CN107373674A - Alimentation composition and its application after a kind of oncotherapy - Google Patents
Alimentation composition and its application after a kind of oncotherapy Download PDFInfo
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- CN107373674A CN107373674A CN201710740919.8A CN201710740919A CN107373674A CN 107373674 A CN107373674 A CN 107373674A CN 201710740919 A CN201710740919 A CN 201710740919A CN 107373674 A CN107373674 A CN 107373674A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C2240/00—Use or particular additives or ingredients
- A23C2240/15—Use of plant extracts, including purified and isolated derivatives thereof, as ingredient in dairy products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Dairy Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses the alimentation composition after a kind of oncotherapy, including following component：In parts by weight, chitosan oligosaccharide is 100~1500 parts, and human milk oligosaccharides are 10~500 parts, and brown alga oligose is 200~3000 parts, and coriolan is 100~500 parts, and Maca extract is 50~2000 parts, and astaxanthin is 50~500 parts；100~9000 parts of auxiliary material.The present invention can be used for conditioning to receive radiotherapy or treat the condition of malignant tumor patient, strengthens healthy tendency, helps it to get well, and safety has no side effect.Said composition is different from medicine, and medicine all toxic side effects are long-term use of inevitably to produce " drug induced disease ", and take said composition and this problem is not present.
Description
Technical field
The invention belongs to technical field of health care food, is related to the alimentation composition after oncotherapy and its application.
Background technology
For malignant tumor patient after radiotherapy or treatment is received, it is impaired etc. to can frequently result in human body gas consumption impairment of yin, taste, so as to
Influence the circulation of qi and blood biochemistry.Now, by carrying out righting to human body, patient's body environment can be balanced, treatment toxicity is put in mitigation
Reaction；There are supplementing qi and nourishing yin, strengthening the spleen and stomach to radiotherapy：There is tonifying speen and tonifying kidney to treatment, relax liver and stomach.
Human body is referred to as healthy tendency by traditional Chinese medicine to the adaptability of external environment, resist ability and rehabilitation ability；And will be various
Pathogenic factor is referred to as perverse trend.Human righteousness is vigorous, and perverse trend should not invade, then health；If deficiency of vial QI, body disease-resistant defence
Inferior capabilities, then exopathogen follow, body is powerless to get rid of evils outgoing and falls ill.Therefore, search for the primary cause of disease in treatment, supplement healthy tendency and adjust and strengthen
The function of body is the basic principle of many diseases of Chinese traditional treatment.
Generally, bacterial micro-ecological balance of the healthy tendency of traditional Chinese medicine also with human body has close correlation, is especially to maintain
Microorganism species species in intestines and stomach, quantity, distribution are normal etc..Research shows, after malignant tumor patient receives radiotherapy or treatment,
One of the main reason for healthy tendency is deficient is to be particularly the unbalance of gut flora Tiny ecosystem in vivo." search for the primary cause of disease in treatment, supplement according to the traditional Chinese medical science
The principle of reatment of healthy tendency ", it is deficient to this healthy tendency, by adjusting internal Tiny ecosystem, the healthy tendency of body is lifted, is to improve such disease
One of effective means.
For the above-mentioned demand for receiving radiotherapy or treating malignant tumor patient, offer one kind is needed badly by adjusting bacterium in enteron aisle
The Tiny ecosystem of group, reach the oligosaccharide composition of righting qigong effect.
The content of the invention
Technical scheme provided by the invention is as follows：
The present invention provides the alimentation composition after a kind of oncotherapy, including following component：In parts by weight, chitosan oligosaccharide
For 10~500 parts, human milk oligosaccharides are 10~500 parts, and brown alga oligose is 200~3000 parts, and coriolan is 100~500 parts, agate
Coffee extract is 50~2000 parts, and astaxanthin is 50~500 parts；200~9000 parts of auxiliary material.
The present invention also provides a kind of application of alimentation composition, applied to being prepared into tumour non-whole nutritional formula food, milk
Powder, cultured milk.
