CN101653283A - Chitosan oligosaccharide drinking water - Google Patents
Chitosan oligosaccharide drinking water Download PDFInfo
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- CN101653283A CN101653283A CN200910187315A CN200910187315A CN101653283A CN 101653283 A CN101653283 A CN 101653283A CN 200910187315 A CN200910187315 A CN 200910187315A CN 200910187315 A CN200910187315 A CN 200910187315A CN 101653283 A CN101653283 A CN 101653283A
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- chitosan oligosaccharide
- drinking water
- oligosaccharide
- chitosan
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- 239000003651 drinking water Substances 0.000 title claims abstract description 15
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Abstract
The invention relates to chitosan oligosaccharide drinking water which belongs to the field of drinks and is prepared by purified water. The chitosan oligosaccharide drinking water is prepared from the following materials by weight percent: 99.76 percent of purified water, 0.1 percent of chitosan oligosaccharide and 0.14 percent of lower polyxylose, wherein the purity of the chitosan oligosaccharide and the lower polyxylose is above 95 percent. The materials are mixed and dissolved into solution and then prepared into bottled or caned drinks according to the prior filling technique. The materials with functions can be added into purified water without affecting the mouth feel of water. The drinking water can be used as a novel drink for popularization and to improve the health of people.
Description
Technical field
The present invention relates to a kind of drink, particularly relate to a kind of drinking water by the chitosan oligosaccharide preparation.
Background technology
Chitosan oligosaccharide is as natural macromolecule amylose, in international chitin conference in 1991, just be described as the necessary the sixth-largest vital principle except sugar, protein, fat, vitamin and mineral matter of human body, itself just can be used as functional health-care food, satisfies people's needs.For the toxicity Journal of Sex Research of chitosan oligosaccharide as far back as nineteen sixty-eight just the someone did experiment, press the chitosan oligosaccharide of 18g/Kg body weight metering every day and feed small white mouse, can not produce harm to its growth, Landes and Bough also have similar report.These experiments all provide favourable evidence for the security of chitosan oligosaccharide.Chitosan oligosaccharide is as the unique alkaline polysaccharide of occurring in nature, and the biologically active height is nontoxic, have no side effect, can be by the human body fast Absorption.The health food that with the chitosan oligosaccharide is main material production can improve the immunity of collective, and activating cell promotes the hyperplasia of beneficial bacteriums such as intestinal bifidobacteria, and suppresses to have the generation of toadstool.The edible food that contains chitosan oligosaccharide, a kind of food of making as chitosan oligosaccharide and acid polysaccharide (carragheen, pectin etc.) adds and fills agent, human body there is the function that reduces cholesterol, raising immunity of organisms, gastric acid inhibitory secretion and regulate the human body microelement level, can be used for treating obesity, coronary heart disease and various gastroenteritic ulcer disease, also have the effect that suppresses activity of tumor cells simultaneously.
The main area of consumption of chitosan oligosaccharide is in countries such as Japan and Korea S., U.S., method, Russia at present.Korea S promptly ratified chitosan oligosaccharide in 1996 be functional health-care food, existing now more than the 20 kind of chitosan oligosaccharide class health food of China.The chitosan oligosaccharide annual requirement reaches 240 tons, estimates that annual requirement will be to be higher than 30% speed increase.
