CN1541701A - Diabetes treating medicine and its preparation - Google Patents
Diabetes treating medicine and its preparation Download PDFInfo
- Publication number
- CN1541701A CN1541701A CNA2003101140097A CN200310114009A CN1541701A CN 1541701 A CN1541701 A CN 1541701A CN A2003101140097 A CNA2003101140097 A CN A2003101140097A CN 200310114009 A CN200310114009 A CN 200310114009A CN 1541701 A CN1541701 A CN 1541701A
- Authority
- CN
- China
- Prior art keywords
- medicine
- diabetes
- treatment
- dosage form
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract 2
- 238000003809 water extraction Methods 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 14
- 239000002552 dosage form Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 229940023488 pill Drugs 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000007935 oral tablet Substances 0.000 claims description 2
- 229940096978 oral tablet Drugs 0.000 claims description 2
- -1 filter Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 210000000952 spleen Anatomy 0.000 abstract description 5
- 230000035922 thirst Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 230000028327 secretion Effects 0.000 abstract description 2
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 244000018716 Impatiens biflora Species 0.000 abstract 1
- 235000015912 Impatiens biflora Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 235000014443 Pyrus communis Nutrition 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 201000001421 hyperglycemia Diseases 0.000 description 5
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 5
- 229960001052 streptozocin Drugs 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 238000010562 histological examination Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 206010036067 polydipsia Diseases 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 206010020710 Hyperphagia Diseases 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004279 orbit Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 208000022530 polyphagia Diseases 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 210000001685 thyroid gland Anatomy 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 206010036105 Polyneuropathy Diseases 0.000 description 1
- 208000022329 Protein metabolism disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000019629 polyneuritis Diseases 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The medicine for treating diabetes is prepared with wild balsam pear, kudzu vine root, lichi stone, dodder seed and Chinese yam. The preparation process includes crushing, water extraction to obtain extractum, mixing, drying, crushing and other steps to form the required preparation form. The medicine has the functions of relieving thirst, moisturizing dryness syndrome, clearing away heat, promoting secretion of saliva, nourishing Yin, invigorating spleen, etc. and thus has obvious diabetes curing effect. The medicine is safe and has no toxic side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, concrete is is a kind of medicine for the treatment of diabetes of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Technical background
Diabetes (diabetes mellitus) are that interior relative or absolute deficiency of insulin of a kind of body and target cell reduce insulin sensitivity, or there is structural defective in insulin itself and a kind of chronic disease of the carbohydrate, fat and the protein metabolism disorder that cause, and its main feature is hyperglycemia, glycosuria.For polydipsia, polyphagia, polyuria and lose weight (i.e. " three-many-one-little "), some tissues or organ generation morphosis are changed and dysfunction clinically, concurrent ketoacidosis, extremity gangrene, polyneuritis, lose one's sight and renal failure etc.Primary disease sickness rate benefit increases, and common, frequently-occurring disease has become international.
In Chinese medicine, diabetes are called quenches one's thirst.By theory of Chinese medical science quench one's thirst be meant because of eating and drinking without temperance and disorder of emotion etc. cause with polydipsia, polyphagia, polyuria, emaciated physique, or urinate pleasantly sweet for the disease of feature.Its pathological change mainly is that the deficiency of YIN is scorching.
Because diabetes cause of disease complexity is closely related with hereditary metabolism and living habit, therefore, at present this disease is only surveyed clinic control, and the life-time service of chemical medicine commonly used, regular meeting causes damage to patient's liver, kidney.Therefore, little from side effect, look for the Therapeutic Method of integration of edible and medicinal herbs in the Chinese medicine national medicine of security property, become the trend of current treating diabetes.
Summary of the invention
The objective of the invention is to propose a kind of medicine that diabetes is had the treatment diabetes of better therapeutical effect and safety.
Another object of the present invention provides the preparation method of the medicine of these treatment diabetes.
A kind of medicine for the treatment of diabetes of the present invention is: with following tcm components (weight portion), comprise the extract obtained medicament of making for raw material the Chinese medicine (weight portion) from following component: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30.The present invention also can add Semen Cuscutae 1-100, Rhizoma Dioscoreae 5-30 or one kind of.
The said dosage form of the present invention is that said dosage form is a said dosage form on any pharmaceutics, particularly oral tablet, granule, capsule, pill.
