CN1299758C - Anti-depression traditional medicinal composition and its preparation method - Google Patents
Anti-depression traditional medicinal composition and its preparation method Download PDFInfo
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- CN1299758C CN1299758C CNB031531040A CN03153104A CN1299758C CN 1299758 C CN1299758 C CN 1299758C CN B031531040 A CNB031531040 A CN B031531040A CN 03153104 A CN03153104 A CN 03153104A CN 1299758 C CN1299758 C CN 1299758C
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Abstract
The present invention discloses a Chinese medicine composition for resisting depression and a preparation method for the composition. The composition is mainly composed of curcuma root, spine date seed, American ginseng and Chinese magnolivine fruit. When the Chinese medicine composition is prepared, the rest three kinds of medicine are respectively added with water for decoction except American ginseng powder, the decoction is filtered and combinated to be concentrated into clear paste of which the relative density is from 1.06 to 1.20, alcohol is added to cause the alcohol content to reach 60 to 75%, the materials are placed overnight to be filtered, supernatant liquid is decompressed for recovering alcohol to be concentrated to a proper quantity for drying, dry paste is ground into fine powder, American ginseng powder and pharmaceutically acceptable excipient are added to prepare clinically acceptable medicine preparation according to a conventional preparation technology. The composition of the present invention for treating depressive neurosis has the advantages of short course of treatment, overall curative effect, no toxicity and no side effect. Particularly the present invention has the characteristics that after the medicine is stopped, the symptoms are not rebounded and no dependence phenomenon exists.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition, particularly be used for Chinese medicine composition of a kind of depression and preparation method thereof.
Background technology
Depressive neurosis be a kind of low with persistence mental state serve as the syndrome of main performance.Depressive neurosis has become the mental disease to human psychosomatic health formation significant threat of former of global ranks, the tool whole world is large-scale investigation of clinical epidemiology result show, depression is at present for all disabling property illness the 4th of the disability rate in the whole world, in the U.S., the expense that is used for treating depression every year maintains an equal level with treatment coronary heart disease expense, up to more than 40,000,000,000 dollars, and be lasting ascendant trend.Committing suiside because of depression becomes the very important cause of death.
The current Social Transformation Period that is in of China, variant stratum all is faced with different challenges and pressure with the crowd of occupation, the cultural tradition of China causes people to pour out mutually and discharges unfavorablely, and the bad crowd of mental state accounts for quite big proportion, and the outbreak of depression has been formed huge soil horizon.
And very few to patient's number of relevant spiritual department of neurology prescription on individual diagnosis, treatment has the psychology of fear to the Western medicine depression to reflect compatriots, is afraid of to be buckled the medicated cap of " mental disease ".And Chinese medicine gets used to this type of illness is considered as " visceral-qi imbalance ", so the Chinese medicine depression has the habituation that psychology is accepted in China.As everyone knows: the prerequisite for the treatment of spiritual neuropathy is exactly patient's a trust.Moreover Chinese medicine treatment must aim at the pathogenesis of disease, psychosoma are held concurrently and are transferred.
Antidepressants belong to spiritual neural medication, and Western medicine antidepressant drug history is for hundreds of years.A new generation's antidepressants prozac is heightening the effect of a treatment and is reducing aspect side effect and the toxicity all progressive huge than its older generation.Yet it costs an arm and a leg, and China does not have the independent intellectual property rights that this medicine is produced.Little herbal mixture and preparation thereof that present present patent application person is held, similar with prozac on curative effect; Has independent intellectual property right; Stable processing technique is reliable, sufficient raw; Avirulence and side effect.With good market prospect and huge social benefit are arranged.
Summary of the invention
One object of the present invention is to disclose a kind of Chinese medicine composition of new depression; Another object of the present invention is the preparation method of a kind of new depression Chinese medicine composition of open preparation.