The present invention also provides a kind of method that alimentation composition is prepared into tumour non-whole nutritional formula food, including following
Step：Crush：After taking chitosan oligosaccharide, brown alga oligose, coriolan, astaxanthin to be ground into fine powder, standby shell is formed after crossing 80 mesh sieves
Oligosaccharides powder, brown alga oligose powder, coriolan powder, astaxanthin powder；Dispensing：In a manner of equivalent progressively increases mixing, by human milk oligosaccharides, agate
Coffee extract, auxiliary material are well mixed with standby chitosan oligosaccharide powder, brown alga oligose powder, coriolan powder, astaxanthin powder to be made powdery and mixes
Compound；It is total mixed：After appropriate auxiliary material is added in the pulverulent mixture being mixed, total mixed 5 in three-dimensional motion mixer
~15min；Sieve, be filling：After pulverulent mixture after total mix is crossed into 24 mesh sieves, specification, is distributed into corresponding specification as desired
Finished product.
Further, the auxiliary material includes glidant, forming agent.
Further, the glidant includes superfine silica gel powder, and the forming agent includes konjaku flour.
The present invention also provides a kind of method that alimentation composition is prepared into milk powder, comprises the following steps：Dispensing：Take shell few
Sugar, human milk oligosaccharides, brown alga oligose, coriolan, Maca extract, astaxanthin, auxiliary material, after adding the pure water of 6-10 times of volume
Form mixed solution；Homogeneous：The mixed solution is poured into the tank body of high pressure homogenizer, homogeneous is carried out under 10~20MPa
30~45min；Dry：By the mixed solution after homogeneous EAT be 120~160 DEG C, feed rate be 10.50~
Under conditions of 14.50mL/min, it is spray-dried, obtains powder product；Packaging：Specification as desired, powder product is entered
Product of the row vacuum packaging into corresponding specification.
Further, the auxiliary material includes forming agent, flavouring.
Further, the forming agent includes amylum pregelatinisatum, and the flavouring includes white granulated sugar.
The present invention also provides a kind of method that alimentation composition is prepared into cultured milk, comprises the following steps：Primary batching system：
Chitosan oligosaccharide, human milk oligosaccharides, brown alga oligose, coriolan, Maca extract, astaxanthin are prepared into preliminary mixture；It is secondary to match somebody with somebody
Material：Stirred after adding auxiliary material in material-compound tank, add after appropriate auxiliary material and continue stirring and form mixed liquor；Preheating：Preheating
Temperature is that the mixed liquor is preheated at 60~65 DEG C；Homogeneous：Will preheating under 180~200bar using high pressure homogenizer
Mixed liquor afterwards carries out homogeneous；Sterilization：Continuous sterilization is carried out 300 seconds to the mixed liquor after homogeneous at being 92~98 DEG C in temperature；
Once cool down：Mixed liquor after sterilization is cooled to 41~43 DEG C of chilling temperature；Inoculation：Mixed liquor after cooling is poured into
Fermentation tank 1/3 when, add auxiliary material again, wait terminate feed after, stir 10~15 minutes；Fermentation：After stopping stirring, start to count
When ferment, by fermentation termination control in 70-75 ° of T；Secondary cooling, addition：Mixed liquor after fermentation is cooled to 18~22 DEG C
Afterwards, preliminary mixture is added；It is filling：Finished product is formed after squeezing into cultured milk basin, finished product was put in storage in 2 hours, and at 2~6 DEG C
It is lower to place more than 12 hours.
Further, second batch：Add in material-compound tank in the auxiliary material and stirred after milk solution, add appropriate institute
Flavouring in auxiliary material is stated, continues stirring after lactic acid bacteria and forms mixed liquor；Wherein, the milk solution is entered by pure water, cow's milk
Row is adjusted breast and made；Inoculation：When mixed liquor after cooling is poured into the 1/3 of fermentation tank, the lactic acid that adds again in the auxiliary material
Bacterium, after terminating to feed, stir 10~15 minutes.
Compared with prior art, the alimentation composition after a kind of oncotherapy provided by the invention and its application, have with
Lower beneficial effect：
1) alimentation composition in the present invention after oncotherapy, radiotherapy or treatment malignant tumor patient are received available for conditioning
Condition, strengthen healthy tendency, help it to get well, and safety have no side effect.Said composition is different from medicine, and medicine has
Toxic side effect, it is long-term use of inevitably to produce " drug induced disease ", and take said composition and this problem is not present.
