CN102258563B - Anti-cancer medicinal composition and Chinese medicinal composition - Google Patents
Anti-cancer medicinal composition and Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses an anti-cancer medicinal composition, which comprises 15-70 parts by weight of plant polysaccharide and mainly comprises the following medicinal crops or mainly comprises a Chinese medicinal composition prepared by the following medicinal crops in parts by weight: 18-22 parts of astragalus, 13-17 parts of ginseng, 22-26 parts of angelica, 13-17 parts of honeysuckle and 13-17 parts of root of straight ladybell, wherein the plant polysaccharide is selected from one more of ganoderma lucidum polysaccharide, lentinan polysaccharide, cordyceps sinensis polysaccharide, coriolus versciclor polysaccharide, agaricus blazei polysaccharide, hericium erinaceus polysaccharide, maitake polysaccharide, ginkgo polysaccharide and ginseng polysaccharide. The invention also discloses the Chinese medicinal composition in the anti-cancer medicinal composition. The anti-cancer medicinal composition provided by the invention is used for treating advanced cancer in the case that surgery and concurrent chemoradiotherapy are unsuitable or invalid, particularly has an obvious treatment effect on the advanced gastric cancer; the total effectiveness ratio reaches about 90 percent; the total cure rate reaches about 30 percent; the three-year survival rate reaches about 40 percent; and the five-year survival rate reaches about 25 percent.
Description
Technical field
The present invention relates to a kind of anticancer pharmaceutical composition and a kind of Chinese medicine composition.
Background technology
Cancer is the formidable enemy of human health, but the significant Therapeutic Method that still is of no curative effect so far, belongs to one of fort that medical circle not yet captures.At present, the Therapeutic Method of cancer is mainly take the operative treatment of doctor trained in Western medicine, chemotherapy and radiation as main.But these method costs are higher, and curative effect is unsatisfactory, and effective percentage is only 20～30%, and cure rate is very low, and main only for the early metaphase cancer.And, although chemotherapy and radiation energy kill cancer cell also can cause greatly infringement to human body itself simultaneously, be very painful process concerning patient.In theory, early diagnosis, early treatment, early metaphase operation, chemicotherapy just have the healing chance of minority, but most patient has just developed into middle and advanced stage because of subjective symptoms when medical, so early treatment's wonderful dream just often.The method of Chinese traditional treatment cancer is mainly used in alleviating patient symptom at present, improves the quality of living, and as operative treatment and the complementary means of chemicotherapy, the Chinese medicine with therapeutic effect is still rare.
Polysaccharide compound extensively is present in the cell wall of animal cell membrane and plant, microorganism.In prior art, many documents mainly report that by experiment in vitro the vegetable polysaccharides compounds has active anticancer, causes the upsurge of polysaccharide health product thus.But at present on the market polyose is only as the auxiliary health means of above-mentioned integrative medicine therapy, and facts have proved, takes these polysaccharide products and do not produce positive effect as its advertising.Still do not report, do not adopt traditional doctor trained in Western medicine operation or chemicotherapy method, only depend on and take polysaccharide compound i.e. effective treatment cancer, especially terminal cancer.
Therefore, demand urgently polysaccharide compound is carried out more deep research, further searching can be given full play to the method for its active anticancer, provides new approach for curing cancer.
Summary of the invention
Technical problem to be solved by this invention is for the anticancer effect that overcomes existing polyose and unconspicuous defective, and a kind of new anticancer pharmaceutical composition with remarkable therapeutic effect that contains polysaccharide and a kind of Chinese medicine composition are provided.
The inventor uses by choosing multiple other components matching polysaccharide, to producing synergism, to significantly improve anticancer therapeutic.Explore by the clinical practices of more than ten years, repeatedly adjust formula, finally draw the pharmaceutical composition that the present invention has unforeseeable anticancer effect.More specifically, the present invention solves the problems of the technologies described above by following technical proposals:
Anticancer pharmaceutical composition of the present invention comprises 15～70 parts, the better vegetable polysaccharides of 40～50 parts, and mainly comprise following medical material or the Chinese medicine composition that is mainly made by following medical material: 18～22 parts of Radixs Astragali, 13～17 parts of Radix Codonopsis, 22～26 parts of Radix Angelicae Sinensis, 13～17 portions of Flos Loniceraes and 13～17 parts of Radix Adenophorae (Radix Glehniae), described part is mass parts; Wherein, described vegetable polysaccharides is selected from one or more in ganoderan, lentinan, Cordyceps polysaccharides, krestin, Agaricus Blazei Murrill polysaccharide, Hericium Erinaceus Polysaccharide, grifolan, lentinan, Semen Ginkgo polysaccharide and ginseng polysaccharide.
Wherein, preferred 35～100% ganoderans of described vegetable polysaccharides and 65～0% be selected from aforesaid other polysaccharide; Percentage ratio is the mass percent that accounts for the vegetable polysaccharides total amount.For dissimilar cancer, preferred following combination: for the gi system cancer, as gastric cancer or intestinal cancer etc., the preferred mass ratio is ganoderan, Semen Ginkgo polysaccharide and the Hericium Erinaceus Polysaccharide of 5: 3: 3, or mass ratio is 5: 3: 3: the ganoderan of 1: 1, Semen Ginkgo polysaccharide, Hericium Erinaceus Polysaccharide, krestin and Cordyceps polysaccharides.For pulmonary carcinoma or breast carcinoma, the preferred mass ratio is ganoderan, ginseng polysaccharide and the grifolan of 5: 3: 2.For hepatocarcinoma or cancer of pancreas, preferred ganoderan, or mass ratio is ganoderan, Cordyceps polysaccharides and the grifolan of 5: 3: 2, or mass ratio is ganoderan, grifolan and the lentinan of 5: 2: 2, or mass ratio is 5: 3: 2: 2 ganoderan, Cordyceps polysaccharides, grifolan and lentinan.For leukemia or lymphosarcoma, the preferred mass ratio is 5: 3: 3: 2 ganoderan, lentinan, krestin and grifolan.For carcinoma of prostate, carcinoma of testis or bladder cancer, the preferred mass ratio is ganoderan and the grifolan of 5: 2.In the present invention, described various vegetable polysaccharidess can be the vegetable polysaccharides of the various extracting method extraction gained of existing various commercially available prod or existing bibliographical information, as the commercially available various vegetable polysaccharidess of Yancheng, Jiangsu Province Dragon Lord health product company limited.Wherein, described ganoderan can be lucidum mycelium polysaccharide or ganoderma lucidum fruitbody polysaccharide, and better is ganoderma lucidum fruitbody polysaccharide.