The crude drug of Chinese medicine composition of the present invention is formed and proportioning following (by weight):
Radix Curcumae 600-1200 weight portion Semen Ziziphi Spinosae 600-1200 weight portion
Radix Panacis Quinquefolii 100-600 weight portion Fructus Schisandrae Chinensis 400-1000 weight portion
The preferred Semen Ziziphi Spinosae (parched) of described Semen Ziziphi Spinosae.
The preparation method of the present composition is:
More than four flavors remove Radix Panacis Quinquefolii powder and add 6-10 times of water gaging respectively and decoct 0.5-1.5 hour at every turn 2-4 time; Filter, collecting decoction, being concentrated into relative density is the clear paste of 1.06-1.20 (50-65 ℃), add ethanol and make and contain the alcohol amount and reach 60-75%, placement is spent the night, and filters, the supernatant decompression recycling ethanol, be concentrated in right amount, drying, dried cream powder is broken into fine powder, add Radix Panacis Quinquefolii powder, add pharmaceutically acceptable excipient, preparation process according to routine is prepared into clinical acceptable drug dosage form, for example, and pill, tablet, granule, oral liquid, capsule, masticatory etc.
Present composition treatment depressive neurosis, short treating period (3-4 week), curative effect is (it is wide to improve the symptom scope) comprehensively, and avirulence has no side effect, and especially the characteristics of this prescription are that symptom does not rebound after the drug withdrawal, do not have the phenomenon of dependence.
Following experimental example is used to further specify the present invention.
The pharmacodynamic study of the experimental example present composition
1. experimental drug product
Present composition Chinese medicine compound: all medical materials reach pharmacy available from Beijing Kang Xin.The clinical adult of prescriptions of Chinese medicine is 0.83g/kg/d with the crude drug amount, 9 times of behaving of mice consumption.
Positive drug: prozac (Lilly Co., Eli.'s product, lot number: 104041).Clinical adult's consumption is 0.83mg/kg, and the mice consumption is 3.3mg/kg.
Animal: the ICR mice, male, body weight 18-20g.Available from dimension tonneau China laboratory animal technology company limited, quality certification numbering: SCXK (capital) 2002-0003.
2. grouping and administration
80 of normal rats are divided into 4 groups at random, that is: solvent matched group (distilled water, promptly blank group), positive drug group, Chinese medicine compound group, No. 2 side's groups of Chinese medicine.
Each is organized all with 0.2ml/10g body weight gastric infusion, once a day, and successive administration 14 days.
3. behavioristics's detection method
The motionless experiment of mouse tail suspension: the above successive administration of respectively organizing is after 14 days, with the dead time in the stopwatch record 6min (the results are shown in Table 1, concrete grammar ginseng Zhang Juntian chief editor pharmacological experiment method).
Mice forced swimming experiment: the mice that will hang after the motionless experiment of tail continued administration after 2 days, observed 6 minutes, write down the back 4 minutes dead time (the results are shown in Table 1, concrete grammar ginseng Zhang Juntian edits the pharmacological experiment method).
The mice integrality is observed: before the record administration, 1 week of administration, the body weight (the results are shown in Table 2) of administration during 2 weeks.And observation mice hair color.
4. monoamine neurotransmitter detects: behavioristics detect finish after, get brain stricture of vagina body, the cortex of 0,1,2,6 group of mice, with the detection of high performance liquid chromatogram method (the results are shown in Table 3, table 4).
5. data processing method: all data represent that with the mean value standard error group difference is checked with t.
6. experimental result
The outstanding motionless experiment of tail: the dead time of each group does not have significant difference.
The forced swimming experiment: the dead time of compound recipe group Chinese medicine and positive drug prozac group reduces than blank group, and has significant difference, and prompting compound recipe group Chinese medicine has the antidepressant effect.
Experimental session, each organizes body weight does not have significant difference.Animal wool coloured light pool, the animal state does not have significant difference between Chinese drug-treated group and contrast medicine (prozac) group and the blank group, illustrates that each group of Chinese medicine and positive drug prozac do not have toxicity substantially.
