CN103860580B - It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function - Google Patents
It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function Download PDFInfo
- Publication number
- CN103860580B CN103860580B CN201410117738.6A CN201410117738A CN103860580B CN 103860580 B CN103860580 B CN 103860580B CN 201410117738 A CN201410117738 A CN 201410117738A CN 103860580 B CN103860580 B CN 103860580B
- Authority
- CN
- China
- Prior art keywords
- grifolan
- strengthen
- polysaccharide
- preparation
- decoction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to it is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function, said preparation is mainly prepared by the raw material of following percentage by weight：Grifolan 10 50%, hericium erinaceum polysaccharide 10 50%, GL-B 5 35%, pachymaran 5 35%.Traditional Chinese Medicine thinks that it is exactly building up healthful vital energy to strengthen the body resistance to consolidate the constitution, and it is basic to consolidate, i.e., so-called strengthen immunity, strengthens human disease resistance, prevention disease, away from inferior health.Grifolan, hericium erinaceum polysaccharide medicine food fungi bacteria polysaccharide, strengthen immunity, protection stomach lining, improve the adverse reaction of chemotherapy of tumors, such as lack appetite, vomiting, nausea and Neuroleptic Leukocytopenia.Ganoderma lucidum (polysaccharide), Poria cocos (polysaccharide), the traditional Chinese medical science think its air making-up and spleen enlivening, antitoxic heart-soothing and sedative, and modern study card shows its strengthen immunity, the treatment of antitumor and adjuvant therapy, treatment insomnia and indigestion.To sum up, four kinds of fungi polysaccharide reasonable compatibilities, have strengthen the body resistance to consolidate the constitution, strengthening the spleen and stomach and strengthen immunity clearly act on, adverse reaction when having remarkable result to inferior health health care, while improving chemotherapy of tumors.
Description
Technical field
The present invention relates to field of health care products, and in particular to one kind have strengthen the body resistance to consolidate the constitution, strengthening the spleen and stomach, strengthen immunity function
Composite fungi amylose preparation.
Background technology
As people live, the quickening of work rhythm, operating pressure increase, while waste gas, rubbish, industry, noise and penetrate
Line etc. pollutes, the serious living environment for damaging people, causes body to be in crowd's substantial increase of inferior health；Improve inferior health shape
State just seems significant.
Following symptom is largely suffered from the crowd of inferior health：Physically-draining, stress, resistance decline etc.；Although
Sub-health state is resisted in the market, and the Chinese medicine composition strengthened the body resistance to consolidate the constitution is many, but effect is not very obvious, and some can also
Produce some dizzy, excessive internal heats, spiritual excited side effect.
Traditional Chinese Medicine thinks that it is exactly building up healthful vital energy to strengthen the body resistance to consolidate the constitution, and it is basic to consolidate, and adjusts the resistance against diseases of human body, prevents disease
Disease, physical fitness, i.e., the strengthen immunity of so-called doctor trained in Western medicine.Fungi polysaccharide is separated from fungus sporophore, mycelium, zymotic fluid
The one kind gone out can control the active polysaccharide of cell division differentiation, regulation cell growth and aging, typically by ten molecules
The macromolecule polymer that monose above is formed by connecting by glycosidic bond.Between fungi polysaccharide molecule monomer, in large quantities with β (1-
3) combined with β (1-6) glycosidic bond, form chain molecule, there is spiral helicine spatial configuration.Scientific experiment shows that fungi polysaccharide has
There is very strong antitumor activity, there is very strong restraint to cancer cell, and in immunological regulation, lowering blood pressure and blood fat, anti-blood
Bolt, promoting digestion and protecting liver etc. plays an important role.Fungi polysaccharide has been widely used in immunodefiiciency disease, autoimmunity
The clinical treatment of the disease such as disease and tumour, thus it is referred to as a kind of important biological response modifiers.
There is also the report of the compound formulation of some fungi polysaccharides in the prior art：CN101618050A discloses a kind of tool
There is the composite fungi amylose of strengthen immunity function, the raw material that the composite fungi amylose is matched by following weight parts is prepared：
Mushroom 8~100, Poria cocos 15~100, dictyophora phalloidea 10~200, white fungus 15~80, peacilomyce hepiahi bacterium filament 2~50.
