CN103749822B - A kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof - Google Patents

Abstract

The invention provides a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw material are: the fruit of glossy privet 10 ~ 50 parts, hawthorn 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, elscholtiza 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Inula britannica chinensis 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the root bark of Chinese wolf-berry 10 ~ 20 parts.The fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect tea flavour road, make people be easy to accept, more can reach effect of hypertension and hyperlipemia preferably.

Description

A kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof.

Background technology

Blood fat mainly refers to cholesterol in serum and triglycerides.No matter be that cholesterol level increases, or the content of triglyceride increases, or both all increase, and are referred to as hyperlipidemia.The infringement of this disease to health be concealment, gradually, Progressive symmetric erythrokeratodermia and general, systemic atherosclerosis is accelerated in its direct infringement, because the vitals of whole body all will rely on artery blood supply, oxygen supply, once artery is blocked by atheromatous plaque, serious consequence will be caused.The renal failure etc. that artery sclerosis causes, all closely related with hyperlipemia.A large amount of research data shows, hyperlipemia is cerebral apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death independently important hazards.A large amount of medical research shows: the methods for the treatment of of high fat of blood only by drug-layer side, also can not will notice taking good care of of health.The expert endeavouring the research of anion Natural medicine claims: negative oxygen ion is treated hyperlipidemia Be very effective, stablized, have no side effect, and be improved the group effect of body function, raising resistance against diseases, be particularly useful for the person in middle and old age's hyperlipidemia patient with multiple chronic disease, be a kind of comparatively ideal non-drug therapy, be worthy to be popularized.

The concentration of the lipid compositions such as hyperlipemia plasma cholesterol, triglycerides, total fat exceedes arm's length standard.The main harm of hyperlipemia causes atherosclerotic, and then cause numerous relevant diseases, and wherein modal a kind of fatal disease is exactly coronary heart disease, and serious chylomicronemia can cause acute pancreatitis, is another fatal disease.

In addition, hyperlipemia is also the important risk factor promoting hypertension, IGT, diabetes.Hyperlipemia also can cause fatty liver, cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.Also can there is xanthoma, embryotoxon etc. around tendon shape, nodositas, palm plane and eye socket in some primary and familial hyperlipemia.Blood pressure is modal chronic disease, and be also the topmost hazards of cardiovascular and cerebrovascular diseases, cerebral apoplexy, myocardial infarction, heart failure and CKD are its major complications.Both domestic and externally facts have proved, hypertension is can the disease of prevention and corntrol, reduces the blood pressure level of hyperpietic, can obviously reduce cerebral apoplexy and the events of heart attack, significantly improve the life quality of patient, effectively reduce Disease Spectrum.The blood pressure level of hypertensive harmfulness and patient mutually outside the Pass, also depend on the situation of other diseases of other cardiovascular risk factors simultaneous, target organ damage and merging.Therefore in hypertensive definition and classification, hypertensive diagnostic criteria is fixed on systolic pressure >=140mmHg and (or) diastolic pressure >=90mmHg, be divided into normally according to blood pressure level, outside High-normal blood pressure and 1,2,3 grade of hypertension, also carry out risk stratification according to hazards, target organ damage and the other diseases that merges simultaneously simultaneously.

Prevalence of Hypertension increases with the age and raises; Women's illness rate before climacteric, a little less than the male sex, but to raise rapidly, even higher than the male sex after climacteric; High latitude cold district illness rate is higher than the warm area of low latitudes, and high altitude localities is higher than low altitude area; Relevant with eating habit, salt and saturated fat are taken in higher, and mean blood pressure level and illness rate are also higher.Population of China hypertension is popular has two to compare outstanding feature: from south to the north, Prevalence of Hypertension is increasing trend; Between different nationalities, Prevalence of Hypertension also has some differences, the national illness rate of living in the north or highlands is higher, the national illness rate of living in south or non-highlands is then lower, this species diversity may be relevant with geographical environment, life style etc., not yet finds there is obvious genetic background difference between various nationalities.

Treating hypertensive main purpose is reduce cardiovascular morbidity and dead total danger to greatest extent, therefore require that doctor is treating hypertensive while, intervene the clinical disease that all invertibity cardiovascular risk factors of patient, target organ damage and merging exist.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.