Wherein, described medical material is better also comprises 3～7 parts of Radix Platycodoniss, 7～11 parts of Fructus Toosendans, 13～17 parts of Oletum Trogopteroris, 18～22 parts of Herba Epimedii, 13～17 portions of Ganodermas, 7～11 parts of cattle sunset and 4～8 parts of Rhizoma Corydalis, better 1～3 part of Pericarpium Citri Reticulatae, 1～3 portion of Herba Ephedrae, 1～3 portion of Rhizoma Zingiberis Preparatum, 1～3 portion of Cortex Cinnamomi and 7～11 portions of Radix Glycyrrhizaes of also further comprising, described part is mass parts.Best, described Chinese medicine composition is 20 parts of Radixs Astragali, 15 parts of Radix Codonopsis, 24 parts of Radix Angelicae Sinensis, 15 portions of Flos Loniceraes, 15 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Radix Platycodoniss, 9 parts of Fructus Toosendans, 15 parts of Oletum Trogopteroris, 20 parts of Herba Epimedii, 15 portions of Ganodermas, 9 parts of cattle sunset, 6 parts of Rhizoma Corydalis, 2 parts of Pericarpium Citri Reticulataes, 2 portions of Herba Ephedraes, 2 portions of Rhizoma Zingiberis Preparatums, 2 portions of Cortex Cinnamomis and 9 portions of Radix Glycyrrhizaes.
In the present invention, the form of described Chinese medicine composition can be the decoction liquor of medical material itself, medical material, the concentrated extract of decoction liquor or the concentrated dry powder of decoction liquor.Described decoction operates by the extracting method of field of Chinese medicines routine.Decoct mixed solvent, preferred water and yellow wine that solvent used can be water or water and field of Chinese medicines alcohols solvent arbitrary proportion commonly used.But the consumption of solvent is as the criterion with submergence crude drug at least.The temperature that decocts is the temperature that makes the solution boiling.What the time that decocts was better is 10～40 minutes.The Chinese medicine composition that the present invention preferably makes as follows: medical material is immersed in water and yellow wine, the consumption of water is the amount of submergence medical material just, and the mass ratio of medical material and yellow wine is 1: 1～1: 1.5, is heated to boil, keep boiling 10～30 minutes, namely get the preferred decoction liquor of the present invention.Further concentrate drying gets final product to get concentrated extract or the concentrated dry powder of this decoction liquor.What described concentrated extract was better is that 60～65 ℃ of lower relative densities are 1.1～1.15 concentrated extract.In the present invention, can respectively each medical material be decocted rear mixing decoction liquor, but also each medical material carries out the follow-up preparation technologies such as decoction after mixing together.
Better, anticancer pharmaceutical composition of the present invention also can contain one or more in calcium ion powder, oligochitosan and bicyclo acid platinum.What wherein, the content of described calcium ion powder was better is 0.0005～0.0015 part.Described calcium ion powder adopts existing various commercially available calcium ion powders.As the commercially available natural calcium ion powder of Ji'an man, the precious calcium ion powder of the natural calcium ion powder in ancient cooking vessel peak or ancient cooking vessel lake etc.What wherein, the content of described oligochitosan was better is 2～4 parts.Described oligochitosan can adopt existing commercially available oligochitosan, oligochitosan as commercially available in Dalian Glycobio Co., Ltd.What wherein, the content of described bicyclo acid platinum was better is 0.1～0.15 part.Described bicyclo acid platinum is the bicyclo acid platinum described in Chinese patent application CN1314357A.It is worth mentioning that, match with vegetable polysaccharides of the present invention and Chinese medicine composition, bicyclo acid platinum dosage can be increased to 4 times, and does not produce serious side effects.
In the present invention's one preferred embodiments, the content of described vegetable polysaccharides is 15～70g, and that better is 40～50g, and the kind of other compositions is selected with aforementioned, and content converts and get final product according to the mass fraction ratio of aforementioned mass fraction and vegetable polysaccharides.
Anticancer pharmaceutical composition of the present invention can be form of mixtures or is divided into the nested form of some independent components.For example, when described Chinese medicine composition during for the concentrated dry powder of the concentrated extract of the decoction liquor that mainly made by aforementioned medical material, decoction liquor or decoction liquor, if Chinese medicine composition and vegetable polysaccharides can be made form of mixtures with the composition mix homogeneously that other need to add, also Chinese medicine composition can be packed as a component separately, even cooperation is a component if separately vegetable polysaccharides and other compositions that need add are mixed, and makes the complete product of two chemical species.When described Chinese medicine composition is medical material, with Chinese medicine composition as an independent component of packing, if separately with vegetable polysaccharides and other composition mix homogeneously that need to add as a component, make the complete product of two chemical species; During use, the medical material of Chinese medicine composition is made the concentrated extract of decoction liquor, decoction liquor or the concentrated dry powder of decoction liquor by preceding method, take together with another component that contains vegetable polysaccharides.
Anticancer pharmaceutical composition of the present invention can be according to specific needs, and selective dose is taken.Preferably take by following dosage, in the anticancer pharmaceutical composition of taking every day, the content of vegetable polysaccharides is 15～70g, and that better is 40～50g, and the amount of other compositions converts and get final product according to the mass fraction ratio of aforementioned mass fraction and vegetable polysaccharides.
