CN1121811A - Drug prescription for treatment of neurosis and preparing method thereof - Google Patents
Drug prescription for treatment of neurosis and preparing method thereof Download PDFInfo
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Abstract
The Chinese-medicinal prescriptions for curing nervous diseases such as insomnia, disturbed sleep, headache, dizziness and hypomnesia with optimal curative effect is prepared from pearl powder, wild jujube seed, tuckahoe, VB1 and VB6.
Description
The present invention relates to one group and treat neurosal pharmaceutical formulation and preparation and method for making.
Neurosis is one group of commonly encountered diseases due to the human central nervous system function disorder, frequently-occurring disease.In neural psychiatric department outpatient service, neurosis accounts for 50%, and in internal medicine or other clinical sections, neurosis is also not rare, suffers from neurasthenic patient, insomnia, dreaminess, dizziness, headache, hypomnesis, can reduce study and work efficiency greatly, the anxiety of serious symptom and depression more have a strong impact on people's physical and mental health, therefore, seek the good and few side effects of a kind of curative effect calmness, calm the nerves, hypnotic drug is the world of medicine's urgent task for a long time.At present the neurosal medicine of this class of treatment is more, and as barbiturates sedative hypnotic, benzodiazepine antianxiety drugs etc., these medicines all are to be main therapeutic purposes to suppress that the central nervous system is overexcited.Obtained many achievements recent decades, but this class medicine all has many shortcomings, as addiction, toleration and sequela shape etc., its basic reason is still to fail to reach to make disorderly central nervous system function recover normal.Modern medicine study shows, neurosis be since the central nervous system because of damage, pathological changes or lack due to the physiological or pathologic obstacle that some nutrient substance takes place, recover normal nervous function, the undue excited neural while must suppressed, replenish essential neurotrophic material, thereby reach invigorating brain and relieving mental uneasiness, the purpose of taking stopgap measures and effecting a permanent cure.Purpose of the present invention just is to develop one group of drug compound preparation with above-mentioned effect, treating both the principal and secondary aspects of a disease, thus solve this class treatment of diseases difficult problem.
The object of the present invention is achieved like this, selects Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B for use
1, vitamin B
6, rhizoma corydalis extract or rotundine form compound preparation, this compound preparation has comprehensive functions such as calmness, hypnosis, analgesia, anxiety, and have brain-strengthening, calm the nerves, splendid curative effect such as liver heat removing and eyesight improving.Margarita layer powder suppressing the hyperactive liver and subsiding YANG, arresting convulsion are calmed the nerves in the side, and the Semen Ziziphi Spinosae tonifying liver nourishes blood, invigorating brain and relieving mental uneasiness, Poria spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming, promoting diuresis to eliminate damp pathogen, vitamin B
1And vitamin B
6All be that nervous system is kept the necessary coenzyme of normal physiological function, vitamin B
1The activity that can suppress acetylcholine esterase reduces the hydrolysis of acetylcholine, nerve conduction obstacle, the digestive function that recovers to cause because of nervous disorder symptom such as go down.Vitamin B
6Be the coenzyme of glutamate decarboxylase, this enzyme can become r-aminobutyric acid (GABA) by the catalysis glutamic acid rotating, and this reaction is a rate-limiting step, significance is arranged on neuro physiology, and GABA when content is low in the maincenter inhibitory transmitter brain, can cause mental excitation, even faint from fear vitimin supplement B
6, helping to make the normal rotundine of mental excitation glucose recovery that causes the decline of GABA content to cause because of maladjusted nervous system is the extract of traditional Chinese medicine corydalis tuber, studies show that this product has pain relieving and sedative-hypnotic effect.This prescription is got the dosage of its tranquilizing soporific, suppress the function of reticular formation of brain stem ascending activating system by it, make itself and other drug that synergism take place mutually, the co-therapy neurosis, in addition, Margarita layer powder, Semen Ziziphi Spinosae and Poria also contain the necessary all kinds of materials of abundant neurotrophy, comprise several amino acids and trace element, therefore, cooperatively interacting of these materials can suppress can replenish the essential all kinds of materials of neurocyte physiology again because of the disorderly neurosiss such as neural excitation that cause of nervous function, help it to recover normal function, promptly both took stopgap measures, effected a permanent cure again, thereby formed best pharmaceutical formulation
This compound preparation can be by following method preparation
1, gets Semen Ziziphi Spinosae, Poria Chinese medicine, pulverize, use soak with ethanol 24h, filter, reclaim ethanol, it is standby to get ethanol extract, and medicinal residues add the water steaming and decocting three times again, merge three times filtrate, filters, and filtrate is concentrated in right amount, add Margarita layer powder and ethanol extract, and suitable adjuvant, vitamin B is added in dry, pulverizing again
1, vitamin B
6With rotundine powder, mix homogeneously, be ground into fine powder again, make granule, tabletting sugar coating or promptly encapsulated
2, get above-mentioned Chinese medicine and pulverize, decoct with water three times, boiled back 1 hour at every turn, filter, merge three times filtrate, concentrate the suitable adjuvant after drying of adding and add Margarita layer powder, vitamin B
1Vitamin B
6And rotundine powder mix homogeneously, be ground into fine powder again, make granule, tabletting, sugar coating or encapsulated.
