CN101618202A - Medicine for treating proctitis ulcerosa and preparation method thereof - Google Patents
Medicine for treating proctitis ulcerosa and preparation method thereof Download PDFInfo
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- CN101618202A CN101618202A CN200910074804A CN200910074804A CN101618202A CN 101618202 A CN101618202 A CN 101618202A CN 200910074804 A CN200910074804 A CN 200910074804A CN 200910074804 A CN200910074804 A CN 200910074804A CN 101618202 A CN101618202 A CN 101618202A
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Abstract
The invention relates to a medicine for treating proctitis ulcerosa, comprising the components of ginseng, radix aconiti coreani, atractylis ovata, rhizoma zingiberis, c.suifinensiskom, stir-baked radixpaeoniae alba, dried orange peel, radix sileris, evodia rutaecarpa, fructus psoraleae, gallnut, nutmeg, radix pulsatillae, rhizoma coptidis, phellodendron and ash brak. The preparation method comprises the following steps: cooking the components twice by adding water; combining cooking liquid; concentrating the cooking liquid into clear paste with the relative density of 1.0411.05 at the temperature of 50 DEG C; drying and crushing the clear paste into fine powder; and putting the powder into capsules to prepare capsulae. The medicine for treating proctitis ulcerosa can recuperate Yin and Yang, strengthen the spleen, replenish Qi, clear heat, dry damp, eliminate coldness and stop pain at warm temperature, treat both principal and secondary aspect of the proctitis ulcerosa and have effective treatment effect. The total effective rate of the medicine for treating proctitis ulcerosa is 90.8 percent by clinical observation.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of proctitis ulcerosa, particularly relating to a kind of is the Chinese patent medicine of the treatment proctitis ulcerosa of crude drug preparation with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Proctitis ulcerosa is a primary symptom with diarrhoea, mucus bloody purulent stool, is that cellular immunization is main autoimmune disease.Proctitis ulcerosa belongs to clinical difficult and complicated illness, and doctor trained in Western medicine still lacks specific method of treatment and square medicine at present.Problems such as to the effective Western medicine of active stage patient still is easily to recur based on the aminosallcylic acid class with after answering matter steroid, above-mentioned two class medicines to have drug withdrawal basically, and the long-term prescription side reaction is more.In recent years, Chinese scholars has been carried out some researchs of cytokine monoclonal antibody and antagonist for treating proctitis ulcerosa.But still be in advanced development.
The Chinese medicine proctitis ulcerosa has certain characteristic and advantage, therefore, under the prerequisite of inheriting theory of Chinese medical science, further excavation and screening have the efficacious prescriptions medicine, multipath, multi-angle are studied, and seeking even more ideal medicine effective, that side reaction is few from tcm field becomes research emphasis, for controlling proctitis ulcerosa as early as possible, thereby reduce the sickness rate of ulcerative colitis, will have comparatively wide prospect.
Summary of the invention
Purpose of the present invention just provides a kind of medicine for the treatment of proctitis ulcerosa, to improve the therapeutic effect of proctitis ulcerosa, reaches the effect for the treatment of both the principal and secondary aspects of a disease.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
8～12 parts of 10～15 parts of Radix Aconiti Lateralis Preparata of Radix Ginseng
8～12 parts of 12～18 portions of Rhizoma Zingiberiss of the Rhizoma Atractylodis Macrocephalae
12～18 parts of 4～8 parts of Radix Paeoniae Alba (parched)s of SUICAO
12～18 parts of 8～12 parts of Radix Saposhnikoviaes of Pericarpium Citri Reticulatae
10～15 parts of 8～12 parts of Fructus Psoraleaes of Fructus Evodiae
12～18 parts of 8～12 parts of Semen Myristicaes of Galla Chinensis
8～12 parts of 10～15 portions of Rhizoma Coptidis of the Radix Pulsatillae
8～12 parts of 4～8 parts of Cortex Fraxinis of Cortex Phellodendri
Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine of the present invention may further comprise the steps:
Said medicine according to described parts by weight mix homogeneously, is decocted with water 2 times, each 4h, collecting decoction filters, and is condensed into the clear paste of 50 ℃ of relative densities 1.04～1.05, and drying is ground into fine powder, makes capsule in incapsulating.
Usage: the adult takes 2 at every turn, and is every day 2 times, oral.
