CN102091306A - Medicine for treating senile chronic colitis - Google Patents
Medicine for treating senile chronic colitis Download PDFInfo
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- CN102091306A CN102091306A CN 201010550322 CN201010550322A CN102091306A CN 102091306 A CN102091306 A CN 102091306A CN 201010550322 CN201010550322 CN 201010550322 CN 201010550322 A CN201010550322 A CN 201010550322A CN 102091306 A CN102091306 A CN 102091306A
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Abstract
The invention provides a medicine for treating senile chronic colitis. A preparation method of the medicine for treating senile chronic colitis comprises the following steps: adding fructus psoraleae, shiandra, nutmeg, fructus evodiae, cooked monkshood, dangshen, bighead atractylodes rhizome, costus root, red halloysite, pomegranate rind, dried ginger and licorice into water for decocting twice for 2-4 hours every time; concentrating the decoction into clear cream the relative density of which is 1.04-1.05 at 50 DEG C; drying under reduced pressure; crushing to obtain fine powder; and evenly mixing to obtain capsule products. The medicine provided by the invention has the functions of conditioning yin and yang, strengthening the spleen and replenishing qi, clearing heat and eliminating dampness and warming middle energizer to dispel cold and relieve pain, can be used for treating senile chronic colitis, can be easily and safely taken by patients, and can reduce the occurrence of complications; and by clinical observation, the effective rate of the medicine is 88.8%.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of chronic senile colitis, particularly relating to a kind of is the medicine of the treatment chronic colitis of crude drug preparation with Chinese medicine.
Background technology
Chronic senile colitis is a kind of commonly encountered diseases, is primary symptom with diarrhoea, mucus bloody purulent stool, is that cellular immunization is main autoimmune disease.Senile chronic colitis belongs to clinical difficult and complicated illness, doctor trained in Western medicine lacks specific method of treatment and square medicine at present, problems such as to the effective Western medicine of active stage patient still is easily to recur based on the aminosallcylic acid class with after answering matter steroid, above-mentioned two class medicines to have drug withdrawal basically, and the long-term prescription side reaction is more.In recent years, Chinese scholars has been carried out some researchs of cytokine monoclonal antibody and antagonist for treating primary disease, but still is in advanced development.Therefore, seek even more ideal medicine effective, that side reaction is few from tcm field and become research emphasis.
Chinese medicine chronic senile colitis has certain characteristic and advantage, under the prerequisite of inheriting theory of Chinese medical science, further excavation and screening have the efficacious prescriptions medicine, multipath, multi-angle are studied, to control and to reduce the sickness rate of senile chronic colitis as early as possible, will have comparatively vast market prospect.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine medicine that is used for the treatment of chronic senile colitis,, reach the purpose for the treatment of both the principal and secondary aspects of a disease to improve the therapeutic effect of colitis.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Fructus Psoraleae 8～10 Fructus Schisandrae Chinensis 8～10 Semen Myristicaes 8～10
Fructus Evodiae 3～6 Radix Aconiti Lateralis Preparata 8～10 Radix Codonopsis 13～16
The Rhizoma Atractylodis Macrocephalae 10～13 Radix Aucklandiae 5～8 Halloysitum Rubrums 13～16
Pericarpium Granati 10～15 Rhizoma Zingiberiss 8～10 Radix Glycyrrhizaes 5～8.
Said medicine can be made any peroral dosage form on the pharmaceutics, as tablet, pill, watered pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each crude drug being made medicine of the present invention is:
Get Fructus Psoraleae, Fructus Schisandrae Chinensis, Semen Myristicae, Fructus Evodiae, Radix Aconiti Lateralis Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Halloysitum Rubrum, Pericarpium Granati, Rhizoma Zingiberis, Radix Glycyrrhizae according to above-mentioned parts by weight, decoct with water 2 times, each amount of water is 3～4 times of crude drug gross weight, decocts 2～4h, collecting decoction, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.04～1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.
Usage: the adult takes 2 at every turn, and is every day 2 times, oral.
Though motherland's medical science does not have the name of disease of chronic colitis, before thousands of years, the record that is similar to this disease was just arranged.As in " having loose bowels ", " intestinal is out-of-the-way ", " chronic dysentery ", " chronic dysentery with frequent relapse ", in the disease categories such as " acute appendicitis ", just promptly include stomachache, tenesmus, defecation with blood and pus, outbreak etc. is similar to the clinical manifestation of primary disease repeatedly.Treatment should be based on invigorating the spleen and benefiting QI, heat clearing and damp drying, warming spleen and stomach for dispelling cold pain relieving.In the prescription of the present invention, the Radix Codonopsis invigorating the spleen to benefit the lung, promote the production of body fluid, the Radix Aconiti Lateralis Preparata dispersing cold for relieving pain, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, Fructus Evodiae, Radix Aucklandiae warming middle-JIAO to relieve pain, the dampness of regulating the flow of vital energy, Semen Myristicae warming middle-JIAO to promote flow of QI antidiarrheal, Fructus Psoraleae reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha, Fructus Schisandrae Chinensis, Halloysitum Rubrum, Pericarpium Granati convergence are astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicine compatibilities have the effect of coordinating YIN and YANG, invigorating the spleen and benefiting QI, heat clearing and damp drying, warming spleen and stomach for dispelling cold pain relieving.