CN1275543C C, which are related to one kind, balanced to supplement a variety of nutrition and good protein, have repair gastrointestinal mucosa, it is antitumor,
Protect liver and regulation immunization composite fungi amylose nutrient, it by lentinan powder 0.5~5%, grifolan powder 0~
2%th, Morchella esculenta (L.) Pers polysaccharide powder 0.1~5%, LBP-X powder 0.5~10%, PURE WHEY 0.1~3.75%, vinegar 1~
10%th, honey 0.1~10%, hawthorn fruit powder 0.1~5%, fructus hordei germinatus powder 0.1~5%, vitamin B compound 0.01~0.1%,
Zinc lactate 0.01~1%, calcium carbonate 0.05~4%, xylo-oligosaccharide 0.5~1.5%, remaining be water, it is remained to greatest extent
The nutrient and active ingredient of various composition in composition, equilibrium supplement a variety of nutrition and good protein, there is stronger anti-chemistry
Mutagenesis, have antiviral, anti-lipid, regulation is immune, anti-platelet aggregation, antitumor, protect liver, anti-gene mutation, anti-Chinese mugwort
Grow the effect such as disease.CN201010279375A is related to a kind of composite edible fungi polysaccharides and preparation method thereof, and it is to choose mushroom, black
It is raw material that agaric, ganoderma lucidum and grifola frondosus, which do fructification, weighs in 1: 2: 2: 1 ratio and is crushed after mixing, and it is equal to add distilled water mixing
Microwave Extraction, condensation cocurrent flow extraction are carried out after even successively；Slag, liquid separation；Residue adds distilled water and carries out Microwave Extraction successively again
And condensing reflux extracts 1-2 times；Merge extract solution, be concentrated in vacuo to the 1/3-1/4 of original volume；Alcohol precipitation, alcohol are dried in vacuo after washing,
Crush, obtain composite edible fungi polysaccharides.Its composite edible fungi polysaccharides physiologically active is good, and effect is comprehensive, have it is antiviral, anti-lipid,
Adjust the functions such as immune system, anti-platelet aggregation, antitumor, protect liver, anti-gene mutation, anti-AIDS.Its preparation method is more
Sugared yield is high, and rational technology is workable.
But the Composition Aspects of compatibility composition are carried out in each polysaccharide, the preparation of these prior arts is all by with similar
The active component of effect has carried out simple combination.
The content of the invention
The purpose of the present invention is in view of the shortcomings of the prior art, there is provided a kind of composite fungi amylose preparation.Four kinds of fungies are more
Sugared reasonable compatibility, have strengthen the body resistance to consolidate the constitution, strengthening the spleen and stomach and strengthen immunity clearly act on, while when improving chemotherapy of tumors not
Good reaction.
Grifolan, hericium erinaceum polysaccharide medicine food fungi bacteria polysaccharide, strengthen immunity, protection stomach lining, can particularly improve
A variety of adverse reactions of chemotherapy of tumors band rice, such as lack appetite, vomiting, nausea and Neuroleptic Leukocytopenia.Ganoderma lucidum (polysaccharide),
Poria cocos (polysaccharide), the traditional Chinese medical science think air making-up and spleen enlivening, antitoxic heart-soothing and sedative, and modern study card shows that its strengthen immunity adjuvant therapy is treated,
Treatment insomnia and indigestion.
Realize that the present composition of above effect adopts the following technical scheme that：
A kind of composite fungi amylose preparation, is made up of the raw material of following weight percent：Grifolan 10-50%, monkey
Head mushroom polysaccharide 10-50%, GL-B 5-35%, pachymaran 5-35%.
Preferably, it is made up of the raw material of following percentage by weight：Grifolan 30%, hericium erinaceum polysaccharide 30%, ganoderma lucidum
Polysaccharide 20%, pachymaran 20%.
Preferably, it is made up of the raw material of following percentage by weight：Grifolan 40%, hericium erinaceum polysaccharide 30%, ganoderma lucidum
Polysaccharide 20%, pachymaran 10%.
Preferably, it is made up of the raw material of following percentage by weight：Grifolan 35%, hericium erinaceum polysaccharide 35%, ganoderma lucidum
Polysaccharide 15%, pachymaran 15%.
