CN102462834A - Medicinal composition for controlling blood sugar of diabetic - Google Patents
Medicinal composition for controlling blood sugar of diabetic Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for controlling blood sugar of a diabetic, which belongs to a medicinal composition for treating diabetes. The Chinese medicinal composition is characterized in that: kudzuvine root, baikal skullcap root, coptis root, roasted liquoric root and ginger are taken as main materials; simultaneously, wine-treated rhubarb serving as an auxiliary material can be added; and American ginseng, red yeast rice or rhizoma anemarrhenae and red yeast rice serving as seasonings are added. The Chinese medicinal composition can be applied to patients suffering from damp-heat retention in spleen type diabetes, has the effects of clearing heat, drying dampness, promoting the production of body fluid and moistening dryness, and can be used for effectively controlling blood sugar.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of pharmaceutical composition that is used for the diabetics glycemic control, i.e. its purposes and dosage form.
Background technology
Diabetes (diabetes) are to act on body by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors to cause hypoinsulinism, insulin resistant (Insulin Resistance; And a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi IR) etc.; Be main feature clinically with the hyperglycemia; Performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom.Diabetes can cause infection, heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc. and become deadly major cause of morbidity.The diabetes height oozes the serious acute complication that syndrome is diabetes; Starting stage can show as polyuria, polydipsia, fatigue and weakness, bradykinesia etc.; Along with the increase state of an illness of body fluid loss sharply develops; Drowsiness, disorientation appears, epileptic is twitched, the symptom of similar apoplexy such as hemiplegia, even stupor.
Treatment of diabetes is stressed Comprehensive Treatment, and present therapy comprises: Diet Therapy, exercise therapy, Drug therapy, blood sugar monitoring and diabetes education, wherein Drug therapy comprises OHA (Western medicine and Chinese medicine), insulin.Orally-taken blood sugar reducing medicine commonly used has a lot; Generally be divided into five big types: biguanides, sulphanylureas, alpha-glucosidase inhibitor, thiazolidinedione oral sugar-lowering drug thing and carbamoyl methyl benzene sulfonic derivative etc.; Its objective is the correction carbohydrate metabolism disturbance; To eliminate symptom, promote the recovery of islet function, improve insulin resistant etc.Its curative effect is affirmed, but life-time service needs dosage gradually, has untoward reaction in various degree mostly, and can not effectively control complication.
The method of TCM treatment of diabetes mainly is determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs and combines to use the blood sugar lowering Western medicine that carry out the three types of diabetes opinion according to clinical symptoms and control, its pattern of syndrome has benefiting qi and nourishing yin, dissipating depression of QI heat clearing away, depressed liver-energy dispersing and QI regulating, spleen invigorating dehumidifying, nourishing kidney yin, blood circulation promoting and blood stasis dispelling etc.Discover in a large number both at home and abroad in recent years; Some Chinese medicine and effective ingredient thereof have tangible blood sugar reducing function; Comprise alkaloid, terpenoid etc., the sensitivity that its mechanism of action has increases insulin secretion, increase insulin, the anerobic glycolysis that increases sugar, minimizing glyconeogenesis etc.Clinical observation and zoopery have confirmed that all Chinese medicine can obviously improve symptom, consolidate hypoglycemic effect, and possess certain independent blood sugar reducing function.
GEGEN QINLIAN TANG comes from " a Treatise on Febrile Diseases sun piece of writing "; Be Zhang Zhongjing name side; Form by Radix Puerariae 24g, Radix Scutellariae 9g, Rhizoma Coptidis, 9g, Radix Glycyrrhizae 6g decocting, be mainly used in treatment " diarrhea due to interior heat with exterior syndrome " disease, bacillary dysentery, acute enteritis and child virus diarrhea etc. are had good efficacy.The preparation that 2010 editions pharmacopeia are recorded this side GEGEN QINLIAN PIAN, micropill are arranged but its major function to cure mainly be the expelling pathogenic factors from muscles expelling pathogenic factors from the exterior, heat-clearing and toxic substances removing, dampness removing antidiarrheal.Be used for due to the damp-heat accumulation the stomachache of having loose bowels, just yellow and stick, burning sensation of the anus; And anemopyretic cold due to fever and aversion to wind, the headache general pain.To not clearly explaination of treatment of diabetes.