The preparation method of the medicine of treatment diabetes of the present invention is made up of following steps:
One, get Radix Puerariae, Semen Cuscutae decocts with water, or only all or part of Radix Puerariae is decocted with water filtration, concentrates, puts cold, adds ethanol, leaves standstill, and gets supernatant, filters, and reclaims ethanol and gets extractum, and is standby:
Two, remaining ingredient is ground into fine powder, sieve, and mixing, with (one) abundant mixing, required dosage form is made in dry, pulverizing.
The preparation method of the medicine of treatment diabetes of the present invention can also be made up of following steps:
Get wild Fructus Momordicae charantiae, Rhizoma Dioscoreae, Semen Litchi, be ground into fine powder, mix homogeneously is made required dosage form, also can add Radix Puerariae, Semen Cuscutae or one kind of, is ground into fine powder jointly, and mix homogeneously is made required dosage form.
Prescription of the present invention is based on Dai Nationality's medical science in the Chinese medicine to the understanding and the summary of experience of onset diabetes mechanism, sums up and forms with reference to modern medicine, pharmacological achievement in research, through repeatedly prescription experiment, meet the Chinese prescription rule, make a distinction between the important and the lesser one, tie in, each medicine complements each other in the preparation, make full side's generation effect, this prescription has to quench the thirst to be moisturized, clearing away heat and promoting production of body fluid, YIN nourishing spleen invigorating, calm down the effect of three types of diabetes, have the obvious treatment effect.According to 282 routine type ii diabetes patient clinical observations are shown: medicine of the present invention is 81% to the type ii diabetes total effective rate.Fasting glucose and 2 hours after the meal contrast blood glucose obviously reduce.Treatment back triglyceride has downward trend, to disease effects of having clear improvement such as excessive thirst polydipsia, unable, the skin itchings of becoming thin.Do not see any untoward reaction during the medication, have no side effect.Clinical and evidence the present invention is a kind of diabetes medicament for the treatment of safely and effectively.
Pharmacodynamics test of the present invention:
One, to acute toxicity test in mice
1, experiment material
Animal: mice, ICR body weight 18---20g, male and female half and half are provided by Kunming General Hospital Chengdu Military Area, the quality certification: No. (9703), the real moving word in Yunnan.
Medicine: this treatment diabetes medicament, the 0.5g/ grain is equivalent to raw material 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., and the suspension that is made into 13.33% (w/v) with water is for using.
Instrument: Kodak of Johnson ﹠ Johnson 750 type dry type biochemistry analyzer
2, experimental technique and result
20 of mices, male and female half and half with the Cmax 13.33% (w/v) of this treatment diabetes medicament, are pressed three gastric infusions in the maximum volume 40ml/kg one day, observe seven days continuously after the administration.20 mices all do not have dead after administration in seven days, and animal appearance, behavioral activity, the mental status, appetite, defecation and color thereof, fur, the colour of skin, breathing are all normal, the also no abnormal secretions in nose, eye, oral cavity, body weight increases to 22.30 ± 1.2g by 19.50 ± 0.5g.
3, conclusion
This treatment diabetes medicament toxicity is less, can not survey LD50, so measure its maximum tolerated dose.Maximum drug level with 13.33% (w/v), the maximum of 40ml/kg is irritated three gastric infusions in the stomach volume one day, the mice daily dose reaches 16g/kg (being equivalent to crude drug in whole 16g), is 320 times of clinical human dosage (3g/kg/d), and does not cause the animal toxicity reaction.This result shows that this treatment diabetes medicament toxicity is minimum, and is oral safer.
Two, to the rat long term toxicity test
1, experiment material
Animal: the SD rat, body weight 60-80g, male and female half and half provide the quality certification by Yunnan Province natural drug pharmacology key lab: No. the 9805th, the real moving card in Yunnan.
Medicine: this diabetes medicament, the 0.5g/ grain is equivalent to crude drug in whole 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., and the concentration that is made into 3.75%, 11.25%, 22.5% (w/v) with water is for using.
2, experimental technique and result
Get 80 of rats, be divided into 4 groups at random, 20 every group, male and female half and half.If blank group (C), feedwater, the basic, normal, high dosage group of this treatment diabetes medicament (L, M, H) is given this treatment diabetes medicinal liquid of basic, normal, high concentration respectively.4 treated animals all regularly are administered once by 20ml/kg (ig) every day, continuous 45 days, weigh weekly once, adjust dosage by body weight, 24h after the last administration, the eye socket rear vein beard is got blood and is made hematology and blood biochemical inspection (end-point method, performance rate method), get 10 animals (male and female each 5) and take off cervical vertebra and put to death and become celestial for every group then, calculate the heart, liver, spleen, lung, kidney organ's coefficient (g/100g body weight), and the heart, liver, spleen, lung, kidney, thyroid, thymus, adrenal gland, stomach and duodenum are done the pathology histological examination.All the other animal drug withdrawals continue breeding observing after two weeks, and the same method is put to death and become celestial, and calculate the acropetal coefficient and do the pathology histological examination.