Though motherland's medical science does not have the name of disease of proctitis ulcerosa, but before thousands of years, the record that is similar to this disease was just arranged, as in " having loose bowels ", " intestinal is out-of-the-way ", " chronic dysentery ", " chronic dysentery with frequent relapse ", in the disease categories such as " acute appendicitis ", promptly include stomachache, tenesmus, just defecation with blood and pus, outbreak etc. is similar to the clinical manifestation of primary disease repeatedly.The treatment primary disease should be based on invigorating the spleen and benefiting QI, heat clearing and damp drying, warming spleen and stomach for dispelling cold pain relieving.In the prescription of the present invention, Radix Ginseng strongly invigorating primordial QI, invigorating the spleen to benefit the lung, beneficial blood promotes the production of body fluid; The Radix Aconiti Lateralis Preparata dispersing cold for relieving pain; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic; Rhizoma Zingiberis, SUICAO warming spleen and stomach for dispelling cold; Radix Paeoniae Alba (parched) nourishing blood to suppress the hyperactive liver, slow middle pain relieving; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; The Radix Saposhnikoviae expelling pathogenic wind from the body surface; Fructus Evodiae warming middle-JIAO to relieve pain, the dampness of regulating the flow of vital energy; Fructus Psoraleae, Galla Chinensis astringe the lung pathogenic fire reducing, relieving diarrhea with astringents; Semen Myristicae warming middle-JIAO to promote flow of QI antidiarrheal; Radix Pulsatillae heat-clearing and toxic substances removing, removing heat from blood dampness; Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini heat clearing and damp drying, eliminating fire and detoxication.All medicine compatibilities have the effect of coordinating YIN and YANG, invigorating the spleen and benefiting QI, heat clearing and damp drying, warming spleen and stomach for dispelling cold pain relieving, and treatment proctitis ulcerosa treating both the principal and secondary aspects of a disease is evident in efficacy.
Drug use of the present invention is convenient, is easy to the patient and takes, and takes safety, can reduce complication and take place, and price is suitable.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 500 routine proctitis ulcerosa patients that the curative effect of medicine of the present invention is carried out clinical observation.
28～60 years old MethodsThe cases enrolled age, average 48 years old; The course of disease 1 month～6 years, average 2 years.To be selected in the patient at random and be divided into two groups, every group 250 example.Wherein male 186 examples are organized in treatment, women 64 examples; Matched group man 182 examples, women 68 examples.Two groups of patient's sexes, age differencess compare not statistically significant, have comparability.
The proctitis ulcerosa diagnostic criteria that diagnostic criteria is formulated according in June, 1993 Taiyuan meeting " whole nation chronic non-infection intestinal tract disease scientific seminar " is made a definite diagnosis: (1) clinical manifestation has persistence or show effect repeatedly mucosanguineous feces, stomachache, with General Symptoms in various degree; (2) colonoscope finding pathological changes is from rectum, and mucosa has multiple fester, and the companion is congested, edema, is diffusivity and distributes, the coarse fine particulate that is of mucosa, the mucosa blood vessel is fuzzy, and is crisp easily hemorrhage, or with pus and blood sexual secretion, visible false polyp, haustra of colon rust or disappearance; (3) glutinous goldbeater's skin biopsy is checked and is inflammatory reaction, with visible erosion, ulcer, crypt abscess and body of gland are arranged unusually often.
The Therapeutic Method matched group gives 1 of metronidazole suppository, includes in the anus every night.The treatment group gives drug oral of the present invention, and each 2, every day 2 times.
The criterion of therapeutical effect that curative effect determinate standard is formulated with reference to the whole nation chronic non-infection intestinal tract disease scientific seminar in 1993.Recovery from illness: clinical symptom disappearance, fibro-colonoscope check mucosa is normal, and drug withdrawal or only use the maintenance dose medicine is observed not have in 6 months and is recurred; Take a turn for the better: clinical symptoms disappears substantially, and mild inflammation reaction of fibro-colonoscope check mucosa and part pseudopolyp form; Invalid: clinical symptoms, scope and pathologic finding do not have improvement after treating.
Curative effect comparative result after two groups of cases are treated sees Table 1.
Table 1 liang group case treatment back curative effect relatively
The specific embodiment
Embodiment 1
Get Radix Ginseng 15g, Radix Aconiti Lateralis Preparata 12g, Rhizoma Atractylodis Macrocephalae 16g, Rhizoma Zingiberis 12g, SUICAO 8g, Radix Paeoniae Alba (parched) 18g, Pericarpium Citri Reticulatae 12g, Radix Saposhnikoviae 16g, Fructus Evodiae 12g, Fructus Psoraleae 10g, Galla Chinensis 12g, Semen Myristicae 16g, Radix Pulsatillae 10g, Rhizoma Coptidis 12g, Cortex Phellodendri 8g, Cortex Fraxini 12g, after choosing most impurity, screening dry in the sun, oven dry, place extraction pot, add water to and flood medicine just, decoct 4h, filter, the decocting that adds same amount again boils 4h, collecting decoction, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying is ground into fine powder, makes capsule in incapsulating.