The invention further relates to a kind of Chinese medicine composition, it mainly comprises following medical material or the Chinese medicine composition that is mainly made by following medical material: 18～22 parts of Radixs Astragali, 13～17 parts of Radix Codonopsis, 22～26 parts of Radix Angelicae Sinensis, 13～17 portions of Flos Loniceraes and 13～17 parts of Radix Adenophorae (Radix Glehniae), described part is mass parts.
Better, described medical material also comprises 3～7 parts of Radix Platycodoniss, 7～11 parts of Fructus Toosendans, 13～17 parts of Oletum Trogopteroris, 18～22 parts of Herba Epimedii, 13～17 portions of Ganodermas, 7～11 parts of cattle sunset and 4～8 parts of Rhizoma Corydalis, better 1～3 part of Pericarpium Citri Reticulatae, 1～3 portion of Herba Ephedrae, 1～3 portion of Rhizoma Zingiberis Preparatum, 1～3 portion of Cortex Cinnamomi and 7～11 portions of Radix Glycyrrhizaes of also further comprising, described part is mass parts.
Best, described Chinese medicine composition is 20 parts of Radixs Astragali, 15 parts of Radix Codonopsis, 24 parts of Radix Angelicae Sinensis, 15 portions of Flos Loniceraes, 15 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Radix Platycodoniss, 9 parts of Fructus Toosendans, 15 parts of Oletum Trogopteroris, 20 parts of Herba Epimedii, 15 portions of Ganodermas, 9 parts of cattle sunset, 6 parts of Rhizoma Corydalis, 2 parts of Pericarpium Citri Reticulataes, 2 portions of Herba Ephedraes, 2 portions of Rhizoma Zingiberis Preparatums, 2 portions of Cortex Cinnamomis and 9 portions of Radix Glycyrrhizaes.
In the present invention, but above-mentioned each optimum condition combination in any namely gets the preferred embodiments of the invention.
Agents useful for same of the present invention and raw material be commercially available getting all.
Positive progressive effect of the present invention is: anticancer pharmaceutical composition of the present invention, have the effect of significant treatment cancer, and especially perform the operation and chemicotherapy to being not suitable for, or underwent operative and the invalid terminal cancer of chemicotherapy have unexpected excellent curative effect.Through the routine all kinds of terminal cancer statistics of more than ten years clinical trails 90, anticancer pharmaceutical composition total effective rate of the present invention reaches approximately 90%, and total cure rate reaches approximately 30%, three annual survival rate and reaches approximately 40%, and five-year survival rate reaches approximately 25%.And anticancer pharmaceutical composition of the present invention is especially outstanding to the curative effect of late gastric cancer, and effective percentage reaches 100%, and cure rate reaches approximately 80%, three annual survival rate and reaches approximately 90%, and five-year survival rate reaches approximately 80%.
The specific embodiment
The below further illustrates the present invention with embodiment, but the present invention is not limited.
In following embodiment, vegetable polysaccharides is available from Yancheng, Jiangsu Province Dragon Lord health product company limited, oligochitosan is available from Dalian Glycobio Co., Ltd, and bicyclo propionic acid platinum is provided by department of chemistry of Peking University, and calcium ion powder is the commercially available natural calcium ion powder of Ji'an man.
Embodiment 1 anticancer pharmaceutical composition
Vegetable polysaccharides: be total to 37.4g, comprising 17g ganoderan, 10.2g Semen Ginkgo polysaccharide and 10.2g Hericium Erinaceus Polysaccharide, mass ratio 5: 3: 3.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 40 minutes, namely gets decoction liquor.With decoction liquor and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Other: the 3g oligochitosan
With decoction liquor, vegetable polysaccharides and oligochitosan mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 2 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 50g, comprising 22.8g ganoderan, 13.6g Semen Ginkgo polysaccharide and 13.6g Hericium Erinaceus Polysaccharide, mass ratio 5: 3: 3.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae and 15g part Radix Adenophorae (Radix Glehniae).Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 100g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.Decoction liquor and vegetable polysaccharides are mixed, namely get anticancer pharmaceutical composition of the present invention.
Vegetable polysaccharides as a component independently, as another component independently, is namely got the anticancer pharmaceutical composition of the present invention's two component nested form with decoction liquor.
Embodiment 3 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 44.2g, comprising 17g ganoderan, 10.2g Semen Ginkgo polysaccharide, 10.2g Hericium Erinaceus Polysaccharide, 3.4g krestin and 3.4g Cordyceps polysaccharides, mass ratio 5: 3: 3: 1: 1.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae and 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi and 6g Rhizoma Corydalis.
Vegetable polysaccharides as a component independently, as another component independently, is namely got the anticancer pharmaceutical composition of the present invention's two component nested form with the medical material of Chinese medicine composition.During use, the medical material of Chinese medicine composition is immersed in water and yellow wine, the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 40 minutes, namely gets decoction liquor.Decoction liquor and vegetable polysaccharides are taken together.
Embodiment 4 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 34g, comprising 17g ganoderan, 10.2g ginseng polysaccharide and 6.8g grifolan, mass ratio 5: 3: 2.
Chinese medicine composition: medical material comprises the 22g Radix Astragali, 17g Radix Codonopsis, 26g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in the water, and the consumption of water is 1.2 times of amount of just submergence medical material, is heated to boil, and keeps boiling 10 minutes, namely gets decoction liquor.
Other: 4g oligochitosan and 1mg calcium ion powder.
With decoction liquor, vegetable polysaccharides, oligochitosan and calcium ion powder mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 5 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 34g, comprising 17g ganoderan, 10.2g ginseng polysaccharide and 6.8g grifolan, mass ratio 5: 3: 2.
Chinese medicine composition: medical material comprises the 18g Radix Astragali, 13g Radix Codonopsis, 22g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 6 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 1020g, comprising 510g ganoderan, 306g Cordyceps polysaccharides and 204g grifolan, mass ratio 5: 3: 2.