Because having three, chitosan oligosaccharide (shitosan) regulates (immunological regulation, pH value adjusting, hormone are regulated), three get rid of (get rid of bad cholesterol, get rid of the in-vivo metal ion, get rid of toxin such as agricultural chemicals and itinei free radical), three fall (reducing blood lipid, hypoglycemic, hypotensive) effect, therefore are considered to the second generation health food after vitamin, the extract of malt and milk and lecithin, spirulina.In health products, can partly utilize these functions of chitosan oligosaccharide/chitosan oligosaccharide.Chitosan oligosaccharide is different from medicine, and medicine is toxic side effect all, takes for a long time unavoidably and can produce " drug induced disease ", does not have this problem and take chitosan oligosaccharide/chitosan oligosaccharide.At present, chitosan oligosaccharide is confirmed to belong to " being known as usually is safe (GRAS) " material by USFDA, and this will further clear away the obstacles for chitosan oligosaccharide is used for food industry.Anticancer food: the PH of the internal environment of human body endolymph cell changes very responsive, when PH descends, its activity also descends thereupon, immune function of human body is destroyed, because chitosan oligosaccharide can make the PH tendency alkalescent of body fluid, thereby improved lymphocytic activity, the vigor of lymphocyte destruction cancer cell is strengthened, it has arrived the effect of cancer-resisting.Can be used for food additives: chitosan oligosaccharide has functions such as can reducing cholesterol, the necessary metal element content of adjusting human body, the heat that reduces food, immunity, slowly-releasing, thereby chitosan oligosaccharide can be used as the additive of many functional food.Chitin, chitosan oligosaccharide and derivative thereof can also be as the additives of the food such as scarvenger, bread and biscuit of the antisettling agent of the clearer of drinks and various beverages, vinegar, raw material syrup.In addition, pyrolytic crust mass shell produces aromatic substance, and the enriching substance that they can be used as natural flavor is added in bread, the cake.Can be used for food antioxidant: owing to contain highly unsaturated fatty acid in the meat product, its be easy to oxidation and cause food spoiled, addle, therefore usually need in this based food, add antioxidant so that preservation.Chitosan oligosaccharide has been obtained many progress in recent years as novel antioxidant.People such as Darmadji have studied the antioxidant of handling beef through chitosan oligosaccharide, and result of the test shows that after 1% chitosan oligosaccharide was handled, beef was preserved 3 days at 4 ℃, and beef matter TBA value has reduced 70%; People such as Shahidi have reported N, and O-carboxymethyl chitosan oligosaccharide salt (NOCC) is to the non-oxidizability of cooked meat and the maintenance of local flavor, and the result shows that after 500g/kgNOCC handled, its average inhibiting rate can reach 66.3%.About oxidation resistant mechanism, mainly think that chitosan oligosaccharide and derivative thereof can form chelate with the free iron ion that meat product discharges at present when heating, thereby suppress the catalytic activity of iron ion, the oxidation resistant effect that plays.Can be used for food preservative: its hydrolysate of chitosan oligosaccharide and chitosan oligosaccharide has good inhibition effect to many fungies, therefore can make anticorrisive agent in food, prolongs the food preservation time.Chitin derivativ gets most of the attention in recent years as a kind of natural antiseptic, and its effect aspect antibacterium is very obvious.People such as Simposn have reported that chitosan oligosaccharide is to different bacterium culture medium anti-microbial property, and different chitosan oligosaccharide concentration are to antibiotic Effect on Performance, the result shows, 0.02% chitosan oligosaccharide concentration is enough to suppress the growth of bacillus, and to Escherichia coli and salmonella, the chitosan oligosaccharide fungistatic effect of 0.005% concentration can reach 90%, and when chitosan oligosaccharide concentration reaches 0.0075%, fully bacteria growing inhibiting.Sudharshan studies the anti-microbial property of water-soluble chitosan oligosaccharide lactate buffer solution, ethylene glycol chitosan oligosaccharide, found that, both have good inhibitory effect to gram-positive bacteria and Gram-negative bacteria.And Papineau further discovers, the bacteriostasis property of ethylene glycol chitosan oligosaccharide is more obvious than the chitosan oligosaccharide lactate buffer solution.People such as Zheng Lianying have investigated the bacteriostasis property of different molecular weight chitosan oligosaccharide to Escherichia coli and golden yellow staphylococcus, find that molecular weight is 20,000 when following, chitosan oligosaccharide weakens along with the increase of molecular weight gradually to the antibacterial action of golden yellow staphylococcus, and the increase along with molecular weight strengthens gradually to colibacillary fungistatic effect, and antibiotic mechanism has been carried out preliminary discussion.
In view of the above effect of chitosan oligosaccharide, it is extremely important just to seem in the exploitation of beverage products, and chitosan oligosaccharide is nontoxic as functional food, safety.By preparing the health beverages that a kind of mouthfeel is good, the chitosan oligosaccharide composition is arranged, particularly milk is made drink, and the social effect of its product, economic implications are very large, and exploitation has the milk system drink of the chitosan oligosaccharide series function of function to bring tremendous influence to human health.
Summary of the invention
The object of the present invention is to provide a kind of based on drinking water, the drink of health products composition such as chitosan oligosaccharide is arranged, the prescription by modulation also makes that this drink price is lower, is suitable for and drinks, thereby reaches the purpose of popularized consumption, healht-care.
The objective of the invention is to be achieved through the following technical solutions:
Chitosan oligosaccharide drinking water is got pure water preparation chitosan oligosaccharide drinking water, is formulated as follows by following percentage by weight:
Pure water 99.76%;
Chitosan oligosaccharide 0.1%;
Xylo-oligosaccharide 0.14%;
Then above components dissolved is mixed into solution, by existing filling process make the bottle or tinned drink get final product.