Described grifolan, hericium erinaceum polysaccharide, the preparation method of GL-B and pachymaran are：Grifola frondosus or monkey
Head mushroom or ganoderma lucidum or Poria cocos, after crushed, obtain corresponding coarse powder；Coarse powder decocting is boiled 1-3 times, every time plus 6-12 times is measured water, is decocted
1-3 hours；Decoction liquor filtering twice is merged into obtain filtrate；Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, it is relatively close to concentrate
Spend for 1.05-1.15；Add 2-6 times and measure 80-95% ethanol progress alcohol precipitation, 8-12 times of alcohol precipitation sediment addition is measured molten in purified water
Solve decoction；Decoction is spray-dried, grifolan or hericium erinaceum polysaccharide or GL-B or pachymaran can be obtained.
Preferably, the preparation method of described grifolan, hericium erinaceum polysaccharide, GL-B and pachymaran is：Ash
Tree flower or Hericium erinaceus or ganoderma lucidum or Poria cocos, after crushed, obtain corresponding coarse powder；Coarse powder decocting is boiled 3 times, every time plus 8 times are measured water, are decocted
Boil 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, it is relatively close to concentrate
Spend for 1.1；Add 5 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol precipitation sediment, which is added in 8 times of amount purified waters, dissolves to obtain decoction；By medicine
Liquid is spray-dried, and can obtain grifolan or hericium erinaceum polysaccharide or GL-B or pachymaran.
Preferably, the preparation method of described grifolan, hericium erinaceum polysaccharide, GL-B and pachymaran is：Ash
Tree flower or Hericium erinaceus or ganoderma lucidum or Poria cocos, after crushed, obtain corresponding coarse powder；Coarse powder decocting is boiled 2 times, every time plus 10 times are measured water,
Decoct 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, it is relative to concentrate
Density is 1.1；Add 4 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol precipitation sediment, which is added in 10 times of amount purified waters, dissolves to obtain decoction；Will
Decoction is spray-dried, and can obtain grifolan or hericium erinaceum polysaccharide or GL-B or pachymaran.
Embodiment
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by specific reality
Any restrictions of example are applied, but are defined in the claims.
Embodiment 1
A kind of composite fungi amylose preparation, its be respectively choose grifola frondosus, Hericium erinaceus, ganoderma lucidum or and Poria cocos, after crushed,
Obtain corresponding coarse powder；Coarse powder decocting is boiled 3 times, every time plus 8 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged and must filtered
Liquid；Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 5 times of 95% ethanol of amount and carry out alcohol
Heavy, alcohol precipitation sediment, which is added in 8 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, can obtain grifolan or
Hericium erinaceum polysaccharide or GL-B or pachymaran.
According to weight than choosing grifolan 30%, hericium erinaceum polysaccharide 30%, GL-B 20%, pachymaran 20%
Cross respectively 80 mesh sieves and add appropriate dextrin, sodium carboxymethylcellulose is well mixed, pelletize, dry, add appropriate stearic acid
Magnesium is well mixed, and direct tablet compressing produces tablet.Every weighs about 0.545g.
Embodiment 2
A kind of composite fungi amylose preparation, its be respectively choose grifola frondosus, Hericium erinaceus, ganoderma lucidum or and Poria cocos, after crushed,
Obtain corresponding coarse powder；Coarse powder decocting is boiled 3 times, every time plus 8 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged and must filtered
Liquid；Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 5 times of 95% ethanol of amount and carry out alcohol
Heavy, alcohol precipitation sediment, which is added in 8 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, can obtain grifolan or
Hericium erinaceum polysaccharide or GL-B or pachymaran.
According to weight than choosing grifolan 40%, hericium erinaceum polysaccharide 30%, GL-B 20%, pachymaran 10%
80 mesh sieves are crossed respectively and add appropriate dextrin, sucrose, mixed pelletization, are drying to obtain granule.
Embodiment 3
A kind of composite fungi amylose preparation, it is to choose grifola frondosus, Hericium erinaceus, ganoderma lucidum and Poria cocos respectively, after crushed, is obtained
Corresponding coarse powder；Coarse powder decocting is boiled 2 times, every time plus 10 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；
Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 4 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol
Heavy starch, which is added in 10 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, grifolan or hedgehog hydnum can be obtained
Mushroom polysaccharide or GL-B or pachymaran.
