CN1463734A - A prepared Chinese medicine for treating diabetes mellitus and method for preparing same - Google Patents
A prepared Chinese medicine for treating diabetes mellitus and method for preparing same Download PDFInfo
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- CN1463734A CN1463734A CN 02122952 CN02122952A CN1463734A CN 1463734 A CN1463734 A CN 1463734A CN 02122952 CN02122952 CN 02122952 CN 02122952 A CN02122952 A CN 02122952A CN 1463734 A CN1463734 A CN 1463734A
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Abstract
The diabetes treating Chinese patent medicine is prepared with six kinds of Chinese medicinal materials including mulberry bark, mulberry fruit, mulberry leaf, mulberry twig, mulberry silkworm and corn stigma, which may be prepared into extractive or ointment and may be compounded with other components and different excipients to form different medicine preparation forms. The Chinese patent medicine has quick and lasting effect and no toxic side effect.
Description
Technical field the present invention relates to a kind of Chinese patent medicine for the treatment of diabetes and preparation method thereof
The background technology diabetes are because insulin is absolute or relative the shortage, cause organizing the ability drop of utilizing glucose with cell, and blood glucose increases, protein, fat metabolic disturbance, and then the clinical symptoms of generation " three-many-one-little ".Diabetes can not be cured throughout one's life, if diabetes can not be well controlled for a long time, will produce the chronic complicating diseases of many organs such as cardio-cerebrovascular, nervous system, eye, kidney, system, disability rate is very high, have a strong impact on patient's quality of life, bring heavy financial burden for simultaneously family and society.
According to statistics, the sickness rate of diabetes is 3%～5% in the world, and the sickness rate for each person more than 50 years old is 10%.In the U.S., nearly 1,600 ten thousand diabeticss, the number of dying from diabetic complication every year surpasses 160,000.Nearly having every year, 65.5 ten thousand new patients are made a definite diagnosis.In China, diabetes prevalence was 0.67% in 1980, and had risen to 3.21% now.Show that according to interrelated data there are more than 3,000 ten thousand diabetics in China, annual newly-increased 150～2,000,000 patients, more than 5,000 ten thousand people are subjected to the threat of diabetes.Diabetes have all become serious social public health problem at world's All Countries.
Commercially available orally-taken blood sugar reducing medicine has Western medicine, traditional Chinese patent medicine and Chinese and Western association class medicine three major types at present: 1, Western medicine, mainly contain several classes such as sulfonylureas drugs for diabetes, biguanides antidiabetic drug, alpha-glucosidase inhibitor and insulin synergist, various in style, but generally speaking, the diabetes treatment by western medicine blood sugar reducing function is obvious, but mostly have significant side effects such as liver, kidney, hemopoietic system infringement, Drug resistance and dependency are bigger, and cost an arm and a leg.2, traditional Chinese patent medicine, with JIANGTANGSHU, YUQUAN WAN etc. also have tens kinds for traditional Chinese patent medicine of representative, but their hypoglycemic activities are slow, and curative effect is not ideal enough, can't become a line medication.3, Chinese and Western association class medicine is the Chinese and Western association class medicine of representative with the diabetes pill, and its main effective ingredient is that Western medicine (as glyburide, still can not be gone beyond the inherent shortcoming of Western medicine itself.
Some new drugs are arranged again recently, as application number is that 99120424.7 " a kind of medicine for the treatment of diabetes and preparation method thereof " and application number are that " silkworm health food of treatment diabetes and hyperlipidemia and preparation method thereof " of 99126534.3 etc. is in the middle of the research and development, but its curative effect is not fairly obvious, and prescription and preparation technology are extremely complicated, the latter is as health food, and its range of application is obviously limited.
It is very sure that summary of the invention the purpose of this invention is to provide a kind of hypoglycemic activity, and again without any toxic and side effects, medicine composition and preparation technology simply treat the Chinese patent medicine of diabetes.
Another object of the present invention provides the preparation method of the Chinese patent medicine of this treatment diabetes.
The Chinese patent medicine of this treatment diabetes is by following 6 flavor Chinese medicines, any one in the particularly preceding 4 flavor Chinese medicines, two or more compositions; Or with this 6 flavor Chinese medicine, particularly preceding 4 distinguish the flavor of in the Chinese medicines any one, two or more are main effective ingredient; Or by following 6 flavor Chinese medicines, any one in the particularly preceding 4 flavor Chinese medicines, two or more extract or extractum composition; Or with this 6 flavor Chinese medicine, particularly preceding 4 distinguish the flavor of in the Chinese medicines any one, two or more extract or extractum is main effective ingredient.The Chinese patent medicine of this treatment diabetes can add different excipient, or extracts its effective ingredient, especially deoxynojirimycin, makes various dosage form.This 6 flavor Chinese medicine is: Cortex Mori, Fructus Mori, Folium Mori, Ramulus Mori, Bombyxmori Linnaeus, Stigma Maydis, its best constituent of the Chinese patent medicine of this treatment diabetes are the preparation in 1: 1: 1 by weight of Cortex Mori, Fructus Mori, Stigma Maydis.
