CN1108159C - Traditional Chinese medicine for curing diabetes and kidney deficiency - Google Patents

Abstract

The present invention discloses traditional Chinese medicine for treating diabetes and the deficiency of kidney. According to the formula principle of nourishing yin, lowering internal heat, promoting blood circulation, removing blood stasis and nourishing kidney and yin, the present invention is prepared from raw materials selected from the sixteen kinds of Chinese herbal medicine of rhodiola root, cherokee rose fruit, red sage root, wolfberry bark, prepared rhizome of rehmannia, mulberry fruit, dogwood fruit, radix trichosanthis, gordon euryale, huaishan medicine, ebony, raw oyster shell, raw astragalus root, glossy privet fruit, barbary wolfberry fruit, dodder seed, etc. by conventional methods. The traditional Chinese medicine of the present invention has conspicuous curative effects on both diabetes and kidney deficiency, and provides both the temporary solution and the permanent solution for the diseases without toxicity or side effects.

Description

A kind of Chinese medicine for the treatment of diabetes, kidney deficiency

The present invention relates to a kind of Chinese medicine for the treatment of diabetes, kidney deficiency, specifically a kind of is the treatment diabetes that form of feedstock production, the oral Chinese patent medicine of kidney deficiency with the Chinese herbal medicine.

Diabetes are a kind of common endocrine metabolism diseases, because the absolute or relative deficiency of insulin in the body, cause that metabolism obstacles of blood glucose is main, and the water-electrolyte metabolism disorder of fat, protein and secondary arranged, asymptomatic in early days, develop into the symptom phase, clinical visible polydipsia, polyuria, polyphagia, tired, become thin etc., and multiple complications can appear.This interior syndrome doctor goes up and belongs to the diabetes category.The name of quenching one's thirst, head sees " interior through Ling Shu Miraculous Pivot or Divine Axis five become " piece of writing, and back physicians from a family for generations family is not all primary and secondary according to the weight of primary disease " more than three " symptom on the basis of clinical practice, again this card is divided into the upper, middle and lower three types of diabetes.Though three types of diabetes is arranged, pathogenesis character is identical actually, all with lung, stomach (spleen), kidney substantial connection is arranged.It is scorching that main pathogenesis shows as the deficiency of YIN.Though the medicine of this two disease of western medical treatment is a lot of at present, can only take stopgap measures, and can not effect a permanent cure, in case drug withdrawal, relapse rate is high.Treating this sick Chinese patent medicine also has much, but effect is not very good yet, and big multiaction is single, can not satisfy different patients' needs.

Therefore, purpose of the present invention just provides a kind of oral Chinese patent medicine better curative effect, that can treat diabetes and kidney deficiency that has.

The objective of the invention is to realize: on the basis of Chinese medicine to diabetes and the pathogenetic understanding of kidney deficiency by following solution, determine with nourishing YIN to lower pathogenic fire, blood circulation promoting and blood stasis dispelling, nourishing kidney-YIN to be principle, and achieve with reference to modern pharmacological research, choosing the traditional Chinese herbal medicine of 16 flavors such as Radix Rhodiolae is that feedstock production forms a kind of oral Chinese patent medicine that can treat diabetes and kidney deficiency simultaneously, and it is made up of following components in portion by weight:

Radix Rhodiolae 25-35 part, Fructus Rosae Laevigatae 6-10 part, Radix Salviae Miltiorrhizae 10-35 part,

Cortex Lycii 6-15 part, Radix Rehmanniae Preparata 15-25 part, Fructus Mori 10-15 part,

Fructus Corni 10-20 part, Radix Trichosanthis 15-30 part, Semen Euryales 10-15 part,

RHIIZOMA DIOSCOREAE frOm Henan of China 10-20 part, Fructus Mume 15-25 part, Concha Ostreae 20-30 part,

Radix Astragali 15-30 part, Fructus Ligustri Lucidi 10-15 part, Fructus Lycii 5-10 part,

Semen Cuscutae 10-15 part.

The optimum weight proportioning of Chinese medicine of the present invention consists of:

30 parts of Radix Rhodiolaes, 10 parts of Fructus Rosae Laevigatae, 30 parts of Radix Salviae Miltiorrhizaes,

15 parts of Cortex Lycii, 25 parts in Radix Rehmanniae Preparata, 15 parts in Fructus Mori,

20 parts of Fructus Corni, 30 parts of Radix Trichosanthis, 15 parts of Semen Euryaless,

20 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 25 parts of Fructus Mumes, 20 parts of Concha Ostreae,

30 parts of Radix Astragali, 15 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Lycii,

15 parts of Semen Cuscutae.

