CN104689246B - A kind of medicine for the treatment of gastric cancer - Google Patents
A kind of medicine for the treatment of gastric cancer Download PDFInfo
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- CN104689246B CN104689246B CN201510126747.6A CN201510126747A CN104689246B CN 104689246 B CN104689246 B CN 104689246B CN 201510126747 A CN201510126747 A CN 201510126747A CN 104689246 B CN104689246 B CN 104689246B
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Abstract
The invention belongs to medical art, being specifically related to a kind of take Chinese herbal medicine as the medicine of the treatment gastric cancer of primary raw material.This medicine comprises peroral dosage form and the exterior-applied formulation composition of conbined usage, exterior-applied formulation is made up of the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film, this medicine is by the different administering mode of oral same external application, work along both lines, reduce the intestines and stomach burden of patient simultaneously, safe and efficient, by adding a small amount of Fe powder and acetic acid, accelerate the infiltration of medicine.Medicine provided by the invention has blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, strengthening the body resistance, effect of strengthening the spleen and nourishing the stomach, and crude drug source is wide, injures little to patient, improves patients ' life quality.
Description
Technical field
The invention belongs to medical art, being specifically related to a kind of take Chinese herbal medicine as the medicine of the treatment gastric cancer of primary raw material.
Background technology
Gastric cancer is modal one in malignant tumor, along with development that is scientific and technological and medical level, the sickness rate of gastric cancer presents downward trend, but is only second to pulmonary carcinoma in worldwide and occupies various malignant tumor cause of the death second, in China, the sickness rate of gastric cancer and mortality rate account in all malignant tumor the first.
The pathogeny of gastric cancer thinks relevant with heredity, blood group, dietary habit and inherited genetic factors mostly, and helicobacter pylori may be the major reason of incidence gastric cancer; The traditional Chinese medical science thinks incidence gastric cancer mechanism, and most importantly stomach is through the stagnation of QI, and feelings will is not relaxed, stomach yang deficiency, and rear formation is swollen thing, and passage, causes food to enter stomach upset.
Existing treatment gastric cancer mostly is excision auxiliary radiation chemotherapy, and relapse rate is high and patients ' life quality is poor, and western medical treatment is expensive, and side effect is obvious.
The traditional Chinese medical science is combined by strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, hard masses softening and resolving, enhancing human body immunity function, interrupts the vicious cycle of tumor growth, restrains growth of cancer cells, thus root out virus.The Chinese medicine preparation of existing treatment gastric cancer mostly is oral medicine, and class medicine cold in nature causes burden to the intestines and stomach, upsets digestive system, affect the dietary habit of patient, and Digestive system easily damages to the effective ingredient of some drugs.Therefore, seek a kind of safe and efficient, the main target that side effect is little, medicine that is that human body the intestines and stomach is born to little treatment gastric cancer becomes medical domain.
Summary of the invention
For prior art Problems existing, the object of the present invention is to provide a kind of medicine for the treatment of gastric cancer, this medicine is that crude drug is formulated by Chinese herbal medicine, by different administering modes, reaches blood circulation promoting and blood stasis dispelling, invigorating the spleen and regulating the stomach, hard masses softening and resolving.Safety of medicine of the present invention is efficient, alleviate patient's the intestines and stomach burden and utilization ratio of drug is high.
The technical scheme that the present invention is adopted for achieving the above object is:
The invention provides a kind of medicine for the treatment of gastric cancer, comprise peroral dosage form and the exterior-applied formulation composition of conbined usage.
Described peroral dosage form is made up of the crude drug of following weight proportion: Radix Ginseng 15-20g, white Herba polygoni hydropiperis 20-30g, Rhizoma Curcumae 20-25g, Rhizoma Sparganii 20-25g, raw pearl barley 30-35g, Rhizoma Dioscoreae 25-35g, Poria 10-15g, Radix Glycyrrhizae 10-15g;
Described exterior-applied formulation is made up of the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film;
Described Chinese medicine extraction liquid is extracted by the crude drug of following weight proportion to make: Scolopendra 10-15g, Rhizoma Phragmitis 15-30g, Radix Puerariae 10-20g, Herba violae patrinii 15-25g, Rhizoma Coptidis 5-10g, Rhizoma Arisaematis 3-5g, Borneolum Syntheticum 30g, glycerol 20g, acetic acid 15g;
Containing iron powder in described absorbent cores.