According to weight than choosing grifolan 30%, hericium erinaceum polysaccharide 30%6, GL-B 20%, pachymaran
20% crosses 80 mesh sieves and adds appropriate magnesium stearate and be well mixed respectively, is fitted into capsule and capsule is made, in every capsule contains
Tolerant 0.25g.
Embodiment 4
A kind of composite fungi amylose preparation, it is to choose grifola frondosus, Hericium erinaceus, ganoderma lucidum and Poria cocos respectively, after crushed, is obtained
Corresponding coarse powder；Coarse powder decocting is boiled 2 times, every time plus 10 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；
Filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 4 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol
Heavy starch, which is added in 10 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, grifolan or hedgehog hydnum can be obtained
Mushroom polysaccharide or GL-B or pachymaran.
According to weight than choosing grifolan 35%, hericium erinaceum polysaccharide 35%, GL-B 15%, pachymaran 15%
Mixing, 80 mesh sieves are crossed respectively and adds appropriate magnesium stearate and is well mixed, is fitted into capsule and capsule is made, in every capsule contains
Tolerant 0.5g.
The model case of embodiment 5
30 volunteers's (age 45-55 year), immunity is more low, often flu, and average every half a year catches a cold 2 times.Will
It is randomly divided into 2 groups, and every group of 15 people, A groups (average age 48.9 years old) are placebo, are taken using capsule made of starch
Agent；B groups (average age 49.5 years old) are of the present invention group, take the capsule of the method preparation using embodiment 3.Two groups daily
Sooner or later each 4 of capsule bfore meals, continuously take 1 year, other habits and customs with it is usually identical.As a result find, in 1 year, A groups
Totally 14 people catch a cold, 15 for each person everyone catch a cold 3.46 times, health, which has no, to be obviously improved；And 11 people catch a cold in B groups, and 15 people
Average everyone catches a cold only 2.12 times, and energy is abundant before substantially relatively taking.
The experimental example of embodiment 6
1. materials and methods
1.1 sample：It is real that following animal is carried out with the composite fungi amylose as made from embodiment 3 (medicine hereinafter referred to as of the present invention)
Test.
1.2 experimental animal
Healthy male mice 60, body weight 18g~22g is selected, is divided into 5 groups, every group 12, it is real to carry out delayed allergy
Test；Healthy male mice 60, body weight 18g~22g is selected, is divided into 5 groups, every group 12, carries out Turnover of Mouse Peritoneal Macrophages phagocytosis
Chicken red blood cell is tested.
1.3 dosage choices are with preparing
Daily intake is 2 times/day, 3 tablets/time, 0.25g/ grains, i.e. 1.50g/60kgBW, equivalent to 0.025g/kg BW,
With the 1 of recommended intake, 10 and 30 times setting given low, i.e., 0.025,0.250,0.750g/kg BW, each dosage group is with pure
Water dilutes.Positive controls give the composite fungi amylose of the preparation of CN101618050A embodiments 3, are diluted with pure water, agent used
Measure as 0.250g/kg BW.Negative control group is made with pure water, each group mouse stomach amount is 0.2mL/10g BW, continuous gavage 30
Every immune indexes are surveyed after it.
1.4 experimental method
Delayed allergy (vola pedis thickens method DTH)
Sheep blood is taken, brine, 2% (V/V) SRBC peritoneal immunities of mouse, every mouse injection 0.2mL/ is only.Exempt from
4 days after epidemic disease, left back foot plantar thickness is measured, 20% (V/V) SRBC is subcutaneously injected in measuring point, and only, 24h is surveyed 20 μ L/ after injection
Measure left back foot plantar thickness three times, calculate average value.
Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment
Mouse peritoneal injection 20% (V/V normal salines) hematocrit chicken red blood cell (2000r/min, 10min) suspension
1mL, 30min being spaced, dislocation is put to death, and takes peritoneal macrophage washing lotion 1mL, is dripped on slide, and 37 DEG C of incubators incubate 20min,
Rinsed in physiological saline, to remove non-paster cell.Drying, methanol is fixed, the dyeing of 4% (V/V) Giemsa- phosphate buffers,
Distilled water rinsing is dried.Counted under oil mirror, 100 macrophages of every counting, calculate phagocytic rate and phagocytic index：
Number of macrophages × 100 of number of macrophages/counting of phagocytic rate %=phagocytosis chicken red blood cells
The number of macrophages of the chicken red blood cell sum/counting for phagocytic index=swallowed
1.5 data statistics
Average ratio is carried out compared with when variance is neat, between each group two-by-two using one-way analysis of variance in SPSS11.5 statistical softwares
Compare and use LSD methods；During heterogeneity of variance, compare two-by-two using Tamhane methods between each group.