Chinese medicine composition: medical material comprises the 600g Radix Astragali, 450g Radix Codonopsis, 720g part Radix Angelicae Sinensis, 450g Flos Lonicerae, 450g part Radix Adenophorae (Radix Glehniae), 150g Radix Platycodonis, 270g Fructus Toosendan, 450g Oletum Trogopterori, 600g Herba Epimedii, 450g Ganoderma, 270g Niu Xi, 180g Rhizoma Corydalis, 60g Pericarpium Citri Reticulatae, 60g Herba Ephedrae, 60g Rhizoma Zingiberis Preparatum, 60g Cortex Cinnamomi and 270g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 7500g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor, and vacuum freezing (50 ℃) is dried to dry powder afterwards.
With dry powder and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.Be distributed into etc. 30 parts, for taking every day.
Embodiment 7 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 1224g, comprising 510g ganoderan, 306g Cordyceps polysaccharides, 204g grifolan and 204g lentinan, mass ratio is 5: 3: 2: 2.
Chinese medicine composition: medical material comprises the 600g Radix Astragali, 450g Radix Codonopsis, 720g part Radix Angelicae Sinensis, 450g Flos Lonicerae, 450g part Radix Adenophorae (Radix Glehniae), 150g Radix Platycodonis, 270g Fructus Toosendan, 450g Oletum Trogopterori, 600g Herba Epimedii, 450g Ganoderma, 270g Niu Xi, 180g Rhizoma Corydalis, 60g Pericarpium Citri Reticulatae, 60g Herba Ephedrae, 60g Rhizoma Zingiberis Preparatum, 60g Cortex Cinnamomi and 270g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 7500g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor, and being evaporated to afterwards relative density is the concentrated extract of 1.1 (60 ℃).
With concentrated extract and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.Be distributed into 30 parts, for taking every day.
Embodiment 8 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 34g, comprising 17g ganoderan, 10.2g Cordyceps polysaccharides and 6.8g grifolan, mass ratio 5: 3: 2.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, get anticancer pharmaceutical composition of the present invention.
Embodiment 9 anticancer pharmaceutical compositions
Vegetable polysaccharides: 40g ganoderan.
Chinese medicine composition: medical material comprises the 22g Radix Astragali, 17g Radix Codonopsis, 26g part Radix Angelicae Sinensis, 17g Flos Lonicerae, 17g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, get anticancer pharmaceutical composition of the present invention.
Embodiment 10 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 63g, comprising 35g ganoderan, 14g lentinan and 14g grifolan, mass ratio 5: 2: 2.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, get anticancer pharmaceutical composition of the present invention.
Embodiment 11 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 40.8g, comprising 17g ganoderan, 10.2g Cordyceps polysaccharides, 6.8g grifolan and 6.8g lentinan, mass ratio 5: 3: 2: 2.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 35 minutes, namely gets decoction liquor.
Other: 0.13g bicyclo propionic acid platinum (structural formula is as shown in CN1314357A, and department of chemistry of Peking University provides)
With decoction liquor, vegetable polysaccharides and bicyclo propionic acid platinum mix homogeneously, get anticancer pharmaceutical composition of the present invention.
Embodiment 12 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 70g, comprising 27g ganoderan, 16.2g lentinan, 16g krestin and 10.8g grifolan, mass ratio is 5: 3: 3: 2.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 13 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 44.2g, comprising 17g ganoderan, 10.2g lentinan, 10.2g krestin and 6.8g grifolan, mass ratio is 5: 3: 3: 2.
Chinese medicine composition: medical material comprises the 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
Other: the 1mg calcium ion powder.
With decoction liquor, vegetable polysaccharides and calcium ion powder mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 14 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 28g, wherein, comprise 20g ganoderan and 8g grifolan, mass ratio is 5: 2.
Chinese medicine composition: medical material comprises the 21g Radix Astragali, 16g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 10g Fructus Toosendan, 15g Oletum Trogopterori, 21g Herba Epimedii, 14g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 10g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
Other: 3.5g oligochitosan and 1mg calcium ion powder.
With decoction liquor, vegetable polysaccharides, oligochitosan and calcium ion powder mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 15 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 15g, comprising 10.7g ganoderan and 4.3g grifolan, mass ratio is 5: 2.
Chinese medicine composition: medical material comprises the 19g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 14g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 1g Rhizoma Zingiberis Preparatum, 1g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 16 anticancer pharmaceutical compositions
Vegetable polysaccharides: be total to 19.3g, comprising 10.7g ganoderan, 4.3g grifolan and 4.3g Agaricus Blazei Murrill polysaccharide, mass ratio is 5: 2: 2.
Chinese medicine composition: medical material comprises the 22g Radix Astragali, 16g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
With decoction liquor and vegetable polysaccharides mix homogeneously, namely get anticancer pharmaceutical composition of the present invention.
Embodiment 17 Chinese medicine compositions
The 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae and 15g part Radix Adenophorae (Radix Glehniae).Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 50g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor.
Embodiment 18 Chinese medicine compositions
The 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi and 6g Rhizoma Corydalis.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 150g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor, and being evaporated to afterwards relative density is the concentrated extract of 1.1 (60 ℃).
Embodiment 19 Chinese medicine compositions
The 20g Radix Astragali, 15g Radix Codonopsis, 24g part Radix Angelicae Sinensis, 15g Flos Lonicerae, 15g part Radix Adenophorae (Radix Glehniae), 5g Radix Platycodonis, 9g Fructus Toosendan, 15g Oletum Trogopterori, 20g Herba Epimedii, 15g Ganoderma, 9g Niu Xi, 6g Rhizoma Corydalis, 2g Pericarpium Citri Reticulatae, 2g Herba Ephedrae, 2g Rhizoma Zingiberis Preparatum, 2g Cortex Cinnamomi and 9g Radix Glycyrrhizae.Above-mentioned medical material is immersed in water and yellow wine, and the consumption of water be the amount of submergence medical material just, and yellow wine is 250g, is heated to boil, and keeps seething with excitement 30 minutes, namely gets decoction liquor, and vacuum freezing (50 ℃) is dried to dry powder afterwards.