The preparation method of the Chinese patent medicine of this treatment diabetes is:
Preparation medicine herbal decoction: with a kind of, two or more (as Cortex Mori, Fructus Mori, Stigma Maydis 1: 1: 1 by weight) in Cortex Mori, Fructus Mori, Folium Mori, Ramulus Mori, the Stigma Maydis, add 10 times to the water of drug weight, place the Chinese medicine extraction jar, under the boiling condition, decocted 3 hours, filter and obtain decoction liquor for the first time.In the spice after decocting for the first time, add and the water that decocts used equivalent for the first time again, under the boiling condition, decocted 2 hours, filter and obtain decoction liquor for the second time.In the spice after decocting for the second time, add and the water that decocts used equivalent for the first time again, under the boiling condition, decocted 1 hour, filter and obtain decoction liquor for the third time.With three decoction liquor mixings, be condensed into heavy-gravity ointment.
The dried cream of preparation medicine: the said medicine herbal decoction is placed baking box, under 80 ℃ of conditions, dry, make the dried cream of medicine.
Preparation patent medicine: the said medicine dried cream powder is broken, and Bombyxmori Linnaeus can be pulverized the back and be added this moment, with it mixing.Add conventional Chinese medicine adjuvant, make various dosage forms, as pill, capsule, powder, tablet, water preparation etc.; Also separable effective component extracting is made capsule, tablet even injection etc.
The traditional Chinese herbal medicine that is used for the treatment of diabetes has a variety of, the general plan of treatment diabetes is based on nourishing YIN and clearing away heat, kidney and spleen invigorating, supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, mainly be to remove patient's clinical symptoms by the method employing aggregate measures of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, prevent and treat multiple chronic complicating diseases, prolong the life-span of diabetics.Yet doctor trained in Western medicine thinks that diabetes are because insulin is absolute or relative the shortage, make cell utilize the ability drop of glucose, cause blood glucose to increase, protein and fat metabolic disturbance, and then the clinical symptoms of generation " three-many-one-little ", long-term blood glucose surpasses normal value, can produce multiple chronic complicating diseases.Therefore the doctor trained in Western medicine starting point that will treat diabetes is placed on the blood sugar lowering aspect, and blood glucose is not high, and the clinical symptoms of " three-many-one-little " will disappear, and multiple chronic complicating diseases will not go out rule or delay appearance.Facts have proved, traditional Chinese herbal medicine of not all treatment diabetes all has definite curative effect, therefore, by investigating traditional Chinese herbal medicine in the effect aspect the blood sugar lowering, be used as the means of the Chinese herbal medicine of preferred therapeutic diabetes, the place of the marrow of therapy of combining Chinese and Western medicine diabetes just, it provides a breach for the quick definite Chinese herbal medicine of preferred therapeutic diabetes curative effect in numerous traditional Chinese herbal medicine.
The inventor confirms 6 flavor Chinese medicines such as Cortex Mori, Fructus Mori, Folium Mori, Ramulus Mori, Bombyxmori Linnaeus, Stigma Maydis by practice, and particularly preceding 4 flavor Chinese medicines all have tangible blood sugar lowering effect, and especially the Cortex Mori blood sugar reducing function is more obvious.The single medication can obtain effective blood sugar lowering, the effect of relief of symptoms, and drug combination can reduce the consumption of each herbal medicine, and does not find any toxic and side effects.This 6 flavor Chinese medicine is except that Bombyxmori Linnaeus, and effective ingredient wherein is inorganic compound, is fit to extract by the way of conventional decocting, and Bombyxmori Linnaeus can directly all be used as medicine after crushed, so production technology is extremely simple, the crude drug wide material sources, cheap, be fit to very much industrialization and accurate wide the application.