Blank group, the herbal mixture group, prozac group brain stricture of vagina body monoamine neurotransmitter content:
The content of HVA, the DOPAC of herbal mixture group and positive drug prozac group raises than blank group, and has significant difference.The DA content of herbal mixture group and positive drug prozac group raises than blank group, and has significant difference.
Prompting: herbal mixture group and prozac group can improve the content of stricture of vagina body DA and metabolite HVA, DOPAC, and the variation tendency of herbal mixture group is consistent with the prozac group.
Blank group, the herbal mixture group, prozac group cortex monoamine neurotransmitter content:
HVA, the DA of herbal mixture group and positive drug prozac group, the content of NE reduce than blank group, and have significant difference.The content of HVA, the 5-HIAA of herbal mixture group and positive drug prozac group reduces than blank group, and has significant difference.
Prompting: 1,2 Chinese drug-treated group and prozac group can reduce the content of cortex NE, DA, HVA, 5-HIAA, and the variation tendency of Chinese drug-treated group is consistent with the prozac group.
7. conclusion
The prompting of this experimental result: the herbal mixture group has the antidepressant effect with the similar level of prozac.
Table 1 medicine is to the influence of mouse tail suspension dead time, forced swimming dead time
| Group | Number of animals (only) | The outstanding tail dead time (s) | Non-swimming time (s) |
| Solvent matched group Chinese medicine compound group positive drug prozac group | 20 20 20 | 39.98±7.23 30.11±4.84 30.47±6.10 | 50.60±8.15 22.51±6.94* 22.34±4.96# |
Annotate: compare with solvent matched group (blank group).*P＜0.05，#P＜0.01。
Table 2 medicine is to the influence of mice body weight
| Group | Number of animals (only) | Beginning body weight (g) | 1w body weight (g) | 2w body weight (g) |
| Solvent matched group Chinese medicine compound group positive drug prozac group | 20 20 20 | 19.8±0.28 19.9±0.23 18.5±0.24 | 24.65±0.46 25.9±0.33 26.5±0.55 | 28.75±0.39 28.95±0.44 28.45±0.63 |
Table 3 medicine is to the influence (ng/mg tissue wet) of mouse striaturn monoamine neurotransmitter
| Group | Number of animals | DA(ng/mg) | DOPAC(ng/mg) | HVA(ng/mg) | 5-HIAA(ng/mg) |
| Solvent matched group Chinese medicine compound group positive drug prozac group | 10 9 10 | 0.23±0.05 0.38±0.06 0.59±0.09# | 0.11±0.02 0.20±0.03* 0.24±0.03# | 0.34±0.06 0.60±0.08# 0.77±0.10# | 0.05±0.02 0.05±0.02 0.04±0.01 |
Annotate: compare with solvent matched group (blank group).*P＜0.05，#P＜0.01。
Table 4 medicine is to the influence (in the group unquote is the animal number of elements) of mouse cortex monoamine neurotransmitter
| Monoamine neurotransmitter | Solvent matched group (14) | Chinese medicine compound group (10) | Positive drug prozac group (9) |
| NE(ng/mg) DA(ng/mg) DOPAC(ng/mg) HVA(ng/mg) 5HT(ng/mg) 5HIAA(ng/mg) | 0.06±0.01 0.09±0.02 0.04±0.01 0.07±0.02 0.03±0.01 0.03±0.01 | 0.03±0.01* 0.02±0.003* 0.03±0.01 0.02±0.01* 0.02±0.04 0.03±0.01 | 0.04±0.01* 0.05±0.01* 0.04±0.01 0.03±0.01* 0.02±0.004 0.05±0.01* |
Annotate: compare with solvent matched group (blank group).*P＜0.05，#P＜0.01。
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1: tablet
Radix Panacis Quinquefolii powder 222 grams; Radix Curcumae 1333 grams; Semen Ziziphi Spinosae (stir-fry) 1333 grams; Fructus Schisandrae Chinensis 889 grams.