3, conclusion
This treatment diabetes medicament gives rat with 0.75g/kg, 2.25g/kg and 4.5g/kg dosage (being equivalent to 10 times, 30 times and 60 times with dosage of the clinical day for human beings according to the weight) stomach, once a day, continuous 45 days, big mouse cage look on examine no abnormal, body weight gain is normal, hematology and blood biochemical are learned index, and the main organs coefficient is all in normal range.The high dose group rat heart, liver, spleen, lung, kidney, thyroid, thymus, adrenal gland, stomach and duodenum are done the pathology histological examination and are shown no obvious abnormalities.
Three, to the hypoglycemic activity of streptozotocin induced hyperglycemia mice
1, experiment material
Animal: mice, ICR body weight 20-22g, male, key lab provides the quality certification by the natural pharmacology in Yunnan Province: No. the 9806th, the real moving card in Yunnan.
Medicine: this treatment diabetes medicament, the 0.5g/ grain is equivalent to crude drug 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., is made into 1.857%, 3.75% and 5.625% concentration confession usefulness with water.Diamicron, lot number 000620, the 80mg/ sheet, Tianjin Hua Jin pharmaceutical factory product is made into 0.2% concentration for using with water.Streptozotocin, lot number BA902, Sigma company provides.Face with preceding with 0.05ml/L, the acid of Chinese holly edge is made into 0.75% concentration for using.
Instrument: Kodak of Johnson ﹠ Johnson 750 type dry type biochemistry analyzer
2, experimental technique and result
Get 60 of mices, be divided into 6 groups at random, 10 every group, establish normal control (N), the basic, normal, high dosage group of this treatment of model control group (C) diabetes medicament (L, M, H), positive controls (S), N, C organize feedwater, and L, M, H group are given this treatment diabetes medicinal liquid of 1.875%, 3.75% and 5.625% respectively, S organizes to 0.2% diamicron medicinal liquid, each is organized all by 20ml/kg (ig) administration, once a day, and continuous 10 days.Administration the 8th day, N organizes to NS20ml/kg (ip), all the other 5 groups equal 0.75% streptozotocin solution 20ml/kg (ip), behind the 48h, the eye socket rear vein beard is got blood and is surveyed blood glucose value (enzyme process).
3, conclusion
The mouse blood sugar value that makes streptozotocin 0.15g/ (ip) obviously rises (P＜0.01), shows and causes hyperglycemia model.And give this treatment diabetes medicament 1.125g/kg the hyperglycemia mouse blood sugar is obviously descended (P＜0.05), show that this treatment diabetes medicament has hypoglycemic activity to the streptozotocin induced hyperglycemia mice.
The specific embodiment
Embodiment 1:
Get Radix Puerariae 140 gram, earlier Radix Puerariae 130 grams are decocted with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, extractum is standby; Get wild Fructus Momordicae charantiae 20 gram, Rhizoma Dioscoreae 5 grams, Semen Litchi 5 grams and be ground into fine powder, sieve with residue Radix Puerariae 10 grams, mixing, dry, pulverize with the abundant mixing of standby extractum, make tablet according to the conventional tablet preparation method.
Embodiment 2:
Get wild Fructus Momordicae charantiae 20 gram, Radix Puerariae 150 grams, Rhizoma Dioscoreae 30 grams, Semen Litchi 30 grams and be ground into fine powder, mix homogeneously, preparation technology makes tablet according to conventional tablet.
Embodiment 3:
Get Radix Puerariae 160 gram, earlier Radix Puerariae 145 grams are decocted with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, and extractum is standby; Get wild Fructus Momordicae charantiae 30 grams, Rhizoma Dioscoreae 7 grams, Semen Litchi 20 restrains with residue Radix Puerariae 15 grams and is ground into fine powder, sieve, and mixing, with the abundant mixing of standby extractum, dry, pulverizing is made granule according to the conventional tablet preparation method.
Embodiment 4:
Get wild Fructus Momordicae charantiae 30 grams, Radix Puerariae 160 grams, Rhizoma Dioscoreae 7 grams, Semen Litchi 15 grams, be ground into fine powder, mix homogeneously, preparation technology makes granule according to the conventional granulates agent.