The inventor amounts to respectively 16.6 kilograms of Cortex Mori, Fructus Mori, Stigma Maydis to 50 kilograms of crude drugs, makes pill 2000 balls as stated above, and every ball weighs 6 grams, and average every ball patent medicine is equivalent to crude drug 25 grams.Under the prerequisite of informed consent, selected age of onset between 42-67 year, the course of disease is at 1-6, health does not have other serious diseases generally in order except that diabetes, through clinical examination really treasure be patient's 90 examples of type 2 diabetes mellitus, wherein male 51 examples, women 39 examples.On the basis of adequate diet control, it is oral when half an hour or meal before the meal to give this medicine.Determining of optimal dose, generally with half ball, promptly 3 gram patent medicine are initial at every turn, and blood glucose, glucose in urine are high especially, and the heavy especially patient of symptom is with a ball, and promptly 6 gram patent medicine are initial at every turn, after taking medicine 3 days, increase and decrease according to blood glucose, glucose in urine and clinical symptoms improvement situation.As patient's two balls of taking medicine at every turn, i.e. 12 gram patent medicine, blood glucose, glucose in urine and clinical symptoms still do not have definite improver, and it is invalid promptly to be judged to be.Most patients before Myrrha on probation once Chinese medicine such as oral western medicine or diabetes pill come disease controlling, at the trial edition medicine preceding 3 days, these patients were required the original medicine of stopping using.All patients all survey blood glucose, glucose in urine before taking this medicine, as reference value, survey liver, renal function and routine blood test simultaneously.After taking medicine 3 days, as fasting glucose＜7.2mmol/L, 2 hours after the meal blood glucose＜8.3mmol/L survey glucose in urine with Tes-Tape and are shown as " normally " or "-", and clinical symptoms is alleviation person fully, then is judged to be produce effects, and with this dose maintenance; As not reaching above-mentioned requirements, then dosage doubles.After 3 days, survey blood glucose, glucose in urine again, analogize, and with two balls of taking medicine at every turn, promptly 12 gram patent medicine are the upper limit according to said method.After taking medicine 1 month, survey blood glucose, glucose in urine, liver, renal function and routine blood test.The result: 35 examples, half ball of at every turn taking medicine can reach above-mentioned requirements; The 24 examples ball of at every turn taking medicine can reach above-mentioned requirements; 6 examples, two balls of at every turn taking medicine can reach above-mentioned requirements; 22 examples, two balls of at every turn taking medicine still can not reach above-mentioned requirements, but fasting glucose＜8.3mmol/L, 2 hours after the meal blood glucose＜10.0mmol/L survey glucose in urine with Tes-Tape and are shown as 1-2 "+", and clinical symptoms is obviously alleviated and is decided to be effectively; Have only 3 examples, two balls of at every turn taking medicine, fasting glucose＞8.3mmol/L, 2 hours after the meal blood glucose＞10.0mmol/L survey glucose in urine with Tes-Tape and are shown as 3-4 "+", and clinical symptoms does not also have obvious alleviation, and it is invalid to be judged to be.This group clinical observation obvious effective rate reaches 72.2%, and total effective rate reaches 96.7%.All tried none example of patient untoward reaction takes place, liver, renal function and routine blood test do not have obvious change before and after the medication.Liver have produce effects patient and part effectively the patient express willingness and continue to take this medicine.Wherein take this medicine than morning person, took continuously 14 months till now, any untoward reaction does not take place.One of them patient is because of not understanding the lifelong incurable characteristics of diabetes, and is conscious very good after taking medicine 2 months, thinks that diabetes cure, satisfies drug withdrawal voluntarily, but still hard given period is surveyed blood glucose, glucose in urine, all maintains normal range.After one month, find that blood glucose, glucose in urine raise again gradually, after continuing to take this medicine, blood glucose, glucose in urine are reduced to normal range again.
In addition the inventor divides the filling stomach with the phonetic fixed inductive diabetic mice of four oxygen three times with the water decoction that is equivalent to crude drug 500mg/ days/Mus, finds that this dosage can produce tangible blood sugar lowering effect in 2 hours after administration.With 50 times of this dosage, promptly be equivalent to give birth to about 25g/ big/water decoction of Mus divides the filling stomach three times, after 2 weeks, gets Mouse Liver and kidney is done pathology, this finds obvious pathological changes.
In sum, treatment diabetes Chinese patent medicine provided by the invention is a kind of rapid-action, and duration of efficacy is long, the medicine that the wide gas of safety range is without any side effects.Its constituent and preparation technology are simple, and the crude drug wide material sources are cheap, are fit to industrialization and popularization on a large scale.
Embodiment 1:
A, preparation medicine herbal decoction: with Cortex Mori, Fructus Mori, Stigma Maydis each 16.6 kilograms (parts by weight 1: 1: 1), add 500 kg of water, place the Chinese medicine extraction jar, under the boiling condition, decocted 3 hours, filter and obtain the～inferior decoction liquor.In the spice after decocting for the first time, add 500 kg of water again, under the boiling condition, decocted 2 hours, filter and obtain decoction liquor for the second time.In the spice after decocting for the second time, add 500 kg of water again, under the boiling condition, decocted 1 hour, filter and obtain decoction liquor for the third time.With three decoction liquor mixings, be condensed into heavy-gravity ointment.