2 results
Influence of 2.1 tested materials to mouse cell immunologic function
Influence of the tested material to mouse delayed allergy (DTH)
Influence of the tested material of table 1. to mouse delayed allergy (DTH)
P values：Each experimental group * * P ＜ 0.01 of * P ＜ 0.05 compared with negative control group
From table 1, it is statistically analyzed, orally administration tested material 30 days, low dose group swelling degree of the paw and feminine gender are right
According to group comparing difference without conspicuousness (P ＞ 0.05), comparing difference has conspicuousness (P ＜ between middle and high dosage group and negative control group
0.05), i.e., the tested material of middle and high dosage can strengthen the delayed allergy of mouse.
Influence of 2.2 tested materials to mouse monokaryon-macrophage phagocytic function
2.2.1 influence of the tested material to mouse monokaryon-macrophage carbonic clearance function
Influence of the tested material of table 2. to mouse monokaryon-macrophage carbonic clearance function
P values：Each experimental group * P ＜ 0.05 compared with negative control group
From table 2, the tested material of orally administration mouse various dose 30 days, it is statistically analyzed, low dose group carbon is wide
With negative control group comparing difference without conspicuousness (P ＞ 0.05), middle and high dosage group has cleaning function with negative control group comparing difference
Conspicuousness (P ＜ 0.05), i.e., middle and high dosage group tested material can improve the carbonic clearance ability of mouse monokaryon-macrophage.
3. brief summary
The tested material of orally administration mouse various dose 30 days, can strengthen mouse delayed allergy, can strengthen thin
Born of the same parents' immunologic function；The carbonic clearance ability of mouse monokaryon-macrophage can be improved, monocytes/macrophages function can be strengthened.Thus
Judge, embodiment 3 has strengthen immunity function.
Claims (4)
1. a kind of composite fungi amylose preparation, is made up of the raw material of following percentage by weight：Grifolan 30%, Hericium erinaceus are more
Sugar 30%, GL-B 20%, pachymaran 20%；Described grifolan, hericium erinaceum polysaccharide, GL-B and Poria cocos are more
Sugar preparation method be：Grifola frondosus or Hericium erinaceus or ganoderma lucidum or Poria cocos, after crushed, obtain corresponding coarse powder；1-3 is boiled into coarse powder decocting
Secondary, every time plus 6-12 times is measured water, decocts 1-3 hours；Decoction liquor filtering twice is merged into obtain filtrate；By filtrate under the conditions of 70 DEG C
It is concentrated under reduced pressure, is 1.05-1.15 to concentrate relative density；Add 2-6 times and measure 80-95% ethanol progress alcohol precipitation, alcohol precipitation precipitation
Thing, which adds 8-12 times and measured, dissolves to obtain decoction in purified water；Decoction is spray-dried, grifolan can be obtained or Hericium erinaceus is more
Sugar or GL-B or pachymaran.
2. composite fungi amylose preparation as claimed in claim 1, it is characterised in that：Formulation be capsule, tablet, granule,
Pulvis.
3. composite fungi amylose preparation as claimed in claim 1, it is characterised in that：Described grifolan, Hericium erinaceus are more
Sugar, the preparation method of GL-B and pachymaran are：Grifola frondosus or Hericium erinaceus or ganoderma lucidum or Poria cocos, after crushed, are obtained accordingly
Coarse powder；Coarse powder decocting is boiled 3 times, every time plus 8 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；Will filter
Liquid is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 5 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol is heavy
Starch, which is added in 8 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, grifolan or hericium erinaceum polysaccharide can be obtained
Or GL-B or pachymaran.
