CN102526657B - Compound propolis composition for treating porcine proliferative enteropathy and preparation method thereof - Google Patents

Abstract

The invention provides a compound propolis composition for treating porcine proliferative enteropathy and a preparation method thereof, and relates to the field of veterinary drugs. The preparation method comprises the following steps of: (1) micronizing each ingredient in the composition and then sieving with a 700 mesh sieve; (2) weighing the following ingredients in parts by weight: 15-30 of propolis, 15-35 of Rhizome coptidis, 15-45 of Pulsatilla chinensis and 15-35 of Fructus Amomi Rotundus, and thoroughly mixing for 5-10 min; (3) weighing the following ingredients in parts by weight: 15-45 of dried Zingiber officinale, 15-35 of Fructus Psoraleae, 15-40 of Flos Hibisci, 15-35 of Galla Chinensis and thoroughly mixing for 5-10 min; and (4) mixing the mixtures obtained in the steps (2) and (3), and thoroughly mixing for 5-10 min. The invention has the benefits that: the formula is reasonable, the preparation method is simple, the composition has no toxic or side effect, no pollution, no drug residue and no drug resistance, the bioavailability is increased by micronization, the therapeutic effectiveness is very obvious, and the clinical trials prove that the compound propolis composition has specially good therapeutic effect on porcine proliferative enteropathy.

Description

A kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment pig Proliferative Enteritis and preparation method thereof.

Background technology

The pig Proliferative Enteritis is a kind of gastrointestinal tract comprehensive disease caused by lawsonia intracellularis.The growth that primary disease often betides 6 weeks age-20 week ages is bred as pig, but also infection morbidity of the piglet at 2 monthly ages of sometimes weaning and boar; Sick pork chop black or kermesinus medicated porridge sample feces, pathological changes is located at ileum, caecum etc., and visible intestinal mucosa thickens, ulcer, enlargement; Sickness rate is between 5%-30%, and mortality rate can reach 5%-10%.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.

This disease almost spreads all over all countries of raising pigs in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug has drug residue and easily produces drug resistance due to life-time service, and worse and worse, and drug residue causes exporting limited and the harm people are healthy for its clinical effectiveness, thereby the use of antimicrobial drug is very restricted.

Therefore research and develop and a kind ofly treat the drug residue free of pig Proliferative Enteritis, the specific medicament produced that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment pig Proliferative Enteritis of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis, by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis 15-45 part, Fructus Psoraleae 15-35 part, Flos Hibisci 15-40 part, Galla Chinensis 15-35 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts, Fructus Amomi Rotundus, 30 parts of Rhizoma Zingiberiss, 25 parts of Fructus Psoraleaes, 30 parts of Flos Hibisci, 25 parts of Galla Chinensiss.

A kind of preparation method for the treatment of the compound bee-glue composition of pig Proliferative Enteritis, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Fructus Amomi Rotundus 15-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Zingiberis 15-45 part, Fructus Psoraleae 15-35 part, Flos Hibisci 15-40 part, Galla Chinensis 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.

Fructus Amomi Rotundus: hot, warm, return lung, spleen, stomach warp, there is the function of the removing dampness of being amusing, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving; Curing mainly spleen-cold syndrome dyspepsia, abdominal distention, inappetence, cold type of pain, vomiting, deficiency and coldness has loose bowels etc.

Rhizoma Zingiberis: hot, hot, return spleen, stomach, kidney, the heart, lung meridian, have warming middle-JIAO by cold, recuperating depleted YANG is promoted blood circulation, the function of dampness expectorant; Cure mainly that cold syndrome of the stomach lack of appetite, cold intestinal are had loose bowels, cold type of pain, extreme cold of the limbs, anemofrigid-damp arthralgia, phlegm retention cough with asthma etc.

Fructus Psoraleae: acrid, bitter, warm, return kidney, spleen channel, there is warming the kidney to invigorate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha function; Curing mainly suffers from a deficiency of the kidney coldly lets out, suffers from a deficiency of the kidney and breathe heavily etc.

Flos Hibisci: sweet, bitter, cool, return lung, spleen, large intestine channel, there is the functions such as clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cure mainly have loose bowels, dysentery, discharging fresh blood stool, leukorrhagia, skin ulcer general edema with yellowish skin poison etc.

Galla Chinensis: sour, puckery, cold, return lung, large intestine, kidney channel, there is the function of the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating arresting seminal emission, astringing to arrest bleeding, removing dampness sore; Cure mainly chronic cough, chronic diarrhea, proctoptosis, sweating due to debility, have blood in stool, skin infection etc.

Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for pathogenic microorganism clinical symptoms and the pathological change of pig Proliferative Enteritis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this eight flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment pig Proliferative Enteritis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 150 parts of Rhizoma Coptidis, 150 parts of the Radix Pulsatillaes, 150 parts, Fructus Amomi Rotundus, mix 5-10 minute to even;

(3) take by weight 150 parts of Rhizoma Zingiberiss, 150 parts of Fructus Psoraleaes, 150 parts of Flos Hibisci, 150 parts of Galla Chinensiss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 250 parts of Rhizoma Coptidis, 300 parts of the Radix Pulsatillaes, 250 parts, Fructus Amomi Rotundus, mix 5-10 minute to even;

(3) take by weight 300 parts of Rhizoma Zingiberiss, 250 parts of Fructus Psoraleaes, 250 parts of Flos Hibisci, 250 parts of Galla Chinensiss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 300 parts of propolis, 350 parts of Rhizoma Coptidis, 450 parts of the Radix Pulsatillaes, 350 parts, Fructus Amomi Rotundus, mix 5-10 minute to even;

(3) take by weight 450 parts of Rhizoma Zingiberiss, 350 parts of Fructus Psoraleaes, 400 parts of Flos Hibisci, 350 parts of Galla Chinensiss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 200kg feeds, and drinking-water 400kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment pig Proliferative Enteritis:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					Ⅰ	The blank group	12.5	69.0	18.1
Ⅱ	The XIELITING group of faling apart	7.6	82.3	10.1
					Ⅲ	Present composition group	4.4	91.3	4.3

This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P<0.01) with the loose group of pig XIELITING aspect cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment pig Proliferative Enteritis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a compound bee-glue composition for the treatment of the pig Proliferative Enteritis, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis 15-45 part, Fructus Psoraleae 15-35 part, Flos Hibisci 15-40 part, Galla Chinensis 15-35 part.

2. a kind of compound bee-glue composition for the treatment of the pig Proliferative Enteritis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts, Fructus Amomi Rotundus, 30 parts of Rhizoma Zingiberiss, 25 parts of Fructus Psoraleaes, 30 parts of Flos Hibisci, 25 parts of Galla Chinensiss.

3. the preparation method of the compound bee-glue composition of a treatment according to claim 1 pig Proliferative Enteritis is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Fructus Amomi Rotundus 15-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Zingiberis 15-45 part, Fructus Psoraleae 15-35 part, Flos Hibisci 15-40 part, Galla Chinensis 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.