Above-mentioned iron powder is 80-100 order, and iron powder is 1:2 with the mass ratio of acetic acid.
Further, the oral component of optimization is made up of the crude drug of following weight proportion: Radix Ginseng 18g, white Herba polygoni hydropiperis 25g, Rhizoma Curcumae 20g, Rhizoma Sparganii 20g, raw pearl barley 35g, Rhizoma Dioscoreae 35g, Poria 12g, Radix Glycyrrhizae 12g.
Further, the Chinese medicine extraction liquid of optimization is extracted by the crude drug of following weight proportion to make: Scolopendra 15g, Rhizoma Phragmitis 20g, Radix Puerariae 18g, Herba violae patrinii 20g, Rhizoma Coptidis 8g, Rhizoma Arisaematis 4g, Borneolum Syntheticum 20g, glycerol 20g, acetic acid 15g.
The preparation method of peroral dosage form is: get by weight ratio after joining, and adds water to and exceeds medicine plane 5-6cm, and intense fire is decocted and turn 25-30min at a simmer to boiling, filters, is repeated to decoct once by medicinal residues, merges twice filtrate, obtain decoction after filtering.
The preparation method of exterior-applied formulation is: get Scolopendra, Rhizoma Phragmitis, Radix Puerariae, Herba violae patrinii, Rhizoma Coptidis, Rhizoma Arisaematis by weight ratio, add the ethanol of 8-10 times of 50-80wt%, extract twice, each 2 hours, be concentrated into 80mL after merge extractive liquid, then add Borneolum Syntheticum, glycerol, acetic acid.
Usage and dosage: every day peroral dosage form with exterior-applied formulation with the use of.Peroral dosage form: every day 1 dose, morning and evening one after each meal, 25 days is a course for the treatment of at twice.Exterior-applied formulation: during use, pours in absorbent cores by the Chinese medicine extraction liquid in medicated bag, is then affixed on ZHONGWAN acupoint, subsides in a day, within 25 days, is a course for the treatment of.
Above medical material formula is according to clinical testing data, obtain through scientific method screening, to different situations patient, as the patient of patients whose symptoms were less severe, symptom very severe patient or Different age group, for reaching same effect, ensureing under the constant condition of each proportioning raw materials, can corresponding increase and decrease dose, but dose amplitude of fluctuation is unsuitable excessive, should not exceed dose 15%.
The present invention is by passing through different administering modes by medicine, first invigorating primordial QI, strengthening the body resistance, nourishing the stomach are regulated the flow of vital energy and Chinese medicine warm in nature by decoction form administration, then heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, pharmacological action will have toxicity, medicine cold in nature by cutaneous permeable agent effect, targeted delivery of drugs, the present invention uses menthol compound Borneolum Syntheticum as absorbent, promote the osmosis of medicine, and harmless.When being poured into after in absorbent cores by the Chinese medicine extraction liquid in medicated bag, the acetic acid in Chinese medicine extraction liquid with the iron powder generation redox reaction in absorbent cores, can be released heat in course of reaction, can accelerate the infiltration rate of human body to medicine, thus accelerates therapeutic process.Acetic acid is the key factor realizing heat with the content of iron powder, too much the easy discomfort causing human body because temperature is too high, and cross little to the Absorption of promotion medicine because heat is few at least, meanwhile, the sour environment that acetic acid is built can extend the stability of extracting solution.The present invention is by the form of medication of combination, and drug waste is few, effective rate of utilization is high and to human body fanout free region, reduction the intestines and stomach is born.
Advantage of the present invention and beneficial effect are:
(1) the present invention is by the combination of oral and that external application is different administering mode, and work along both lines, exterior-applied formulation can accelerate the infiltration of medicine by mode of heating, instant effect.