Above-mentioned ten Six-element medicines are chosen decontamination, and oven dry is developed into fine powder, crosses 100 mesh sieves, and mix homogeneously, incapsulates and promptly gets capsule; Or add suitable quantity of water and make pill, amount of water is difficult for disruptive pill and is advisable making.Also available method well known to those skilled in the art is made other conventional peroral dosage forms.

In the above-mentioned raw materials compatibility of medicine, reused a kind of newfound Chinese herbal medicine Radix Rhodiolae in the present invention, confirmed, this medicine can a medicine rule together diabetes, two kinds of diseases of kidney deficiency according to clinical research, test.After carrying out reasonable compatibility according to theory of Chinese medical science, effect is especially remarkable, can reach the effect of clinical cure two diseases, and have no side effect.In the side, the effect of the existing blood sugar lowering of Radix Rhodiolae, glucose in urine has tonic yang-invigorating again, the double effects of enriching yin and nourishing kidney; Radix Salviae Miltiorrhizae, blood circulation promoting and blood stasis dispelling; Fructus Rosae Laevigatae, Concha Ostreae can be restrained controlling nocturnal emission with astringent drugs; Cortex Lycii, Radix Rehmanniae Preparata, Radix Trichosanthis, Fructus Mume, Radix Astragali, the heresy that expels the heat-evil is ended excessive thirst; Fructus Mori, RHIIZOMA DIOSCOREAE frOm Henan of China, nourishing YIN to lower pathogenic fire; Fructus Corni, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, nourishing the liver and kidney; Semen Euryales, the spleen reinforcing damp eliminating.The above-mentioned drug matching of respectively distinguishing the flavor of, treating both the principal and secondary aspects of a disease has the effect of nourishing YIN to lower pathogenic fire, blood circulation promoting and blood stasis dispelling, nourishing kidney-YIN, and diabetes, kidney deficiency are had the good curing effect.

Beneficial effect of the present invention has obtained checking in clinical experiment, existing that the clinical observation situation report is as follows:

One, diagnostic criteria

Glucose, protein, lipid metabolism get muddled in the diabetics body, cause in the blood glucose content too high, exceed arm's length standard, reach one and delimit so that occur containing sugar in the urine.Clinical four types that are divided into, that is: insulin-dependent (I type), non-insulin-depending type (II type), dystrophic diabetes, its alloytype diabetes (secondary diabetes).In addition, also have impaired glucose tolerance and gestational diabetes amphitypy.By severity extent clinical generally be divided into light, in, weigh three types.This typing is divided according to fasting blood sugar:

1, light-duty: blood glucose is many below 11.1mmol/L.

2, medium-sized: blood glucose is many between 11.1-16.6mmol/L.

3, heavy type: blood glucose is many more than 16.6mmol/L.Heavy unstable condition, undulatory property is big, and ketoacidosis easily takes place, and hypoglycemia also easily takes place.

Two, clinical data

Select light, the medium-sized and heavy patient of type ii diabetes to observe by clinical manifestation, based on light, medium-sized patient.For ease of Comparison of therapeutic, the patient is divided into test group and matched group.Test group 108 examples wherein, male 55 examples, women 53 examples; Senile diabetes 7 examples, medium-sized 70 examples, heavy 31 examples.Matched group 96 examples, male 50 examples, women 46 examples; Light-duty 5 examples, medium-sized 57 examples, heavy 34 examples.

Three, treatment and medication

Test group is taken medicine of the present invention, and every days 6, gram divided morning, late secondary to take.It is a course of treatment that senile diabetes patient took medicine 1 month, generally takes to get final product a course of treatment.It is a course of treatment that middle diabetes mellitus type is also obeyed 1 month, generally takes two courses of treatment.Heavy diabetics is all taken medicine three more than the course of treatment.Matched group is selected other oral antidiabetic drug for use according to the state of an illness, treats with conventional medication.

Two groups of patients all select for use non-pharmaceutical method to assist treatment except that healing with medicine simultaneously, as: keep on a diet (1); (2) note being emotionally stable, eliminating worry, keep happy; (3) suitably perform physical exercises.

All patients adopt same procedure to make regular check on fasting glucose and glucose in urine in therapeutic process.

Four, curative effect determinate standard and therapeutic outcome

1, criterion of therapeutical effect:

Clinical cure: drug withdrawal is after 1 month, and blood glucose still can be kept normal level, and cardinal symptoms such as polydipsia, many thirsty, polyuria disappear the normal person of every index inspection; Produce effects: the back blood glucose of taking medicine drops to normal level, and the diabetes cardinal symptom disappears substantially, glucose in urine (-), and blood glucose still can be kept normal person after two weeks of drug withdrawal; Effectively: the back blood glucose of taking medicine descends to some extent, and the diabetes cardinal symptom alleviates; Invalid: the back blood glucose of taking medicine descends very little or does not fall, and diabetic symptom is constant.