The fruit of glossy privet begins to be loaded in Eastern Han Dynasty's Shennong's Herbal and is classified as top grade.Compendium of Material Medica is recorded: " to insult winter verdant for this wood, has the behaviour that chastity is kept, therefore with glossy privet shape it ... to put wax insect time near, therefore be commonly called as wax tree." " Bencao Jingshu " carry: " fruit of glossy privet, smell is all cloudy, and just entering kidney except what vulcanize essence and wanting product, kidney must be mended, then the five internal organs are from peace, and spirit is self-sustaining, and all kinds of diseases and ailments are gone and body is fertile is good for." " book on Chinese herbal medicine is stated " carries: " Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty is real, admittedly enter sea of blood benefit blood, and gentle above flourish ... by the main lung of kidney, and be skillful in up and down with excessive, lower only beard is so also, namely in wide heir side, multiplex." " herbal classic is met former " carries: " Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty, property reports pure the moon, and taste is partially cold sliding, and the empty people of taste takes it, often subtracts food and rushes down." in the book such as " rebuilding is had stable political situation through history card class book on Chinese herbal medicine for subsequent use ", Compendium of Material Medica, " Illustrated Book on Plants ", contained glossy privet and accompanying drawing all refer to this kind, illustrate that medication is at all times consistent.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, the leucocyte decline quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, Escherichia coli.

The acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in the fruit of glossy privet, also containing 15 seed amino acids, 11 kinds of trace elements and volatilization wet goods.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Medium degree inhibitory action is had to Type B adenovirus.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines to leucocyte caused by chemotherapy rising effect.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can accelerate the mobility of platelet cell, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Significantly improve mice serum hemolytic antibody active, impact mouse spleen lymphocyte being produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea.

The various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective hypertension and hyperlipemia method has very real significance, and hypertension and hyperlipemia active material is the key that people expect to deal with problems always safely and effectively.The step-down of Chinese medicine hypoglycemic, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the product that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, the various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective hypertension and hyperlipemia method has very real significance.The fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition.Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect tea flavour road, makes people be easy to accept, more can reach effect of hypertension and hyperlipemia preferably.

For solving above-mentioned technical barrier, the invention provides a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw material are: the fruit of glossy privet 10 ~ 50 parts, hawthorn 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, elscholtiza 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Inula britannica chinensis 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the root bark of Chinese wolf-berry 10 ~ 20 parts.

Described fruit of glossy privet hypertension and hyperlipemia health protection tea, in fruit of glossy privet hypertension and hyperlipemia health protection tea described in it, the parts by weight of various raw material can be: the fruit of glossy privet 10 ~ 30 parts, hawthorn 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, elscholtiza 10 ~ 15 parts, sealwort 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 15 parts, cogongrass rhizome 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Radix Codonopsis 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Inula britannica chinensis 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the root bark of Chinese wolf-berry 10 ~ 20 parts.

Described fruit of glossy privet hypertension and hyperlipemia health protection tea, in fruit of glossy privet hypertension and hyperlipemia health protection tea described in it, the parts by weight of various raw material can also be: the fruit of glossy privet 10 ~ 40 parts, hawthorn 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, elscholtiza 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Codonopsis 10 ~ 15 parts, root of Chinese trichosanthes 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Inula britannica chinensis 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the root bark of Chinese wolf-berry 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, and described in it, the preparation process of fruit of glossy privet hypertension and hyperlipemia health protection tea comprises following aspect:

A. the preparation of the fruit of glossy privet;

B. by other raw material soaking ethanol described, heating, refluxing extraction 2 times;

C. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the fruit of glossy privet prepared, be prepared into health care medicinal tea.

In described step a, can have during white powder in annual fruit of glossy privet fruit blackening in December and lay, removing stalk, leaf and impurity, dry or put after scalding in hot water and dry; Then steeping in wine one day, steams and thoroughly dries, for subsequent use.

In described step b, raw material can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

In described steps d, particle prepared by the fruit of glossy privet prepared and surplus stock can be mixed, ultraviolet disinfection, pack and get final product.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, the process for producing granula of described fruit of glossy privet hypertension and hyperlipemia health protection tea can also be: steep into ethanol by all the other raw materials, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; Above-mentioned two kinds of extracts are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, puts into oven drying and obtain powder, adds dextrin and granulates.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, the paste preparation method of described fruit of glossy privet hypertension and hyperlipemia health protection tea can be: other raw materials are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste.

