, return liver, large intestine channel, there is the function of removing pathogenic heat from blood and toxic substance from the body, arresting bleeding and healing up ulcer; Cure mainly dysentery, the yellow furunculosis of skin ulcer.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly diarrhea due to damp-heat, the removing toxic substances protect the liver, antiallergic.

Radix Bupleuri: hot, bitter, be slightly cold, return liver, gallbladder, lung meridian, there is the function of delivering with inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea etc.

Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.

Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, be slightly cold, return liver, lung, stomach warp, there is the function of astringing to arrest bleeding, detumescence and promoting granulation, tonifying the lung and stopping cough; Cure mainly lung gastrorrhagia, cough and asthma due to lung deficiency, carbuncle etc.

Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for gosling plague's pathogenic microorganism and clinical symptoms and pathological change, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this nine flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, to treatment, gosling plague has specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

Compound bee-glue composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 100 parts of Radix Angelicae Sinensis, 100 parts of Ramulus Cinnamomi, 150 parts of Radix Isatidis, mix 5-10 minute to even;

(3) take by weight 100 parts of charred Radix Sanguisorbae, 100 parts of Radix Bupleuri, 150 parts of Folium Isatidiss, 100 parts, Semen phaseoli radiati, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

Compound bee-glue composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 150 parts of Radix Angelicae Sinensis, 200 parts of Ramulus Cinnamomi, 250 parts of Radix Isatidis, mix 5-10 minute to even;

(3) take by weight 200 parts of charred Radix Sanguisorbae, 200 parts of Radix Bupleuri, 300 parts of Folium Isatidiss, 250 parts, Semen phaseoli radiati, 150 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

Compound bee-glue composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of propolis, 250 parts of Radix Angelicae Sinensis, 350 parts of Ramulus Cinnamomi, 350 parts of Radix Isatidis, mix 5-10 minute to even;

(3) take by weight 300 parts of charred Radix Sanguisorbae, 300 parts of Radix Bupleuri, 450 parts of Folium Isatidiss, 350 parts, Semen phaseoli radiati, 350 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 150kg feeds, and drinking-water 280kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the present invention and other medicines treatment gosling plague's field applicable cases contrast:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	33.4	36.4	30.2
II	Gosling plague's group of faling apart	18.9	68.2	12.9
					III	Present composition group	10.3	79.8	9.9

This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P<0.01) with the loose group of gosling plague aspect cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment gosling plague and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a compound bee-glue composition for the treatment of gosling plague, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Sinensis 10-25 part, Ramulus Cinnamomi 10-35 part, Radix Isatidis 15-35 part, charred Radix Sanguisorbae 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Semen phaseoli radiati 10-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-35 part.

2. treatment gosling plague's according to claim 1 compound bee-glue composition, is characterized in that described various component optimum ratio amount is: 30 parts of propolis, 15 parts of Radix Angelicae Sinensis, 25 parts of Ramulus Cinnamomi, 25 parts of Radix Isatidis, 20 parts of charred Radix Sanguisorbae, 20 parts of Radix Bupleuri, 35 parts of Folium Isatidiss, 25 parts, Semen phaseoli radiati, 25 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).

3. the preparation method of a treatment according to claim 1 gosling plague compound bee-glue composition is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get propolis 15-35 part, Radix Angelicae Sinensis 10-25 part, Ramulus Cinnamomi 10-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;

(3) take by weight charred Radix Sanguisorbae 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Semen phaseoli radiati 10-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.