In the GEGEN QINLIAN TANG, Radix Puerariae is the Yangming Channel medicine, to remove positive bright interior-heat, rises Tianjin and moisturizes for curing mainly ancient Chinese medicine doctor its treatment diabetes commonly used.In the side Radix Scutellariae, Rhizoma Coptidis lung heat clearing sthenia gastropyrexia to medicine, can separate in the blood sugar poison, wherein the Rhizoma Coptidis heat clearing and damp drying is let out the fire detoxifcation, promptly is described as the panacea of controlling diabetes by Liu's interchannel period as far back as gold dollar; Radix Scutellariae ability lung heat clearing sthenia gastropyrexia is taken into account the lung kidney.The Rhizoma Coptidis consumption too much is prone to the bitter cold damaging the spleen and stomach, consumption impairment of body fluid liquid, and Radix Puerariae and Rhizoma Coptidis match and can restrict the dry property of Rhizoma Coptidis.Radix Glycyrrhizae is supported taste, born fluid and middle seasoning, and heat clearing and damp drying is played, the merit of promoting the production of body fluid and moisturizing altogether by full side.Zoopery and clinical research show that single medicinal material of the Radix Puerariae in the GEGEN QINLIAN TANG side, Radix Scutellariae, Rhizoma Coptidis and effective ingredient thereof have positive effect for the various symptoms of improving diabetes and complication thereof.For avoiding Radix Scutellariae, Rhizoma Coptidis bitter cold to injure one's stomach, compatibility Rhizoma Zingiberis or Rhizoma Zingiberis Recens are with the property of its bitter cold of assistant system, to avoid issuable gastrointestinal reaction in the prolonged application in the side.So with GEGEN QINLIAN TANG is basic compatibility Rhizoma Zingiberis or Rhizoma Zingiberis Recens treatment damp-heat stagnating in the spleen type diabetes.
Summary of the invention
Main purpose of the present invention is to provide a kind of Chinese medicine composition of treating diabetes.
Another object of the present invention is to provide the dosage form of this pharmaceutical composition.
The composition of the prescription of pharmaceutical composition of the present invention is following by weight ratio:
Radix Puerariae 5-86 part, Radix Scutellariae 2-72 part, Rhizoma Coptidis 2-72 part, Radix Glycyrrhizae Preparata 2-44 part, Rhizoma Zingiberis 1-35 part.
Radix Puerariae 5-86 part, Radix Scutellariae 2-72 part, Rhizoma Coptidis 2-72 part, Radix Glycyrrhizae Preparata 2-44 part, Rhizoma Zingiberis Recens 1-35 part.
Be preferably:
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens.
Better, the present invention can add Radix et Rhizoma Rhei (stir-fried with wine) on the said medicine basis.This is because Radix et Rhizoma Rhei (stir-fried with wine), purging heat and dredging bowels, and removing pathogenic heat from blood and toxic substance from the body can prevent the thick the intestines and stomach of Rhizoma Coptidis and the constipation that causes, each amounts of components of medicine is:
Radix Puerariae 4-75 part, Radix Scutellariae 1-67 part, Rhizoma Coptidis 1-67 part, Radix Glycyrrhizae Preparata 2-67 part, Rhizoma Zingiberis 1-47 part, Radix et Rhizoma Rhei (stir-fried with wine) 1-17 part.
Radix Puerariae 4-75 part, Radix Scutellariae 1-67 part, Rhizoma Coptidis 1-67 part, Radix Glycyrrhizae Preparata 2-67 part, Rhizoma Zingiberis Recens 1-47 part, Radix et Rhizoma Rhei (stir-fried with wine) 1-17 part.
Be preferably:
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine)
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine).
In order to obtain best therapeutic effect, the present invention can also add Radix Panacis Quinquefolii 1-12 part, Monas cuspurpureus Went 1-18 part or Rhizoma Anemarrhenae 3-40 part, Monas cuspurpureus Went 1-12 part on the said medicine basis.Radix Panacis Quinquefolii is not only early on the books in the Chinese medicine ancient books and records as the important Chinese medicine of treatment diabetes, and multinomial modern study proves that also Radix Panacis Quinquefolii and effective ingredient thereof have the effect that improves diabetic symptom.The Rhizoma Anemarrhenae has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing, and its water extract and polysaccharide have hypoglycemic activity to normal rabbits, alloxan is caused diabetic rabbit, mice and insulin antiserum cause diabetic mice more obvious functions of blood sugar effect is arranged.Japan's Monas cuspurpureus Went research report shows that Monas cuspurpureus Went has blood fat reducing, blood glucose, blood pressure effect, and can strengthen liver function and promote immunity.