The products taste of the present invention is good, makes simply, and nutritious, physiologically active ingredient content is high, has healthy dietotherapy concurrently
Effect, the health of people and quality of life can be improved as a kind of new formula food with healthcare function.
2) it is first that chitosan oligosaccharide, brown alga is few when 2) alimentation composition is prepared into tumour non-whole nutritional formula food by the present invention
Sugar, coriolan, astaxanthin crush, and add human milk oligosaccharides, Maca extract, auxiliary material；Component is carried out in batches according to valuable
Add, amount takes the mode of equal increments to add less；Always mixed purpose is to mix；After crossing 80 mesh so that component raw material is in granularity 80
Below mesh, it is easy to absorb；24 mesh are after preparation technology, and 24 mesh prevent middle caking or have debris, and simultaneous band is again
The effect of mixing.
3) no longer it is directly to crush when alimentation composition is prepared into milk powder by the present invention, and is formed into mixed solution, 10
Under~20MPa carry out 30~45min of homogeneous, EAT be 120~160 DEG C, feed rate be 10.50~14.50mL/
It is dried under conditions of min, its purpose make it that formed product and outward appearance are preferable.
4) when alimentation composition is prepared into cultured milk by the present invention, first preheated at 60~65 DEG C, under 180~200bar
Homogeneous, it is easy to so that component raw material is disperseed.
Embodiment
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, it is described below the present invention's
Embodiment.It should be evident that description is only some embodiments of the present invention below, for ordinary skill people
For member, on the premise of not paying creative work, other embodiments can also be obtained.
Embodiment 1
1st, each component raw material of the alimentation composition after oncotherapy：
In parts by weight, 100 parts of chitosan oligosaccharides are taken, 15 parts of human milk oligosaccharides, 2500 parts of brown alga oligoses, 130 parts of coriolans, 70
Part Maca extract, 110 parts of astaxanthins；30 parts of superfine silica gel powders, 70 portions of konjaku flours；The superfine silica gel powder is glidant, the evil spirit
Taro powder is forming agent；The glidant, forming agent are auxiliary material.
The 2nd, above-mentioned alimentation composition is prepared into the method for tumour non-whole nutritional formula food：
Crush：100 parts of chitosan oligosaccharides, 2500 parts of brown alga oligoses, 130 parts of coriolans, 110 parts of astaxanthins are ground into fine powder
Afterwards, standby mixed powder is formed after crossing 80 mesh sieves；
Dispensing：In a manner of equivalent progressively increases mixing, 15 parts of human milk oligosaccharides, 70 parts of Maca extracts are mixed with standby mixed powder
Uniformly pulverulent mixture is made in conjunction；
It is total mixed：After 30 parts of superfine silica gel powders, 70 portions of konjaku flours are added in the pulverulent mixture being mixed, in three maintenance and operations
5~15min is always mixed in dynamic mixer；
Sieve, be canned：After pulverulent mixture after total mix is crossed into 24 mesh sieves, specification, is distributed into corresponding specification as desired
Finished product.
3rd, a kind of application of alimentation composition, applied to being prepared into tumour non-whole nutritional formula food.
Instructions of taking：When taking, after dissolving tumour non-whole nutritional formula food with appropriate warm water, directly drink,
All operations are meeting《Special medicine purposes formula food Good Manufacture Practice》It is required that clean dried environment in carry out.
Embodiment 2
1st, each component raw material of the alimentation composition after oncotherapy：
In parts by weight, 800 parts of chitosan oligosaccharides are taken, 10 parts of human milk oligosaccharides, 1500 parts of brown alga oligoses, 500 parts of coriolans, 50
Part Maca extract, 500 parts of astaxanthins；35 parts of superfine silica gel powders, 65 portions of konjaku flours；The superfine silica gel powder is glidant, the evil spirit
Taro powder is forming agent；The glidant, konjaku flour are auxiliary material.