Medicine patient of the present invention is easy to take, and takes safety, can reduce complication and take place, and clinical effectiveness is good, and easy to use, and price is suitable.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 500 routine chronic senile colitis that the curative effect of medicine of the present invention is carried out clinical observation.
58～81 years old MethodsThe cases enrolled age, average 72 years old; The course of disease 1 month～6 years, average 2 years.Selected altogether 500 routine patients are divided into two groups at random, every group 250 example, and wherein male 186 examples are organized in treatment, women 64 examples; Matched group man 182 examples, women 68 examples.Two groups of patient's sexes, age differencess compare not statistically significant, have comparability.
The chronic senile colitis diagnostic criteria that diagnostic criteria is formulated by in June, 1993 Taiyuan meeting " seminar of national chronic noninfective enteropathy " is made a definite diagnosis: persistence is arranged in (1) clinical manifestation or the mucosanguineous feces that shows effect repeatedly, stomachache with in various degree General Symptoms; (2) colonoscope finding pathological changes is from rectum, and mucosa has multiple fester, and the companion is congested, edema, is diffusivity and distributes, the coarse fine particulate that is of mucosa, the mucosa blood vessel is fuzzy, and is crisp easily hemorrhage, or with pus and blood sexual secretion, visible false polyp, haustra of colon rust or disappearance; (3) glutinous goldbeater's skin biopsy is checked and is inflammatory reaction, with visible erosion, ulcer, crypt abscess and body of gland are arranged unusually often.
The Therapeutic Method matched group gives 1 of metronidazole suppository, includes in the anus every night.The treatment group gives drug oral of the present invention, and each 2, every day 2 times.
The criterion of therapeutical effect that curative effect determinate standard is formulated with reference to national chronic noninfective enteropathy seminar in 1993.Recovery from illness: clinical symptom disappearance, fibro-colonoscope check mucosa is normal, and drug withdrawal or only use the maintenance dose medicine is observed not have in 6 months and is recurred; Take a turn for the better: clinical symptoms disappears substantially, and mild inflammation reaction of fibro-colonoscope check mucosa and part pseudopolyp form; Invalid: clinical symptoms, scope and pathologic finding do not have improvement after treating.
Curative effect comparative result after two groups of cases are treated sees Table 1.
Table 1 liang group case treatment back curative effect relatively
The specific embodiment
Embodiment 1
Medicine is chosen most impurity, screening dry in the sun, after the oven dry, get Fructus Psoraleae 8Kg, Fructus Schisandrae Chinensis 8Kg, Semen Myristicae 8Kg, Fructus Evodiae 3Kg, Radix Aconiti Lateralis Preparata 8Kg, Radix Codonopsis 13Kg, Rhizoma Atractylodis Macrocephalae 10Kg, Radix Aucklandiae 5Kg, Halloysitum Rubrum 13Kg, Pericarpium Granati 10Kg, Rhizoma Zingiberis 8Kg, Radix Glycyrrhizae 5Kg adds 3 times to the water of medical material weight, decoct 4h, leach decocting liquid, add the water of 3 times of weight of medical material again, decoct 3h, leach decocting liquid, merge decocting liquid twice, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.Usage: the adult takes 2 at every turn, and is every day 2 times, oral.
Embodiment 2
Medicine is chosen most impurity, screening dry in the sun, after the oven dry, get Fructus Psoraleae 10Kg, Fructus Schisandrae Chinensis 10Kg, Semen Myristicae 10Kg, Fructus Evodiae 6Kg, Radix Aconiti Lateralis Preparata 10Kg, Radix Codonopsis 16Kg, Rhizoma Atractylodis Macrocephalae 13Kg, Radix Aucklandiae 8Kg, Halloysitum Rubrum 16Kg, Pericarpium Granati 15Kg, Rhizoma Zingiberis 10Kg, Radix Glycyrrhizae 8Kg adds 3 times to the water of medical material weight, decoct 4h, leach decocting liquid, add the water of 3 times of weight of medical material again, decoct 3h, leach decocting liquid, merge decocting liquid twice, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.
