CN106075056A - A kind of Ganoderma lucidum and preparation method improving immunity and improving gastrointestinal function - Google Patents
A kind of Ganoderma lucidum and preparation method improving immunity and improving gastrointestinal function Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses and a kind of improve immunity and the Ganoderma lucidum improving gastrointestinal function and preparation method thereof.These health product are made up of the raw material of following weight portion: Ganoderma 20～30 parts, Radix Ginseng 5～15 parts, Rhizoma Polygonati 13～20 parts, Fructus Jujubae 8～15 parts, Fructus Lycii 10～20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18～25 parts, the Rhizoma Atractylodis Macrocephalae 15～25 parts, Radix Inulae 5～10 parts.The steps such as above-mentioned raw materials is size-reduced, soak, decoct, filter, concentration, gained concentrated solution coordinates common process to make required preparation.Take the Ganoderma lucidum of the present invention, can effectively strengthen body immunity and resistance against diseases, be particularly the sub-health population for gastrointestinal disease, effect of strengthening the spleen and nourishing the stomach can be played.
Description
Technical field
The present invention relates to field of health care products, particularly to a kind of glossy ganoderma health-care improving immunity and improving gastrointestinal function
Product, the invention still further relates to the preparation method of these health product.
Background technology
In recent years, research to sub-health state both at home and abroad has become as focus.In sub-health population, major part is with body
Degradation phenomenon under power decline, psychentonia, resistance.And gastrointestinal disease is one of modal disease in sub-health population, often
The gastrointestinal disease seen has acute or chronic gastritis, digestive tract ulcer and functional dyspepsia etc..Taste are the foundation of acquired constitution, and QI and blood is biochemical
Source, the pivot of ascending or descending movement of vital Qi, insufficiency of the spleen, vital QI cannot conquer pathogen and disease is entered, spleen is prosperous, is just winning heresy and is moving back and recover.The preventing and treating of subhealth state is crucial
It is function of spleen and stomach regulating.
Motherland's medical science just attaches great importance to the preventing and treating to subhealth state as far back as "Nei Jing" period, and this thought embodies a concentrated reflection of " to be controlled
Sick " theory in.Chinese medicine is the characteristic of China's medical science, is made that prominent contribution for thousands of years in terms of health care.Mesh
Having many strengthening the spleen and nourishing the stomach, the health product of enhancing body immunity in patent documentation disclosed in before, wherein part has selected Ganoderma, monkey
Head mushrooms etc. are raw material.As the Chinese patent of Application No. 201410117738.6 discloses a kind of with Grifola frondosa, Hericium erinaceus (Bull. Ex Fr.) Pers., Ganoderma
With the composite fungi amylose preparation that Poria is raw material；The Chinese patent of Application No. 201110104696.9 discloses a kind of hedgehog hydnum
Mushroom and Ganoderma preparation.In prior art relatively simple with Ganoderma and the Hericium erinaceus (Bull. Ex Fr.) Pers. health product composition as primary raw material, or be only by
There is the active component of similar effect and carried out simple combination, but single not Cheng Fang, multiple medicine is particular about in tcm health preserving health care
Material complements each other, symbiosis special effect.
Summary of the invention
It is an object of the invention to for the deficiencies in the prior art, it is provided that the glossy ganoderma health-care of a kind of multi-flavor medical material reasonable compatibility
Product, it is possible to strengthening the spleen and nourishing the stomach, health invigorating, raising immunologic function, particularly play effective improvement result to gastrointestinal function.
The present invention is achieved through the following technical solutions:
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function of the present invention, by the raw material system of following weight portion
Become: Ganoderma 20～30 parts, Radix Ginseng 5～15 parts, Rhizoma Polygonati 13～20 parts, Fructus Jujubae 8～15 parts, Fructus Lycii 10～20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18
～25 parts, the Rhizoma Atractylodis Macrocephalae 15～25 parts, Radix Inulae 5～10 parts.
The present invention more preferably scheme is made up of the raw material of following weight portion: Ganoderma 23～27 parts, Radix Ginseng 8～12 parts, Rhizoma Polygonati
15～17 parts, Fructus Jujubae 10～13 parts, Fructus Lycii 14～16 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 20～23 parts, the Rhizoma Atractylodis Macrocephalae 18～23 parts, Radix Inulae 6～8
Part.