(2) each crude drug of compatibility that the present invention is scientific and reasonable, safe and efficient, reinforcement and elimination in combination, each medical material complements each other using, synergism, and enhancing human body immunity function, restrains growth of cancer cells, thus reaches the object for the treatment of gastric cancer.
Detailed description of the invention
In order to understand essence of the present invention better, below by specific embodiment and clinical testing data, technical scheme of the present invention is further elaborated.
Embodiment 1
Treat a medicine for gastric cancer, comprise peroral dosage form and the exterior-applied formulation composition of conbined usage.
Peroral dosage form is made up of the crude drug of following weight proportion: Radix Ginseng 18g, white Herba polygoni hydropiperis 25g, Rhizoma Curcumae 20g, Rhizoma Sparganii 20g, raw pearl barley 35g, Rhizoma Dioscoreae 35g, Poria 12g, Radix Glycyrrhizae 12g.
Described exterior-applied formulation is by the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film (10cm × 10cm);
Above-mentioned Chinese medicine extraction liquid is extracted by the crude drug of following weight proportion to make: Scolopendra 15g, Rhizoma Phragmitis 20g, Radix Puerariae 18g, Herba violae patrinii 20g, Rhizoma Coptidis 8g, Rhizoma Arisaematis 4g, Borneolum Syntheticum 20g, glycerol 20g, acetic acid 15g.
The 100 order iron powders containing 7.5g in above-mentioned absorbent cores.
The preparation method of peroral dosage form is: get by weight ratio after joining, and adds water to and exceeds medicine plane 5-6cm, and intense fire is decocted and turn 25-30min at a simmer to boiling, filters, is repeated to decoct once by medicinal residues, merges twice filtrate, obtain decoction after filtering.
The preparation method of exterior-applied formulation is: get Scolopendra, Rhizoma Phragmitis, Radix Puerariae, Herba violae patrinii, Rhizoma Coptidis, Rhizoma Arisaematis by weight ratio, add the ethanol of 8-10 times of 50-80wt%, extract twice, each 2 hours, be concentrated into 80mL after merge extractive liquid, then add Borneolum Syntheticum, glycerol, acetic acid.
Embodiment 2
Treat a medicine for gastric cancer, comprise peroral dosage form and the exterior-applied formulation composition of conbined usage.
Peroral dosage form is made up of the crude drug of following weight proportion: Radix Ginseng 20g, white Herba polygoni hydropiperis 20g, Rhizoma Curcumae 25g, Rhizoma Sparganii 20g, raw pearl barley 30g, Rhizoma Dioscoreae 25g, Poria 15g, Radix Glycyrrhizae 10g;
Described exterior-applied formulation is by the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film (10cm × 10cm);
Above-mentioned Chinese medicine extraction liquid is extracted by the crude drug of following weight proportion to make: Scolopendra 10g, Rhizoma Phragmitis 30g, Radix Puerariae 20g, Herba violae patrinii 15g, Rhizoma Coptidis 10g, Rhizoma Arisaematis 3g, Borneolum Syntheticum 30g, glycerol 20g, acetic acid 15g;
The 80 order iron powders containing 7.5g in above-mentioned absorbent cores.
Peroral dosage form with the preparation method of exterior-applied formulation with embodiment 1.
Embodiment 3
Treat a medicine for gastric cancer, comprise peroral dosage form and the exterior-applied formulation composition of conbined usage.
Peroral dosage form is made up of the crude drug of following weight proportion: Radix Ginseng 15g, white Herba polygoni hydropiperis 30g, Rhizoma Curcumae 22g, Rhizoma Sparganii 22g, raw pearl barley 33g, Rhizoma Dioscoreae 30g, Poria 10g, Radix Glycyrrhizae 15g;
Described exterior-applied formulation is by the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film (10cm × 10cm);
Above-mentioned Chinese medicine extraction liquid is extracted by the crude drug of following weight proportion to make:
Scolopendra 12g, Rhizoma Phragmitis 15g, Radix Puerariae 10g, Herba violae patrinii 25g, Rhizoma Coptidis 5g, Rhizoma Arisaematis 5g, Borneolum Syntheticum 30g, glycerol 20g, acetic acid 15g;
The 90 order iron powders containing 7.5g in above-mentioned absorbent cores.