B, the dried cream of preparation medicine: the said medicine herbal decoction is placed baking box, under 80 ℃ of conditions, dry, make the dried cream of medicine.
C, adding excipient, preparation patent medicine: the said medicine dried cream powder is broken, add conventional Chinese medicine adjuvant, mixing.Make pill 2000 balls, every ball weighs 6 grams, is equivalent to crude drug 25 grams.After the paraffin paper packing, standby.
Claims (9)
1, a kind of Chinese patent medicine for the treatment of diabetes, its constituent is: 6 flavor Chinese medicines such as Cortex Mori, Fructus Mori, Folium Mori, Ramulus Mori, Bombyxmori Linnaeus and Stigma Maydis; Or with this 6 the flavor Chinese medicine be main effective ingredient.
2, according to the Chinese patent medicine of the described treatment diabetes of claim 1, its best constituent is: Cortex Mori, Fructus Mori, Stigma Maydis, preparation in 1: 1: 1 by ratio of weight and the number of copies.
3, a kind of Chinese patent medicine for the treatment of diabetes, its constituent are any one in the described 6 flavor Chinese medicines of claim 1, particularly Sang Du; Or with this 6 flavor any one in Chinese medicine, particularly Cortex Mori is main effective ingredient.
4, a kind of Chinese patent medicine for the treatment of diabetes, its constituent be described 6 flavors of claim 1 in the Chinese medicines any two or more; Or be main effective ingredient with any two or more of this 6 flavor in Chinese medicine.
5, a kind of Chinese patent medicine for the treatment of diabetes, its constituent be described 6 flavors of claim 1 in the Chinese medicines any one, two or more extract or extractum; Or with this 6 flavor in Chinese medicine any one, two or more extract or extractum is main effective ingredient.
6, especially refer to deoxynojirimycin according to the described extract of claim 5.
7,, add the Chinese patent medicine that other submember constitutes according to the Chinese patent medicine of claim 1,2,3,4,5,6 described treatment diabetes.
8, according to the Chinese patent medicine of claim 1,2,3,4,5,6,7 described treatment diabetes, its characteristics are to add different excipient, also can extract its effective ingredient, especially refer to deoxynojirimycin, make various dosage form.
9, according to the preparation method of the Chinese patent medicine of claim 1,2,3,4,5,6,7,8 described treatment diabetes, its characteristics are that this 5 flavor medicine of Cortex Mori, Fructus Mori, Folium Mori, Ramulus Mori and Stigma Maydis can be prepared by the decocting method of routine, Bombyxmori Linnaeus directly all is used as medicine after can pulverizing, preparation technology is simple, is easy to industrialization.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02122952 CN1463734A (en) | 2002-06-13 | 2002-06-13 | A prepared Chinese medicine for treating diabetes mellitus and method for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02122952 CN1463734A (en) | 2002-06-13 | 2002-06-13 | A prepared Chinese medicine for treating diabetes mellitus and method for preparing same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234142B (en) * | 2007-01-29 | 2012-02-08 | 北京国森科技发展有限责任公司 | Mulberry series health care functional beverage for auxiliary reduction of blood sugar |
| CN102726577A (en) * | 2012-06-30 | 2012-10-17 | 姜阔 | Hypertension lowering tea |
| CN103110698A (en) * | 2013-02-19 | 2013-05-22 | 青岛正大海尔制药有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
| CN103798441A (en) * | 2012-11-06 | 2014-05-21 | 重庆广亚生态农业发展有限公司 | Mulberry tea |
| CN106138217A (en) * | 2016-08-08 | 2016-11-23 | 陕西君碧莎制药有限公司 | Fructus Mori granule prevents and treats the application in diabetes and complication medicine thereof in preparation |
-
2002
- 2002-06-13 CN CN 02122952 patent/CN1463734A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234142B (en) * | 2007-01-29 | 2012-02-08 | 北京国森科技发展有限责任公司 | Mulberry series health care functional beverage for auxiliary reduction of blood sugar |
| CN102726577A (en) * | 2012-06-30 | 2012-10-17 | 姜阔 | Hypertension lowering tea |
| CN103798441A (en) * | 2012-11-06 | 2014-05-21 | 重庆广亚生态农业发展有限公司 | Mulberry tea |
| CN103110698A (en) * | 2013-02-19 | 2013-05-22 | 青岛正大海尔制药有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
| CN106138217A (en) * | 2016-08-08 | 2016-11-23 | 陕西君碧莎制药有限公司 | Fructus Mori granule prevents and treats the application in diabetes and complication medicine thereof in preparation |
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