CN107468747A - A kind of ginseng composition for being advantageous to anticancer, anti-cancer and preparation method thereof - Google Patents
A kind of ginseng composition for being advantageous to anticancer, anti-cancer and preparation method thereof Download PDFInfo
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- CN107468747A CN107468747A CN201710935523.9A CN201710935523A CN107468747A CN 107468747 A CN107468747 A CN 107468747A CN 201710935523 A CN201710935523 A CN 201710935523A CN 107468747 A CN107468747 A CN 107468747A
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Abstract
The present invention relates to a kind of beneficial to anticancer, the ginseng composition to give protection against cancer and preparation method thereof, its active ingredient is made up of following raw material：1 500 parts of red ginseng, 1 500 parts of dandelion, 1 500 parts of tapioca flour, 1 500 parts of pumpkin powder, vitamin C and right amount of auxiliary materials.Preparation method is:Raw material is weighed, screened, is cleaned, crush it is standby.The ginseng raw material of crushing is extracted with water, alcohol reflux respectively, merges concentrate after filtrate concentration, is concentrated into regulation density, control ph, HTHP.The raw material that dandelion is crushed is extracted with water, alcohol reflux respectively, filtering, concentration, alcohol precipitation, carbon adsorption, is merged concentrate after filtrate concentration, is concentrated into regulation density.Two kinds of concentrates are merged, various customary adjuvants required when tapioca flour, pumpkin powder, vitamin C prepare different dosage forms is added and any conventional peroral dosage form is made with conventional method of Chinese medicinal.
Description
Technical field
The present invention relates to food, health food, Medical Nutritional product, non-medical nutriment, special formulation food, medicine technology
Field, and in particular to it is a kind of to be advantageous to anticancer, the ginseng composition of anti-cancer, preparation method, have in anticancer, give protection against cancer, prevent cancer
Cell shifts and aided in the purposes of cancer post-operative recovery etc..
Background technology
Cancer is to have a strong impact on the hazards of residents ' health, and cancer burden is in sustainable growth in global range nearly ten years
Situation, one of WHO issues in 2006 are entitled《It is face-to-face with chronic disease：Cancer》Report in say：Complete 59 kinds of crowd is pernicious swollen
The knurl incidence of disease raises about 50% between 20 years, the patient about 7,600,000 of malignant tumour is died from the whole world every year, accounts for global death toll
13%.Expecting the year two thousand twenty whole world tumour new cases will be up to 20,000,000, and death will turn into global maximum up to 12,000,000
Public health problem.
In China, tumor mortality accounts for the 1/4 of whole causes of the death, occupies dead first.At present China's cancer it is occurred frequently it is main because
Element is aging population, in other carcinogenic factors also include air ambient pollution, unhealthy diet, body movement deficiency, obesity/
Overweight, smoking etc..As the aggravation of China human mortality aging trend and bad life style are widely present, China's pathogenesis of cancer
To also constantly it rise with the death rate, preventing and treating task abnormity is arduous.
Cancer belongs to the category of " heavily fortified point product " in the traditional Chinese medical science, and for the genesis mechanism of cancer, the traditional Chinese medical science thinks：In the formation of cancer
Cheng Zhong, positive unsaturated vapor are preconditions, and perverse trend is key factor away from it, and it is most basic to be only by both caused imbalance of yin and yang
Reason, in addition, dietary factor and feelings will internal injury play an important role in the forming process of carcinoma.
Treat both principal and secondary aspect of disease the characteristics of being Chinese traditional treatment cancer and advantage, should strengthening vital QI to eliminate pathogenic factors Zhi Qiben, symptomatic treatment blood stasis, phlegm again
Stagnant, the wet common sympton such as solidifying.The auxiliary treatment for adjusting seven feelings to be treated both principal and secondary aspect of disease as the traditional Chinese medical science of cancer in treatment method is also to closing weight
Want.Therefore the effect of with strengthening vital QI to eliminate pathogenic factors, clearing heat and detoxicating, softening and resolving hard mass, for anticancer, give protection against cancer, prevent cancer metastasis and auxiliary
The health food of cancer post-operative recovery is helped to be applied to cancer crowd.
The content of the invention
Be advantageous to anticancer, the ginseng composition of anti-cancer, preparation method and its usage, energy it is an object of the invention to provide a kind of
Enough effective anticancers, give protection against cancer, prevent cancer metastasis and aid in the food compositions of cancer post-operative recovery, its used raw material
It is the Chinese herbal medicine of integration of drinking and medicinal herbs, its effect is good, Small side effects.
It is a kind of to be advantageous to anticancer, the ginseng composition of anti-cancer, it is characterized in that its active ingredient is made up of following raw material：Red ginseng
1-500 parts, dandelion 1-500 parts, tapioca flour 1-500 parts, pumpkin powder 1-500 parts, vitamin C 1-500 parts.Right amount of auxiliary materials.
It is preferred that a kind of be advantageous to anticancer, the ginseng composition of anti-cancer, it is characterized in that its active ingredient is by following raw material system
Into：Ginseng 50-100 parts, dandelion 15-30 parts, tapioca flour 5-50 parts, pumpkin powder 5-50 parts, vitamin C 1-10 parts.Auxiliary material is fitted
Amount.