The present invention more preferably scheme is made up of the raw material of following weight portion: Ganoderma 25 parts, Radix Ginseng 10 parts, Rhizoma Polygonati 16 parts, big
Fructus Jujubae 12 parts, Fructus Lycii 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Inulae 7 parts.
The preparation method of Ganoderma lucidum of the present invention comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add medical material weight 10～the water of 15 times, 50～70 again
Carry out supersound extraction power 300～500W, time 15～30 minutes at DEG C, second time extracting solution is collected by filtration；Merge and carry for twice
Take liquid standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
Concentrated solution adds 75% ethanol and carries out precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
Compared with prior art, it is an advantage of the current invention that: have chosen eight kinds of raw materials targetedly and carry out reasonable compatibility, reach
To improving body immunity and improving the effect of gastrointestinal function, and effect is notable.
Chinese crude drug effect involved in the present invention is as follows: Ganoderma, as the traditional valuable ingredient of Chinese medicine of China, has the highest medicine
By value, there is the biological activitys such as antitumor, antioxidation, defying age and blood sugar lowering, can effectively strengthen immune function of human body；Radix Ginseng
Can antitumor, immunomodulating, antioxidation, blood sugar lowering, radioprotective etc.；Rhizoma Polygonati has spleen invigorating, the kidney invigorating, lung moistening, promotes the production of body fluid, regulates and exempt from
Epidemic diseases etc. act on widely；Fructus Jujubae is also commonly used for Chinese medicine, and it has the effects such as enrich blood, brain-strengthening, anticancer and spleen invigorating are kept fit；Fructus Lycii is medicine
Food dual purpose plant, to health invigorating, improves sleep quality, blood circulation promoting, resisting fatigue, and improving attention and memory etc. has
Effect；Hericium erinaceus (Bull. Ex Fr.) Pers. beneficially the five internal organs, aid digestion, the effect such as nourish the body, particularly to gastric ulcer, duodenal ulcer and nerve
Weak patient such as grade has good health-care effect；The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, the effect of dampness diuretic；Radix Inulae acrid in the mouth is bitter, warm in nature,
There are invigorating the spleen and regulating the stomach, the function of promoting the flow of QI for relieving the stagnancy pain relieving, for diseases such as chronic flatulence, gastrointestinal dysfunctions.
The present invention uses superfine communication technique to improve the bioavailability of Ganoderma, increases on the basis of conventional hot water's extraction method
Ultrasonic extraction, can improve the extraction ratio of effective ingredient, by limiting preparation parameter strict and each component specific
Proportioning, while giving full play to respective effect, also creates certain synergism so that these health product both had between each component
There is effect of enhancing immunity, there is again the effect of strengthening the spleen and nourishing the stomach, particularly can be effectively improved gastrointestinal function.
Detailed description of the invention
With specific embodiment, the present invention is further illustrated below, but the invention is not limited in these embodiments.
Embodiment 1
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function, is made up of the raw material of following weight portion: Ganoderma
25 parts, Radix Ginseng 10 parts, Rhizoma Polygonati 16 parts, 12 parts of Fructus Jujubae, Fructus Lycii 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Radix Inulae 7 parts.
Preparation method comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add the water of medical material weight 12 times again, carry out at 60 DEG C
Supersound extraction power 400W, 20 minutes time, is collected by filtration second time extracting solution；Merge twice extracting solution standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
Embodiment 2
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function, is made up of the raw material of following weight portion: Ganoderma
20 parts, Radix Ginseng 15 parts, Rhizoma Polygonati 13 parts, 15 parts of Fructus Jujubae, Fructus Lycii 10 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 25 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Inulae 10 parts.
Preparation method comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add the water of medical material weight 15 times again, carry out at 70 DEG C
Supersound extraction power 300W, 30 minutes time, is collected by filtration second time extracting solution；Merge twice extracting solution standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
Embodiment 3
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function, is made up of the raw material of following weight portion: Ganoderma
30 parts, Radix Ginseng 5 parts, Rhizoma Polygonati 20 parts, 8 parts of Fructus Jujubae, Fructus Lycii 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Radix Inulae 5 parts.
Preparation method comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add the water of medical material weight 10 times again, carry out at 50 DEG C
Supersound extraction power 500W, 15 minutes time, is collected by filtration second time extracting solution；Merge twice extracting solution standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
Embodiment 4
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function, is made up of the raw material of following weight portion: Ganoderma
23 parts, Radix Ginseng 12 parts, Rhizoma Polygonati 17 parts, 10 parts of Fructus Jujubae, Fructus Lycii 16 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 20 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Radix Inulae 8 parts.