More than four flavors remove Radix Panacis Quinquefolii powder and add 8 times of water gagings respectively and decoct each 1 hour three times; Filter, collecting decoction, being concentrated into relative density is the clear paste of 1.12-1.18 (60 ℃), add ethanol and make and contain the alcohol amount and reach 70%, placement is spent the night, and filters, the supernatant decompression recycling ethanol is concentrated in right amount drying, dried cream powder is broken into fine powder, add Radix Panacis Quinquefolii powder, microcrystalline Cellulose, carboxymethyl starch and magnesium stearate right amount of auxiliary materials, mixing, system granule, be pressed into 1000, film coating.Specification: every 0.6 gram.Usage and dosage: oral, one time 3,3 times on the one.
Embodiment 2: capsule
Radix Panacis Quinquefolii powder 300 grams; Radix Curcumae 1000 grams; Semen Ziziphi Spinosae (stir-fry) 1000 grams; Fructus Schisandrae Chinensis 600 grams.
More than four flavors remove Radix Panacis Quinquefolii powder and add 8 times of water gagings respectively and decoct each 1 hour three times; Filter, collecting decoction, being concentrated into relative density is the clear paste of 1.12-1.18 (60 ℃), add ethanol and make and contain the alcohol amount and reach 70%, placement is spent the night, and filters, the supernatant decompression recycling ethanol is concentrated in right amount drying, dried cream powder is broken into fine powder, add Radix Panacis Quinquefolii powder, microcrystalline Cellulose, carboxymethyl starch and magnesium stearate right amount of auxiliary materials, mixing, system granule, incapsulate, make 1000.
Embodiment 3: granule
Radix Panacis Quinquefolii powder 200 grams; Radix Curcumae 1200 grams; Semen Ziziphi Spinosae (stir-fry) 1200 grams; Fructus Schisandrae Chinensis 800 grams.
More than four flavors remove Radix Panacis Quinquefolii powder and add 8 times of water gagings respectively and decoct each 1 hour three times; Filter, collecting decoction, being concentrated into relative density is the clear paste of 1.12-1.18 (60 ℃), add ethanol and make and contain the alcohol amount and reach 70%, placement is spent the night, and filters, the supernatant decompression recycling ethanol, be concentrated in right amount, drying, dried cream powder is broken into fine powder, add Radix Panacis Quinquefolii powder and microcrystalline Cellulose, carboxymethyl starch and magnesium stearate right amount of auxiliary materials, preparation process according to routine is prepared into clinical acceptable drug dosage form, for example, and pill, tablet, granule, oral liquid, capsule, masticatory etc.
Claims (8)
1. the Chinese medicine composition of a depression is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Curcumae 600-1200 weight portion Semen Ziziphi Spinosae 600-1200 weight portion
Radix Panacis Quinquefolii 100-600 weight portion Fructus Schisandrae Chinensis 400-1000 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Curcumae 1200 weight portion Semen Ziziphi Spinosaes 1200 weight portions
Radix Panacis Quinquefolii 200 weight portion Fructus Schisandrae Chinensis 800 weight portions.
3. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Panacis Quinquefolii 222 weight portion Radix Curcumaes 1333 weight portions
Semen Ziziphi Spinosae 1333 weight portion Fructus Schisandrae Chinensis 889 weight portions.
4. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Panacis Quinquefolii powder 300 weight portion Radix Curcumaes 1000 weight portions
Semen Ziziphi Spinosae 1000 weight portion Fructus Schisandrae Chinensis 600 weight portions.
5. Chinese medicine composition as claimed in claim 1 is characterized in that Semen Ziziphi Spinosae is a Semen Ziziphi Spinosae (parched) in this Chinese medicine composition.