Peroral dosage form with the preparation method of exterior-applied formulation with embodiment 1.
Clinical laboratory data
Case: clarify a diagnosis as the patient 150 of primary gastric cancer.
Tcm syndrome:
Recovery from illness: symptom all disappears, functional activity recovers normal;
Remarkable: symptomatology is eliminated or cardinal symptom is eliminated, and sign has clear improvement, and function is recovered substantially, functional rehabilitation;
Effective: cardinal symptom disappears substantially, sign take a favorable turn;
Invalid: to compare with before treatment, each side is all without progressive.
The present invention carries out clinical trail treatment to 150 routine patients, wherein male 100 example, women 50 example, the age be 30-60 year patient, what the course for the treatment of was long is 3.5 years, short 2 years, is all diagnosed as patients with gastric cancer.
Therapeutic Method: according to conditions of patients, is ensureing under the constant condition of each proportioning raw materials, can corresponding increase and decrease dose, but dose amplitude of fluctuation is unsuitable excessive, should not exceed dose 15%.Every day oral decoction with exterior-applied formulation with the use of.Oral decoction: every day 1 dose, morning and evening one after each meal, 25 days is a course for the treatment of at twice.Exterior-applied formulation: during use, pours in absorbent cores by the Chinese medicine extraction liquid in medicated bag, is then affixed on ZHONGWAN acupoint, subsides in a day, within 25 days, is a course for the treatment of, period in a medicine, and patient need control the emotion, wine for giving off smoking, reasonable arrangement diet, other drug of stopping using.
Therapeutic effect: through clinical observation, 3-4 the course for the treatment of of canceration initial stage can effectively or fully recover, and 6 courses for the treatment of of later stage, adhere to using, cure rate reaches 50%, and remarkable rate is 16%, and effective percentage is 20%, and total effective rate is 86%, and inefficiency is 14%.
The pharmacodynamics test of the anti-gastric cancer of Chinese medicine composition of the present invention
1. for reagent thing: the crude drug that the embodiment of the present invention 1 provides obtains.
2. experimental animal: Kunming mouse 60, male, body weight 18-22g, Third Military Medical University's Experimental Animal Center.
Concrete operation method:
Inoculate after people gastric cancer SGC7901 cell culture, after three weeks there is transplanted tumor in mice, gets tumor tissue under aseptic condition, afterwards by routine operation, implant in Mice Body, about 20 days, there is lump in mice oxter, mice is divided into 4 groups, S1, S2, S3, and blank group K1, administration, S1, S2, S3 adopt embodiment 1 respectively, administration after 2, the 3 medicine decoctings provided, blank group K1 feeds water, carry out gavage according to 0.5g/kg body weight, once a day, administration was put to death after 10 days.Pluck tumor, weigh, calculate tumour inhibiting rate, the results are shown in Table 1.
Table 1
The computing formula of above-mentioned tumour inhibiting rate (tumour inhibiting rate >=30% judges to have certain antitumaous effect) as:
Tumour inhibiting rate (%)=(the average tumor weight-administration group of blank group average tumor weight) average tumor of/matched group heavy × 100%.
As can be seen from Table 1, medicine provided by the invention has antitumaous effect, and after administration 10d, during rat medication, rat, all without poisoning, the phenomena of mortality, is respectively organized activities in rats, appetite is normal.
Clinical model case
1. Zhang, man, 45 years old, in June, 2012, inspection suffered from early gastric cancer, and patient has Nausea and vomiting symptom, and with pain, lose weight.After using medicine provided by the invention, after 1 course for the treatment of, patient mental's state is clearly better, Nausea and vomiting phenomenon alleviates, appetite increases, and after continuing to take a course for the treatment of, after CT examination, contrast finds, focus reduces, continue to occur without new focus for 4 weeks, patient's appetite recovers normal, and body weight is gone up, and patient to medicine without repulsion, do not affect its dietary habit at ordinary times.