Embodiment 2
Get Radix Ginseng 12g, Radix Aconiti Lateralis Preparata 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Zingiberis 10g, SUICAO 5g, Radix Paeoniae Alba (parched) 15g, Pericarpium Citri Reticulatae 10g, Radix Saposhnikoviae 15g, Fructus Evodiae 10g, Fructus Psoraleae 12g, Galla Chinensis 10g, Semen Myristicae 15g, Radix Pulsatillae 12g, Rhizoma Coptidis 10g, Cortex Phellodendri 5g, Cortex Fraxini 10g, after choosing most impurity, screening dry in the sun, oven dry, place extraction pot, add water to and flood medicine just, decoct 4h, filter, the decocting that adds same amount again boils 4h, collecting decoction, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying is ground into fine powder, makes capsule in incapsulating.
Embodiment 3
Get Radix Ginseng 10g, Radix Aconiti Lateralis Preparata 8g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 10g, SUICAO 6g, Radix Paeoniae Alba (parched) 12g, Pericarpium Citri Reticulatae 8g, Radix Saposhnikoviae 12g, Fructus Evodiae 8g, Fructus Psoraleae 15g, Galla Chinensis 8g, Semen Myristicae 12g, Radix Pulsatillae 15g, Rhizoma Coptidis 8g, Cortex Phellodendri 6g, Cortex Fraxini 8g, after choosing most impurity, screening dry in the sun, oven dry, place extraction pot, add water to and flood medicine just, decoct 4h, filter, the decocting that adds same amount again boils 4h, collecting decoction, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying is ground into fine powder, makes capsule in incapsulating.
Claims (3)
1, a kind of medicine for the treatment of proctitis ulcerosa is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:
8～12 parts of 10～15 parts of Radix Aconiti Lateralis Preparata of Radix Ginseng
8～12 parts of 12～18 portions of Rhizoma Zingiberiss of the Rhizoma Atractylodis Macrocephalae
12～18 parts of 4～8 parts of Radix Paeoniae Alba (parched)s of SUICAO
12～18 parts of 8～12 parts of Radix Saposhnikoviaes of Pericarpium Citri Reticulatae
10～15 parts of 8～12 parts of Fructus Psoraleaes of Fructus Evodiae
12～18 parts of 8～12 parts of Semen Myristicaes of Galla Chinensis
8～12 parts of 10～15 portions of Rhizoma Coptidis of the Radix Pulsatillae
8～12 parts of 4～8 parts of Cortex Fraxinis of Cortex Phellodendri.
2, the medicine of treatment proctitis ulcerosa according to claim 1 is characterized in that described medicine is made capsule.
3, the preparation method of the medicine of the described treatment proctitis ulcerosa of claim 2, be according to described parts by weight mix homogeneously with said medicine, decoct with water 2 times, each 4h, collecting decoction filters, be condensed into the clear paste of 50 ℃ of relative densities 1.04～1.05, drying is ground into fine powder, makes capsule in incapsulating.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309740A (en) * | 2011-09-21 | 2012-01-11 | 万燕丽 | Traditional Chinese medicine for treating chronic enteritis |
| CN102526657A (en) * | 2011-12-16 | 2012-07-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine proliferative enteropathy and preparation method thereof |
| CN102600283A (en) * | 2011-12-07 | 2012-07-25 | 中国人民解放军第二军医大学 | Chinese herbal compound preparation used for clearing heat, drying damp, resisting dysentery, tonifying deficiency, calming central nervous system and resisting diarrhoea and application thereof |
| CN102670987A (en) * | 2012-06-28 | 2012-09-19 | 高娟 | Traditional Chinese medicine combination for treating ulcerative colitis and preparation method thereof |
| CN103495081A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating ulcerative colitis |
-
2009
- 2009-07-01 CN CN200910074804A patent/CN101618202A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309740A (en) * | 2011-09-21 | 2012-01-11 | 万燕丽 | Traditional Chinese medicine for treating chronic enteritis |
| CN102309740B (en) * | 2011-09-21 | 2013-08-14 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating chronic enteritis |
| CN102600283A (en) * | 2011-12-07 | 2012-07-25 | 中国人民解放军第二军医大学 | Chinese herbal compound preparation used for clearing heat, drying damp, resisting dysentery, tonifying deficiency, calming central nervous system and resisting diarrhoea and application thereof |
| CN102526657A (en) * | 2011-12-16 | 2012-07-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine proliferative enteropathy and preparation method thereof |
| CN102526657B (en) * | 2011-12-16 | 2013-12-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine proliferative enteropathy and preparation method thereof |
| CN102670987A (en) * | 2012-06-28 | 2012-09-19 | 高娟 | Traditional Chinese medicine combination for treating ulcerative colitis and preparation method thereof |
| CN103495081A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating ulcerative colitis |
| CN103495081B (en) * | 2013-10-16 | 2015-03-11 | 刘运波 | Traditional Chinese medicine for treating ulcerative colitis |
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Open date: 20100106 |