Described chitosan oligosaccharide drinking water is characterized in that, the purity of described chitosan oligosaccharide, xylo-oligosaccharide should be more than 95%.
Advantage of the present invention and effect are:
Chitosan oligosaccharide is the intrinsic material of cell, does not have rejection, and pair cell has good compatibility; Be the positively charged animal-type cellulose of unique existence in the universe of finding at present, can adsorb the electronegative pathogen of body, and pathogen is excreted; Alkalescent physique helps healthy, and chitosan oligosaccharide is the valuable material that meta-alkalescence in the body is advanced at the place, in the energy and acidic constitution, purifies internal milieu; Can activate and repair damaged cells; Shitosan and chitosan oligosaccharide can effectively be regulated immunity of organism, build up resistance.The chitosan oligosaccharide deficiency causes the damaged of oligonucleotide chain easily, and the cell surface layer oligonucleotide chain is in a single day damaged, will cause all kinds of diseases.Xylo-oligosaccharide claims wood oligose again, has to promote calcium, iron to absorb, suppress pathogen and diarrhoea, protection liver, anticancer, etc. function.Have the material composition of functional effect to be blended in the milk liquid these, popularize and promote people's physical constitution as a kind of novel drink, its meaning is very huge.
Description of drawings
Fig. 1 is the chemical structural formula of chitin;
Fig. 2 is the chemical structural formula of shitosan.
The specific embodiment
The present invention is described in detail with reference to the accompanying drawings:
Name to chitin and shitosan, chitosan oligosaccharide is various, if not from essence, promptly on the molecular structure understanding it just be easy to obscure.Chitin English is referred to as chitin, is that it means the meaning of " shell, armor, tunicle, coating, big envelope " by the Greek development.The Chinese translation is a lot.From chemical constitution name, " chitin ", " shitosan ", " polyethylene Glucosamine ", " chitin ", " chitin ", " chitosan " or the like.
Chitin (Chitin, monomer)
Chitin, chemical constitution name, N-acetyl-2 amino-2 DDG.(Fig. 1)
Shitosan (Chitosan, monomer) with the chemistry method, methods such as enzyme process, oxidizing process, sodium perborate acetyl group is taken off (CO-CH3), that is, 2-amino-2 DDG (Fig. 2).The basic composition unit of shitosan.Its molecular weight is at 50-100 ten thousand.
Chitosan oligosaccharide (chitosan oligosaccharides)
Promptly be referred to as chitosan oligosaccharide if with methods such as acid-hydrolysis method, oxidizing process, enzymolysis big molecular chitosan is made little molecule again.If make molecular weight about 2000, or water-soluble, be referred to as low-molecular weight chitoglycan.But the scope of the definite molecular weight of chitosan oligosaccharide has the scholar to think to be referred to as chitosan oligosaccharide at 20 monomers with interior (20 Glucosamines, or claim 20 Glucosamine bases).It is generally acknowledged that water-soluble (molecular weight is about 2000D) can become chitosan oligosaccharide.How many chitosan oligosaccharides is to determine it to bring into play the key of its function the alimentary canal absorption.Studies confirm that, how many molecular weight sizes of chitosan oligosaccharide has tangible relation with intestinal absorption, the big more absorption of molecular weight is few more, their result of study is, the absorptivity of molecular weight 3.8k (MW:3.8KDa) wants high 23-25 doubly than the absorptivity of molecular weight 230k (MW:230Kda), simultaneously proved that also chitosan oligosaccharide is safe in the application of pharmaceutical preparation, value is higher.After chitosan oligosaccharide was absorbed from alimentary canal, the compatibility of it and human body cell was very good, and it is also very good to coordinate intercellular correlation.Because its nontoxic (non-medicine) and be the synthesis material of cell tissue main component, so bad rejection can not take place in it, and in a single day it be absorbed and enter in the human body, will be utilized by systemic cell and tissue.It is the important composition composition of cell and tissue still not, the more important thing is that it can regulate the function of cell, strengthen the vigor of cell.The final catabolite of chitosan oligosaccharide is the peace Glucosamine, because the molecule of chitosan oligosaccharide is little, the speed of degraded is also greatly faster than shitosan, and the probability that it is utilized (by utilizations such as tissue, tissue fluid, cells) also is far longer than shitosan.We know that amino sugar is the main component of human connective tissue, it is the important component of proteoglycans, if lack and not only to influence they self biological action (communication, transmission, identification, regulation and control ... Deng effect) and can cause some tissues, cell, matrix and a matter impaired, the function of these histoorgans of remote-effects and cell.Shitosan, chitosan oligosaccharide be this structurally to be had amino (unique texture NH2) has determined it that many unique biological functions are arranged.Man-6-P structure in the N-glycan is that glycoprotein is sorted to the sign in the lysosome, just a certain composition that function arranged is sorted to and brings into play its biological function elsewhere.Xylo-oligosaccharide claims wood oligose again, is by the functional polymerization sugar of 2-7 wood sugar molecule with β-1,4 glycosidic bond be combined into.Have and can promote calcium, iron to absorb, suppress pathogen and diarrhoea, protection liver, anticancer, etc. function.