Embodiment 5:
Get Radix Puerariae 155 gram, earlier Radix Puerariae 143 grams are decocted with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, and extractum is standby; Get wild Fructus Momordicae charantiae 25 gram, Rhizoma Dioscoreae 10 grams, Semen Litchi 10 grams and be ground into fine powder, sieve with residue Radix Puerariae 12 grams, mixing, dry, pulverize with the abundant mixing of standby extractum, make capsule according to the conventional tablet preparation method.
Embodiment 6:
Get wild Fructus Momordicae charantiae 25 grams, Radix Puerariae 155 grams, Rhizoma Dioscoreae 10 grams, Semen Litchi 10 grams, be ground into fine powder, mix homogeneously is made capsule according to conventional capsule preparation technology.
Embodiment 7:
Get Radix Puerariae 130 gram, earlier with Radix Puerariae 122 grams, Semen Cuscutae 100 grams, decoct with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, extractum is standby; Get wild Fructus Momordicae charantiae 15 gram, Rhizoma Dioscoreae 8 grams, Semen Litchi 8 grams and be ground into fine powder, sieve with residue Radix Puerariae 8 grams, mixing, dry, pulverize with the abundant mixing of standby extractum, make pill according to the conventional tablet preparation method.
Embodiment 8:
Get wild Fructus Momordicae charantiae 15 grams, Radix Puerariae 130 grams, Rhizoma Dioscoreae 8 grams, Semen Litchi 8 grams, Semen Cuscutae 40 grams, be ground into fine powder, mix homogeneously is made pill according to conventional pill preparation technology.
Claims (7)
1, a kind of medicine for the treatment of diabetes is characterized in that with following tcm components (weight portion), comprises the extract obtained medicament of making for raw material the Chinese medicine (weight portion) from following component: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30.
2, a kind of medicine for the treatment of diabetes as claimed in claim 1 is characterized in that containing Semen Cuscutae 1-100, Rhizoma Dioscoreae 5-30, or one kind of.
3,, it is characterized in that said dosage form is a said dosage form on any pharmaceutics as claim 1,2 described a kind of medicines for the treatment of diabetes.
4, a kind of medicine for the treatment of diabetes as claimed in claim 3 is characterized in that said dosage form is oral tablet, granule, capsule, pill.
5, as claim 1,2,3,4 described a kind of preparation methoies for the treatment of the medicine of diabetes, it is characterized in that all or part of medicine pulverizing, all the other medicine water extraction are made extractum, and required dosage form is made in both mixings, drying, pulverizing.
6, a kind of preparation method for the treatment of the medicine of diabetes as claimed in claim 5 is characterized in that being made up of following steps:
One, get Radix Puerariae, Semen Cuscutae or an one kind of or part wherein, decoct with water, filter, concentrate, put cold, add ethanol, leave standstill, get supernatant, filter, reclaim ethanol and get extractum, standby;
Two, remaining ingredient is ground into fine powder, sieve, and mixing, with (one) abundant mixing, required dosage form is made in dry, pulverizing.
7, a kind of preparation method for the treatment of the medicine of diabetes as claimed in claim 5, it is characterized in that forming: get wild Fructus Momordicae charantiae, Rhizoma Dioscoreae, Semen Litchi by following steps, be ground into fine powder, mix homogeneously, make required dosage form, also can add Radix Puerariae, Semen Cuscutae or one kind of, be ground into fine powder jointly, mix homogeneously is made required dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310114009 CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310114009 CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541701A true CN1541701A (en) | 2004-11-03 |
| CN1234386C CN1234386C (en) | 2006-01-04 |
Family
ID=34337013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310114009 Expired - Lifetime CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1234386C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512567A (en) * | 2011-12-27 | 2012-06-27 | 温先敏 | Dropping pill medicinal preparation for treating diabetes mellitus and preparation method |
| CN102626452A (en) * | 2012-04-25 | 2012-08-08 | 吴庆林 | Hawthorn, radix puerariae, gingko and balsam pear four-in-one flavone capsule |
| CN104873617A (en) * | 2015-05-27 | 2015-09-02 | 广西壮族自冶区中国科学院广西植物研究所 | Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver |
| CN104873616A (en) * | 2015-05-27 | 2015-09-02 | 广西壮族自冶区中国科学院广西植物研究所 | Application of litchi rind polyphenol to preparation of medicines or health products for reducing triglyceride of liver |