Effect embodiment treats cases of cancer statistics and part model case
One, 90 routine cancer curative effect statistics
Follow the tracks of 90 examples and adopt embodiment 1～16 all kinds of terminal cancer of anticancer pharmaceutical composition treatment, the curative effect statistics is as shown in table 1.90 routine cases are terminal cancer, and be not suitable for performing the operation, chemicotherapy or perform the operation, chemicotherapy is invalid, sentenced the patient of " death sentence " by hospital.
Table 1 treatment cases of cancer curative effect statistics
Annotate: " effectively " comprises that doing well,improving, cancerous tissue are suppressed, dwindle, and cures.
By upper data as seen, anticancer pharmaceutical composition of the present invention has outstanding curative effect for above-mentioned all kinds of terminal cancer.Do not adopting traditional operation, chemicotherapy or underwent operative, chemicotherapy invalid, and be in the situation of terminal cancer, take anticancer pharmaceutical composition of the present invention and reach overall effective percentage 92%, cure rate reaches 32%, three annual survival rates reach 39%, five-year survival rate reaches 23%, head and shoulders above the effect of existing cancer treatment method.Anticancer pharmaceutical composition of the present invention especially has outstanding therapeutic effect to late gastric cancer, and effective percentage reaches 100%, and cure rate reaches 78%, three annual survival rate and reaches 89%, and five-year survival rate reaches 78%.
Two, part model case
The below enumerates part model case in above-mentioned 90 examples, with the significant therapeutic effect of further embodiment anticancer pharmaceutical composition of the present invention.
1, gastric cancer case one example
Patient: Wei Li, female, 42 years old.
Before medical: gastric cancer, extensively shift, forward ovary to, carried out operation, dyscrasia is very serious, and life can't be taken care of oneself.
Anticancer pharmaceutical composition: embodiment 1
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, two days later, the patient gets up voluntarily and washes one's face and rinses one's mouth, and can eat half little bowl meal on the 3rd day, can make a phone call in bed to do insurance on the 4th day, after two weeks with husband's new house of together going out to see.Unfortunate, after one month, the patient slightly feels nauseating, and family members send to hospital and carry out chemotherapy, and are dead in hospital.
2, gastric cancer case one example
Patient: Jing Suohai, certain teacher of, man, 73 years old.
Before medical: stomach cancer metastasis, dyscrasia is serious, and body weight falls to 107 jin of left and right under 180 jin.
Anticancer pharmaceutical composition: embodiment 1
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after one month, weight in patients increases by 5 kilograms, has now returned to 130 jin, also grows a not only black but also thick hair, and the skin senile plaque loses.So far, survival is more than 6 years.
3, gastric cancer case one example
Patient: Lu Yunxi, female, 79 years old.
Before medical: suffer from the stomach cardiac cancer, shift after operation, the various symptoms such as stomach poor appetite, insomnia are arranged.Take the plurality kinds of health care product, comprise commercially available polysaccharide health-care product, invalid.
Anticancer pharmaceutical composition: embodiment 2
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after one and a half months, the various doing well,improvings of patient can also be played mahjong half a day.Dead because of heart disease after 5 years.
4, gastric cancer case one example
Patient: Tang Daming, man, 37 years old, people from Funing County, Jiangsu.
Before medical: suffer from the stomach cardiac cancer, be hospitalized for treatment because of massive hemorrhage, be diagnosed as cancer of late stage, the companion shifts.
Anticancer pharmaceutical composition: embodiment 3
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after three months, all transference cures, receipt position working.After 6 years (this year), esophagus generation cancer is in existing treatment.
5, pulmonary carcinoma case one example
Patient: Ling Xuemei, female, 82 years old.
Before medical: in by the end of February, 2010, removes east, city hospital admission because of symptoms such as chest pain are out of breath, is diagnosed as advanced lung cancer through every inspection, and because the patient suffers from coronary heart disease, hospital does not adopt any treatment, advises patient's mastery of going home.Before medical, family members once took the plurality kinds of health care product such as Ganoderma spore powder and took to her, all invalid.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through about one month, the patient has got up and can arrange simple housework, treat through one and a half months the health status that patient's muscle power has returned in November, 2009 (when not diagnosing out cancer), appetite increases to one can eat 10 large wonton, and various symptoms are all improved.
6, pulmonary carcinoma case one example
Patient: Li Shengxian, 43 years old.
Before medical: bone metastases of lung cancer.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through about three months, the basic healing.So far survived more than ten years.
7, pulmonary carcinoma case one example
Patient: Wang Jian, female, 56 years old.
Before medical: ovarian cancer is transferred to lung and bone.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through about three months, the basic healing.So far survived more than eight years.
8, pulmonary carcinoma case one example
Patient: Xie Shi, female, 79 years old.
Before medical: suffer from pulmonary carcinoma (adenocarcinoma) thoracic cavity transfer
Anticancer pharmaceutical composition: embodiment 5
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through treatment in two months, lung tumors all disappeared, and survives 20 months, and rear dead because of diabetes, when dead, pulmonary is without cancerous protuberance.
9, pulmonary carcinoma case one example
Patient: Shen Zongming, man, 65 years old, people from Waigaoqiao of Shaihai.
Before medical: suffer from pulmonary carcinoma (scale cancer) and be transferred to brain.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through about one month, lung tumors all disappears, and the brain metastasis is dwindled half, has survived more than 3 years so far.
10, pulmonary carcinoma case one example
Patient: Wang Yuehua, man, 58 years old, the former deputy commissioner of Inland Revenue of Pudong New District.
Before medical: pulmonary carcinoma (adenocarcinoma) is transferred to mediastinum thoracic cavity and bone, and after hospital adopted the import chemotherapeutic to treat four courses for the treatment of, patient's unceasing hematemesis was told one glass of left and right at every turn, can't stop blooding.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, a week spits blood and namely stops, and various symptoms are obviously improved, and through treatment in six months, pulmonary masses all disappeared, and only vertical the disease due to obstruction of QI of middle-JIAO also stays Semen Glycines size shade.Unfortunate, the patient is insurance, then does radiotherapy, destroys immune system, and the state of an illness sharply worsens, and is dead after one and a half months.