Ginseng in the ginseng composition is fresh ginseng, sun-dried ginseng, red ginseng or other ginseng products.
Dandelion in the ginseng composition is the medicinal material for meeting standards of pharmacopoeia.
Pachyrhizus in the ginseng composition is the dried root of convolvulaceous plant sweet potato.
Pumpkin in the ginseng composition is the fruit of cucurbitaceous plant pumpkin.
Vitamin C 1 in the ginseng composition is the raw material for meeting standards of pharmacopoeia.
" part " used herein can be any one fix with milligram, grams or a kilogram number represent weight (such as lmg,
1g or 1kg etc.) for example, a composition being made up of 2 parts of component A and 8 parts of component B, can be 2 grams of component A and 8 grams of component B,
It can also be the composition of the compositions such as 20 grams of component A and 80 grams of component B.
Above-mentioned prescription raw material has anticancer, gives protection against cancer, prevents the specific function such as cancer metastasis and auxiliary cancer post-operative recovery.
Certain adjustment effect is played to health, raw material is also the composition of integration of drinking and medicinal herbs, can coordinate the work(for playing and treating both principal and secondary aspect of disease
Effect, the function of each constitutive material are respectively：
Ginseng:Ginseng is Araliaceae ginseng Panax ginseng C.A.Mey. dry root and rhizome.《Legendary god of farming's book on Chinese herbal medicine
Through》Middle ginseng：It is sweet, it is slightly cold, tepor, it is nontoxic.Main tonifying five zang organs, soothe the nerves determine soul, stop palpitate with fear, remove pathogenic factor, improving eyesight, happily
Intelligence development, intestines cold in the stomach is treated, trusted subordinate rouses pain, and feeling of fullness and discomfort in the hypochondrium, cholera is told inverse, in tune, is only quenched one's thirst, promoting blood circulation, breaks hard product, makes us not
Forget, long term usage is made light of one's life by commiting suicide macrobiosis.It, which has, reinforces vital energy, veins takes off admittedly, tonifying lung benefit spleen, blood-nourishing of promoting the production of body fluid, the effect of tranquilize the mind and promote the intelligence.
The card of hard product, for disease in internal organs, weakened body resistance and evil knot is two fundamentals of its morbidity,《Jing Yue's complete work》Quote Zhang Jie
The opinion meaning of Gu：" strong people then has it without product, empty people.Taste are timid and weak-willed, and qi and blood two declines, thoughts when four, all can be into product.” Er Disorder days of year
Long, healthy tendency day hinders, and declines temper day, now more avoids high attack and breaks suddenly, need only fade slow scattered, therefore Zhang Jiegu is called：" control long-pending person to support in the ban just
And product is removed certainly, but make its vital qi real, gas is strong, and product disappears certainly.”
《Bencao Jingshu》Pointed out in opinion ginseng：" why perverse trend, which stays for a long time, is not gone person, and without him, the true deficiency of vital energy can not oppose, thus linger on and
Do not understand, must hereby mend and true strength is enriched, then it is evil from that can not hold, heavily fortified point product person is broken, true unsaturated vapor can not then hike and grind thing, and day accumulates the moon
It is tired, returned then into heavily fortified point product, the main digestion of spleen, the gas of kidney-Yang, then spleen can disappear by force, and He Jian products are not ground." ginseng can reinforce vital energy,
Invigorating spleen and reinforcing stomach, righting gas of rectifying, and sensible blood vessels, the work(for the heavily fortified point that disappeared with grinding aid product.
Modern study shows：Ginseng to mastocytoma, osteosarcoma, malignant lymphoma, melanoma, glioma,
Teratoma, thyroid cancer, the carcinoma of the rectum, lung cancer, liver cancer, the cancer of the esophagus, cholangiocarcinoma, breast cancer, stomach cancer, adenocarcinoma of the uterine cervix, oophoroma etc.
The growth of tumour is respectively provided with obvious inhibitory action, can substantially reduce tumor number, reduces knurl body, inducing apoptosis of tumour cell,
Differentiation and the transfer of suppression tumour cell, diffusion etc..Its antitumor action and mechanism are relatively broad：Influence and work(is immunized in regulation
Can, strengthen resistivity of the body to disease, so as to suppress the growth of tumour；Cancer cell specific induction of apoptosis, the growth for suppressing tumour
Or induction Carcinoma cell differentiation makes its reverse；Suppress the infiltration and transfer and the formation of tumour cell new vessels of tumour；Reverse swollen
The drug resistance of oncocyte, strengthen the drug effect of anticarcinogen.
Dandelion:Dandelion is feverfew dandelion Taraxacum mongolicum Hand.-Mazz, alkali ground Pu
Public English Taraxacum borealisinense Kitam. or the drying herb for belonging to several plants together.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Say：" apply
All pyogenic infections from tumour or sore, the insane ringworm of scabies；Wind-dispelling；Disappear all sores, dissipates scrofula tuberculosis, only small to have blood in stool, and controls the five leaching retention of urines, sharp bladder；《Book on Chinese herbal medicine is just
Justice》Say：" its property of dandelion is refrigerant, controls all and treats sore, large carbuncle, all cards of red and swollen heat toxin, and can take to apply, and quite has confirmed, and controls acute mastitis
The furuncle of the breast, red and swollen hard block, particularly prompt effect ".《Chinese Pharmacopoeia》Record：It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.