The 2nd, above-mentioned alimentation composition is prepared into the method for tumour non-whole nutritional formula food：
Crush：800 parts of chitosan oligosaccharides, 1500 parts of brown alga oligoses, 500 parts of coriolans, 500 parts of astaxanthins are ground into fine powder
Afterwards, standby mixed powder is formed after crossing 80 mesh sieves；
Dispensing：In a manner of equivalent progressively increases mixing, by 10 parts of human milk oligosaccharides, 50 parts of Maca extracts, superfine silica gel powder with it is standby
Pulverulent mixture is made with mixed powder is well mixed；
It is total mixed：After 35 parts of superfine silica gel powders, 65 portions of konjaku flours are added in the pulverulent mixture being mixed, in three maintenance and operations
5~15min is always mixed in dynamic mixer；
Sieve, be canned：After pulverulent mixture after total mix is crossed into 24 mesh sieves, specification, is distributed into corresponding specification as desired
Finished product.
3rd, a kind of application of alimentation composition, applied to being prepared into tumour non-whole nutritional formula food.
Instructions of taking：When taking, after dissolving tumour non-whole nutritional formula food with appropriate warm water, directly drink,
All operations are meeting《Special medicine purposes formula food Good Manufacture Practice》It is required that clean dried environment in carry out.
Embodiment 3
1st, each component raw material of the alimentation composition after oncotherapy：
In parts by weight, 1500 parts of chitosan oligosaccharides are taken, 300 parts of human milk oligosaccharides, 3000 parts of brown alga oligoses, 350 parts of coriolans,
1500 parts of Maca extracts, 50 parts of astaxanthins；250 parts of auxiliary materials；The auxiliary material includes forming agent, flavouring；The forming agent is adopted
With amylum pregelatinisatum, the flavouring uses white granulated sugar；The accounting of amylum pregelatinisatum and white granulated sugar is the 3%-10% of total amount.
The 2nd, above-mentioned alimentation composition is prepared into the method for milk powder：
Dispensing：Take 1500 parts of chitosan oligosaccharides, 300 parts of human milk oligosaccharides, 3000 parts of brown alga oligoses, 350 parts of coriolans, 1500 parts
Maca extract, 50 parts of astaxanthins, 250 parts of amylum pregelatinisatums and white granulated sugar, formation is mixed after adding the pure water of 6-10 times of volume
Close solution；
Homogeneous：The mixed solution is poured into the tank body of high pressure homogenizer, under 10~20MPa carry out homogeneous 30~
45min；
Dry：By the mixed solution after homogeneous EAT be 120~160 DEG C, feed rate be 10.50~
Under conditions of 14.50mL/min, it is spray-dried, obtains powder product；
Packaging：Specification as desired, powder product is vacuum-packed into the product of corresponding specification.
3rd, a kind of application of alimentation composition, applied to being prepared into milk powder.
Instructions of taking：When taking, after dissolving milk powder with appropriate warm water, directly drink, all operations are meeting
《Special medicine purposes formula food Good Manufacture Practice》It is required that clean dried environment in carry out.
Embodiment 4
1st, each component raw material of the alimentation composition after oncotherapy：
In parts by weight, 500 parts of chitosan oligosaccharides are taken, 500 parts of human milk oligosaccharides, 200 parts of brown alga oligoses, 100 parts of coriolans,
2000 parts of Maca extracts, 500 parts of astaxanthins；250 parts of auxiliary materials；The auxiliary material includes forming agent, flavouring；The forming agent is adopted
With amylum pregelatinisatum, the flavouring uses white granulated sugar；Amylum pregelatinisatum or with 3%-10% that the accounting of white granulated sugar is total amount.
The 2nd, above-mentioned alimentation composition is prepared into the method for milk powder：
Dispensing：Take 500 parts of chitosan oligosaccharides, 500 parts of human milk oligosaccharides, 200 parts of brown alga oligoses, 100 parts of coriolans, 2000 parts of agates
Coffee extract, 500 parts of astaxanthins, 250 parts of amylum pregelatinisatums and white granulated sugar, mixing is formed after adding the pure water of 6-10 times of volume
Solution；
Homogeneous：The mixed solution is poured into the tank body of high pressure homogenizer, under 10~20MPa carry out homogeneous 30~
45min；
Dry：By the mixed solution after homogeneous EAT be 120~160 DEG C, feed rate be 10.50~
Under conditions of 14.50mL/min, it is spray-dried, obtains powder product；
Packaging：Specification as desired, powder product is vacuum-packed into the product of corresponding specification.