Preparation method comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add the water of medical material weight 13 times again, carry out at 60 DEG C
Supersound extraction power 400W, 20 minutes time, is collected by filtration second time extracting solution；Merge twice extracting solution standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
Embodiment 5
A kind of Ganoderma lucidum improving immunity and improving gastrointestinal function, is made up of the raw material of following weight portion: Ganoderma
27 parts, Radix Ginseng 8 parts, Rhizoma Polygonati 15 parts, 13 parts of Fructus Jujubae, Fructus Lycii 14 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 23 parts, the Rhizoma Atractylodis Macrocephalae 23 parts, Radix Inulae 6 parts.
Preparation method comprises the following steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma ultra micro less than 10 μm except thick slag, finely divided, nano-pulverization
Powder；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, soak 1 little
Shi Hou, extracts 2 hours at 100 DEG C, and for the first time extracting solution is collected by filtration；Add the water of medical material weight 14 times again, carry out at 55 DEG C
Supersound extraction power 500W, 15 minutes time, is collected by filtration second time extracting solution；Merge twice extracting solution standby；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol to be carried out
Precipitate with ethanol, filters, and reclaims ethanol, and concentrated filtrate is to without alcohol taste；
(5) concentrated solution adds acceptable excipient in pharmacy through normal process steps, can be made into tablet, granule, capsule,
Any one dosage form in oral liquid, syrup or pill.
The glossy ganoderma health-care of the present invention has raising body immunity and improves the effect of gastrointestinal function, made to embodiment 1
Product carries out biological test and clinic trial, all achieve significant effect:
Zoopery example 1
Select SPF level health Male Kunming strain mice, enter respectively by basic, normal, high dosage (0.5,1.5,3.0g/kg body weight)
Row gastric infusion surveys every immune indexes after 30 days.
(1) 48 mices being randomly divided into 4 groups, often group 12, is divided into negative control group (gavage pure water), low dosage
Group, middle dosage group and high dose group, carry out carbonic clearance experiment.Each group record phagocytic rate be respectively 21.3 ± 4.23,22.8 ±
3.19,23.7 ± 4.08,25.3 ± 6.28, high dose group phagocytic index compare with negative control group have significant difference (P <
0.05)。
(2) 48 mices being randomly divided into 4 groups, often group 12, is divided into negative control group (gavage pure water), low dosage
Group, middle dosage group, high dose group, carry out half hemolysis value (HC50) and measure.Each group record half hemolysis value be respectively 159.9 ±
6.8,162.28 ± 7.2,175.7 ± 7.1,179.3 ± 7.8, the half hemolysis value of middle and high dosage group compares with negative control group
There is significant difference (P < 0.05).
(3) 48 mices being randomly divided into 4 groups, often group 12, is divided into negative control group (gavage pure water), low dosage
Group, middle dosage group, high dose group, carry out delayed allergy experiment (the foot sole of the foot thickens method) and Turnover of Mouse Peritoneal Macrophages phagocytosis
Chicken red blood cell is tested.Before not injecting SRBC, each group foot sole of the foot thickness (mm) is respectively 1.65 ± 0.1203,1.59 ± 0.1011,1.62
± 0.0874,1.59 ± 0.0698, after injection SRBC each group foot sole of the foot thickness (mm) be respectively 2.375 ± 0.1002,2.312 ±
0.0879,2.414 ± 0.1098,2.432 ± 0.0931, its swelling degree of the paw (foot the sole of the foot thicken) after injection SRBC 24h, in,
Compare between high dose group with negative control group and all have significant difference (P < 0.05)；Terminate (left in above-mentioned delayed allergy
The most no longer swelling of the metapedes sole of the foot) after, carrying out Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment with this treated animal, each group swallows system
Number is respectively 0.374 ± 0.0832,0.432 ± 0.0814,0.483 ± 0.0354,0.498 ± 0.0668, and each dosage group is with right
Comparing discovery according to group, the phagocytic index of middle and high dosage group has significant difference (P < 0.05).