The technique effect that the present invention is useful is, the fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily in endangium deposition, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition.Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect tea flavour road, makes people be easy to accept, more can reach effect of hypertension and hyperlipemia preferably.The fruit of glossy privet contains a large amount of oleanolic acid, have hypotensive, reduce peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce MCO, cardiac stimulant, increase cardiac output, resist myocardial ischemia, platelet aggregation-against, improve hemorheological property, eliminate oxygen radical, fall the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis.Clinical is all safe and effective for preventing and treating coronary disease and angina pectoris, hypertension, arrhythmia cordis and hyperlipidemia, atherosclerotic etc., is worthy of popularization.

Detailed description of the invention

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Modern pharmacological research shows, fruit of glossy privet decocting liquid has the effect reducing blood sugar and blood fat to rabbit experiment diabetes and hyperlipidemia.The fruit of glossy privet is rich in bioflavonoid, linoleic acid, chromium element.Flavones not only can effectively promoting blood circulation and removing blood stasis, embolism resistance, reducing blood lipid, hypotensive, reduce cholesterol, reduce blood sugar, the composition of blood is purified, but also the fragility of microcirculation, reduction capillary can be improved, reduce its permeability, impaired vascular wall can be repaired.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, the leucocyte decline quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, Escherichia coli.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.The fruit of glossy privet is the dry mature fruit of oleaceae plant glossy privet, and taste is sweet, bitter, cool in nature, returns liver kidney two warp.The acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in the fruit of glossy privet, also containing 15 seed amino acids, 11 kinds of trace elements and volatilization wet goods.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Medium degree inhibitory action is had to Type B adenovirus.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines to leucocyte caused by chemotherapy rising effect.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can accelerate the mobility of platelet cell, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Significantly improve mice serum hemolytic antibody active, impact mouse spleen lymphocyte being produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea.

Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has develop immunitypty, hemangiectasis, step-down, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition the leucocyte caused chemotherapy radiotherapy declines and has castering action.Radix Codonopsis has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst." new compilation of materia medica " is recorded: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, mends in order to adjust, very smooth and proper.”

Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and health care.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia RehmanniaglutinosaLibosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.

The root bark of white mulberry is the root skin of moraceae plants mulberry MorusalbaL..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.

Cogongrass rhizome cures mainly: cooling blood and hemostasis, clearing heat and detoxicating.For spitting blood, hematuria, heat is drenched, oedema, jaundice, difficult urination, pyreticosis polydipsia, and stomach energy is vomitted the sound of vomiting, coughs." herbal classic ": " main internal lesion caused by overexertion void is thin, tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills, diuresis." " not Lu ": " lower five drenches, and except visitor's heat is at stomach, quenches the thirst, hard muscle, married woman's metrorrhagia.", " book on Chinese herbal medicine justice ": cogongrass rhizome, cold and cool and taste is very sweet, the heat that to purify the blood point, and do not hinder drying, not sticky again, therefore cool blood and do not consider its long-pending stasis of blood, tell nosebleed spitting blood to lead.Drop-down fire is inverse, and its effect is very prompt, therefore main stomach fire hiccup vomiting again, the lung heat circulation of vital energy in the wrong direction is breathed heavily full.And sweet cold and greasiness liquid, though fall inverse and differ from bitter dry, then slake thirst and help produce saliva again, and wash clearly the latent heat between lung stomach and intestine, can the paddy that disappears be treated yearningly dry.Again can treating stranguria closing and control blood under haematuria, and housewife female's blood-heat bleeding, metrorrhagia drenches band.The little water of tonneau again, the oedema of the knot that expels the heat-evil, leads the jaundice of stagnant heat, all sweet cold actual effect of removing heat by catharsis.So its sweet cold power, let out clearly lung stomach, especially have speciality, all dentalgia gums swell, all sores of noma dispute, and the strongly fragrant pharyngalgia of stopping up of lung heat is rotted all cards, and make in order to assistant, effect is the most outstanding, and without abuses.