With the capsule that said method is made, every 200mg contains Margarita layer powder and Chinese medicine extract 150mg, rotundine 25mg, vitamin B
112.5mg, vitamin B
612.5mg.Be that its ratio is Margarita layer powder and Chinese medicine extract, rotundine, vitamin B
1, vitamin B
6Be respectively 12: 2: 1: 1
Through the zoopery proof good sedative sedative action is arranged with pharmaceutical formulation of the present invention, spontaneous activity to animal has significant inhibitory effect, passive activity to animal also has the obvious suppression effect, can obviously prolong and defend the mouse sleep time of crust due to the appropriate sodium, and heavy dose does not cause Animal Anesthesia, significant analgesia role is still arranged in addition, the long-term continuous application of rat 3 months, each vitals such as routine blood test, routine urinalysis, liver, renal function and the heart, liver, kidney, lung, spleen, stomach, intestinal are not all found pathologic lesion
Make " Margarita ANSHEN JIAONANG " with pharmaceutical formulation of the present invention, observe the therapeutic effect of 80 routine patients with neurosis at the court's department of neurology through strictness, the result shows that to neurosal symptom control curative effect be: the Cure for insomnia effective percentage is 88.8%; Dream many 77%; Dizzy 78%; Headache 78.3%; Anxiety symptom control effective percentage reaches 95%; Depressive symptom 83.4%; Nervous 74%; Attention laxes 33.3%; Hypomnesis 40%.Effective percentage to all kinds of disease treatments is: the neurasthenia 91.8%; Anxiety neurosis 100%; Nerve depression 100%; Total effective rate 93.8%
Side effect to this product is observed, do not find significant side effects, the patient takes medicine 1～2/time, and clothes backs does not have dizziness due to other tranquilizer, side effect such as drowsy, and increases deep sleep, patient's aftersensation of waking up gets that mind is clear-headed especially to be in the best of spirit, and the sensation of " eye clear order bright " is arranged, and individual patient can have slightly tired, phenomenons such as drowsy or xerostomia, but the very fast alleviation of symptom does not influence daily life and work and study.Observation shows that this product does not have addiction, toleration and withdrawal symptom, is the good prescription of the neurosal spy of treatment.
This preparation is added some Chinese prescription, and is better to some neurosis effect.Now be exemplified below:
One, to neurosal optimum formula based on " insomnia ":
Patient's insomnia of this disease is generally difficulty falling asleep.Patient often tosses about, dysphoria, can't fall asleep, the nose heave body of side in early morning is weary, sleepiness is not removed yet, have dizzy spells daytime, worries not sleep wellly again to night, forms vicious cycle, some patient-side performance sleep is shallow, easily wake up with a start, many nightmares.This class patient can add that Radix Polygalae, Semen Juglandis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) are formed optimum formula (1) or adds Rhizoma Chuanxiong and vitamin C on the basis of above-mentioned basic prescription, forms optimum formula (2), and Chinese medicine of these two prescriptions press preceding method extraction, vitamin C and vitamin B
1, vitamin B
6Add together, this two side is good to the neurosis curative effect spy based on insomnia
Two, to neurosal optimum formula based on " anxiety or depression "
This disease patient usually upset, insecure, with a heavy heart, with knitted brows, be on tenterhooks, helpless, often with sleep and the unsettled phenomenon of autonomic nervous system, i.e. so-called " anxiety neurosis ", melancholy passive emotion also takes place in some patient, and this class patient adds Ganoderma, Radix Polygalae, Rhizoma Gastrodiae composition optimum formula (3) or adds Caulis Sinomenii, Radix Ginseng, Radix Scrophulariae and oryzanol and form optimum formula (4) on the basis of above-mentioned basic prescription, the Chinese medicine of these two prescriptions is pressed preceding method and is extracted, oryzanol and vitamin B
1, vitamin B
6Add together, through clinical observation, this two side is that the neurosis curative effect led is good to anxiety or depression, and obvious effective rate is higher widely than former side.