Claims (3)
1. medicine that is used for the treatment of chronic senile colitis is that crude drug prepares by the Chinese medicine of following portions by weight:
Fructus Psoraleae 8～10 Fructus Schisandrae Chinensis 8～10 Semen Myristicaes 8～10
Fructus Evodiae 3～6 Radix Aconiti Lateralis Preparata 8～10 Radix Codonopsis 13～16
The Rhizoma Atractylodis Macrocephalae 10～13 Radix Aucklandiae 5～8 Halloysitum Rubrums 13～16
Pericarpium Granati 10～15 Rhizoma Zingiberiss 8～10 Radix Glycyrrhizaes 5～8.
2. the medicine that is used for the treatment of chronic senile colitis according to claim 1 is characterized in that described medicine is made capsule.
3. the described preparation method that is used for the treatment of the medicine of chronic senile colitis of claim 2, it is characterized in that according to above-mentioned parts by weight, get Fructus Psoraleae, Fructus Schisandrae Chinensis, Semen Myristicae, Fructus Evodiae, Radix Aconiti Lateralis Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Halloysitum Rubrum, Pericarpium Granati, Rhizoma Zingiberis, Radix Glycyrrhizae, decoct with water 2 times, each amount of water is 3～4 times of crude drug gross weight, decoct 2～4h, collecting decoction, filter, be concentrated into the clear paste of 50 ℃ of relative densities 1.04～1.05, drying under reduced pressure, be ground into fine powder, mixing, encapsulated, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201010550322 CN102091306A (en) | 2010-11-15 | 2010-11-15 | Medicine for treating senile chronic colitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010550322 CN102091306A (en) | 2010-11-15 | 2010-11-15 | Medicine for treating senile chronic colitis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949688A (en) * | 2012-10-25 | 2013-03-06 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof |
| CN104548015A (en) * | 2014-12-29 | 2015-04-29 | 平阴县人民医院 | Medicine for treating chronic colitis |
| CN104940894A (en) * | 2015-07-31 | 2015-09-30 | 朱克兰 | Foot-bath composition for treating chronic colitis and preparation method thereof |
| CN106265882A (en) * | 2016-08-29 | 2017-01-04 | 凯里市新元药店 | A kind of Chinese medicine formula treating enteritis |
| US10045541B2 (en) * | 2016-10-19 | 2018-08-14 | Sultan Qaboos University | Anti-microbial composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449780A (en) * | 2002-04-08 | 2003-10-22 | 胡庆武 | Medicine for treating colitis and preparation process thereof |
| CN1634235A (en) * | 2004-11-12 | 2005-07-06 | 赵福勤 | Medicine for treating colitis |
| CN1919330A (en) * | 2006-08-22 | 2007-02-28 | 夏金陵 | Traditional medicine composition for treating chronic colitis and its preparing process |
-
2010
- 2010-11-15 CN CN 201010550322 patent/CN102091306A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1449780A (en) * | 2002-04-08 | 2003-10-22 | 胡庆武 | Medicine for treating colitis and preparation process thereof |
| CN1634235A (en) * | 2004-11-12 | 2005-07-06 | 赵福勤 | Medicine for treating colitis |
| CN1919330A (en) * | 2006-08-22 | 2007-02-28 | 夏金陵 | Traditional medicine composition for treating chronic colitis and its preparing process |
Non-Patent Citations (3)
| Title |
|---|
| 《中外医疗》 20091221 任中宝 93例慢性结肠炎患者临床治疗效果观察 32 1-3 , 2 * |
| 《广东医学》 20060425 曾宽 中医治疗结肠易激综合征70例疗效观察 595-596 1-3 , 第04期 2 * |
| 《新疆中医药》 20030425 黄明等 结肠宁散治疗溃疡性结肠炎90例 20 1-3 , 第02期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949688A (en) * | 2012-10-25 | 2013-03-06 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof |
| CN102949688B (en) * | 2012-10-25 | 2015-05-27 | 安徽金太阳生化药业有限公司 | Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof |
| CN104548015A (en) * | 2014-12-29 | 2015-04-29 | 平阴县人民医院 | Medicine for treating chronic colitis |
| CN104548015B (en) * | 2014-12-29 | 2017-08-29 | 平阴县人民医院 | A kind of medicine for treating chronic colitis |
| CN104940894A (en) * | 2015-07-31 | 2015-09-30 | 朱克兰 | Foot-bath composition for treating chronic colitis and preparation method thereof |
| CN106265882A (en) * | 2016-08-29 | 2017-01-04 | 凯里市新元药店 | A kind of Chinese medicine formula treating enteritis |
| US10045541B2 (en) * | 2016-10-19 | 2018-08-14 | Sultan Qaboos University | Anti-microbial composition |
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Application publication date: 20110615 |