Elscholtiza acrid-sweet flavor, warm in nature, nontoxic.Return lung, stomach, the spleen channel.Inducing sweat and dispelling exogenous evils, dampness elimination and in, inducing diuresis for removing edema; Sweating relieving summer-heat, row water is loose wet, during warm stomach is adjusted.Control the cold drink of Xia Yue sense cold, have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, oedema, beriberi.The Ileum From A White Spontaneous Contraction activity of Herba Moslae volatile oil to mouse, rat, cavy and rabbit all has stronger direct repression, but it is different to the sensitiveness of the animal of different genera, by contrast, stronger to the inhibitory action of cavy and Rabbit Ileum, effective dose 50 is respectively 3.6 and 7.6 μ g/ml, and slightly weak to the effect of rat and mouse, effective dose 50 is 14.2 and 35.1 μ g/ml.To GPI because the anaphylaxis contraction caused by egg and the anaphylaxis contraction caused by barium chloride all have antagonism." book on Chinese herbal medicine " cloud: main abdominal pain due to acute vomiting and diarrhea is told down, aproll swells.

Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, and interior heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing sealwort.The person of being used as medicine is dried for clean sealwort steams rear section with the auxiliary material such as wine and black soya bean.Have the merit of channels and collaterals of escaping concurrently.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.Sealwort strengthens the bone, beneficial marrow, bleaches and sends out; The cough phlegm be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Dried orange peel is warm in nature, and taste is pungent, bitter.Enter the spleen channel, stomach warp, lung channel.Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, reduces phlegm.Cure mainly abdominal fullness and distention or pain, the indigestion of the taste stagnation of the circulation of vital energy.Abdominal distension uncomfortable in chest in wet turbid resistance, indigestion and loss of appetite loose stool.The wet cough and asthma stopping up lung of phlegm.For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.Compendium of Material Medica: it is to hundred and always get chess and to regulate the flow of vital energy the merit of eliminating dampness, then mending with tonic, then rushes down with cathartic, then rise with hydrargyrum oxydatum crudum, then falling with falling medicine.Spleen is the mother of vigour, lung be take the photograph gas want, therefore orange peel be two through gas divide want, but with join and reinforcing and reducing methods lifting also." daily book on Chinese herbal medicine ": can fall apart and can rush down, can temperature can mend, can disappear diaphragm gas, and reduce phlegm saliva, and spleen is only coughed, and logical five drench.

Cassia seed bitter, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Relax bowel, lipopenicillinase improving eyesight, treatment constipation and high fat of blood, hypertension.Clear liver and improve vision, sharp water defaecation, has laxative action, reducing blood pressure and blood fat.Cassia seed can be arranged in pairs or groups with other Herb Teas, has good greasy effect of toxin expelling oil extraction.Can effect be reached: the flat liver of heat-clearing, blood fat-reducing blood pressure-decreasing, relax bowel, improving eyesight benefit eyeball.Modern " TV race ", " cybraian " etc. easily cause the crowd of eye fatigue often to drink, but night preferably drinks less.

Hawthorn tepor is sweet, sour.Function stomach strengthening and digestion promoting is promoting blood circulation and removing blood stasis.Hawthorn energy prevention and cure of cardiovascular disease, has hemangiectasis, increases CF, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and sedation.Hawthorn energy prevention and cure of cardiovascular disease, has hemangiectasis, cardiac stimulant, increase CF, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and sedation; Prevent and treat artery sclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also benefits to senile heart disease.Its energy appetite-stimulating indigestion-relieving, offsets carnivorous stagnant effect especially better, all have employed hawthorn in a lot of digestant medicine; Hawthorn has contraction to uterus, pregnant woman just before giving birth time have the effect expedited the emergence of, and uterine involution in postpartum can be promoted; The immunity of body can be strengthened, have anti-aging, anticancer effect.Having in hawthorn relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

RADIX POLYGONI MULTIFLORI PREPARATA: the Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA with black soya bean liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, and is usually used in treatment scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow for the deficiency of blood, dizzy tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body is empty etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Root of Chinese trichosanthes is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing heat-fire class medicine, its concrete effect is clearing heat-fire, promotes the production of body fluid to quench thirst, and apocenosis is subsided a swelling.Cure mainly: control pyreticosis thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle are swollen, hemorrhoid impotence.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both principal and secondary aspect of disease." book on Chinese herbal medicine converge with speech ": root of Chinese trichosanthes, it is hot and suffocating to move back the five internal organs, and as internal heat is contained and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, and spleen fire is contained and dispute tooth swells, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.Walk note if the side of body of irascibility is swollen, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer is not burst, and hot poison does not fall apart, or five subcutaneous ulcer yellow skin and eyes, and if if the pouring of little water is puckery, be all intimately caused by pent-up, convulsive seizure due to phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling polydipsia from blood medicine, is control thirsty key medicine also.

Inula britannica chinensis: bitter; Pungent; Salty; Tepor.Return lung; Stomach; Large intestine channel.Sending down abnormally ascending, dissolving phlegm, row water, preventing or arresting vomiting.For cough due to wind-cold evil, phlegm and retained fluid stores knot, and chest diaphragm ruffian is full, dyspnea and cough with excessive sputum, vomiting gas.Shennong's Herbal: " main knot gas hypochondrium fullness, palpitation with fear.Dewater, remove fever and chills between the five internal organs, bowl spares, lower gas." modern study, Inula britannica chinensis has protective effect to immunological liver injury, and its chemical composition gaillardin has antitumaous effect.In addition, its root and cauline leaf or aerial part also can be used as medicine, and control knife wound, serious case of furuncle, decoction can antiasthmatic effect.

Root bark of Chinese wolf-berry heat-clearing, cool blood.Control consumptive disease hectic fever night sweat, lung heat is coughed and is breathed heavily, and spits blood, bleeding from five sense organs or subcutaneous tissue, and blood drenches, and quenches one's thirst, hypertension, and carbuncle swells, and dislikes sore." herbal classic ": " perverse trend in main five, hankers quenching one's thirst, general arthralgia." " not Lu ": " main air wets, lower breast side of body gas, the headache of visitor's heat, mends internal injury great Lao and to hiss suction, hard muscle, reinforcing yin essence, sharp intestine and small intestine, resistance to cold and heat.″

Specific embodiment 1:

First prepared by the fruit of glossy privet.

Again by all the other raw material hawthorn, RADIX POLYGONI MULTIFLORI PREPARATA, elscholtiza, sealwort, the dried rhizome of rehmannia, cassia seed, cogongrass rhizome, Poria cocos, the red sage root, Radix Codonopsis, root of Chinese trichosanthes, gynostemma pentaphylla, the root bark of white mulberry, dried orange peel, the Radix Astragali, Inula britannica chinensis, the bighead atractylodes rhizome, the root bark of Chinese wolf-berry, extracts to concentrate and makes granule, pulvis or paste.

The extract of the fruit of glossy privet prepared and other raw materials, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.

Specific embodiment 2:

Prepared by the fruit of glossy privet: have during white powder in annual fruit of glossy privet fruit blackening in December and lay, and gets the fruit of glossy privet 5000g obtained and cleans, removing stalk, leaf and impurity, dry or put after scalding in hot water and dry; Then soak one with yellow rice wine, steam and thoroughly dry, for subsequent use.

Get all the other raw material hawthorn 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, elscholtiza 1500g, sealwort 1500g, dried rhizome of rehmannia 1500g, cassia seed 1500g, cogongrass rhizome 1500g, Poria cocos 1500g, red sage root 1500g, Radix Codonopsis 1500g, root of Chinese trichosanthes 1500g, gynostemma pentaphylla 1500g, root bark of white mulberry 1500g, dried orange peel 1500g, Radix Astragali 1500g, Inula britannica chinensis 1500g, bighead atractylodes rhizome 1500g, root bark of Chinese wolf-berry 1500g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use.The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.Particle prepared by the fruit of glossy privet prepared and surplus stock is mixed, ultraviolet disinfection, pack and get final product.

Specific embodiment 3:

Have during white powder in annual fruit of glossy privet fruit blackening in December and lay, get the fruit of glossy privet 3500g obtained and clean, removing stalk, leaf and impurity, dry or put after scalding in hot water and dry; Then soak one with yellow rice wine, steam and thoroughly dry, for subsequent use; By surplus stock hawthorn 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, elscholtiza 1200g, sealwort 1200g, dried rhizome of rehmannia 1200g, cassia seed 1100g, cogongrass rhizome 1200g, Poria cocos 1200g, red sage root 1100g, Radix Codonopsis 1200g, root of Chinese trichosanthes 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1200g, dried orange peel 1200g, Radix Astragali 1200g, Inula britannica chinensis 1200g, bighead atractylodes rhizome 1200g, root bark of Chinese wolf-berry 1200g, is ground into particle, soaks 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Again the fruit of glossy privet prepared is mixed with the granule made, ultraviolet disinfection, pack and get final product.

Specific embodiment 4:

Have during white powder in annual fruit of glossy privet fruit blackening in December and lay, get the fruit of glossy privet 4500g obtained and clean, removing stalk, leaf and impurity, dry or put after scalding in hot water and dry; Then soak one with 60 degree of white wine, steam and thoroughly dry, for subsequent use; By surplus stock hawthorn 1100g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, elscholtiza 1200g, sealwort 1200g, dried rhizome of rehmannia 1200g, cassia seed 1100g, cogongrass rhizome 1300g, Poria cocos 1200g, red sage root 1100g, Radix Codonopsis 1200g, root of Chinese trichosanthes 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1100g, dried orange peel 1100g, Radix Astragali 1200g, Inula britannica chinensis 1200g, bighead atractylodes rhizome 1300g, root bark of Chinese wolf-berry 1200g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, then puts into baking oven inner drying powdered, and hybrid packed with the fruit of glossy privet prepared after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Modern pharmacological research shows, fruit of glossy privet decocting liquid has the effect reducing blood sugar and blood fat to rabbit experiment diabetes and hyperlipidemia, existing for further study to its hypoglycemic decompression lipid-lowering effect, for the Clinical practice fruit of glossy privet provides theoretical foundation.

1 materials and methods

1.1 material

1.1.1 medicine: glossy privet fruit health-care tea boiling of the present invention (preparation of the embodiment of the present invention 2 method), is prepared into the reagent containing crude drug 9g/10ml, is provided by inventor; Metformin hydrochloride (Shanghai Fahrenheit pharmacy).

1.1.2 animal Kunming mouse 96, male and female half and half, body weight (22.5 ± 2.5) g, provides by Shandong University's animal experimental center.

1.1.3 reagent and instrument Streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (plum Teller-Tuo Co., Ltd of Switzerland); Hitachi 7150 type automatic clinical chemistry analyzer (Japan).

1.2 method

1.2.1 modeling and grouping

Diabetes: animal is bought back, after adaptability feeds 1 week, be divided into normal non-diabetic group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood sugar, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and continue constant person, be defined as diabetes and formed.Modeling success mouse is divided into 5 groups, the high, medium and low concentration group of model control group, melbine group, decocting liquid of the present invention at random.

Hyperlipidemia: animal is bought back, after adaptability feeds 1 week, be divided into normal non-hyperlipidemia group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling gives more than 1 week containing 1% cholesterol, the high lipoprotein emulsion of 20% lard, 2% sodium taurocholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mouse is divided into 5 groups, model control group, melbine group, the high, medium and low concentration group of leaves of Hawthorn decocting liquid of the present invention at random.

1.2.2 administration and assay method Normal group and model control group (the isopyknic physiological saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Decocting liquid group of the present invention (ig every day decocting liquid 2.0g/kg of the present invention respectively, 3.0g/kg, 4.0g/kg).Each group of difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, measures blood sugar and blood fat with automatic clinical chemistry analyzer.

1.2.3 all data of statistical procedures represent with "-χ ± S ", data acquisition SPSS11.5 statistical software analyzing and processing, if compare homogeneity of variance One-way ANOVA between many groups, if heterogeneity of variance rank test, compare and use paired t-test before and after in group.

2 results

2.1 hypoglycemic experiments

As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all significantly can reduce the blood sugar of hyperglycaemia mouse model, compares with model control group, and difference has statistical significance (P < 0.05).

2.3 lipopenicillinase experiment as shown in Table 2, the high, medium and low concentration of decocting liquid of the present invention all obviously can reduce TC, TG content of hyperlipemia mice model, compare with model control group, difference has statistical significance (P < 0.05, P < 0.01).

Table 1 liquid of the present invention is on the impact (-χ ± S) of mouse blood sugar

Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, physiological saline.

Table 2 decocting liquid of the present invention is on the impact (-χ ± S) of lipid of mice

Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, physiological saline.

3, microcirculation experimental technique:

3.1. materials and methods: get 50 mouse, be divided into 5 groups at random, often organizes 10 (male and female half and half), and it is a little that control group every mouse auris dextra is coated with physiological saline; Positive controls every mouse auris dextra trains first blood-activating analgesic plaster, and test component is dosage group 600mg/kg/h in low dose group 400mg/kg/h of the present invention, the present invention, high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum injects 0.1% yellow Jackets 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% adrenaline 0.1mL/10g, observes mouse right ear fine motion vein bore (μm) and 0.2mm immediately ²capillary net number .t checks process experimental data.

3.2 results and discussion

3.2.1. on microcirculatory impact

Table 1, the present invention are on the impact of mouse fine motion, vein bore and capillary open number

Compared with control group, tested group 1 pair mouse capillary open number has showed increased (P < 0.01); Tested group of 2 pairs of venule bores and capillary open number have remarkable increase (P < 0.01); Tested group of 3 pairs of mouse fine motions, vein bore and capillary open number all have increase (P < 0.01); Illustrate and be subject to reagent to improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

4, discuss

In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipidemia.The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acid, the mobility of platelet cell can be accelerated, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Fruit of glossy privet flavones have hypotensive, reduce peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce MCO, cardiac stimulant, increase cardiac output, resist myocardial ischemia, platelet aggregation-against, improve hemorheological property, eliminate oxygen radical, fall the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis.Clinical is all safe and effective for preventing and treating coronary disease and angina pectoris, hypertension, arrhythmia cordis and hyperlipidemia, atherosclerotic etc., is worthy of popularization.Particularly Resources of The West Area In China is very abundant in China various places for the fruit of glossy privet, has very high Development volue.Ancients' its treatment diabete multiplex, is equivalent to the diabetes in modern medicine.This experiment, for verifying its hypoglycemic, effect for reducing fat and establishing, found that it truly has obvious hypoglycemic, effect for reducing fat.

Claims (7)

1. a fruit of glossy privet hypertension and hyperlipemia health protection tea, it is characterized in that, described fruit of glossy privet hypertension and hyperlipemia health protection tea is made up of the bulk drug of following parts by weight: the fruit of glossy privet 10 ~ 50 parts, hawthorn 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, elscholtiza 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Inula britannica chinensis 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the root bark of Chinese wolf-berry 10 ~ 20 parts.

2. fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 1, it is characterized in that, described fruit of glossy privet hypertension and hyperlipemia health protection tea is made up of the bulk drug of following parts by weight: the fruit of glossy privet 10 ~ 30 parts, hawthorn 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, elscholtiza 10 ~ 15 parts, sealwort 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 15 parts, cogongrass rhizome 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Radix Codonopsis 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Inula britannica chinensis 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the root bark of Chinese wolf-berry 10 ~ 20 parts.

3. fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 1, it is characterized in that, described fruit of glossy privet hypertension and hyperlipemia health protection tea is made up of the bulk drug of following parts by weight: the fruit of glossy privet 10 ~ 40 parts, hawthorn 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, elscholtiza 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, cassia seed 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Radix Codonopsis 10 ~ 15 parts, root of Chinese trichosanthes 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Inula britannica chinensis 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the root bark of Chinese wolf-berry 10 ~ 15 parts.

4. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described fruit of glossy privet hypertension and hyperlipemia health protection tea comprises following aspect:

A. the preparation of the fruit of glossy privet;

B. by other raw material soaking ethanol, heating, refluxing extraction 2 times;

C. again the concentration of liquid medicine that other raw material extracts is become granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the fruit of glossy privet prepared, be prepared into health care medicinal tea.

5. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, is characterized in that, in described step a, having during white powder lay in annual fruit of glossy privet fruit blackening in December, removing stalk, leaf and impurity, dries or puts after scalding in hot water and dry; Then steeping in wine one day, steams and thoroughly dries, for subsequent use.

6. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

7. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, is characterized in that, in described steps d, mixed by particle prepared by the fruit of glossy privet prepared and surplus stock, ultraviolet disinfection, pack and get final product.