11, pulmonary carcinoma case one example
Patient: Xia Shaoyang, man, 63 years old.
Before medical: pulmonary carcinoma (squama type), the right lung 5cm of section size lump.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through one month, pulmonary masses was contracted to rapidly 1cm, and life can be taken care of oneself, and also goes out to go on a tour.Unfortunate, the patient treats for strengthening, then the paclitaxel treatment that carries out import to hospital, wipes out patient's immunity two courses for the treatment of, and the cancerous cell whole body shifts, death.
12, cancer of pancreas case one example
Patient: Xue Jinsheng, 67 years old, people from Yuyao, Zhejiang.
Before medical: suffer from cancer of pancreas, cancer section is positioned at the head of pancreas place is wrapped up by trunk, has all confirmed and can't perform the operation at Tung Wah hospital and middle mountain hospital.
Anticancer pharmaceutical composition: embodiment 6
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after one month, the symptoms such as soreness of waist shoulder pain all disappear, and after two months, check cancer of pancreas piece disappears, and has survived so far 12 years.
13, cancer of pancreas case one example
The patient: S. Korea and the USA are flourish, female, 63 years old, Spring in Pig House of Shanghai Fengxian people.
Before medical: cancer of biliary duct postoperative, cancerometastasis are unable to leave the bed to head of pancreas.
Anticancer pharmaceutical composition: embodiment 7
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after seven days, can get up and drop in, the check pancreatic head mass disappeared in one month, had survived more than 3 years so far.
14, cancer of pancreas case one example
Patient: Li doctor, Yangpu, Shanghai cadre's sanitarium medical officer.
Before medical: cancer of pancreas, operation wide excision.
Anticancer pharmaceutical composition: embodiment 7
Curative effect after medical: took above-mentioned anticancer pharmaceutical composition every day three months, and survived so far 5 years.
15, hepatocarcinoma case one example
The patient: recruit quiet, female, 50 years old, the No. One Department Store accounting of former Shanghai City.
Before medical: suffer from renal carcinoma, be transferred to liver after operation.For this reason, the various places of hurrying back and forth seek treatment, and disease is not cured and but used up the savings in all one's life.
Anticancer pharmaceutical composition: embodiment 8.
Curative effect after medical: take the vegetable polysaccharides (not comprising Chinese medicine composition) in embodiment 8 formulas, continuous three months, hepatoncus was inhibited, and did not continue to enlarge.The patient cures the disease anxious, hears that gamma knife is effective, carries out the gamma knife treatment of two courses for the treatment of to eight or five hospitals costs 60,000, and lump is grown up to 15.7cm rapidly from 8.5cm, and produces and have an intense pain, and is restless by day and sleepless by night.Begin to take the above-mentioned anticancer pharmaceutical composition that comprises vegetable polysaccharides and Chinese medicine composition, pain disappeared in one month, after three months, the hepatocarcinoma lump is contracted to below 8cm, other indices are negative, orthobiosis as Healthy People, 5 years (rear because of once overtired, liver cancer recurrence causes that hepatic coma is dead) survives.
By this case as seen, adopt that in anticancer pharmaceutical composition of the present invention, the vegetable polysaccharides formula has certain curative effect, adopt Chinese medicine composition of the present invention and vegetable polysaccharides to match, produce synergism, improve more significantly therapeutic effect.
16, hepatocarcinoma case one example
Patient: Wu Qingsheng, man, 48 years old, Wuhu peasant.
Before medical: the treatment that gets a cancer of the stomach is transferred to liver soon, produces ascites.Advanced liver cancer is made a definite diagnosis by the People's Hospital, Wuhu, thinks and can't cure, and advises family members' deathbed care of going home.The spore powder (including vegetable polysaccharides) that the household buys on commercially available is taken, and is invalid.
Anticancer pharmaceutical composition: embodiment 9.
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, one month, patient's appetite increased, and every meal jorum meal of taking food can arrive outdoor walking, cures in three months, and the cancerous tumors disappearance has been survived so far and had a surplus in 7 years.The patient does the yellow ground business now.
17, hepatocarcinoma case one example
Patient: Li Zhihong, man, 43 years old, the Changsha director's of the National People's Congress nephew.
Before medical: the patient is former must cross hepatitis B, after transfer chronic hepatitis to, hepatalgia appears at the beginning of 2009, alpha-fetoprotein and transaminase all increase, People's Hospital, Hunan Prov. is diagnosed as diffuse liver cancer.
Anticancer pharmaceutical composition: embodiment 10.
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, three months, the index that the patient checks every relevant hepatocarcinoma all within normal range, was started working, and a year and a half so far, about every half a year, all are normal in check.
18, hepatocarcinoma case one example
Patient: Sun Jinhai, the man, 40 years old, people from Yuyao, Zhejiang Province did the copper business.
Before medical: suffer from explosive hepatocarcinoma, a plurality of cancer pieces on liver, the Hangzhou hospital admission thinks that cancer piece position is bad, should not perform the operation.
Anticancer pharmaceutical composition: embodiment 10
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, six months, stable disease, the hepatocarcinoma lump dwindles.
19, hepatocarcinoma case one example
Patient: Wei Zhongqiao, 68 years old, Yuyao village, Zhejiang Enterprise Staff.
Before medical: through CT examination, the hepatocarcinoma lump reaches 8cm, after the east doctor of Genneral Surgery opens the abdominal cavity, sees lump by trunk, and operation risk is large, therefore excise.Afterwards, symptom aggravation.
Anticancer pharmaceutical composition: embodiment 10
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after one month, symptom is greatly improved, and icteric index reaches normally substantially, receipt position working after two months.
20, hepatocarcinoma case one example
Patient: Xu Shengying, female, 80 years old, Shanghai people.