3rd, a kind of application of alimentation composition, applied to being prepared into milk powder.
Instructions of taking：When taking, after dissolving milk powder with appropriate warm water, directly drink, all operations are meeting
《Special medicine purposes formula food Good Manufacture Practice》It is required that clean dried environment in carry out.
Embodiment 5
1st, each component raw material of the alimentation composition after oncotherapy：
In parts by weight, 110 parts of chitosan oligosaccharides are taken, 20 parts of human milk oligosaccharides, 800 parts of brown alga oligoses, 150 parts of coriolans, 100
Part Maca extract, 200 parts of astaxanthins；8620 parts of auxiliary materials；The auxiliary material includes milk solution, flavouring, lactic acid bacteria；It is described to rectify
Taste agent includes honey element, pectin.
The 2nd, above-mentioned alimentation composition is prepared into the method for cultured milk：
Primary batching system：By 110 parts of oligosaccharides, 20 parts of human milk oligosaccharides, 800 parts of brown alga oligoses, 150 parts of coriolans, 100 parts of agates
Coffee extract, 200 parts of astaxanthins are prepared into preliminary mixture；
Second batch：In material-compound tank add 8500 parts of milk solutions after stir, add 40 parts honey element, 20 portions of fruits
Continue stirring after glue, 30 parts of lactic acid bacterias and form mixed liquor；Wherein, the milk solution by pure water, cow's milk carry out adjust breast and
System；
Preheating：The mixed liquor is preheated at being 60~65 DEG C in preheating temperature；
Homogeneous：The mixed liquor after preheating is subjected to homogeneous under 180~200bar using high pressure homogenizer；
Sterilization：Continuous sterilization is carried out 300 seconds to the mixed liquor after homogeneous at being 92~98 DEG C in temperature；
Once cool down：Mixed liquor after sterilization is cooled to 41~43 DEG C of chilling temperature；
Inoculation：When mixed liquor after cooling is poured into the 1/3 of fermentation tank, 30 parts of lactic acid bacterias are added again, are entered to the end of
After material, stir 10~15 minutes；
Fermentation：After stopping stirring, start timing fermentation, fermentation termination is controlled in 70-75 ° of T；
Secondary cooling, addition：After mixed liquor after fermentation is cooled into 18~22 DEG C, preliminary mixture is added；
It is filling：Finished product is formed after squeezing into cultured milk basin, finished product was put in storage in 2 hours, and placement 12 is small at 2~6 DEG C
When more than.
3rd, a kind of application of alimentation composition, applied to being prepared into cultured milk.Instructions of taking：After opening basin, directly drink
With；Cultured milk has simultaneously promotes the nutritional ingredient recovered after tumor operation, nutritious, mouthfeel is novel.
It should be noted that：Except the alimentation composition after oncotherapy is prepared into the non-full nutrient formulation food of tumour
Product, milk powder, outside cultured milk, the alimentation composition after oncotherapy can also be prepared into solid beverage etc..
In the above-described embodiments, chitosan oligosaccharide (Chtiosnaoligosaccharide, COS), it is called Chitosan poly oligosaccharide, oligomeric
Chitosan, it is a kind of degree of polymerization for obtaining chitosan through special bio-enzyme degradation oligosaccharide product, molecular weight between 2~20
≤ 3200Da, water-soluble preferable, easy absorption, low molecular weight product degradable, bioactivity is high.Chitosan oligosaccharide has regulation dynamic
The metabolic activity of microorganism in thing enteron aisle, improve intestinal microflora distribution, promote bifid bar mattress growth and breeding, so as to improve
Immunity of organisms, decline pH in enteron aisle, suppress harmful intestinal tract bacteria growing, produce B family vitamin, decompose carcinogen, promote
Enterocinesia, promote protein adsorption and other effects.It is widely used in food and field of medicaments.