6. the preparation method of Chinese medicine composition as claimed in claim 5 is characterized in that this method is: above four flavors remove Radix Panacis Quinquefolii powder and add 6-10 times of water gaging respectively and decoct 0.5-1.5 hour at every turn 2-4 time; Filter, collecting decoction, the clear paste that to be concentrated into 50-65 ℃ of relative density be 1.06-1.20 adds ethanol and makes and contain the alcohol amount and reach 60-75%, placement is spent the night, filter, the supernatant decompression recycling ethanol is concentrated into an amount of, dry, dried cream powder is broken into fine powder, adds Radix Panacis Quinquefolii powder and pharmaceutically acceptable excipient, is prepared into pill, tablet, granule, capsule or masticatory according to the preparation process of routine.
7. the preparation method of Chinese medicine composition as claimed in claim 6 is characterized in that the preparation method of tablet is:
More than four flavors remove Radix Panacis Quinquefolii powder and add 8 times of water gagings respectively and decoct each 1 hour three times; Filter collecting decoction, the clear paste that to be concentrated into 60 ℃ of relative densities be 1.12-1.18, add ethanol and make and contain the alcohol amount and reach 70%, placement is spent the night, and filters, the supernatant decompression recycling ethanol is concentrated in right amount drying, dried cream powder is broken into fine powder, add Radix Panacis Quinquefolii powder, microcrystalline Cellulose, carboxymethyl starch and magnesium stearate adjuvant, mixing, system granule, tablet forming, film coating.
8. as the application of any one Chinese medicine composition as described in the claim 1-5 in preparation treatment depressive neurosis medicine.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101301357B (en) * | 2008-06-26 | 2012-01-25 | 湖南省中药提取工程研究中心有限公司 | Use of schisandra chinensis extract in anti-depression medicament |
| CN101703622B (en) * | 2009-09-17 | 2013-04-17 | 杭州六易科技有限公司 | Preparation method of buccal tablet for improving sleeping |
| CN102302137A (en) * | 2011-05-13 | 2012-01-04 | 范圣刚 | Health-care food for improving sleep |
| CN105832872A (en) * | 2016-05-30 | 2016-08-10 | 青岛云天生物技术有限公司 | Pharmaceutical composition for treating depression and application of pharmaceutical composition for treating depression |
| CN106039238A (en) * | 2016-08-10 | 2016-10-26 | 单团结 | Traditional Chinese medicinal composition for treating depressive neurosis, and preparation method and application thereof |
| CN109602884A (en) * | 2019-02-21 | 2019-04-12 | 广东思济药业有限公司 | A kind of application of the Chinese medicine composition in adjusting Immune inflammatory reaction for treating depression |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121811A (en) * | 1994-05-12 | 1996-05-08 | 广东医学院医药科技开发中心 | Drug prescription for treatment of neurosis and preparing method thereof |
| CN1219416A (en) * | 1997-12-12 | 1999-06-16 | 陈金燕 | Medicinal composite for curing negative depressive psychosis |
| CN1222376A (en) * | 1998-01-06 | 1999-07-14 | 唐玉厚 | Decoction for treatment of mental diseases |
| CN1395956A (en) * | 2002-08-28 | 2003-02-12 | 唐启盛 | Chinese medicine for treating depression and anxiety |
-
2003
- 2003-08-07 CN CNB031531040A patent/CN1299758C/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121811A (en) * | 1994-05-12 | 1996-05-08 | 广东医学院医药科技开发中心 | Drug prescription for treatment of neurosis and preparing method thereof |
| CN1219416A (en) * | 1997-12-12 | 1999-06-16 | 陈金燕 | Medicinal composite for curing negative depressive psychosis |
| CN1222376A (en) * | 1998-01-06 | 1999-07-14 | 唐玉厚 | Decoction for treatment of mental diseases |
| CN1395956A (en) * | 2002-08-28 | 2003-02-12 | 唐启盛 | Chinese medicine for treating depression and anxiety |
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