Modern study shows：Dandelion has antitumor action.Dandelion active ingredient polysaccharide can effectively prevent pancreas
Adenocarcinoma cell is bred, the apoptosis of inducing leukemia cell and breast cancer cell, suppresses the propagation of lung carcinoma cell；Dandelion triterpenes
Compound suppresses stomach cancer cell, weakens the activity of breast cancer cell, suppresses the self-renewing of liver cancer initiator cell；Dandelion steroid
Alcohol can suppress Cells Proliferation of Human Breast Cancer, suppress Colon Cancer Cells, induction human cervical carcinoma cell apoptosis etc..
Pachyrhizus：Pachyrhizus, also known as sweet potato, sweet potato, sweet potato, sweet potato etc..Rich in protein, starch, pectin, cellulose, amino
Acid, vitamin, several mineral materials and cancer-resisting substance " deoxidation epiandrosterone " etc., there is the reputation of " life prolonging food ".With anticancer, protection
Heart, prevention pulmonary emphysema, diabetes, fat-reducing and other effects.Ming Dynasty's Li Shizhen《Compendium of Materia Medica》Note have " sweet potato qi-restoratives is weary, benefiting energy,
Strengthening the spleen and stomach, strong kidney yin ".Li Shizhen (1518-1593 A.D.) was once said:" marine people more longevity, and eat sweet potato admittedly ".So pachyrhizus just has since ancient times
The title of " long life food ".
Modern study shows：There is a kind of physiological activator for being " deoxidation epiandrosterone " in pachyrhizus, can prevent colon cancer
And breast cancer, there is very big facilitation to the vigor of brain cell and endocrine parathyrine；And adjustable obesity, diabetes, virus
Infection, memory, immune response and stress reaction are improved, mitigates nervous, resistance cortex disease, delays sad old effect, promotes albumen
Matter synthesis etc. acts on.
Pumpkin：Pumpkin is also known as kind pumpkin, pumpkin, pumpkin etc..Belong to the fruit of the annual trailing plant of Curcurbitaceae, warm-natured taste
It is sweet.Rich in protein, fiber, vitamin, amino acid, adenine, pectin, mannitol, phylloerythrin, lutein and calcium, potassium, zinc,
The mineral matters such as chromium, particularly rare amino acid citrulling content are up to the g of 20.9 mg/100, and vitamin A content occupies melon in pulp
First of dish.Traditional Chinese medical science history records《The southern regions of the Yunnan Province book on Chinese herbal medicine》Described in：" pumpkin is warm-natured, sweet nothing, enters spleen, stomach two passes through, can moistening lung qi-benefitting, resolving sputum
Apocenosis, expelling parasite removing toxic substances, control the diseases such as cough, asthma, lung carbuncle, constipation ".《Medical center summary》Record his energy " invigorating heart is astringed the lung ".《Book on Chinese herbal medicine
Detailed outline》In, Li Shizhen (1518-1593 A.D.) puts pumpkin and ganoderma lucidum together, says that he has " bowl spares, tonifying liver gas, invigorating heart gas, beneficial lung qi, strengthening the essence gas "
Effect.
Modern age nutrition and medical science show that pumpkin has various health-care and medical value, and edible squash can effectively be prevented
Hypertension, diabetes and hepatic disease are controlled, also with prevention of asthma disease, anti-cancer, avoid constipation, prevention and treatment Atherosclerosis
Change, improve the multiple efficacies such as human immunological competence.In addition, often eating pumpkin, free movement of the bowels, skin can be made lush, especially to female
Property, there is beautification function.
Vitamin C：Vitamin C also known as ascorbic acid, it is a kind of highly important water soluble vitamin, while is also internal
Collagen, carnitine and neurotransmitter etc. carry out material necessary to biosynthesis.The mankind are due to lacking gulonolactone
Oxidizing ferment and vitamin C can not be synthesized in vivo, it is necessary to absorb exogenous vitamin C.
Modern pharmacological research shows：Vitamin C has anti-oxidant, anticancer, antiatherosclerosis, regulation immune, pre-
The functions such as anti-flu.Ascorbic antitumaous effect is by the extracellular substantial amounts of H of generation2O2, cell is diffused into, passes through production
Liveliness proof oxygen kills cancer cell.The increase of other activity keto concentration can also cause a series of oxidative stress, suppress cell itself
Antioxidant system, in turn result in DNA damage, aggravate cancer cell death.
In summary, the pharmacological action of each medicinal material in the present composition is shown, the present invention has anticancer, anti-cancer, prevented
The only function of cancer metastasis and auxiliary cancer post-operative recovery.
The invention provides a kind of preparation method of composition as described above, it is characterised in that described method includes step
Suddenly:
1st, raw material weighed, screened, being cleaned, crush it is standby.
2nd, the extraction of ginseng extract is with refining.
The ginseng raw material of crushing is added 8-15 times by prescription actual ratio and measures the ethanol immersion that volume fraction is 50-80%
Ethanol is reclaimed in 0.5-1 hours, refluxing extraction 2-4 times, each 1-2 hours, filtering, and the remaining dregs of a decoction add 8-10 times and measure purified water again
Extraction 1-2 times, each 1-2 hours, filter-cloth filtering, filtrate concentration merge with ethanol concentrate, are concentrated into regulation density, control pH
Below value 6.0, in more than 100 DEG C, pressure 0-0.2MPa, heat 10-60 minutes, it is standby.The method can be effectively by ginseng
Saponin(e is converted into the rare saponin(e of ginseng.
3rd, the dandelion raw material of crushing is added 8-12 times by prescription actual ratio and measures volume fraction as the leaching of 60-80% ethanol
0.5-1 hours are steeped, refluxing extraction 1-2 hours, filtrate is standby.The remaining dregs of a decoction add 8-10 times to measure purified water extraction 1-2 times, each 1-
2 hours, filter, concentration, with ethanol filtrate alcohol precipitation 12-48 hours, filtering, filtrate adds crude drug amount 1-5% charcoal absorption 10-
40 minutes, filtering, ethanol is reclaimed, adds purified water to water to sink 12-48 hours, filtered, filtrate adds crude drug amount 1-5% activated carbon again
10-30 minutes are adsorbed, filtering, filtrate is concentrated into regulation density, standby.
4th, two kinds of concentrates made of step 2 and 3 are merged, adds tapioca flour, pumpkin powder, vitamin C, prepares different doses
Required various customary adjuvants during type, such as diluent, disintegrant, adhesive, lubricant, filler, preservative, flavouring, steady
Determine agent, surfactant etc., any conventional peroral dosage form be made with conventional method of Chinese medicinal, as tablet, capsule,
Pill, powder, syrup, tincture, oral solution, emulsion, supensoid agent, mixture, soft extract, vina, medicinal tea, liquid extract with
Extract etc..
The present invention starts with from theory of traditional Chinese medical science, using ginseng, dandelion, pachyrhizus, pumpkin and vitamin C, through reasonable compatibility, opens
Send a ginseng food with anticancer, the function of giving protection against cancer, prevent cancer metastasis and aid in cancer post-operative recovery.
Advantages of the present invention：
1st, the generation of tumour and imbalance of yin and yang, positive unsaturated vapor, dietary factor and feelings will are not smooth etc. multifactor closely related.《Cure ancestor
Accumulation pieces must be read》Record:" winner of product, positive unsaturated vapor, then perverse trend is away from it ", it is believed that the formation of tumour is primarily due to human body
Positive unsaturated vapor, cause qi and blood, visceral dysfunction, so that disease and evil is detained, the vital organs of the human body store poison and do not flowed, and qi depression to blood stasis, phlegm coagulates
Wet poly-, knot forms tumour in evil poison.
Ginseng in the composition of the present invention, sweet, slight bitter is warm-natured, returns spleen, lung, the heart, kidney channel.It is loaded in《Sheng Nong's herbal classic》,
Be classified as top grade, be longer than and reinforce vital energy, nourishes blood and promotes the production of body fluid, wide beneficial the five internal organs, save danger emergency treatment of collapse, for well known to doctor, therefore have " control consumptive disease internal injury it
The reputation of first key medicine "；《Mingyi Bielu》Meaning " energy promoting blood circulation, breaks hard product "；Ginseng reinforces vital energy, thriving, the function of body
It can just run well, body just can health.Old friend's ginseng thinks that the work(of help solely stalwart group's grass, and ginseng are described as by compatriots by doctor
The reason for " kings of hundred grass ".Modern pharmacological research shows：Ginseng is to thyroid cancer, the carcinoma of the rectum, lung cancer, liver cancer, the cancer of the esophagus, bile duct
The growth of the kinds of tumors such as cancer, breast cancer, stomach cancer, adenocarcinoma of the uterine cervix, oophoroma is respectively provided with inhibitory action, can substantially reduce number of tumors
Mesh, reduces knurl body, inducing apoptosis of tumour cell, differentiation and suppresses the transfer of tumour cell, diffusion etc., therefore is our monarch drug in a prescription.
Dandelion bitter, sweet, cold in nature, Return liver, stomach.With clearing heat and detoxicating, dispersing swelling and dissipating binds, the work(of inducing diuresis for treating strangurtia,《Book on Chinese herbal medicine
Justice》Say：" dandelion property is refrigerant, controls all and treats sore, large carbuncle, all cards of red and swollen heat toxin, and can take to apply, and quite has confirmed, and controls acute mastitis
The furuncle of the breast, red and swollen hard block, particularly prompt effect ".Dandelion heat-clearing cold in nature, is clearing heat and detoxicating good medicine, is good at dissipation carbuncle swells, clinical
On be widely used in heat toxin syndrome.Such as acute mastitis, acute appendicitis, treat the not scattered disease of sore, furuncle, carbuncle swells.Research shows：Taraxacum Polysaccharides can have
The apoptosis of the suppression cancer of pancreas of effect and the propagation of lung carcinoma cell, inducing leukemia cell and breast cancer cell；Dandelion triterpenes
Compound suppresses stomach cancer cell, weakens the activity of breast cancer cell, suppresses the self-renewing of liver cancer initiator cell；Taraxasterol
Breast cancer and Colon Cancer Cells, induction human cervical carcinoma cell apoptosis etc. can be suppressed, therefore be our ministerial drug.
Pachyrhizus is rich in protein, starch, pectin, cellulose, amino acid, vitamin, several mineral materials and cancer-resisting substance
" deoxidation epiandrosterone " etc., there is the reputation of " life prolonging food ".With work(such as anticancer, cardioprotection, prevention pulmonary emphysema, diabetes, fat-reducing
Effect.Its active material " deoxidation epiandrosterone ", beta carotene energy anti-cancer, anticancer, strengthen immunity.
Pumpkin can effectively prevent and treat hypertension, glycosuria, disease anti-cancer, hepatic disease, also have treatment atherosclerosis, carry
The multiple efficacies such as high human immunological competence, old place melon and pumpkin are our adjutant.
Ginseng, dandelion, pachyrhizus, the medicine compatibility of pumpkin four play strengthening vital QI to eliminate pathogenic factors altogether, clearing heat and detoxicating, dispersing swelling and dissipating binds work(, make this
Contrivance has anticancer, gives protection against cancer, prevents cancer metastasis and aid in the function of cancer post-operative recovery.
2nd, people participates in dandelion combination, and composition of the invention uses the medicine compatibility method of fever and chills mutual aid.The property used in composition
To suppress the warm of ginseng, this measure can restrict the property of the temperate-dryness of ginseng, mend without dry, do not get angry cold dandelion, embody
Go out the reasonable compatibility of fever and chills and warm medicine of a cold nature thing, organically combine, reach bidirectional modulation, balance coordination, so that the property of medicine of full side is more
To be gentle.
3rd, the present invention combines traditional theory of traditional Chinese medical science and principle of medication, based on the pharmacological research in modern times, by ginseng, Pu
Public English, tapioca flour, pumpkin powder and vitamin C combination.Modern pharmacological research confirms that the medicinal material in above-mentioned prescription has anticancer, prevented
Cancer, prevent cancer metastasis and aid in the function of cancer post-operative recovery.And be the article of integration of drinking and medicinal herbs, medicine is can not only be used for,
Daily bread can be used as, good adjustment effect is played to health, the effect for the treatment of both principal and secondary aspect of disease is played in ancillary drug treatment.
4th, production technology of the present invention uses HTHP sour water solution method for transformation, and the effective ginsenoside that is catalyzed is converted into tool
There are rare ginsenoside Rg3, Rg5, CK, Rh1, Rh2 and Rh3 of anticancer high activity etc..Ginseng after being handled using process above
Rare saponin content increases 10-30 times.The rare saponin of ginseng has high medical value and application prospect, because rare saponin exists
Content in red ginseng and wild ginseng only has 100,000/it is several, by above transformation technology change in ginseng the higher glycols of content and
Three alcohols saponins, it is allowed to orientation and is converted into the rare saponin of ginseng.The rare saponin of ginseng has very high physiologically active；Such as ginseng soap
Glucoside Rh1, Rh2, Rh3 and Rg3 have anticancer, intelligence development, immunological regulation and anti-cerebral ischemia, neurocyte protection effect.So as to strengthen
The anticancer of the present composition, give protection against cancer, prevent cancer metastasis and aid in the effect of cancer post-operative recovery.
5th, the present composition can suppress the propagation of cancerous swelling cell, suppress the growth of tumour cell；Meet TCM on tumor to distinguish
Card opinion is controlled and the principle of reatment of organic conception, can strengthen and improve immunity of organisms, play and start the excellent of systemic anticancer killing cancer cell
Gesture, transfer to cancer cell, it is diffused with inhibitory action.
Embodiment
The present invention will be further elaborated by following examples by the present invention, it is not limited to this.
Embodiment 1：Oral liquid
The dosage of medicine each component of the present invention can be:Ginseng 50g, dandelion 35g, tapioca flour 50g, pumpkin powder 40g, dimension life
Plain C and other Chinese medicines and right amount of auxiliary materials；Its preparation method is：Raw material is weighed, screened, crush it is standby；By the people of crushing
It is that 50% ethanol soaks 0.5 hour to join raw material to add 10 times of amount volume fractions, refluxing extraction 2 times, 1 hour every time, is filtered, recovery
Ethanol, the remaining dregs of a decoction add 8 times of amount purified waters to extract 1 time again, and 1 hour every time, filtering, filtrate concentration merged with ethanol concentrate,
Regulation density is concentrated into, control ph 5.5-6.0, in 110 DEG C, pressure 0.1-0.2MPa, is heated 30 minutes, it is standby.
It is that the immersion 0.5 of 60% ethanol is small that the dandelion raw material of crushing is added into 8 times of amount volume fractions by prescription actual ratio
When, refluxing extraction 1 hour, filtering.The remaining dregs of a decoction add 6 times of amount purified waters to extract 1 time, 1 hour every time, filter, concentration, use ethanol
Extract solution alcohol precipitation 12 hours, filtering, filtrate add the charcoal absorption 10 minutes of crude drug amount 1%, filtering, reclaim ethanol, add purified water
To sink 12 hours, filter to water, filtrate adds the activated carbon of crude drug amount 1% to adsorb again 10 minutes, filters, and filtrate is concentrated into regulation density,
It is standby.Will made of 2 kinds of condensed creams merge, add tapioca flour, pumpkin powder, vitamin C, flavouring, stabilizer, diluent and
Water, filling, sterilizing can be prepared by oral liquid.
Embodiment 2：Capsule
The dosage of medicine each component of the present invention can be:Ginseng 100g, dandelion 80g, tapioca flour 90g, pumpkin powder 80g, dimension life
Plain C and other Chinese medicines and right amount of auxiliary materials；Its preparation method is：Raw material is weighed, screened, crush it is standby；By the people of crushing
It is that 60% ethanol soaks 1 hour to join raw material to add 7 times of amount volume fractions, refluxing extraction 3 times, 1.5 hours every time, filtering, reclaims second
Alcohol, the remaining dregs of a decoction add 6 times of amount purified waters to extract 2 times again, and 1 hour every time, filtering, filtrate concentration merged with ethanol concentrate, dense
Regulation density is reduced to, control ph 5.0-5.0, in 115 DEG C, high pressure 20 minutes is standby.
It is that the immersion 0.5 of 50% ethanol is small that the dandelion raw material of crushing is added into 7 times of amount volume fractions by prescription actual ratio
When, refluxing extraction 1.5 hours, filtering.The remaining dregs of a decoction add 6 times of amount purified waters to extract 2 times, 1.5 hours every time, filter, concentrate, use
Ethanol extract alcohol precipitation 24 hours, filtering, filtrate add the charcoal absorption 20 minutes of crude drug amount 2%, filtering, reclaim ethanol, add pure
Change water to water to sink 24 hours, filter, filtrate adds the activated carbon of crude drug amount 2% to adsorb again 20 minutes, filters, and filtrate is concentrated into regulation
Density, it is standby.Will made of 2 kinds of condensed creams merge, add tapioca flour, pumpkin powder, vitamin C, diluent, filler, help stream
Particle is made in agent etc., is filled with capsule and can be prepared by capsule.
Embodiment 3：Paste
The dosage of medicine each component of the present invention can be:Ginseng 150g, dandelion 100g, tapioca flour 150g, pumpkin powder 120g,
Vitamin C and other Chinese medicines and right amount of auxiliary materials；Its preparation method is：Raw material is weighed, screened, crush it is standby；It will crush
Ginseng raw material add 8 times amount volume fractions be 80% ethanol soak 0.5 hour, refluxing extraction 2 times, 1 hour every time, filter, return
Ethanol is received, the remaining dregs of a decoction add 8 times of amount purified waters to extract 2 times again, and 1 hour every time, filtering, filtrate concentration was closed with ethanol concentrate
And regulation density is concentrated into, control ph 4.5-5.0, in 120 DEG C, high pressure 10 minutes is standby.
To be that the immersion 0.5 of 70% ethanol is small except the dandelion raw material of crushing adds 9 times of amount volume fractions by prescription actual ratio
When, refluxing extraction 1 hour, filtering.The remaining dregs of a decoction add 7 times of amount purified waters to extract 3 times, 1 hour every time, filter, concentration, use ethanol
Extract solution alcohol precipitation 48 hours, filtering, filtrate add the charcoal absorption 20 minutes of crude drug amount 4%, filtering, reclaim ethanol, add purified water
To sink 48 hours, filter to water, filtrate adds the activated carbon of crude drug amount 4% to adsorb again 10 minutes, filters, and filtrate is concentrated into regulation density,
It is standby.Will made of 2 kinds of concentrates merge, add tapioca flour, pumpkin powder, vitamin C, adhesive, filler, lubricant, help
Agent is flowed, being prepared according to Chinese medicine preparation conventional method turns into paste.（See below experimental example）
Embodiment 4：Granule
The dosage of medicine each component of the present invention can be:Ginseng 400g, dandelion 300g, tapioca flour 400g, pumpkin powder 350g,
Vitamin C and other Chinese medicines and right amount of auxiliary materials；Its preparation method is：Raw material is weighed, screened, crush it is standby；It will crush
Ginseng raw material by prescription actual ratio add 7 times amount volume fractions be 70% ethanol soak 0.5 hour, refluxing extraction 2 times, often
Secondary 2 hours, ethanol was reclaimed in filtering, and the remaining dregs of a decoction add 6 times of amount purified waters to extract 2 times, 1.5 hours every time, filter-cloth filtering, filtered again
Liquid concentration merges with ethanol concentrate, is concentrated into regulation density, control ph 4.0-4.5, in 110 DEG C, high pressure 20 minutes is standby
With.
It is that the immersion 0.5 of 80% ethanol is small that the dandelion raw material of crushing is added into 10 times of amount volume fractions by prescription actual ratio
When, refluxing extraction 1 hour, filtrate is standby.The remaining dregs of a decoction add 9 times of amount purified waters to extract 2 times, 1 hour every time, filter, concentrate, use
Ethanol filtrate alcohol precipitation 24 hours, filtering, filtrate add the charcoal absorption 30 minutes of crude drug amount 3%, filtering, reclaim ethanol, add purifying
Water to water sinks 24 hours, and filtering, filtrate adds the activated carbon of crude drug amount 3% to adsorb again 30 minutes, filters, and it is close that filtrate is concentrated into regulation
Degree, it is standby.2 kinds of condensed creams merge by made of, add tapioca flour, pumpkin powder, vitamin C, diluent, filler, glidant
Etc. granule is made.
The third aspect of the present invention, there is provided a kind of purposes of composition provided by the invention as described above, its feature
It is to be used as or for anticancer, the purposes for giving protection against cancer, preventing cancer metastasis and auxiliary cancer post-operative recovery.
Embodiment 1
The present invention tests to animal transplanting tumor Heps (liver cancer) inhibitory action（Paste）.
ICR mouse are taken, by transplanted tumor organon, inoculation solid type knurl (takes tumor mass under sterile working, weighed, use
Glass tissue homogenizer is ground, and is put into after mill is even in sterile chamber, is added normal saline dilution into 1:3 cell suspension is every small
Mouse right fore armpit subcutaneous vaccination 0.2ml cell suspensions), claim mouse weight, and be randomly divided into 5 groups within 24 hours after inoculation, every group 10：
Model control group (distilled water 1.0ml/kg, gavage), positive drug control group (5-fluor-uracil:10mg/kg, intraperitoneal injection) and this
Contrivance administration group (dosage is according to crude drug gauge, respectively 2g/kg, 4g/kg and 8g/kg, gavage), each group animal are swollen in inoculation
Knurl next day starts to be administered, one time a day, each 1.0ml/20g, the d of successive administration 10.The 11st day after administration lotus knurl of weighing and put to death
Mouse, weighed after separating tumor mass, the data obtained carries out statistical procedures (t inspections).
Experimental result is shown in Table 1.The result explanation：Compared with model control group, this law contrivance 8g/kg, positive drug 5- fluorine
Urea pyrimidine 10mg/kg has extremely significant inhibitory action (P to Heps tumour growths<0.01)；This law contrivance 4g/kg is to Heps
Tumour growth has significant inhibitory action (P<0.05).
Influence of the table 1 to mice Heps growth of tumour cell（± SD, n=10）
Remarks：The * P ﹤ 0.05 compared with control group, * * P ﹤ 0.01.
Embodiment 2
The present invention tests to animal transplanting tumor S180 (sarcoma) inhibitory action（Paste）.
ICR mouse are taken, by transplanted tumor organon, inoculation solid type knurl (takes tumor mass under sterile working, weighed, use
Glass tissue homogenizer is ground, and is put into after mill is even in sterile chamber, is added normal saline dilution into 1:3 cell suspension is every small
Mouse right fore armpit subcutaneous vaccination 0.2ml cell suspensions), claim mouse weight, and be randomly divided into 5 groups within 24 hours after inoculation：Every group 10：
Model control group (distilled water 2.0ml/kg, gavage), positive drug control group (5-fluor-uracil:10mg/kg, intraperitoneal injection) and this
Contrivance administration group (dosage is according to crude drug gauge, respectively 4g/kg, 8g/kg and 16g/kg, gavage), each group animal is in inoculation
Tumour next day starts to be administered, one time a day, each 2.0ml/20g, the d of successive administration 10.The 11st day after administration lotus of weighing and put to death
Knurl mouse, weighed after separating tumor mass, the data obtained carries out statistical procedures (t inspections).
Experimental result is shown in Table 2.The result explanation：Compared with model control group, thing 16g/kg and 5-fluor-uracil of the present invention
10mg/kg has extremely significant inhibitory action (P to S180 tumour growths<0.01)；Thing 8g/kg of the present invention is to S180 tumour growths
With significant inhibitory action (P<0.05).
Influence of the table 2 to mouse S180 cell growths（± SD, n=10）
Remarks：* * P ﹤ 0.01, * P ﹤ 0.05 compared with control group.
Embodiment 3
The present invention is to human lung cancer A549 nude mouse xenograft tumor growth inhibition effects（Paste）.
Take the logarithm human lung cancer cell A549's cell line in growth period, be aseptically prepared into 2x107 cell/ml's
Cell suspension, it is subcutaneous that armpit on the right side of nude mouse is inoculated in 0.lml.Claim mouse weight, and be randomly divided into 5 groups within 24 hours after inoculation：Often
Group 10：Model control group (distilled water 2.0ml/kg, gavage), positive drug control group (5-fluor-uracil:10mg/kg, abdominal cavity note
Penetrate) and thing administration group of the present invention (dosage is according to crude drug gauge, respectively 3g/kg, 6g/kg and 12g/kg, gavage), each group is moved
Thing starts to be administered in inoculated tumour next day, one time a day, each 2.0ml/20g, the d of successive administration 10.Weigh within the 11st day after administration
And tumor-bearing mice is put to death, weighed after separating tumor mass, the data obtained carries out statistical procedures (t inspections).
Experimental result is shown in Table the 3 result explanations:Compared with model control group, thing 12g/kg and 5-fluor-uracil of the present invention
10mg/kg has extremely significant inhibitory action (P to human lung cancer A549 Nude Mices<0.01)；6g/kg pairs of thing of the present invention
S180 tumour growths have significant inhibitory action (P<0.05).
Influence of the table 3 to mouse A549 cell growths（± SD, n=10）
Remarks：* P ﹤ 0.01, * P ﹤ 0.05 compared with control group.
In summary, the pharmacological experiment study of thing treatment tumour of the present invention and invention feature show, first, can suppress cancerous swelling
The propagation of cell, suppress the growth of tumour cell；Second, meet the principle of reatment of TCM on tumor diagnosis and treatment and organic conception,
Can enhancing improve immunity of organisms, play the advantage for starting systemic anticancer killing cancer cell, transfer to cancer cell, be diffused with suppression
Make and use.Therefore the present composition is that a kind of have anticancer well, give protection against cancer, prevent that cancer metastasis and auxiliary cancer are postoperative extensive
Multiple article, definite effect, has no toxic side effect.
Claims (3)
1. a kind of be advantageous to anticancer, the ginseng composition of anti-cancer, it is characterized in that its active ingredient is made up of following raw material：Red ginseng 1-
500 parts, dandelion 1-500 parts, tapioca flour 1-500 parts, pumpkin powder 1-500 parts, vitamin C 1-500 parts.
2. be advantageous to the ginseng composition of anticancer, anti-cancer according to a kind of described in claim 1, it is characterized in that its active ingredient by
Following raw material is made：Ginseng 50-100 parts, dandelion 15-30 parts, tapioca flour 5-50 parts, pumpkin powder 5-50 parts, vitamin C 1-
10 parts.
A kind of 3. ginseng composition preparation method as claimed in claim 1 or 2 for being advantageous to anticancer, giving protection against cancer, it is characterised in that
Step is as follows：
（1）Raw material is weighed, screened, is cleaned, crush it is standby；
（2）The extraction of ginseng extract is with refining：The ginseng raw material of crushing is added 8-15 times by prescription actual ratio and measures volume
Fraction is that 50-80% ethanol soaks 0.5-1 hours, refluxing extraction 2-4 times, each 1-2 hours, filtering, reclaims ethanol, remaining medicine
Slag adds 8-10 times to measure purified water extraction 1-2 times again, and each 1-2 hours, filter-cloth filtering, filtrate concentrates to be merged with ethanol concentrate,
Regulation density is concentrated into, control ph is below 6.0, in more than 100 DEG C, pressure 0-0.2MPa, heats 10-60 minutes, standby；
（3）The dandelion raw material of crushing is added 8-12 times by prescription actual ratio and measures volume fraction as the immersion of 60-80% ethanol
0.5-1 hours, refluxing extraction 1-2 hours, filtrate is standby；The remaining dregs of a decoction add 8-10 times to measure purified water extraction 1-2 times, each 1-2
Hour, filter, concentration, with ethanol filtrate alcohol precipitation 12-48 hours, filtering, filtrate adds crude drug amount 1-5% charcoal absorption 10-40
Minute, filtering, ethanol is reclaimed, adds purified water to water to sink 12-48 hours, filtered, filtrate adds crude drug amount 1-5% activated carbon to inhale again
Attached 10-30 minutes, filtering, filtrate is concentrated into regulation density, standby；
（4）By step（2）With（3）Manufactured two kinds of concentrates merge, and add tapioca flour, pumpkin powder, vitamin C, are prepared into not
Same formulation.
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Cited By (4)
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|---|---|---|---|---|
| CN108578501A (en) * | 2018-06-22 | 2018-09-28 | 金志华 | Ginseng composition with anticancer function |
| CN109170892A (en) * | 2018-09-29 | 2019-01-11 | 首益特殊医学用途配方食品科技研究（北京）有限公司 | Diet therapy nutritional element solid beverage and preparation method thereof for tumor recovering |
| CN112998268A (en) * | 2021-03-17 | 2021-06-22 | 吉林省长白山生物科技有限公司 | A method for processing ginsenoside with tumor inhibiting and immunity enhancing effects |
| CN115260269A (en) * | 2022-06-28 | 2022-11-01 | 成都大学 | Composition containing ginseng glucoside and aglycone thereof, preparation method and application |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578501A (en) * | 2018-06-22 | 2018-09-28 | 金志华 | Ginseng composition with anticancer function |
| CN109170892A (en) * | 2018-09-29 | 2019-01-11 | 首益特殊医学用途配方食品科技研究（北京）有限公司 | Diet therapy nutritional element solid beverage and preparation method thereof for tumor recovering |
| CN112998268A (en) * | 2021-03-17 | 2021-06-22 | 吉林省长白山生物科技有限公司 | A method for processing ginsenoside with tumor inhibiting and immunity enhancing effects |
| CN115260269A (en) * | 2022-06-28 | 2022-11-01 | 成都大学 | Composition containing ginseng glucoside and aglycone thereof, preparation method and application |
| CN115260269B (en) * | 2022-06-28 | 2024-04-05 | 成都大学 | Composition containing ginseng secondary glycoside and aglycone thereof, preparation method and application |
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