| CN108703282A (en) * | 2018-08-17 | 2018-10-26 | 陈文才 | A kind of wild bitter gourd sugar-reducing beverage and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211965A (en) * | 2013-03-28 | 2013-07-24 | 叶立新 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
-
2003
- 2003-11-06 CN CN 200310114009 patent/CN1234386C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512567A (en) * | 2011-12-27 | 2012-06-27 | 温先敏 | Dropping pill medicinal preparation for treating diabetes mellitus and preparation method |
| CN102626452A (en) * | 2012-04-25 | 2012-08-08 | 吴庆林 | Hawthorn, radix puerariae, gingko and balsam pear four-in-one flavone capsule |
| CN104873617A (en) * | 2015-05-27 | 2015-09-02 | 广西壮族自冶区中国科学院广西植物研究所 | Application of litchi rind polyphenol in preparation of medicine or health-care food for reducing low-density lipoprotein cholesterol of liver |
| CN104873616A (en) * | 2015-05-27 | 2015-09-02 | 广西壮族自冶区中国科学院广西植物研究所 | Application of litchi rind polyphenol to preparation of medicines or health products for reducing triglyceride of liver |
| CN104873616B (en) * | 2015-05-27 | 2018-05-04 | 广西壮族自冶区中国科学院广西植物研究所 | Application of the litchi rind polyphenol in the medicine or health products that reduce liver tg is prepared |
| CN104873617B (en) * | 2015-05-27 | 2018-05-04 | 广西壮族自冶区中国科学院广西植物研究所 | Application of the litchi rind polyphenol in the medicine or health products that reduce liver low density lipoprotein cholesterol is prepared |
| CN108703282A (en) * | 2018-08-17 | 2018-10-26 | 陈文才 | A kind of wild bitter gourd sugar-reducing beverage and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1234386C (en) | 2006-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1682991A (en) | Chinese medicine composition for treating dermatosis and its preparing method | |
| CN101856405B (en) | Medicinal composition for treating type II diabetes mellitus and preparation method thereof | |
| CN101085039B (en) | Composition for preventing and treating diabetes (hyperglycaemia) and its preparation method | |
| CN1726953A (en) | Combination for treating diabetes and complicating diseases, and preparation | |
| CN1234386C (en) | Diabetes treating medicine and its preparation | |
| CN1772261A (en) | Oral medicine for treafing eye inflammation, lession and hemorrhage and its prepn | |
| CN100333758C (en) | Gout resisting Chinese medicine composition and its prepn process | |
| CN101264203B (en) | Chinese and western medicine composition for treating diabetes | |
| CN1232291C (en) | Medicine for treating diabetes | |
| CN108404088B (en) | Traditional Chinese medicine for treating type II diabetes and preparation method thereof | |
| CN103520684B (en) | Traditional Chinese medicine compound for reducing blood sugar | |
| CN1108159C (en) | Traditional Chinese medicine for curing diabetes and kidney deficiency | |
| CN1176690C (en) | Medicine for treating chronic nephritis | |
| CN1272054C (en) | Medicine for treating diabetes and its preparing process | |
| CN1042597C (en) | Vision-brighting and blood sugar decreasing composition and its produciton | |
| CN1186052C (en) | Medicine for treatment of pelvic inflammation, its preparation and preparing method | |
| CN102225082A (en) | Medicament for preventing and treating diabetes and complications thereof and preparation method thereof | |
| CN1181876C (en) | Medicine for curing diabetes and its preparing method | |
| CN100363000C (en) | Chinese and western medicines composition contg. Avandia and its prepn. method | |
| CN1463734A (en) | A prepared Chinese medicine for treating diabetes mellitus and method for preparing same | |
| CN1682980A (en) | Medicine for treating diabetes and its preparing method | |
| CN1709298A (en) | Chinese medicine formulation for treating chronic prostatitis and its preparing method | |
| CN1686365A (en) | Medicinal composition for treating diabetes and its preparation method | |
| CN1301733C (en) | Compound medicine for treating diabetes and its preparation process | |
| CN100486612C (en) | Soft capsule containing Bupleurum and Radix scutellariae, preparation method and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200817 Address after: 650200 Da Cun Xiao Changshan, osanqiao sub district office, Guandu District, Kunming City, Yunnan Province Patentee after: Yunnan Sunsail Pharmaceutical Co.,Ltd. Address before: 650051 Yunnan Province, Kunming city Beijing Road No. 152 building four floor. Patentee before: Wen Xianmin |
|
| TR01 | Transfer of patent right | ||
| CX01 | Expiry of patent term |
Granted publication date: 20060104 |
|
| CX01 | Expiry of patent term |