Human milk oligosaccharides (HMO) are the oligosaccharide that the one kind being present in natural breast milk is made up of 2-10 monose, are generally acknowledged
There is the natural molecule of very high potentiality in nutrition and biomedical applications field.Available for improvement baby, child, Er Tonghuo
The digestive tract function of adult and the alimentation composition of immunity, the immune of baby is mainly influenceed by the influence to flora indirectly
System, growth and the maturation of alimentary canal barrier, regulation gut flora, the growth for being advantageous to probiotics, defence breathing system can be improved
The infection of system and urinary system, regulation immune system improve immunity of organisms and Subhealth treating.
Brown alga oligose (Alginateoligosaccharides), also known as algin oligosaccharide, it is by degrading by algin
Obtained oligomer.The brown algae plant such as sea-tangle, sargassum, bulk kelp is mostly come from, there is antitumor, enhancing to be immunized, growth-promoting
A variety of physiologically actives such as long.
Algae oligosaccharides is the oligomer of algin, is a kind of functional oligosaccharide.Brown alga oligose is by β-D mannuronic acids (ManA)
It is formed by connecting with its C-5 epimer α-L guluronic acid (GulA) by 1-4 glycosidic bonds.Brown alga oligose molecular weight is low, no
Only water-soluble strong, stability is high, and has many bioactivity, such as antitumor, anti-oxidant, antibacterial, growth promotion.
Coriolan (PSK), it is a kind of active polysaccharide extracted from prepared from coriolus versicolor mycelium or rainbow conk nutrient solution, has a variety of
Bioactivity, it is internationally recognized efficient immunopotentiating agent.Cancer metastasis can be not only resisted, immunological regulation can also be promoted
Effect, and learning and memory function can be effectively improved, it is a kind of polysaccharide of good protection organism physiological function.
Maca (Lepidium meyenii), also known as agate card, Peru's ginseng etc. are more containing maca ene, macamide, maca
The multiple components such as sugar, glucosinolate and its derivative, it is nutritious, there is dispelling fatigue, compressive resistance, improve immune, alleviation more
Term syndrome, anti-prostatic hyperplasia, improve the physiological actions such as sexual function.Research shows that maca is recovered to sub-health state crowd
Health has good corrective action.But due to some functional components in maca, such as polysaccharide, glucosinolate, alkaloid,
Structure can be destroyed under long-time high temperature action, lose effect, and normal temperature extraction time is very long, recovery rate is low, causes resource unrestrained
Take, and the both effectiveness existing water-soluble components of maca, also there are lipid soluble ingredients, single solvent extracts not exclusively to effective component,
Cause the wasting of resources, therefore, Maca extract used in the present invention, using the concentration of ultrasound-enhanced normal temperature rapid extraction-low temperature and
Dry and be made, it is therefore prevented that thermal sensitivity effective component activity is destroyed, and obtained high activity Maca extract.
Astaxanthin (Astaxanthin) is a kind of former carotenoid of non-vitamin A, be primarily present in haematococcus pluvialis,
In the biology such as shrimp, crab, salmon.As a kind of natural pigment, astaxanthin is safe and non-toxic, aboundresources, bright in luster.With anti-
The bioactivity such as oxidation, prevention of cardiovascular disease and diabetic nephropathy, are a kind of potential resource medicines.
It should be noted that above-described embodiment can independent assortment as needed.Described above is only the preferred of the present invention
Embodiment, it is noted that for those skilled in the art, do not departing from the premise of the principle of the invention
Under, some improvements and modifications can also be made, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (10)
1. the alimentation composition after a kind of oncotherapy, it is characterised in that including following component：
In parts by weight, chitosan oligosaccharide is 100~1500 parts, and human milk oligosaccharides are 10~500 parts, and brown alga oligose is 200~3000 parts,
Coriolan is 100~500 parts, and Maca extract is 50~2000 parts, and astaxanthin is 50~500 parts；Auxiliary material 100~9000
Part.
A kind of 2. application of alimentation composition as claimed in claim 1, it is characterised in that：Applied to being prepared into, tumour is non-to seek entirely
Support formula food, milk powder, cultured milk.