Embodiment:
Get pure water 500 gram, get chitosan oligosaccharide 0.5 gram of 95% purity, get xylo-oligosaccharide 0.7 gram of 95% purity, carry out mixed dissolution, make bottle by existing filling process again or tinned drink gets final product.For ease of store, transportation can add a little anticorrisive agents in right amount, also can add other batching, as fruit juice etc. to increase kind and attraction.
There is the raw material of functional effect to be blended in the drinking water these, do not influence the mouthfeel of water, but can be used as the physical constitution that people were popularized and promoted to a kind of novel drink.
Claims (2)
1. chitosan oligosaccharide drinking water is got pure water preparation chitosan oligosaccharide drinking water, it is characterized in that described chitosan oligosaccharide drinking water is formulated as follows by following percentage by weight:
Pure water 99.76%;
Chitosan oligosaccharide 0.1%;
Xylo-oligosaccharide 0.14%;
Then above components dissolved is mixed into solution, by existing filling process make the bottle or tinned drink get final product.
2. chitosan oligosaccharide drinking water according to claim 1 is characterized in that the purity of described chitosan oligosaccharide, xylo-oligosaccharide should be more than 95%.
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| CN103549612A (en) * | 2013-11-07 | 2014-02-05 | 雷小康 | Drink and preparation method thereof |
| CN104824513A (en) * | 2015-05-26 | 2015-08-12 | 云南和融生物科技有限公司 | Maca moringa oleifera tablets and preparation method thereof |
| CN105639339A (en) * | 2015-12-29 | 2016-06-08 | 珠海市金隆生物科技有限公司 | Fatigue-resistance and immunity-enhancement chitosan oligosaccharide beverage and preparation method thereof |
| CN106190768A (en) * | 2016-07-22 | 2016-12-07 | 重庆修贤生物科技有限公司 | Oligofructose and oligochitosan application in vinegar goods |
| CN107373674A (en) * | 2017-08-25 | 2017-11-24 | 西宝生物科技（上海）股份有限公司 | Alimentation composition and its application after a kind of oncotherapy |
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| CN1559242A (en) * | 2004-03-12 | 2005-01-05 | 北京奥信通科技发展有限公司 | Oligo-xylose milk |
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| CN103549612A (en) * | 2013-11-07 | 2014-02-05 | 雷小康 | Drink and preparation method thereof |
| CN104824513A (en) * | 2015-05-26 | 2015-08-12 | 云南和融生物科技有限公司 | Maca moringa oleifera tablets and preparation method thereof |
| CN105639339A (en) * | 2015-12-29 | 2016-06-08 | 珠海市金隆生物科技有限公司 | Fatigue-resistance and immunity-enhancement chitosan oligosaccharide beverage and preparation method thereof |
| CN106190768A (en) * | 2016-07-22 | 2016-12-07 | 重庆修贤生物科技有限公司 | Oligofructose and oligochitosan application in vinegar goods |
| CN107373674A (en) * | 2017-08-25 | 2017-11-24 | 西宝生物科技（上海）股份有限公司 | Alimentation composition and its application after a kind of oncotherapy |
| CN108056353A (en) * | 2017-12-07 | 2018-05-22 | 青岛明药堂医疗股份有限公司 | A kind of isotonic solid beverage and its preparation, application method containing chitin derivativ |
| CN108157971A (en) * | 2018-02-08 | 2018-06-15 | 沈勇子 | A kind of chitosan oligosaccharide liquid oral medicine and preparation method thereof |
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| CN101653283B (en) | 2012-10-17 |
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