2, result

Each diabetics is because state of an illness weight difference, thus the course of treatment length difference, after finishing the course of treatment, test group and matched group patient's curative effect situation is handled by statistical method by curative effect determinate standard, the results are shown in following table 1 and table 2.

Table 1, test group clinical observation result

The diabetes Clinical typing	Test group
										The example number	Cure		Produce effects		Effectively		Invalid
	The example number	Percentage ratio %	The example number	Percentage ratio %	The example number	Percentage ratio %	The example number	Percentage ratio %
									Light-duty		7	7	100
Medium-sized	70	47	67.1	15	21.4	7	10.0	1		1.5
									Heavy		31	17	54.8	10	32.2	3	9.7	1	3.2
Amount to	108	71	65.7	25	23.1	10	9.3	2		1.9

Table 2, matched group clinical observation result

The diabetes Clinical typing	Matched group
										The example number	Cure		Produce effects		Effectively		Invalid
	The example number	Percentage ratio %	The example number	Percentage ratio %	The example number	Percentage ratio %	The example number	Percentage ratio %
									Light-duty		6	5	83.3	1	16.7
Medium-sized	58	26	44.8	21	36.2	10	17.2	1		1.8
									Heavy		32	5	15.6	19	59.4	6	18.8	2	6.2
Amount to	96	36	37.5	41	42.7	16	16.6	3		3.2

The curative effect situation of test group and matched group as can be seen from the table.The test group clinical cure rate is 65.7%, and total effective rate is 98.1%; The matched group cure rate is 37.5%, and total effective rate is 96.8%.The cure rate of test group and total effective rate all are higher than matched group.

Prove that through clinical trial medicine blood sugar decreasing effect of the present invention is obvious, stable lasting, treating both the principal and secondary aspects of a disease is cured and total effective rate all is better than matched group, is a kind of medicine of treatment diabetes with practical value, and the while has also been improved patient's the symptom of suffering from a deficiency of the kidney greatly.

Further specify the present invention below in conjunction with embodiment, but the present invention is not played any qualification effect.

Embodiment 1

Take by weighing raw material by following prescription:

Radix Rhodiolae 30g, Fructus Rosae Laevigatae 10g, Radix Salviae Miltiorrhizae 30g,

Cortex Lycii 15g, Radix Rehmanniae Preparata 25g, Fructus Mori 15g,

Fructus Corni 20g, Radix Trichosanthis 30g, Semen Euryales 15g,

RHIIZOMA DIOSCOREAE frOm Henan of China 20g, Fructus Mume 25g, Concha Ostreae 20g,

Radix Astragali 30g, Fructus Ligustri Lucidi 15g, Fructus Lycii 10g,

Semen Cuscutae 15g;

Preparation method: with above-mentioned 16 flavor herbal raw material decontaminations, be ground into fine powder earlier, cross 100 mesh sieves, and mix homogeneously.Add suitable quantity of water then and make pill, amount of water is difficult for disruptive pill and is advisable making.

Instructions of taking: every day twice, early 15 before the meal, after the dinner 15.

Claims (2)

1, a kind of Chinese medicine for the treatment of diabetes, kidney deficiency is characterized in that it is made up of following components in portion by weight:

Radix Rhodiolae 25-35 part, Fructus Rosae Laevigatae 6-10 part, Radix Salviae Miltiorrhizae 10-35 part,

Cortex Lycii 6-15 part, Radix Rehmanniae Preparata 15-25 part, Fructus Mori 10-15 part,

Fructus Corni 10-20 part, Radix Trichosanthis 15-30 part, Semen Euryales 10-15 part,

RHIIZOMA DIOSCOREAE frOm Henan of China 10-20 part, Fructus Mume 15-25 part, Concha Ostreae 20-30 part,

Radix Astragali 15-30 part, Fructus Ligustri Lucidi 10-15 part, Fructus Lycii 5-10 part,

Semen Cuscutae 10-15 part.

2, the Chinese medicine of treatment diabetes as claimed in claim 1, kidney deficiency is characterized in that each component and weight proportion thereof are:

30 parts of Radix Rhodiolaes, 10 parts of Fructus Rosae Laevigatae, 30 parts of Radix Salviae Miltiorrhizaes,

15 parts of Cortex Lycii, 25 parts in Radix Rehmanniae Preparata, 15 parts in Fructus Mori,

20 parts of Fructus Corni, 30 parts of Radix Trichosanthis, 15 parts of Semen Euryaless,

20 parts of RHIIZOMA DIOSCOREAE frOm Henan of China, 25 parts of Fructus Mumes, 20 parts of Concha Ostreae,

30 parts of Radix Astragali, 15 parts of Fructus Ligustri Lucidi, 10 parts of Fructus Lycii,

15 parts of Semen Cuscutae.