4. composite fungi amylose preparation as claimed in claim 1, it is characterised in that：Described grifolan, Hericium erinaceus are more
Sugar, the preparation method of GL-B and pachymaran are：Grifola frondosus or Hericium erinaceus or ganoderma lucidum or Poria cocos, after crushed, are obtained accordingly
Coarse powder；Coarse powder decocting is boiled 2 times, every time plus 10 times are measured water, are decocted 2 hours；Decoction liquor filtering twice is merged into obtain filtrate；Will filter
Liquid is concentrated under reduced pressure under the conditions of 70 DEG C, is 1.1 to concentrate relative density；Add 4 times of 95% ethanol of amount and carry out alcohol precipitation, alcohol is heavy
Starch, which is added in 10 times of amount purified waters, dissolves to obtain decoction；Decoction is spray-dried, grifolan can be obtained or Hericium erinaceus is more
Sugar or GL-B or pachymaran.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410117738.6A CN103860580B (en) | 2014-03-27 | 2014-03-27 | It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410117738.6A CN103860580B (en) | 2014-03-27 | 2014-03-27 | It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103860580A CN103860580A (en) | 2014-06-18 |
| CN103860580B true CN103860580B (en) | 2017-11-28 |
Family
ID=50899968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410117738.6A Active CN103860580B (en) | 2014-03-27 | 2014-03-27 | It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103860580B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104543666A (en) * | 2014-12-04 | 2015-04-29 | 徐立华 | Composite polysaccharide heath food with anti-radiation function and preparation process of composite polysaccharide heath food |
| CN105733864A (en) * | 2015-05-29 | 2016-07-06 | 田小龙 | Polysaccharide beer for regulating functions of spleen and stomach and preparation process thereof |
| CN106562164A (en) * | 2016-10-31 | 2017-04-19 | 上海市农业科学院 | Compound edible-fungus solid beverage |
| CN107518357A (en) * | 2017-08-25 | 2017-12-29 | 深圳市康道生物有限公司 | A kind of enhancing immune composition containing Effects of Extracts of Grifola frondosa on Active and preparation method thereof |
| CN107501435A (en) * | 2017-09-30 | 2017-12-22 | 南京正宽医药科技有限公司 | The extracting method of pachymaran and its application |
| CN108991529B (en) * | 2018-08-22 | 2021-09-03 | 湖南中医药大学 | Food composition for invigorating spleen and nourishing vitality and preparation method thereof |
| CN108936590A (en) * | 2018-09-21 | 2018-12-07 | 贵州灵康士生物科技有限公司 | A kind of Hericium erinaceus nourishing the stomach composition |
| CN108853366B (en) * | 2018-09-28 | 2021-07-09 | 南宁常春藤肿瘤研究院 | A Chinese medicinal composition for improving sleep quality, and its preparation method |
| CN109288061A (en) * | 2018-10-08 | 2019-02-01 | 徐晓飞 | A kind of composition and its application containing fungi polysaccharide and Rosa roxburghi Juice |
| CN112772926A (en) * | 2021-01-04 | 2021-05-11 | 江中食疗科技有限公司 | Edible fungus polysaccharide compound formula capable of improving organism immunity |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007026A (en) * | 2006-01-24 | 2007-08-01 | 黄振华 | An anticancer medicinal composition, preparing method and use thereof |
| CN101249097A (en) * | 2008-04-08 | 2008-08-27 | 天津生机集团股份有限公司 | Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament |
| CN101336661A (en) * | 2008-07-14 | 2009-01-07 | 西北农林科技大学 | Nonspecific compound polysaccharide immune milk and preparation method thereof |
| CN101375839A (en) * | 2008-07-31 | 2009-03-04 | 山东京博控股发展有限公司 | Grifola frondosa polysaccharide soft capsules and preparation method thereof |
| CN101744846A (en) * | 2009-12-25 | 2010-06-23 | 福州汉方生物技术有限公司 | Edible mycotic composite amylase nutritional agent |
| CN102258563A (en) * | 2010-05-28 | 2011-11-30 | 浦元清 | Anti-cancer medicinal composition and Chinese medicinal composition |
| CN102461775A (en) * | 2010-11-04 | 2012-05-23 | 张修贵 | Nutrient for strengthening immunity and repairing gastrointestinal function |
-
2014
- 2014-03-27 CN CN201410117738.6A patent/CN103860580B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007026A (en) * | 2006-01-24 | 2007-08-01 | 黄振华 | An anticancer medicinal composition, preparing method and use thereof |
| CN101249097A (en) * | 2008-04-08 | 2008-08-27 | 天津生机集团股份有限公司 | Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament |
| CN101336661A (en) * | 2008-07-14 | 2009-01-07 | 西北农林科技大学 | Nonspecific compound polysaccharide immune milk and preparation method thereof |
| CN101375839A (en) * | 2008-07-31 | 2009-03-04 | 山东京博控股发展有限公司 | Grifola frondosa polysaccharide soft capsules and preparation method thereof |
| CN101744846A (en) * | 2009-12-25 | 2010-06-23 | 福州汉方生物技术有限公司 | Edible mycotic composite amylase nutritional agent |
| CN102258563A (en) * | 2010-05-28 | 2011-11-30 | 浦元清 | Anti-cancer medicinal composition and Chinese medicinal composition |
| CN102461775A (en) * | 2010-11-04 | 2012-05-23 | 张修贵 | Nutrient for strengthening immunity and repairing gastrointestinal function |
Non-Patent Citations (3)
| Title |
|---|
| 真菌多糖与人体健康;周小鹭;《黑龙江生态工程职业学院学报》;20090930;第22卷(第05期);72-74 * |
| 真菌多糖的免疫效应抗肿瘤作用机理的探讨;陈金烟等;《福建轻纺》;20020430(第04期);4-7 * |
| 神奇的多糖家族连载②;王倩;《科技信息》;20021231(第03期);36-43 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103860580A (en) | 2014-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103860580B (en) | It is a kind of have strengthen the body resistance to consolidate the constitution, the composite fungi amylose preparation of strengthening the spleen and stomach, strengthen immunity function | |
| CN102145024B (en) | Fungal composition with effect of enhancing immunity and preparation method thereof | |
| CN101491334B (en) | Health food with immunity reinforcement function | |
| CN104397535A (en) | Composite edible-medicinal fungal oral liquid for enhancing immunity and production method for composite edible-medicinal fungal oral liquid | |
| CN102755346A (en) | Compound polysaccharide formula of edible fungus as well as preparation method and application thereof | |
| CN102488278A (en) | Composite fungus nutrient solution with bifunctional health care effect | |
| WO2021114586A1 (en) | Immune response-improving composition, preparation method and application thereof | |
| CN106822190B (en) | Composition for enhancing immunity and preparation method thereof | |
| CN102805284B (en) | The health food and its production method of a kind of strengthen immunity | |
| CN102948748A (en) | Anti-fatigue health care product | |
| CN110651941A (en) | Cordyceps militaris and Chinese yam solid beverage and production device thereof | |
| CN104872775B (en) | A kind of compound fat-reducing solid beverage of green tea tea polysaccharide and application | |
| CN102579837B (en) | Soft dendrobium huoshanense capsule and preparation method thereof | |
| CN104137992B (en) | A kind of hypoglycemia healthcare food and preparation method thereof | |
| CN104013733B (en) | Chitosan composition for prevention and treatment of chemical liver injury and preparation method thereof | |
| CN104857334A (en) | Hypoglycemic wine and preparation method thereof | |
| CN108066384A (en) | A kind of Chinese medicine preparation with strengthen immunity and preparation method thereof | |
| CN107467456A (en) | A kind of nourshing kidney moistening lung sealwort Chinese angelica root health beverage and preparation method thereof | |
| CN106075056A (en) | A kind of Ganoderma lucidum and preparation method improving immunity and improving gastrointestinal function | |
| CN104738626B (en) | A kind of Halth-care composition, its preparation method and application with strengthen immunity effect | |
| CN107375509B (en) | Health food for improving immunity | |
| CN106511915B (en) | A kind of compound traditional Chinese medicine composite is inhibiting the application in cutaneous melanoma Lung metastases drug | |
| CN101129192B (en) | Cordyceps sinensis highland barley coarse sizing particle and method of preparing the same | |
| CN107568538A (en) | One kind improves immunity Radix Astragali Chinese herbal health-caring beverage and preparation method thereof | |
| CN107348071A (en) | One kind improves female dimacteric syndrome Chinese herbal medicine tea-drinking and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 101100, No. 2, building 58, 25 Xinhua West Street, Beijing, Tongzhou District, 2523 Applicant after: Huaxia Xianbao (Beijing) Traditional Chinese Medicine Research Institute Co., Ltd. Address before: 101121 Tongzhou District Cloud View Road Beijing City 706 Applicant before: Huaxia Xianbao (Beijing) Traditional Chinese Medicine Research Institute Co., Ltd. |
|
| COR | Change of bibliographic data | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |