CN106177432A - A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati - Google Patents
A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati Download PDFInfo
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- CN106177432A CN106177432A CN201510212597.0A CN201510212597A CN106177432A CN 106177432 A CN106177432 A CN 106177432A CN 201510212597 A CN201510212597 A CN 201510212597A CN 106177432 A CN106177432 A CN 106177432A
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Abstract
The invention discloses a kind of health composition containing leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati, its percentage by weight can be 5-80%: 5-80%: 5-80%: 10-85%.Described health composition can also comprise the one in Folium Ilicis, black tea, Folium Lycii, buckwheat leaf, Folium Longan, Folium Myricae rubrae, Folium Ipomoeae, Folium Eriobotryae or its combination in any.Present invention also offers the application in terms of preparation auxiliary treatment hyperglycemia, hypertension or hyperlipidemia health composition of the described health composition.The health composition of the present invention, based on natural drug, has no side effect, and has clear curative effect, synergism and substantially and is prone to the advantages such as masses take.
Description
Technical field
The invention belongs to field of health care food, be specifically related to one comprise leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and
The health composition of Rhizoma Polygonati Odorati and preparation thereof and purposes.
Background technology
Diabetes (diabetes mellitus, DM) be a kind of common multi-pathogenesis have the interior of genetic predisposition
Secretion metabolism disorder disease, along with growth in the living standard, its sickness rate in the trend risen year by year,
Becoming the 3rd killer being detrimental to health after cancer, cardiovascular and cerebrovascular disease, diabetes are with hyperglycemia
For outstanding feature, and cause series of clinical manifestations.The relevant diabetes that China completes for 1997 are popular
Sick investigation problem of learning show, and national onset diabetes rate rises to 3.2%, more from 1% in 1980
Seriously in the old people of more than 60 years old the sickness rate of diabetes more than 11%.Up-to-date in 2012 grinds
Studying carefully report display, China diabetes patient occupies the whole world first.
" quenching one's thirst " or " diseases due to endogenous heat of ZANG FU organs " category of the diabetes spp traditional Chinese medical science.Diabetes are broadly divided into by modern medicine
Two types a: class is the insulin-dependent (TDDM) of I type, based on inherited genetic factors, mostly occurs
In teenager.The another kind of non-insulin-depending type for II type (NIDDM), because of insulin resistant and pancreas
Island element secretion relative deficiency or delay, cause blood glucose to raise, and course of disease elder may occur in which the complication of diabetes,
It is mainly in and grows up or middle-aged and elderly people.In all diabeticss, 90% is above suffering from type ii diabetes.
At present, the treatment of diabetes is except with going back some orally-taken blood sugar reducing medicines of adapted in addition to insulin, such as: sulfonylurea,
Metformin class, alpha-glucosidase inhibitor, thiazolidone etc..Although western medicine effect comparison is bright
Aobvious, but side effect is big, as easily caused hypoglycemia, lactic acidosis, intestinal discomfort etc..This disease such as can not get
Control, it will cause severe chronic complication and then disable lethal.Therefore, the preventing and treating strengthening diabetes is arranged
Executing and paid attention to by countries in the world, research prevents and treats the newtype drug of diabetes and health food is domestic and international
The advanced subject of association area.Non-medication treatment diabetes have become current medical science, threpsology, food
One of focus of scientific research.Although the enterprise that lot of domestic and international is big and scientific research institution, fall over each other research and open
Send out hypoglycemic medicine or substitute products, but mostly the most all because of expensive, carrier is undesirable, effect is unstable
Or take trouble and not by people's recognition and acceptance.
Additionally, hypertension, hyperlipidemia are also puzzlements people " modern civilization diseases " in recent years, to human body
Healthy is very harmful, similar with diabetes to its difficulty prevented and treated.
Hypertension (hypertension) is a kind of with the abnormal cardiovascular disease rising a height of principal character of arterial pressure
Sick.The cause of disease is divided into essential hypertension and secondary hypertension.The former accounts for the 90% of hypertension, is referred to as height
Blood pressure diseases.Primary disease belongs to the categories such as " dizziness ", " headache " of the traditional Chinese medical science.
Hyperlipemia (hyperlipemia) also known as hyperlipoproteinemia, can behave as hypercholesterolemia,
Hypertriglyceridemia or both have concurrently, it is with tremulous pulse medicated porridge sample hardening, diabetes, fatty liver, nephropathy
The closest etc. relation.Consequence is especially had day by day to cause people in the morbidity of cardiovascular and cerebrovascular disease
Attention.The traditional Chinese medical science thinks that hyperlipemia belongs to the categories such as " turbid resistance ", " phlegm-damp ", " fat ", " damp and hot ".
Hyperglycemia, hypertension, hyperlipidemia (" three high ") cause of disease are complicated, and the current cause of disease is the clearest and the most definite.
Although the comparitive study of western medical treatment is certainly at present, but is combined the treatment difficulty of disease and complication thereof relatively
Greatly, can cause the side effect that degree is different, patient is often difficult to stand simultaneously, it is impossible to adhere to treatment.In
Cure the understanding to above-mentioned disease and preventing and treating, be then to start with from entirety conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, although do not have
Western medicine is quick, but is nursed one's health by entirety, and symptom and index all can be effectively controlled, simultaneously can be effective
Protection target organ etc..From clinically, hyperlipidemia, hyperglycemia, hypertensive patients occur, mutually often
For cause and effect.Recently, more result of study confirms, in order to reach to prevent and delay complication to occur and send out
The purpose of exhibition, it should extremely emphasize the control of many factors, such as in type ii diabetes, except strictly
Control, outside blood glucose, blood pressure level, also to take strictly to control blood lipid level, strictly control body weight,
The measures such as conventional anticoagulant therapy, to reduce the risk of macroangiopathy further.But so far can be same
Time prevention or the Chinese medicine composition for the treatment of " three high " know clearly very few, it is possible to obtain satisfied curative effect and patient
The pharmaceutical composition that compliance is high rarely has report especially, and therefore, research and development can prevent simultaneously and treat
The safely and effectively medicine of " three high ", is the task of top priority, extremely urgent.
In the last few years, from natural product, the new composition having physiologically active or lead compound are found to open
Send out new drug or health food base section has become the focus of global concern and research.Seek blood sugar lowering, blood pressure lowering and fall
Its functional factor is also dissected, and then Development and Production goes out blood sugar lowering, blood pressure lowering, fall by fat food resource
The Material for Health Food of blood fat food is expected to become the good approach treating these diseases.
Cyclocarya paliurus Iljinskaja (cyclocarya paliurus (Batal.) Ijinsk) belongs to the arbor of Juglandaceae cyclocarya and plants
Thing.The most only deposit one, peculiar for China, it is one of the endangered plants of special-protection-by-the-State, widely distributed
In Yangtze river basin each province, Jiangxi Province is northern and hilly and mountainous land distribution in middle part is more.According to " China's book on Chinese herbal medicine " note
Carry, Cyclocarya paliurus Iljinskaja have dispel the wind, the effect such as anti-inflammatory analgetic and killing parasites for relieving itching.Its main component has saponin, Huang
Ketone, terpenoid, polysaccharide, trace element etc..Research shows that leaf of Cyclocarya paliurus Iljinskaja has multiple efficacies, such as blue or green money
Folium Salicis Babylonicae can substantially suppress lipase active, reduce digesting and assimilating of fat, and can promote the generation of lipid material
Thank to decomposition, can effectively reduce blood glucose, be obviously improved carbohydrate tolerance, antioxidation, resisting fatigue etc..Leaf of Cyclocarya paliurus Iljinskaja
The exploitation of serial health product, will enrich the health-product market of China, improves the healthy living water of the people
Flat.
Folium Mori (Mulberry Leaf, formal name used at school: Folium Mori) are the dried leaves of moraceae plants Mulberry,
Having another name called a Mulberry, Jing Sang, Fructus Mori tree, yellow wood leaf etc., mulberry is extensively planted in various places, China north and south, and Folium Mori produce
Amount is abundant.Gas is light, and mildly bitter flavor is puckery.Folium Mori are medicine-food two-purpose product, and Folium Mori among the people decoct juice for tea, research
Show that Folium Mori have the effect such as antihypertensive diuretic, blood fat reducing, energy Inhibiting α-glucosidase, and energy is competitive
Ground blocks the disaccharidase hydrolytic enzyme such as the maltase in small intestinal cell brush border and saccharase, makes to ingest
Polysaccharide, oligosaccharide and disaccharidase are digested to the absorption process of the monosaccharide such as glucose, fructose and are prevented from, thus drop
Low levels, plays effective blood sugar reducing function.
Green tea is one of main teas of China, refers to take Camellia sinensis young leaves or bud, the most fermented, through killing
The product that the blue or green or typical process such as shaping, drying is made.Extensively, Henan, Guizhou, Jiangxi,
Anhui, Zhejiang, Jiangsu, Sichuan, Shaanxi, Hunan, Hubei, Guangxi, Fujian are the green tea masters of China
Produce province.Green tea has refreshment, diuresis is recovered from fatigue, fatigue alleviating, anti-ageing edible effect of waiting for a long time, suitable
The crowd that too much person, hypertension, dysuria, heating are thirsty is eaten for rich food dish.Often drink green tea
Can give protection against cancer, blood fat reducing and fat-reducing.Owing to green tea is the most fermented tea made, therefore remain fresh leaf
Natural materials, the tea polyphenols contained, catechin, chlorophyll, caffeine, aminoacid, vitamin etc. are sought
Form point the most more.These natural nutrition compositions in green tea to anti-aging, anti-cancer, anticancer, sterilization,
Antiinflammatory etc. have special-effect, are less than other teas.
Rhizoma Polygonati Odorati (Polygonatum odoratum (Mill.) Druce), for Liliaceae herbaceos perennial.
Originate in In Southwest China, but wild distribution is the widest.Cold-resistant, the most resistance to the moon, like wet environment, suitably give birth to
It is longer than the chesson abundant containing humus." stem is tetanic, like bamboo arrow shaft, has for Collective Notes to the Canon of Materia medica cloud
Joint ", therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine.Rhizoma Polygonati Odorati tool yin nourishing, moisturize, heat clearing away, life
The effect such as Tianjin, cough-relieving, can be used as tonic, cures mainly consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, sugar
The diseases such as urine disease, tuberculosis, and high-grade nourishing food, delicacies and beverage can be made, with health role.
Although producing at present and there is the medicine of function of polysaccharide and substitute products are of a great variety, but have fall blood concurrently
Sugar, blood pressure lowering and the health product mainly comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati of hypolipemic function
It is not reported so far.
Summary of the invention
The present inventor, through long-term research and practice, obtains one unexpectedly and has blood sugar lowering, fall blood concurrently
Pressure and hypolipemic function, comprise the health composition of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati, thus gram
Take drawbacks described above present in prior art.
It is an object of the present invention to provide a kind of guarantor comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Strong compositions, its percentage by weight is 5-80%: 5-80%: 5-80%: 10-85%.
In one embodiment of the invention, the weight percent of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Ratio is for 10-70%: 10-70%: 10-70%: 10-70%.
In one embodiment of the invention, the weight percent of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Ratio is for 20-40%: 20-40%: 20-40%: 20-40%.
In yet other embodiments, the weight of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Percentage ratio is 80%: 5%: 5%: 10%.
In yet other embodiments, the weight of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Percentage ratio is 60%: 15%: 15%: 10%.
In yet other embodiments, the weight of leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati
Percentage ratio is 30%: 25%: 25%: 20%.
In another embodiment of the present invention, described health composition can also comprise Folium Ilicis,
One in black tea, Folium Lycii, buckwheat leaf, Folium Longan, Folium Myricae rubrae, Folium Ipomoeae, Folium Eriobotryae or its
Meaning combination.
In another embodiment of the present invention, described health composition can also comprise Pericarpium Citri Reticulatae, mountain
One in medicine, Radix Scrophulariae, Radix Panacis Quinquefolii, Folium Ginkgo, Herb Gynostemmae Pentaphylli and Stigma Maydis or its combination in any.
Preferably, in described health composition the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 20-30%,
Folium Mori 20-70%, green tea 15-25%, Rhizoma Polygonati Odorati 5-15%, Folium Ilicis 5-15%.
It is further preferred that the percentage by weight of each taste medicine is leaf of Cyclocarya paliurus Iljinskaja in described health composition
20%, Folium Mori 50%, green tea 20%, Rhizoma Polygonati Odorati 5%, Folium Ilicis 5%.
Preferably, in described health composition the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 20-30%,
Folium Ilicis 10-20%, Folium Mori 10-20%, black tea 10-20%, Rhizoma Polygonati Odorati 10-20%, green tea 10-20%,
Folium Eriobotryae 10-20%, buckwheat leaf 10-20%, Folium Longan 10-20%.
It is further preferred that the percentage by weight of each taste medicine is leaf of Cyclocarya paliurus Iljinskaja in described health composition
20%, Folium Ilicis 10%, Folium Mori 10%, black tea 10%, Rhizoma Polygonati Odorati 10%, green tea 10%, Folium Eriobotryae
10%, buckwheat leaf 10%, Folium Longan 10%.
Preferably, in described health composition the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 10-20%,
Green tea 10-20%, Pericarpium Citri Reticulatae 10-20%, Rhizoma Dioscoreae 10-20%, black tea 10-20%, Radix Scrophulariae 10-20%,
Radix Panacis Quinquefolii 10-20%, Folium Ginkgo 10-20%, Herb Gynostemmae Pentaphylli 10-20%, Stigma Maydis 10-20%.
It is further preferred that the percentage by weight of each taste medicine is leaf of Cyclocarya paliurus Iljinskaja in described health composition
10%, green tea 10%, Pericarpium Citri Reticulatae 10%, Rhizoma Dioscoreae 10%, black tea 10%, Radix Scrophulariae 10%, Radix Panacis Quinquefolii
10%, Folium Ginkgo 10%, Herb Gynostemmae Pentaphylli 10%, Stigma Maydis 10%.
In yet another embodiment of the present invention, above-mentioned health composition also can comprise choosing the most yellow
Essence, Thallus Laminariae (Thallus Eckloniae), Fructus Momordicae, Fructus Mume, Radix Notoginseng, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Chuanxiong, Rhizoma Atractylodis, Radix Rehmanniae,
The Radix Paeoniae Alba, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, Fructus Tribuli, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Momordicae charantiae,
One in the group that Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii are formed or more
Multiple.
In the present invention, described health composition can be carried out by the preparation method of any routine in this area
Preparation.
Further object is that providing described health composition treats high blood in preparation auxiliary
Application in terms of sugar, hypertension or hyperlipidemia health composition.
A further object of the present invention there are provided a kind of pharmaceutical preparation containing described health composition.
The health composition of the present invention can be prepared as any with pharmaceutically acceptable adjuvant as required
Suitably oral formulations is for blood sugar lowering, blood pressure lowering or the treatment of blood fat reducing.
In yet other embodiments, described oral formulations can be tablet, capsule,
The dosage forms such as granule, powder, effervescent, alternative tea, bagged steeping drug.
In yet other embodiments, described pharmaceutically acceptable adjuvant such as can select
From pregelatinized Starch, beta-schardinger dextrin-, carbomer, microcrystalline Cellulose, hydroxypropyl methyl cellulose, low take
For hydroxypropyl cellulose, Polyethylene Glycol (PEG), sodium carboxymethyl cellulose, methylcellulose, ethyl
Cellulose, mannitol, cross-linking sodium carboxymethyl cellulose, lactose, polyvinylpyrrolidone (PVP),
One in magnesium stearate, Pulvis Talci, micropowder silica gel, aspartame, sodium bicarbonate, sodium carbonate or more
Multiple.
Effect activity of each primary raw material medicine in the present invention
Leaf of Cyclocarya paliurus Iljinskaja: mildly bitter flavor, pungent, property is put down.Have invigorating the spleen for eliminating dampness, Clearing heat and removing obstruction of fu-organs, depressed liver-energy dispersing and QI regulating,
The effect of enriching yin and nourishing kidney, to because dysfunction of the spleen, expectorant are turbid, addiction delicious food savoury, lazy dynamic, abdominal distention food stagnation,
The liver silt stagnation of QI and the obesity that causes, have good improvement.
Folium Mori: gas is light, mildly bitter flavor is puckery.There is the effect such as antihypertensive diuretic, blood fat reducing, α-Fructus Vitis viniferae can be suppressed
Glycosidase, and it is double to block the maltase in small intestinal cell brush border and saccharase etc. competitively
Glycosylhydrolase, has blood sugar reducing function.
Green tea: have refreshment, diuresis is recovered from fatigue, effect of fatigue alleviating, defying age, it is adaptable to oil
The crowd that the too much person of greasy food consumption, hypertension, dysuria, heating are thirsty.
Rhizoma Polygonati Odorati: yin nourishing, moisturize, heat clearing away, promote the production of body fluid, cough-relieving, can be used as tonic, cure mainly calentura wound
The disease such as the moon, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis.
Cortex Mori: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, can be used for lung-heat cough with asthma, the edema of the face, dysuria
Deng disease.There is blood pressure lowering, diuresis, sedation and analgesia, antiinflammatory, antibacterial and blood sugar lowering isoreactivity.
Herba Dendrobii: property slightly sweet flavor is micro-salty, cold, return stomach, kidney, lung meridian；There is reinforcing stomach reg fluid, nourishing YIN and clearing away heat
Effect, lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite are retched, deficiency-heat, poor vision after being ill.
Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature；Return lung, spleen channel；There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm,
For diseases such as distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Dioscoreae: sweet in the mouth, property are flat, return spleen, lung, kidney channel；Having spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating
Effect of arresting seminal emission, be used for treating insufficiency of the spleen, chronic diarrhea, the deficiency of the lung, suffer from a deficiency of the kidney, the disease such as leukorrhagia, frequent micturition.
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Attach to the lung and stomach meridians.Have expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst,
Effect of yang invigorating antidiarrheal, the deficiency of YIN thirsty for exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura disappears
Yearningly, the disease such as diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Fructus Momordicae: have refreshment, diuresis is recovered from fatigue, effect of fatigue alleviating, defying age, it is adaptable to
Rich food dish eats the crowd that too much person, hypertension, dysuria, heating are thirsty.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For syndrome of yin deficiency of liver and kidney.
The sweet flat matter of this product is moistened, and flat invigorating the liver and kidney has strengthening by means of tonics effect, all cards of all hepatic and renal YIN deficiency all can apply.
Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian.Effect: strongly invigorating primordial QI, multiple arteries and veins
Gu de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, anti-
Stomach tell food, stool lingering diarrhea, empty cough with asthma rush, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence,
Frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the card of all qi-blood-body fluid deficiencies.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent.GUIXIN, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize cunning
Intestinal.Controlling menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia；Headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome；Intestinal
Dry dyschezia, weight after bloody dysentery；Carbuncle skin ulcer is stolen, injury from falling down.
Radix Rhodiolae: sweet, bitter, flat.Return lung, heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For deficiency of vital energy blood
The stasis of blood, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Technical scheme has the advantage that
Compared with prior art, the health composition of the present invention is based on natural drug, and the present inventor exists
Numerous Chinese medicines and food have carried out a large amount of screening, thus obtain unexpectedly one comprise leaf of Cyclocarya paliurus Iljinskaja,
The health composition of the Chinese medicines such as Folium Mori, green tea and Rhizoma Polygonati Odorati, described health composition has blood sugar lowering, fall blood concurrently
Pressure and the excellent effect of blood fat reducing, and create in terms of blood sugar lowering, blood pressure lowering and hypolipemic function substantially
Synergism.Have clear curative effect, have no side effect, easy to use, synergism substantially and is prone to
The advantages such as masses take.
Detailed description of the invention
To further describe the present invention below in detail.It is pointed out that following description is only to this
The illustration of the technical scheme that invention is claimed, the not any restriction to these technical schemes.This
The content that the protection domain of invention is recorded with appended claims is as the criterion.
Embodiment 1
Formula forms: leaf of Cyclocarya paliurus Iljinskaja 8.0kg, Folium Mori 0.5kg, green tea 0.5kg, Rhizoma Polygonati Odorati 1.0kg.
Preparation method:
2.1 accurately weigh each taste Chinese medicine according to above-mentioned formula, are crushed respectively by raw material, cross 60 mesh sieves, with
Remove raw material fine powder；
2.2 leaf of Cyclocarya paliurus Iljinskaja, green tea, Folium Mori are mixed in mixer about 20 minutes to mix homogeneously,
Mixed material；
2.3 carry out subpackage, triangle bag-like by 1.5g/ bag, and packaging material are nylon membrane；
Embodiment 2
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 6.0kg, Folium Mori 1.5kg, green tea 1.5kg, Rhizoma Polygonati Odorati 1.0kg.
2, preparation method: with embodiment 1.
Embodiment 3
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 3.0kg, Folium Mori 2.5kg, green tea 2.5kg, Rhizoma Polygonati Odorati 2.0kg.
2, preparation method: with embodiment 1.
Embodiment 4
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 2.0kg, green tea 5.0kg, Folium Mori 2.0kg, Rhizoma Polygonati Odorati 0.5kg,
Folium Ilicis 0.5kg.
2, preparation method: with embodiment 1.
Embodiment 5
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 2.0kg, Folium Ilicis 1.0kg, Folium Mori 1.0kg, black tea 1.0kg,
Rhizoma Polygonati Odorati 1.0kg, green tea 1.0kg, Folium Eriobotryae 1.0kg, buckwheat leaf 1.0kg, Folium Longan 1.0kg.
2, preparation method: with embodiment 1.
Embodiment 6
1, formula composition: leaf of Cyclocarya paliurus Iljinskaja 1.0kg, green tea 1.0kg, Pericarpium Citri Reticulatae 1.0kg, Rhizoma Dioscoreae 1.0kg,
Black tea 1.0kg, Radix Scrophulariae 1.0kg, Radix Panacis Quinquefolii 1.0kg, Folium Ginkgo 1.0kg, Herb Gynostemmae Pentaphylli 1.0kg, Semen Maydis
Must 1.0kg.
2, preparation method: with embodiment 1.
Comparative example 1
Choose the sample as a comparison case 1 that green tea 10kg is prepared by the preparation method in embodiment 1.
Comparative example 2
Choose the sample as a comparison case 2 that fragrant solomonseal rhizome tea 10kg is prepared by the preparation method in embodiment 1.
Comparative example 3
Choose leaf of Cyclocarya paliurus Iljinskaja 3.5kg, green tea 3.5kg, Folium Mori 3.0kg by the preparation method in embodiment 1
Prepared sample as a comparison case 3
The scope of the present invention is not limited to above example, and each component in above-described embodiment is all selected from
Commercial goods, by the preparation process that this area is conventional, can make multiple dosage form described on pharmaceutics,
Such as capsule, granule, powder, tablet, oral liquid, teabag etc..
Experimental example 1: blood sugar lowering is tested
1, material and method
1.1 samples and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；Streptozotocin, SIGMA Products,
Specification: 1g/ props up, lot number: SLBJ7785V；The sodium chloride injection (normal saline) of 0.9%, rule
Lattice: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High lipid food
Formula (79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), picric acid etc..
1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler
Toledo, made by mettler-toledo group, model: pl303；LDZ5-2 centrifuge, north
Jing Yiyonglixinjichang；Johnson & Johnson surely person of outstanding talent's blood glucose meter (Johnson & Johnson (Chinese) medical device company limited)；
BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer (U.S.)；Microplate reader, bio-rad
(U.S.), model: iMark；Other: platform balance, fixing cage etc..
1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general
Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier
Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviationRepresenting, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
2.1 method
2.1.1 rat feed normal diet: Semen Maydis powder 80%, flour 15%, analysis for soybean powder 5%；High fat
Feedstuff: 79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica.
2.1.2 modeling: take 160-180gSPF level SD rat 110, male, body weight 160～180g,
Adaptability takes 10 after feeding one week and is only used as Normal group, feeds with chow diet, and other respectively organizes elder generation
Feed 1 month with high lipid food, after selective examination blood lipids index is significantly raised, lumbar injection STZ 35mg/kg
(STZ is before use by the citric acid/sodium citrate buffering of 0.1mmol/LpH=4.5 for induced Diabetic model
Liquid is made into the solution of 6mg/mL, and is finished in 60min).7d after injection, docking gathers sky
Abdomen venous blood, measures blood glucose with blood glucose meter, is considered as being modeled as more than or equal to 16.7mmol/L by blood glucose value
Merit.After model stability, according to blood-fat and blood sugar height packet, it is orally administered to test medicine and control drug,
Observe indices.
2.1.3 it is grouped and is administered: preferable 100 the modeling success animals of state of choosing are according to blood glucose value and body
Weight average is even is divided into 10 groups: often group 10, i.e. type ii diabetes model control group (giving distilled water),
S1 group, S2 group, S3 group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.Normally
The SD rat of not modeling 10 is Normal group (giving distilled water).Each group is administered orally by corresponding dosage
It is administered, is administered once daily, dosage period: 4 weeks (4W).
2.2 testing index
2.2.1 use blood glucose meter respectively measure administration before and be administered after 4W blood glucose value.
2.2.2 carbohydrate tolerance test: terminate a few days ago to detect in experiment；Carbohydrate tolerance detects: animal fasting
About 6 hours, each group gave variable concentrations given the test agent, oral administration of glucose 2.0g/kg after 15-20 minute,
Measuring to the blood glucose value of after glucose 0,0.5,2 hours, observing and nursing matched group is given with given the test agent group
The change of each time point Area under the curve of blood glucose after glucose.Area under the curve of blood glucose=1/2 × (0 hour blood
Sugar value+0.5 hours blood glucose value) × 0.5+1/2 × (2 hours blood glucose value+0.5 hours blood glucose value) × 1.5=
0.25 × (0 hours blood glucose value+4 × 0.5 hours blood glucose value+3 × 2 hours blood glucose value).
2.3 result
2.3.1 the impact on type ii diabetes rat blood sugar
From table 1, comparing with Normal group, it is notable that the front Glycemia Decline of administration respectively organizes rat blood sugar
Raise, show diabetes model modeling success.After being administered 4w, S1-S6 group blood glucose all has decline.
The impact on type ii diabetes rat blood sugar of table 1. sample
| Group | n | Blood glucose (mmol/L) before being administered | It is administered 4W blood glucose (mmol/L) |
| Normal group | 10 | 5.61±1.15 | 5.58±1.26 |
| Model control group | 10 | 17.48±3.86## | 21.85±4.37## |
| S1 group | 10 | 17.52±4.12 | 15.22±3.64* |
| S2 group | 10 | 17.49±3.94 | 15.16±3.75* |
| S3 group | 10 | 17.45±3.88 | 15.10±3.47* |
| S4 group | 10 | 17.44±3.96 | 15.93±3.82* |
| S5 group | 10 | 17.53±4.12 | 16.08±3.66* |
| S6 group | 10 | 17.46±4.08 | 16.19±3.73* |
| D1 group | 10 | 17.51±3.87 | 18.84±5.27 |
| D2 group | 10 | 17.49±3.88 | 18.90±5.63 |
| D3 group | 10 | 17.55±4.26 | 19.04±5.71 |
Note: compare with Normal group:##P ＜ 0.01；Compare with model group:*P ＜ 0.05
2.3.2 to type ii diabetes rat carbohydrate tolerance test result
From table 2, comparing with model control group, the Area under the curve of blood glucose of S1-S6 group all has decline.
Table 2. sample is to type ii diabetes rat carbohydrate tolerance test result
| Group | n | Area under the curve of blood glucose |
| Normal group | 10 | 16.32±4.16 |
| Model control group | 10 | 37.18±5.98## |
| S1 group | 10 | 25.43±5.42* |
| S2 group | 10 | 24.98±5.27* |
| S3 group | 10 | 25.18±5.61** |
| S4 group | 10 | 25.49±5.78* |
| S5 group | 10 | 25.93±5.77* |
| S6 group | 10 | 24.94±6.03* |
| D1 group | 10 | 33.68±6.71 |
| D2 group | 10 | 34.84±6.85 |
| D3 group | 10 | 35.24±6.90 |
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model control group: p is equal
More than 0.05.
3. conclusion: S1-S6 has an obvious hypoglycemic activity to diabetic model rats, and S1-S6
Compositions creates significant synergy in terms of blood sugar lowering.
Experimental example 2: lipid-lowering test
1, material and method
1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%,
Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High fat is raised
Material formula (79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), distilled water, picric acid,
Deng.
1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler
Toledo, made by mettler-toledo group, model: pl303；LDZ5-2 centrifuge, north
Jing Yiyonglixinjichang；BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer is (beautiful
State)；Other: platform balance, fixing cage etc..
1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general
Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier
Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
2.1 packets take SPF level SD rat 110 with method, male, and body weight 160～180g is suitable
Answering property takes 10 after feeding one week and is only used as Normal group, feeds with chow diet；Residue gives high fat
Forage feed.Continuous nursing 4 weeks (determining that modeling is the most successful by timing blood drawing detection four items of blood lipid tests)
After, preferable 100 the modeling success animals of state of choosing uniformly are divided into 10 according to blood fat numerical value and body weight
Group: often group 10, i.e. hyperlipemia model matched group (giving distilled water), S1 group, S2 group, S3
Group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.
High lipid food is started to be administered and continue (just feeding high lipid food by above packet situation after feeding 4 weeks
Often matched group feeds normal diet), every day 1 time, successive administration 4w.After last is administered, fasting overnight,
After next day weighs in, chloral hydrate anesthesia, put to death after postcava blood sampling.Take supernatant after Li Xin to survey
Biochemical indicator in serum.
2.2 Testing index:
(1) general status is observed, and records body weight weekly.
(2) each group rat blood serum lipid index: orbital venous plexus takes blood every two weeks, separation Virus monitory:
T-CHOL (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein, LDL
(LDL-C)。
2.3 result
2.3.1 on the impact of TC, TG, HDL-C, LDL-C in serum
Iipid data in rat blood serum after table 3. modeling success even group-division
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model control group: p is equal
More than 0.05.
Table 4. is each after being administered 4W organizes Iipid data in rat blood serum
Note: compare with Normal group:#P ＜ 0.05,##P ＜ 0.01；Compare with model group:*P ＜ 0.05,*P ＜ 0.01
From table 3, compare with Normal group, after model control group feeds high lipid food 4W, rat
Serum TC, LDL-C significantly raise (p ＜ 0.01), TG significantly raised (p ＜ 0.05), show hyperlipemia
Disease rat model modeling success.4 groups uniformly it are divided into according to blood lipid level.
From table 4, after being administered 4W, comparing with model control group, S1-S6 group can reduce in serum
TC, TG, LDL-C level (p ＜ 0.05 or p ＜ 0.01).
3. conclusion: S1-S6 has an obvious effect for reducing blood fat to Hyperlipemia model rat, and S1-S6
Compositions creates significant synergy in terms of blood fat reducing.
Experimental example 3: blood pressure lowering is tested
1, material and method
1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1,
S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%,
Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；Distilled water,
Picric acid, etc..
1.2 instrument DKB-501A type super constant temperature water tanks, reliable test Instrument Ltd. for Shanghai is gloomy
Product；Constant Temp. Oven, for Changsha medical apparatus and instruments factory product；Powlab/4sp ML125 type without
Wound pressure measuring system (ML125/R NIBP, MLT1199BPTrans-ducer/Cable Kit), Australia is big
Leah Ai De Instrument Ltd. product；MP120-1 electronic balance, for Shanghai Second Balance Factory
Product.
1.3 laboratory animal SPF level SHR rats, body weight 190～230g, male, logical by Beijing dimension
Li Hua laboratory animal Technology Co., Ltd. provides, the quality certification number: SCXK (capital) 2012-0001.Animal in
SPF level barrier level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081,
SPF level WISTAR male rat, Beijing Vital River Experimental Animals Technology Co., Ltd. provides, real
Testing animal productiong credit number is: SCXK (capital) 2012-0001.
1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat
Dosage, dosage is with crude drug gauge.
1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ±
Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics
Learn difference.
2. method and result
10 groups are divided at random, often group 10 by male for 9-10 week old spontaneous hypertensive rat (SHR),
I.e. hypertension model matched group (giving distilled water), S1 group, S2 group, S3 group, S4 group, S5 group,
S6 group, D1 group, D2 group and D3 group.Separately take normal WISTAR rat 10 for Normal group
(giving distilled water).Each treated animal gavage respectively gives various dose drug, every day 1 time, is administered 4 altogether
Week.Within 4 weeks, rat tail artery blood is detected with noinvasive arteria caudalis pressure measuring system before being administered and after being administered
Pressure value (shrinks pressure, SAP, mmHg).
Noinvasive tail sleeve method (NIBP): rat is put into rat fixator, exposes rat-tail.Take with infrared
Warmer, temperature is set to 38 DEG C, and after irradiating heating rat-tail about 10min, rat-tail deliquescing, rat-tail is moved
Arteries and veins is fully expanded.Be passed through pressurizeing tail sleeve and being fixed on the root of rat-tail, make rat tail artery with
PowerlabML125/R noinvasive arteria caudalis blood pressure determination is analyzed the pulse transducer of system and is in close contact, with
Time observation system pulse wave, can start when stable pulse wave occurs to measure blood pressure.Treat that animal is pacified
After quiet, select 90～420BPM (rat pressurization shelves) to tail sleeve inflating pressure, it is seen that pulse wave gradually subtracts
Little to disappearing, then tail sleeve starts venting, and Mus set pressure reduces, and when pressure is equal to when shrinking pressure, starts
Pulse wave occur, the pressure value of this point is rat-tail and shrinks pressure.Repeated measure 3 times, averages.Meter
Calculating voltage drop value (drop-out value of blood pressure), before after administration, SAP deducts administration, SAP obtains.The results are shown in Table 5:
The impact to SHR rat blood pressure (SAP, mmHg) of table 5 sample
Note: compare with Normal group: # is P ＜ 0.01；Compare with model control group: * is P ＜ 0.05.
Result shows, compares with Normal group, and model control group rat blood pressure significantly raises, it is seen that from
The success of Essential hypertension rat model.With model control group, S1-S6 group can significantly reduce at administration 4W
The blood pressure (P ＜ 0.05) of SHR rat.
3. conclusion: S1-S6 sample has significant hypotensive activity, and the compositions of S1-S6 is at blood pressure lowering
Aspect creates significantly association
Present invention merely illustrates some claimed specific embodiments, one of them or
Technical characteristic described in more technical schemes can be with arbitrary one or more technical scheme phases
Combination, these are combined and the technical scheme that obtains also in the application protection domain, just as these are through group
As the technical scheme closed and obtain specifically is recorded in the disclosure of invention.
Claims (14)
1. a health composition, it comprises leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati.
Health composition the most according to claim 1, wherein leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea
It is 5-80%: 5-80%: 5-80%: 10-85% with the percentage by weight of Rhizoma Polygonati Odorati.
Health composition the most according to claim 1, wherein leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea
It is 10-70%: 10-70%: 10-70%: 10-70% with the percentage by weight of Rhizoma Polygonati Odorati.
Health composition the most according to claim 1, wherein leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea
It is 20-40%: 20-40%: 20-40%: 20-40% with the percentage by weight of Rhizoma Polygonati Odorati.
Health composition the most according to claim 1, wherein leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea
It is 30%: 25%: 25%: 20% with the percentage by weight of Rhizoma Polygonati Odorati.
6. according to the health composition described in any one of claim 1-5, wherein said health composition
In also comprise Folium Ilicis, black tea, Folium Lycii, buckwheat leaf, Folium Longan, Folium Myricae rubrae, Folium Ipomoeae, Pi
One in rake leaf or its combination in any.
7. according to the health composition described in any one of claim 1-5, wherein said health composition
In also comprise the one in Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Radix Scrophulariae, Radix Panacis Quinquefolii, Folium Ginkgo, Herb Gynostemmae Pentaphylli and Stigma Maydis
Or its combination in any.
8. according to the health composition described in any one of claim 1-6, wherein said health composition
In the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 20-30%, Folium Mori 20-70%, green tea 15-25%,
Rhizoma Polygonati Odorati 5-15%, Folium Ilicis 5-15%.
9. according to the health composition described in any one of claim 1-6, wherein said health composition
In the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 20-30%, Folium Ilicis 10-20%, Folium Mori
10-20%, black tea 10-20%, Rhizoma Polygonati Odorati 10-20%, green tea 10-20%, Folium Eriobotryae 10-20%,
Buckwheat leaf 10-20%, Folium Longan 10-20%.
10. according to the health composition described in claim 1-5 and 7 any one, wherein said health care
In compositions the percentage by weight of each taste medicine be leaf of Cyclocarya paliurus Iljinskaja 10-20%, green tea 10-20%, Pericarpium Citri Reticulatae
10-20%, Rhizoma Dioscoreae 10-20%, black tea 10-20%, Radix Scrophulariae 10-20%, Radix Panacis Quinquefolii 10-20%,
Folium Ginkgo 10-20%, Herb Gynostemmae Pentaphylli 10-20%, Stigma Maydis 10-20%.
11. according to the health composition described in any one of claim 1-10, it is characterised in that described
Compositions also comprises selected from Rhizoma Polygonati, Thallus Laminariae (Thallus Eckloniae), Fructus Momordicae, Fructus Mume, Radix Notoginseng, Fructus Ligustri Lucidi, Fructus Corni,
Rhizoma Chuanxiong, Rhizoma Atractylodis, Radix Rehmanniae, the Radix Paeoniae Alba, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, puncture
Herba chenopodii, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and
One or more of in the group that Bulbus Allii is formed.
Health composition described in 12. any one of claim 1-10 is at preparation treatment hyperglycemia, high blood
Application in pressure or hyperlipidemia health composition.
The pharmaceutical preparation of 13. 1 kinds of health compositions comprised described in any one of claim 1-10, its
Middle described health composition and pharmaceutically acceptable adjuvant are prepared as oral formulations.
14. pharmaceutical preparatioies according to claim 13, wherein said oral formulations be tablet,
Capsule, granule, powder, effervescent, alternative tea or bagged steeping drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510212597.0A CN106177432A (en) | 2015-04-29 | 2015-04-29 | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510212597.0A CN106177432A (en) | 2015-04-29 | 2015-04-29 | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati |
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| Publication Number | Publication Date |
|---|---|
| CN106177432A true CN106177432A (en) | 2016-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510212597.0A Withdrawn CN106177432A (en) | 2015-04-29 | 2015-04-29 | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107788180A (en) * | 2017-12-01 | 2018-03-13 | 贵州健瑞安药业有限公司 | A kind of health protecting tea of stable hypotensive and preparation method thereof |
| CN109224021A (en) * | 2018-10-29 | 2019-01-18 | 常现辉 | Treat diabetes, the health protecting tea of lowering blood pressure and blood fat and preparation method |
| CN109266477A (en) * | 2018-09-29 | 2019-01-25 | 南京林业大学 | A kind of blue or green money willow red wine and its preparation method and application |
| US11207366B2 (en) * | 2017-05-24 | 2021-12-28 | Guosheng CHANG | Traditional Chinese medicine composition comprising dried tangerine peels and dark tea for treating diabetes and preparation method thereof |
-
2015
- 2015-04-29 CN CN201510212597.0A patent/CN106177432A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11207366B2 (en) * | 2017-05-24 | 2021-12-28 | Guosheng CHANG | Traditional Chinese medicine composition comprising dried tangerine peels and dark tea for treating diabetes and preparation method thereof |
| CN107788180A (en) * | 2017-12-01 | 2018-03-13 | 贵州健瑞安药业有限公司 | A kind of health protecting tea of stable hypotensive and preparation method thereof |
| CN109266477A (en) * | 2018-09-29 | 2019-01-25 | 南京林业大学 | A kind of blue or green money willow red wine and its preparation method and application |
| CN109224021A (en) * | 2018-10-29 | 2019-01-18 | 常现辉 | Treat diabetes, the health protecting tea of lowering blood pressure and blood fat and preparation method |
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Application publication date: 20161207 |