(4) 48 mices being randomly divided into 4 groups, often group 12, is divided into negative control group (gavage pure water), low dosage
Group, middle dosage group, high dose group, the mice spleen lymphocytes proliferation capacity experimental and the NK cytoactive that carry out ConA induction are surveyed
Fixed.Obtain each group of OD difference after measured and be respectively 0.308 ± 0.0223,0.334 ± 0.0313,0.378 ± 0.0247,0.401
± 0.0299, middle and high dosage group all can dramatically increase multiplication capacity (the p ＜ of mouse spleen lymphocyte under ConA induces
0.05)；Each group records NK cell killing rate and is respectively 25.76 ± 8.185,29.68 ± 6.012,39.36 ± 7.231,41.28
± 8.978, NK cells in mice activity significantly improves, and in dose relationship, middle dosage group and high dose group NK cell killing rate with
Matched group compares that there were significant differences (p ＜ 0.05).
In summary, Ganoderma lucidum of the present invention can increase the generation of mice hemolysin significantly, improve mice delayed
Allergy ability, the carbonic clearance function strengthening mice and the phagocytic function of peritoneal macrophage, stimulation B cell and T cell
Multiplication capacity and the activity of NK cell, can significantly improve the immunologic function of mice, and effect becomes apparent from dosage increase.
Zoopery example 2
Select SPF level health Male Kunming strain mice be subjects, if distilled water matched group and basic, normal, high (0.5,
1.5,3.0g/kg body weight) three dosage groups, observe the Ganoderma lucidum of the present invention impact on Mouse Stomach intestinal function.
(1) 48 mice is randomly divided into matched group and high, medium and low dosage group, often group 12, gastric infusion 15 days, detection
The number change of mouse intestinal flora (bacillus bifidus, lactobacillus, enterococcus, enterobacteria) before and after administration.It was found that low dosage
Mouse intestinal flora is not made significant difference by group, and the bacillus bifidus of middle and high dosage group and the increasing number of lactobacillus, enterobacteria subtracts
Few, enterococcus is unchanged.
(2) mice is carried out Intestinal pushing test and emptying test.Mice 48, is randomly divided into matched group and high, medium and low
Dosage treatment group, often after group 12, mice fasting 10 hours, treatment group various dose group+activated carbon+arabic gum suspension enters
Row gavage, matched group then with activated carbon+arabic gum aqueous suspensions, is put to death after 15 minutes, is measured and calculate Stomach residue rate and small intestinal
Ink propulsive rate.After measured, the Stomach residue rate of matched group and high, medium and low dosage treatment group is respectively 35.1 ± 5.2%, 33.6
± 3.52%, 25.8 ± 4.5%, 21.6 ± 4.6%, illustrate that middle and high dosage group can promote that Mouse Stomach empties, have ratio with matched group
More significant difference ((P ＜ 0.05, P ＜ 0.01)；The Intestinal propulsive rate of matched group and high, medium and low dosage treatment group is respectively
34.87 ± 3.12%, 35.69 ± 3.52%, 37.31 ± 4.5%, 42.01 ± 4.6%, illustrate that intestinal is pushed away by high-dose therapy group
Enter motion and be obviously promoted effect.
The most each dosage group all can strengthen intestinal smooth muscle shrinkage amplitude and frequency to varying degrees, accelerates gastrointestinal
Road content fltting speed, has the effect of obvious Gastrointestinal motility adjustment and gastrointestinal function.
Clinical case 1
Patient: Zhang, female, 57 years old；Clinical manifestation: often feel fatigue and weak, inappetence, and with sleep barrier
Hinder, the seriality belch of recurrent exerbation, uncomfortable in chest, glutted after food.The glossy ganoderma health-care taking the present invention 1 time by continuous March, every day
Product, the mental status and sleep quality all have clear improvement, and belch, the symptom such as uncomfortable in chest substantially alleviate, without other any ill symptomses
Occur.
Clinical case 2
Patient: Wang, man, 49 years old；Clinical manifestation: poor memory, insomnia and dreamful sleep, work listless, flu is sent out repeatedly
Making, stomachache, flatulence, Nausea and vomiting, stool are irregular.The Ganoderma lucidum taking the present invention 1 time by continuous March, every day,
Stomach discomfort symptom substantially alleviates, and defecation is smooth and easy, and body constitution has strengthened, radiant, occurs without other any ill symptomses.
Claims (5)
1. one kind is improved immunity and improves the Ganoderma lucidum of gastrointestinal function, it is characterised in that by the raw material of following weight portion
Make: Ganoderma 20～30 parts, Radix Ginseng 5～15 parts, Rhizoma Polygonati 13～20 parts, Fructus Jujubae 8～15 parts, Fructus Lycii 10～20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers.