Before medical: suffer from hepatocarcinoma more than a year, Beijing PLA General Hospital hospitalization, without positive effect, cancer has diffused to the positions such as many places bone and pharynx, and the patient can not walk.
Anticancer pharmaceutical composition: embodiment 11
After medical: take above-mentioned anticancer pharmaceutical composition every day, after two weeks, symptom is greatly improved, and can leave the bed, and can also touch wall and bed oneself moving, and quality of life improves greatly.
21, carcinoma of prostate one example
Patient: Lv Wo, man, 52 years old, the former little east gate director of subdistrict office in Shanghai.
Before medical: suffer from carcinoma of prostate more than 2 years, each hospital treatment gets nowhere, and companion's bone shifts, and frequent micturition, the symptom such as weak are arranged.
Anticancer pharmaceutical composition: embodiment 14
Curative effect after medical: took above-mentioned anticancer pharmaceutical composition every day three months, but the relevant meeting of participant lives that all are normal, survives 3 years.
22, breast carcinoma one example
Patient: Zhao Yingxia, female, 50 years old.
Before medical: left breast cancer is transferred to the oxter, and the lymph node fist is large, can't perform the operation, and has no after chemotherapy effectively, and the patient is short of physical strength, and can only stop chemotherapy.
Anticancer pharmaceutical composition: embodiment 4
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after 22 days, CT check lump in breast all disappears, and the lymph node of oxter enlargement also disappears half, suggestion operation this moment, and postoperative is still taken above-mentioned anticancer pharmaceutical composition March, has survived so far 6 years.
23, bladder cancer one example
Patient: Liu Zhankai, man, 73 years old, the teacher that leaves one's post of Beijing section.
Before medical: recur after bladder cancer operation chemotherapy, hematuria, dysurea, the symptoms such as urgent micturition are outstanding.
Anticancer pharmaceutical composition: embodiment 15
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, after one and a half months, all transference cures, CT examination is normal, is on home leave to the U.S. after six months, survives so far 3 years.
24, intestinal cancer one example
Patient: Lei Shi, the female, 72 years old, the Shanghai thunder was permitted upper founder children.
Before medical: suffer from intestinal cancer, excision, six the course for the treatment of chemotherapy, realize that afterwards the tumor abdominal cavity shifts, people's dead-soft, poor appetite is become thin.
Anticancer pharmaceutical composition: embodiment 2
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through treatment in two months, muscle power, energy progressively recovered, and can out take a walk.After three months, the examination in hospital Abdominal Masses disappears, and has survived more than 8 years so far.
25, intestinal cancer one example
Patient: Wang Mingmei, female, 56 years old.
Before medical: suffer from intestinal cancer, shift after excision.
Anticancer pharmaceutical composition: embodiment 3
Curative effect after medical: take above-mentioned anticancer pharmaceutical composition every day, through treatment in two months, lump disappeared, and before antisecosis arrives operation, dress is anti-, has survived more than 7 years so far.
Claims (18)
1. anticancer pharmaceutical composition, it is characterized in that: it comprises the vegetable polysaccharides of 15～70 parts, and mainly comprise following medical material or the Chinese medicine composition that is mainly made by following medical material: 18～22 parts of Radixs Astragali, 13～17 parts of Radix Codonopsis, 22～26 parts of Radix Angelicae Sinensis, 13～17 portions of Flos Loniceraes and 13～17 parts of Radix Adenophorae (Radix Glehniae), described part is mass parts; Wherein, described vegetable polysaccharides is selected from one or more in ganoderan, Cordyceps polysaccharides, krestin, Agaricus Blazei Murrill polysaccharide, Hericium Erinaceus Polysaccharide, grifolan, lentinan, Semen Ginkgo polysaccharide and ginseng polysaccharide.
2. anticancer pharmaceutical composition as claimed in claim 1, it is characterized in that: the mass fraction of described vegetable polysaccharides is 40～50 parts.
3. anticancer pharmaceutical composition as claimed in claim 1, it is characterized in that: described vegetable polysaccharides comprises 35～100% ganoderans; Percentage ratio is the mass percent that accounts for the vegetable polysaccharides total amount.
4. anticancer pharmaceutical composition as claimed in claim 1 is characterized in that:
When described cancer is the gi system cancer, described vegetable polysaccharides is that mass ratio is ganoderan, Semen Ginkgo polysaccharide and the Hericium Erinaceus Polysaccharide of 5: 3: 3, or mass ratio is 5: 3: 3: the ganoderan of 1: 1, Semen Ginkgo polysaccharide, Hericium Erinaceus Polysaccharide, krestin and Cordyceps polysaccharides;
When described cancer was pulmonary carcinoma or breast carcinoma, described vegetable polysaccharides was that mass ratio is ganoderan, ginseng polysaccharide and the grifolan of 5: 3: 2;
When described cancer is hepatocarcinoma or cancer of pancreas, described vegetable polysaccharides is ganoderan, or mass ratio is ganoderan, Cordyceps polysaccharides and the grifolan of 5: 3: 2, or mass ratio is ganoderan, grifolan and the lentinan of 5: 2: 2, or mass ratio is 5: 3: 2: 2 ganoderan, Cordyceps polysaccharides, grifolan and lentinan;
When described cancer was leukemia or lymphosarcoma, described vegetable polysaccharides was that mass ratio is 5: 3: 3: 2 ganoderan, lentinan, krestin and grifolan;
When described cancer was carcinoma of prostate, carcinoma of testis or bladder cancer, described vegetable polysaccharides was that mass ratio is ganoderan and the grifolan of 5: 2;
Described ganoderan is lucidum mycelium polysaccharide or ganoderma lucidum fruitbody polysaccharide.
5. anticancer pharmaceutical composition as described in claim 1～4 any one, it is characterized in that: described medical material also comprises 3～7 parts of Radix Platycodoniss, 7～11 parts of Fructus Toosendans, 13～17 parts of Oletum Trogopteroris, 18～22 parts of Herba Epimedii, 13～17 portions of Ganodermas, 7～11 parts of Radix Achyranthis Bidentataes and 4～8 parts of Rhizoma Corydalis, and described part is mass parts.