Three, to neurosal optimum formula based on " mental fatigue ":
This disease patient often tells inefficiency, difficult concentrating, the time, long slightly i.e. sense was dizzy, fatigue and weak, can't adhere to, hypomnesis, it is the most obvious to go down with short term memory power especially, in addition, patient is often with inappetence, acra cold and cyanosis, hyposexuality, irregular menses or amenorrhea.This class patient is on the basis of above-mentioned basic prescription, after adding Radix Ginseng, Fructus Schisandrae Chinensis, Herba Patriniae, Rhizoma Cyperi, Ramulus Cinnamomi, Radix Bupleuri composition optimum formula (5) extract Chinese medicine by preceding method, add in this basis side, this product is to being that the neurosis curative effect of primary symptom is better with the mental fatigue type.
Four, to neurosal optimum formula based on nervousness
This disease patient emotional lability, tired make an uproar, irritability, shortage patience, often because of minor matter and people's quarrel, work lacks main threads, stimulate to external world as sound, light etc. responsive especially, often disturbed their work and sleep anger because of this class stimulation, sleep shallow and dreaminess.Sensation strengthens in the body, often feel the five internal organs uneasiness, malasia, particularly owing to neck flesh, masticatory muscles, the nervous headache that causes of temporalis often are the main suits that this class patient gives prominence to, the characteristics of this headache are just as rest pain head is with lock ring, side, this class patient this basis commonly used adds Folium et Ramulus Clerodendri Trichotomi, Cortex Moutan, Periostracum Cicadae, Semen Coicis, Radix Gentianae Macrophyllae, Cortex Fraxini composition optimum formula (6), after the Chinese medicine of this prescription is partly pressed preceding method extraction preparation, add in the side, this basis, this product is better to the neurosis curative effect based on nervousness.
Five, to the neurosal optimum formula of traditional Chinese medical science typing based on " yang hyperactivity ":
This disease patient often shows as yang hyperactivity phenomenons such as headache, dizziness, dizzy or tinnitus, irritability, pulse condition be strong; can on the basis of side, this basis, increase Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Herba Ecliptae, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Rehmanniae composition optimum formula (7); the Chinese medicine of this prescription partly is equipped with extraction by preceding legal system; add in the above-mentioned basis side, this side is preferable to yang-excess type neurastheniac curative effect through clinic trial.
Six, to the neurosal optimum formula of traditional Chinese medical science typing based on " weakness "
This disease patient often shows as weak phenomenons such as dizziness, fatigue and lack of strength, cardiopalmus, lusterless complexion, pulse condition are unable, sore waist and aching in the waist and the back, can on our basis, increase Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Arillus Longan, Radix Rehmanniae Preparata composition optimum formula (8), the Chinese medicine of this prescription is partly by after preceding method preparation and extracting, add in the above-mentioned basis side, this side is that main neurastheniac's curative effect is preferable through clinic trial to " weakness "
Seven, to the neurosal optimum formula due to the gastrointestinal upset
This disease patient is often based on inappetence, often tell in nauseating, vomiting, flatulence, uncomfortable in chest, insomnia, the vexed dim gas of gastral cavity, the abdomen distension a series of neurosiss, this class patient of causing such as not well of not relaxing or defecate and to add on the basis of above-mentioned basic recipe that Fructus Crataegi, Radix Et Rhizoma Rhei, Caulis Sinomenii, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata form optimum formula (9) or add that Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), the Radix Rehmanniae, Rhizoma Dioscoreae, Radix Panacis Quinquefolii form optimum formula (10).After Chinese medicine of these two prescriptions partly extracted by preceding method, it was preferable to the neurosis curative effect because of " due to the gastrointestinal upset " through clinic trial to add in the above-mentioned basic prescription this side.
Eight, to because of " anemia " and due to neurosal optimum formula
The common palor of this disease patient, lusterless complexion, lassitude and weak, dizzy, tinnitus, hypomnesis and anemia such as absent-minded are that main this class of symptom patient can be on the basis of aforementioned basic recipe, add the Radix Astragali, Radix Angelicae Sinensis, the Radix Rehmanniae, Fructus Corni, Radix Notoginseng, Fructus Jujubae, Caulis Spatholobi is formed optimum formula (11) or adds Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Rhizoma Polygoni Cuspidati, Radix Ginseng Rubra, Fructus Lycii, Fructus Psoraleae, Colla Corii Asini, the Radix Polygoni Multiflori is formed optimum formula (12), after the Chinese medicine of these two prescriptions partly extracts preparation by aforesaid technology, add in the above-mentioned basis side, this two side is that neurosis curative effect due to main is preferable through clinic trial to anemia.
In sum, with Margarita layer powder, Semen Ziziphi Spinosae, Poria, Rhizoma Corydalis extract or rotundine, vitamin B
1And vitamin B
6The neurosal compound preparation of treatment for the basis composition, neurosiss such as the insomnia due to a variety of causes, headache, dizziness, dreaminess, hypomnesis had splendid therapeutic effect, add some other drugs on this basis, better to the neurosis curative effect of some special type
Above-mentioned 12 kinds of optimum formulas except that basic components of enumerating can be made tablet or capsule confession oral application by aforementioned technology 1 or 2, and partly preparation can be made injection and be used for clinical through further technological transformation
Claims (10)
1, neurosal pharmaceutical formulation of a kind of treatment and method for making thereof is characterized in that this prescription contains Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6, rotundine.This prescription can be by following two kinds of prepared:
A, get that Chinese medicines such as Semen Ziziphi Spinosae, Poria are pulverized, ethanol extractions, medicinal residues steaming and decocting three times is again filtered, and merges three times filtrate, is concentrated in right amount, adds Margarita layer powder and ethanol extract, and suitable adjuvant, drying, and vitamin B is added in pulverizing again
1, vitamin B
6With rotundine powder, mix homogeneously, be ground into fine powder again, make granule, tabletting, sugar coating or promptly encapsulated;
B, get Chinese medicine and pulverize, decoct with water three times, filter, concentrate, add and live, add Margarita layer powder, vitamin B when the adjuvant after drying
1, vitamin B
6And rotundine powder mix homogeneously, be ground into fine powder again, make granule, tabletting, sugar coating or encapsulated, promptly
2, the neurosal pharmaceutical formulation of treatment as claimed in claim 1 is characterized in that the optimal proportion of the medicine composition of this prescription is Chinese medicine and Margarita layer powder 12: rotundine 2: vitamin B
11: vitamin B
61; Promptly 12: 2: 1: 1.
3, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Radix Polygalae again, Semen Juglandis and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae); Or add Rhizoma Chuanxiong and vitamin C.
4, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Ganoderma, Radix Polygalae and Rhizoma Gastrodiae or add Caulis Sinomenii, Radix Ginseng, Radix Scrophulariae and oryzanol.
5, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Radix Ginseng again.Fructus Schisandrae Chinensis, Herba Patriniae, Rhizoma Cyperi, Ramulus Cinnamomi, Radix Bupleuri.
6, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Folium et Ramulus Clerodendri Trichotomi, Cortex Moutan, Periostracum Cicadae, Semen Coicis, Radix Gentianae Macrophyllae, Cortex Fraxini again.
7, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Flos Chrysanthemi, an ancient unit of weight rattan, Herba Ecliptae, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, the Radix Rehmanniae again.
8, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Arillus Longan, Radix Rehmanniae Preparata again.
9, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add Fructus Crataegi, Radix Et Rhizoma Rhei, Caulis Sinomenii, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata again or add Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Radix Ophiopogonis, the Radix Rehmanniae, Radix Adenophorae (Radix Glehniae), Rhizoma Dioscoreae, Radix Panacis Quinquefolii again.
10, neurosal pharmaceutical formulation of treatment as claimed in claim 1 and method for making thereof is characterized in that the optimum formula of this prescription can be with Margarita layer powder, Semen Ziziphi Spinosae, Poria, vitamin B
1, vitamin B
6With rotundine be on the basis of basic components, add the Radix Astragali, Radix Angelicae Sinensis, the Radix Rehmanniae, Fructus Corni, Radix Notoginseng, Fructus Jujubae, Caulis Spatholobi again or add Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Rhizoma Polygoni Cuspidati, Radix Ginseng Rubra, Fructus Lycii, Fructus Psoraleae, Colla Corii Asini, the Radix Polygoni Multiflori again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94104052 CN1121811A (en) | 1994-05-12 | 1994-05-12 | Drug prescription for treatment of neurosis and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94104052 CN1121811A (en) | 1994-05-12 | 1994-05-12 | Drug prescription for treatment of neurosis and preparing method thereof |
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|---|---|
| CN1121811A true CN1121811A (en) | 1996-05-08 |
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| CN 94104052 Pending CN1121811A (en) | 1994-05-12 | 1994-05-12 | Drug prescription for treatment of neurosis and preparing method thereof |
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