Be preferably:
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 6 parts of Radix Panacis Quinquefoliis, 9 parts in Monas cuspurpureus Went.
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 6 parts of Radix Panacis Quinquefoliis, 9 parts in Monas cuspurpureus Went.
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 30 parts of the Rhizoma Anemarrhenaes, 9 parts in Monas cuspurpureus Went.
72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 30 parts of the Rhizoma Anemarrhenaes, 9 parts in Monas cuspurpureus Went.
In order to make medicine have better mouthfeel, also can contain the correctives of 1-2 ratio of weight and number in the said medicine.
For the messenger drug object space just uses, said medicine also can contain various conventional adjuvant such as disintegrating agent, lubricant, binding agent of 1-2 part ratio of weight and number etc. processes acceptable dosage form on any one pharmaceutics with conventional method, like oral or ejection preparation.
Medicine of the present invention can adopt formulation example that the conventional method of Chinese medicine preparation is prepared into any routine as above-mentioned raw materials liquid medicine is fried in shallow oil, water decoction-alcohol sedimentation or be ground into powder and take after mixing it with water; Or process tablet; Granule, oral liquid, pill or capsule (comprising soft capsule) are oral, perhaps process injection etc.But these can not be used to limit protection scope of the present invention.
The present invention explains application of the present invention through following test data
1 experimenter's selection
From China Academy of Sciences Guanganmen Hospital department of endocrinology out-patient.
1.1 diagnostic criteria
(1) DM diagnostic criteria: according to the diabetes diagnosis standard of World Health Organization's announcement in 1999.
(2) Chinese medical discrimination standard: according to the diabetes tcm syndrome diagnostic criteria of version " new Chinese medicine clinical research guideline " in 2002 formulation, card belongs to damp and hot tired spleen card person.
1.2 include the case standard in
All diabetes diagnosis standards that meets in the Western medicine diagnose accord with again and Chinese medical discrimination typing standard, fasting glucose<20mmol/L, and the age is adhered to the outpatient service pill taker voluntarily below 75 years old, can include the test case in.
1.3 get rid of the case standard
1. the age is more than 75 years old; 2. gestation or women breast-feeding their children; 3. original blood sugar lowering Western medicine, insulinize kind, dosage can not keep the person of stablizing; 4. hepatic and kidney function obstacle person; Diabetes acute complications such as ketoacidosis, lactic acidosis, hyperosmolar coma and the infected take place in 6. nearly 1 month in 5. concurrent hypertension, coronary heart disease and other serious primary disease persons; 7. to the Chinese medicine ingredients allergy sufferers; 8. partner's (refer to cooperate diet control maybe can not be by the regulation medication person of affecting the treatment) and psychotic are unwilling.
2 treatment and observational techniques
2.1 Therapeutic Method
All persons that do not use the Western medicine no longer share Western medicine in the test.As used Western medicine, and kind and dosage are more than fixing 2 weeks, and blood glucose is still controlled gastrointestinal disease patient, and hypoglycemic medicine kind during the treatment, consumption are constant.Go into to organize the GEGEN QINLIAN TANG plus-minus treatment that the patient gives the various dose group.Low dose group is Radix Puerariae 24g Radix Scutellariae 9g Rhizoma Coptidis 9g Radix Glycyrrhizae Preparata 6g Rhizoma Zingiberis 1.5g; Middle dose groups is that Radix Puerariae 72g Radix Scutellariae 27g Rhizoma Coptidis 27g processs sweet 18g Rhizoma Zingiberis 4.5g; High dose group is Radix Puerariae 120g Radix Scutellariae 45g Rhizoma Coptidis 45g Radix Glycyrrhizae Preparata 30g Rhizoma Zingiberis 7.5g.Insomnia adds Semen Ziziphi Spinosae (parched), and constipation adds Radix et Rhizoma Rhei (stir-fried with wine), and excessive rising of liver-YANG adds Spica Prunellae, Ramulus Uncariae Cum Uncis, and hyperlipidemia adds to be used Monas cuspurpureus Went, metabolic arthritis to add to use Radix Clematidis.1 dose of every day, early, late (medicine) being taken before meal uses.12 weeks of the course of treatment.