6. anticancer pharmaceutical composition as claimed in claim 5, it is characterized in that: described medical material also comprises 1～3 part of Pericarpium Citri Reticulatae, 1～3 portion of Herba Ephedrae, 1～3 portion of Rhizoma Zingiberis Preparatum, 1～3 portion of Cortex Cinnamomi and 7～11 portions of Radix Glycyrrhizaes; Described part is mass parts.
7. anticancer pharmaceutical composition as claimed in claim 5, it is characterized in that: described Chinese medicine composition is 20 parts of Radixs Astragali, 15 parts of Radix Codonopsis, 24 parts of Radix Angelicae Sinensis, 15 portions of Flos Loniceraes, 15 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Radix Platycodoniss, 9 parts of Fructus Toosendans, 15 parts of Oletum Trogopteroris, 20 parts of Herba Epimedii, 15 portions of Ganodermas, 9 parts of Radix Achyranthis Bidentataes, 6 parts of Rhizoma Corydalis, 2 parts of Pericarpium Citri Reticulataes, 2 portions of Herba Ephedraes, 2 portions of Rhizoma Zingiberis Preparatums, 2 portions of Cortex Cinnamomis and 9 portions of Radix Glycyrrhizaes; Described part is mass parts.
8. anticancer pharmaceutical composition as described in claim 1～7 any one, it is characterized in that: the form of described Chinese medicine composition is the decoction liquor of medical material itself, medical material, the concentrated extract of decoction liquor or the concentrated dry powder of decoction liquor.
9. anticancer pharmaceutical composition as claimed in claim 8, it is characterized in that: described decoction liquor makes as follows: medical material is immersed in water and yellow wine, the consumption of water is the amount of submergence medical material just, the mass ratio of medical material and yellow wine is 1: 1～1: 1.5, be heated to boil, keep boiling 10～30 minutes, namely get decoction liquor; The concentrated extract of described decoction liquor or the concentrated dry powder of decoction liquor make as follows: with the further concentrate drying of decoction liquor, get final product to get concentrated extract or the concentrated dry powder of this decoction liquor; Described concentrated extract is that 60～65 ℃ of lower relative densities are 1.1～1.15 concentrated extract.
10. anticancer pharmaceutical composition as described in claim 1～9 any one, it is characterized in that: described anticancer pharmaceutical composition also contains one or more in calcium ion powder, oligochitosan and bicyclo acid platinum.
11. anticancer pharmaceutical composition as claimed in claim 10 is characterized in that: the content of described calcium ion powder is 0.0005～0.0015 part; The content of described oligochitosan is 2～4 parts; The content of described bicyclo acid platinum is 0.1～0.15 part, and described part is mass parts.
12. anticancer pharmaceutical composition as described in claim 1～11 any one is characterized in that: the content of described vegetable polysaccharides is 15～70g.
13. anticancer pharmaceutical composition as claimed in claim 12 is characterized in that: the content of described vegetable polysaccharides is 40～50g.
14. anticancer pharmaceutical composition as described in claim 1～13 any one is characterized in that:
When described Chinese medicine composition during for the concentrated dry powder of the concentrated extract of the decoction liquor that mainly made by aforementioned medical material, decoction liquor or decoction liquor, described anticancer pharmaceutical composition is form of mixtures, or with Chinese medicine composition and the independent two component nested form as independent component of other compositions difference;
When described Chinese medicine composition was medical material, described anticancer pharmaceutical composition was with Chinese medicine composition and the independent two component nested form as independent component of other compositions difference.
15. Chinese medicine composition, it is characterized in that: it mainly comprises following medical material or the Chinese medicine composition that is mainly made by following medical material: 18～22 parts of Radixs Astragali, 13～17 parts of Radix Codonopsis, 22～26 parts of Radix Angelicae Sinensis, 13～17 portions of Flos Loniceraes and 13～17 parts of Radix Adenophorae (Radix Glehniae), and described part is mass parts; Described Chinese medicine composition is used for producing synergism with polysaccharide, to improve anticancer therapeutic.
16. Chinese medicine composition as claimed in claim 15 is characterized in that: described medical material also comprises 3～7 parts of Radix Platycodoniss, 7～11 parts of Fructus Toosendans, 13～17 parts of Oletum Trogopteroris, 18～22 parts of Herba Epimedii, 13～17 portions of Ganodermas, 7～11 parts of Radix Achyranthis Bidentataes and 4～8 parts of Rhizoma Corydalis.
17. Chinese medicine composition as claimed in claim 16 is characterized in that: described medical material also further comprises 1～3 part of Pericarpium Citri Reticulatae, 1～3 portion of Herba Ephedrae, 1～3 portion of Rhizoma Zingiberis Preparatum, 1～3 portion of Cortex Cinnamomi and 7～11 portions of Radix Glycyrrhizaes, and described part is mass parts.
18. Chinese medicine composition as claimed in claim 15 is characterized in that: described Chinese medicine composition is 20 parts of Radixs Astragali, 15 parts of Radix Codonopsis, 24 parts of Radix Angelicae Sinensis, 15 portions of Flos Loniceraes, 15 parts of Radix Adenophorae (Radix Glehniae), 5 parts of Radix Platycodoniss, 9 parts of Fructus Toosendans, 15 parts of Oletum Trogopteroris, 20 parts of Herba Epimedii, 15 portions of Ganodermas, 9 parts of Radix Achyranthis Bidentataes, 6 parts of Rhizoma Corydalis, 2 parts of Pericarpium Citri Reticulataes, 2 portions of Herba Ephedraes, 2 portions of Rhizoma Zingiberis Preparatums, 2 portions of Cortex Cinnamomis and 9 portions of Radix Glycyrrhizaes.
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| CN103446205A (en) * | 2012-05-29 | 2013-12-18 | 江中药业股份有限公司 | Composition for prevention and treatment of chemoradiotherapy induced leukopenia and its application |
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