3. a kind of method that alimentation composition as claimed in claim 1 is prepared into tumour non-whole nutritional formula food, it is special
Sign is, comprises the following steps：
Crush：After taking chitosan oligosaccharide, brown alga oligose, coriolan, astaxanthin to be ground into fine powder, standby mixing is formed after crossing 80 mesh sieves
Powder；
Dispensing：In a manner of equivalent progressively increases mixing, human milk oligosaccharides, Maca extract, auxiliary material are well mixed with standby mixed powder
Pulverulent mixture is made；
It is total mixed：After appropriate auxiliary material is added in the pulverulent mixture being mixed, total mixed 5 in three-dimensional motion mixer~
15min；
Sieve, be filling：Will it is total mixed after pulverulent mixture cross 24 mesh sieves after, specification as desired, be distributed into corresponding specification into
Product.
4. the preparation method of tumour non-whole nutritional formula food as claimed in claim 3, it is characterised in that：The auxiliary material includes
Glidant, forming agent.
5. the preparation method of tumour non-whole nutritional formula food as claimed in claim 4, it is characterised in that：The glidant bag
Superfine silica gel powder is included, the forming agent includes konjaku flour.
A kind of 6. method that alimentation composition as claimed in claim 1 is prepared into milk powder, it is characterised in that including following step
Suddenly：
Dispensing：Chitosan oligosaccharide, human milk oligosaccharides, brown alga oligose, coriolan, Maca extract, astaxanthin, auxiliary material are taken, adds 6-10
Mixed solution is formed after the pure water of times volume；
Homogeneous：The mixed solution is poured into the tank body of high pressure homogenizer, 30~45min of homogeneous is carried out under 10~20MPa；
Dry：By the mixed solution after homogeneous EAT be 120~160 DEG C, feed rate be 10.50~14.50mL/
Under conditions of min, it is spray-dried, obtains powder product；
Packaging：Specification as desired, powder product is vacuum-packed into the product of corresponding specification.
7. method for preparing milk as claimed in claim 6, it is characterised in that：The auxiliary material includes forming agent, flavouring.
8. method for preparing milk as claimed in claim 7, it is characterised in that：The forming agent includes amylum pregelatinisatum, described
Flavouring includes white granulated sugar.
A kind of 9. method that alimentation composition as claimed in claim 1 is prepared into cultured milk, it is characterised in that including following
Step：
Primary batching system：Chitosan oligosaccharide, human milk oligosaccharides, brown alga oligose, coriolan, Maca extract, astaxanthin are prepared into standby
Mixture；
Second batch：Stirred after adding auxiliary material in material-compound tank, add after appropriate auxiliary material and continue stirring and form mixed liquor；
Preheating：The mixed liquor is preheated at being 60~65 DEG C in preheating temperature；
Homogeneous：The mixed liquor after preheating is subjected to homogeneous under 180~200bar using high pressure homogenizer；
Sterilization：Continuous sterilization is carried out 300 seconds to the mixed liquor after homogeneous at being 92~98 DEG C in temperature；
Once cool down：Mixed liquor after sterilization is cooled to 41~43 DEG C of chilling temperature；
Inoculation：When mixed liquor after cooling is poured into the 1/3 of fermentation tank, auxiliary material is added again, after terminating to feed, stirring 10
~15 minutes；
Fermentation：After stopping stirring, start timing fermentation, fermentation termination is controlled in 70-75 ° of T；
Secondary cooling, addition：After mixed liquor after fermentation is cooled into 18~22 DEG C, preliminary mixture is added；
It is filling：Form finished product after squeezing into cultured milk basin, finished product was put in storage in 2 hours, and place at 2~6 DEG C 12 hours with
On.
10. cultured milk preparation method as claimed in claim 9, it is characterised in that：
Second batch：Add in material-compound tank in the auxiliary material and stirred after milk solution, add in the appropriate auxiliary material and rectify
Continue stirring after taste agent, lactic acid bacteria and form mixed liquor；Wherein, the milk solution carries out adjusting breast to make by pure water, cow's milk；
Inoculation：When mixed liquor after cooling is poured into the 1/3 of fermentation tank, the lactic acid bacteria that adds again in the auxiliary material waits to tie
After beam charging, stir 10~15 minutes.
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Application publication date: 20171124 |