18～25 parts, the Rhizoma Atractylodis Macrocephalae 15～25 parts, Radix Inulae 5～10 parts.
Raising immunity the most according to claim 1 and improve the Ganoderma lucidum of gastrointestinal function, it is characterised in that by with
The raw material of lower weight portion is made: Ganoderma 23～27 parts, Radix Ginseng 8～12 parts, Rhizoma Polygonati 15～17 parts, Fructus Jujubae 10～13 parts, Fructus Lycii
14～16 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 20～23 parts, the Rhizoma Atractylodis Macrocephalae 18～23 parts, Radix Inulae 6～8 parts.
Raising immunity the most according to claim 1 and improve the Ganoderma lucidum of gastrointestinal function, it is characterised in that by with
The raw material of lower weight portion is made: Ganoderma 25 parts, Radix Ginseng 10 parts, Rhizoma Polygonati 16 parts, 12 parts of Fructus Jujubae, Fructus Lycii 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 22 parts,
The Rhizoma Atractylodis Macrocephalae 20 parts, Radix Inulae 7 parts.
4. according to raising immunity arbitrarily described in claims 1 to 3 and the Ganoderma lucidum that improves gastrointestinal function, its feature
Being, described health product dosage form is any one in tablet, granule, capsule, oral liquid, syrup or pill.
Raising immunity the most according to claim 1 and improve the preparation method of Ganoderma lucidum of gastrointestinal function, it is special
Levy and be, comprise the steps:
(1) Ganoderma is sliced, coarse pulverization, obtain the particle diameter Ganoderma superfine powder less than 10 μm except thick slag, finely divided, nano-pulverization；
(2) 80 mesh sieves are crossed in the coarse pulverization respectively of Radix Ginseng, Rhizoma Polygonati, Hericium erinaceus (Bull. Ex Fr.) Pers., the Rhizoma Atractylodis Macrocephalae, Radix Inulae, are mixed to get coarse powder；
(3) Ganoderma superfine powder, mixing coarse powder are mixed with Fructus Jujubae, Fructus Lycii, add the water of medical material weight 20 times, after soaking 1 hour,
Extract 2 hours at 100 DEG C, for the first time extracting solution is collected by filtration；Add medical material weight 10～the water of 15 times again, enter at 50～70 DEG C
Row supersound extraction power 300～500W, time 15～30 minutes, is collected by filtration second time extracting solution；Merge twice extracting solution standby
With；
(4) extracting solution being concentrated in vacuo, vacuum-0.01Mpa, temperature 60 C, concentrated solution adds 75% ethanol and carries out precipitate with ethanol,
Filtering, reclaim ethanol, concentrated filtrate is to without alcohol taste；
(5) concentrated solution acceptable excipient in normal process steps adds pharmacy, can be made into tablet, granule, capsule, is administered orally
Any one dosage form in liquid, syrup or pill.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106819967A (en) * | 2016-12-23 | 2017-06-13 | 南京贝杉国际贸易有限公司 | A kind of ginseng sealwort of strengthen immunity compound fine powder and preparation method and application |
| CN106962569A (en) * | 2017-02-14 | 2017-07-21 | 王亚萍 | One kind has stomach-nourishing function coffee and preparation method thereof |
| CN109662250A (en) * | 2019-01-18 | 2019-04-23 | 湖南泽迈生物科技有限公司 | A kind of health care product and formula preparation method with enhancing immune function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172383A (en) * | 2011-01-12 | 2011-09-07 | 涂传荣 | Chinese medicinal preparation having functions of enhancing immunity, promoting digestion and improving sleep |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172383A (en) * | 2011-01-12 | 2011-09-07 | 涂传荣 | Chinese medicinal preparation having functions of enhancing immunity, promoting digestion and improving sleep |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106819967A (en) * | 2016-12-23 | 2017-06-13 | 南京贝杉国际贸易有限公司 | A kind of ginseng sealwort of strengthen immunity compound fine powder and preparation method and application |
| CN106962569A (en) * | 2017-02-14 | 2017-07-21 | 王亚萍 | One kind has stomach-nourishing function coffee and preparation method thereof |
| CN109662250A (en) * | 2019-01-18 | 2019-04-23 | 湖南泽迈生物科技有限公司 | A kind of health care product and formula preparation method with enhancing immune function |
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Application publication date: 20161109 |