2. Xu certain, female, 60 years old, in February, 2013, inspections got a cancer of the stomach, and patient has melena, abdominal pain, inappetence, and weight loss is serious, and the mental status is poor, because the age is bigger than normal, selection Chinese medicine expectant treatment.After using 3 courses for the treatment of of medicine of the present invention, pain alleviates and appetite is recovered to some extent, and melena symptom alleviates, after continuing 3 courses for the treatment of of use, patient's appetite recovers normal substantially, cardinal symptom obtains obvious improvement, and after CT examination, contrast finds, focus reduces, 2 courses for the treatment of of after treatment, the mental status is good, occurs, state of an illness complete incidence graph after 4 weeks without new focus.
Claims (5)
1. treat a medicine for gastric cancer, it is characterized in that, comprise peroral dosage form and the exterior-applied formulation composition of conbined usage;
Described peroral dosage form is made up of the crude drug of following weight proportion: Radix Ginseng 15-20g, white Herba polygoni hydropiperis 20-30g, Rhizoma Curcumae 20-25g, Rhizoma Sparganii 20-25g, raw pearl barley 30-35g, Rhizoma Dioscoreae 25-35g, Poria 10-15g, Radix Glycyrrhizae 10-15g;
Described exterior-applied formulation is made up of the medicated bag containing Chinese medicine extraction liquid and the absorbent cores be attached on film;
Described Chinese medicine extraction liquid is extracted by the crude drug of following weight proportion to make: Scolopendra 10-15g, Rhizoma Phragmitis 15-30g, Radix Puerariae 10-20g, Herba violae patrinii 15-25g, Rhizoma Coptidis 5-10g, Rhizoma Arisaematis 3-5g, Borneolum Syntheticum 30g, glycerol 20g, acetic acid 15g;
Containing ferrum powder in described absorbent cores;
The preparation method of described Chinese medicine extraction liquid is: get Scolopendra, Rhizoma Phragmitis, Radix Puerariae, Herba violae patrinii, Rhizoma Coptidis, Rhizoma Arisaematis by weight ratio, add the ethanol of 8-10 times of 50-80wt%, extract twice, each 2 hours, be concentrated into 80mL after merge extractive liquid, then add Borneolum Syntheticum, glycerol, acetic acid.
2. medicine according to claim 1, is characterized in that, the crude drug of described oral formulations is: Radix Ginseng 18g, white Herba polygoni hydropiperis 25g, Rhizoma Curcumae 20g, Rhizoma Sparganii 20g, raw pearl barley 35g, Rhizoma Dioscoreae 35g, Poria 12g, Radix Glycyrrhizae 12g.
3. medicine according to claim 1, is characterized in that, the crude drug of described Chinese medicine extraction liquid is: Scolopendra 15g, Rhizoma Phragmitis 20g, Radix Puerariae 18g, Herba violae patrinii 20g, Rhizoma Coptidis 8g, Rhizoma Arisaematis 4g, Borneolum Syntheticum 20g, glycerol 20g, acetic acid 15g.
4. medicine according to claim 1, is characterized in that: described iron powder is 80-100 order, and iron powder is 1:2 with the mass ratio of acetic acid.
5. medicine according to claim 1, is characterized in that, the using method of described exterior-applied formulation is: during use, is poured in absorbent cores by the Chinese medicine extraction liquid in medicated bag.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1817366A (en) * | 2005-11-04 | 2006-08-16 | 纪冠军 | Medicinal composition for treating rheumatosis and preparation thereof |
| CN103751721A (en) * | 2014-01-20 | 2014-04-30 | 山东省千佛山医院 | Traditional Chinese medicinal composition for treating bladder cancer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1817366A (en) * | 2005-11-04 | 2006-08-16 | 纪冠军 | Medicinal composition for treating rheumatosis and preparation thereof |
| CN103751721A (en) * | 2014-01-20 | 2014-04-30 | 山东省千佛山医院 | Traditional Chinese medicinal composition for treating bladder cancer |
Non-Patent Citations (1)
| Title |
|---|
| 苏晓妹等.胃癌的中医药诊疗进展.《辽宁中医学院学报》.2004,第06卷(第01期), * |
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