2.3 observation index and method
Glycolated hemoglobin, fasting glucose, two hours after the meal blood glucose.
Safety evaluatio index: the situation of itemized record adverse events, and the dependency of judgement and medicine.Detect and treat preceding back hepatic and renal function and the changes of vital signs treated.
2.4 statistical method
All measurement datas all adopt mean ± standard deviation form.Different according to observation index and data, measurement data adopts covariance analysis, and enumeration data adopts the trend chi-square criterion, and P<0.05 is a significant difference, and P<0.01 is a significant differences.
3 results
3.1 physical data
3 groups of selected patients' demography data comparing difference not statistically significant (P>0.05), the tool comparability is seen table 1.
Table 1. physical data relatively
3.2 various dose group GEGEN QINLIAN TANG is to the glycemic control general effect
Curative effect determinate standard: fasting glucose, 2 hours after the meal blood glucose descend and surpass 20% before the treatment, or the glycolated hemoglobin value descends and surpass 10% before the treatment and be designated as effectively, otherwise then are invalid.This data is two-way ordinal data, so the X 2 test of employing trend, chi-square value is 7.781, P=0.005<0.05, and difference has the significance meaning.Prompting, along with the increase of dosage, GEGEN QINLIAN TANG also increases (see figure 1) to the overall control effective percentage of blood glucose.
3.3 various dose group GEGEN QINLIAN TANG to glycolated hemoglobin reduction amplitude relatively
With high dose comparison ▲ P<0.05, ▲ ▲ P<0.001
The glycolated hemoglobin difference adopts covariance analysis relatively before and after three groups of treatments, and three groups are relatively, F value=33.613, and P<0.001 points out three groups of comparing differences that the significance meaning is arranged.High dose reduces amplitude and low dose group relatively has significant difference, in, low dose group and height, middle dose groups only have a declining tendency.Prompting GEGEN QINLIAN TANG high dose group has better controlling glycolated hemoglobin curative effect, and along with the minimizing of dosage, middle dose groups is effective in cure to have downward trend, the low dose group curative effect (see figure 2) that obviously descends.
3.4 various dose group GEGEN QINLIAN TANG to blood glucose reduction amplitude relatively
With high dose comparison ▲ P<0.05, ▲ ▲ P<0.001
Before and after three groups of treatments the blood glucose difference with initial value as covariant; Through covariance analysis; Fasting glucose reduces amplitude and compares F value=9.860 for three groups, P<0.001, and the amplitude of 2h blood glucose reduction after the meal compares F value=19.154 for three groups; P<0.001 is pointed out three groups of two hours after the meal blood glucose to reduce the amplitude difference and is had significant difference.High dose group and low dose group relatively have significant difference, during high, middle dose groups relatively reaches, low dose group more only has reduction trend, but not statistically significant.2 hours after the meal blood glucose has the trend along with the minimizing reduction of dosage, not statistically significant before and after three groups of treatments.Prompting GEGEN QINLIAN TANG high dose group has better controlling fasting glucose curative effect, along with the minimizing of dosage, and middle low dose group curative effect descend gradually (like Fig. 3).
3.5 untoward reaction
The back high dose group 1 routine patient that takes medicine has a stomachache after medicine appears in viewing duration, changes the back of taking medicine after the meal into and disappears, and middle dose groups has 1 routine patient constipation to occur.Liver, renal function have no significant change (P>0.05) before and after three groups of medications, and each dose groups of prompting GEGEN QINLIAN TANG does not make significant difference to hepatic and renal function.
4 discuss
GEGEN QINLIAN TANG comes from the treatise on Febrile Diseases that Zhang Zhongjing is shown, and is used for treating diarrhoea and dysentery due to damp and hot, is the classic prescriptions of treatment by Chinese herbs acute diarrhea.It consists of: half jin of Radix Puerariae, two liang in Radix Glycyrrhizae, three liang of Radix Scutellariae (processed), three liang of Rhizoma Coptidis.In the process that medical treatment constantly develops, this prescription is widely used, and has given a lot of new adaptation diseases.Radix Puerariae is the Yangming Channel medicine in the side, to remove positive bright interior-heat, rises Tianjin and moisturizes for curing mainly ancient Chinese medicine doctor its treatment diabetes commonly used.In the side Radix Scutellariae, Rhizoma Coptidis lung heat clearing sthenia gastropyrexia to medicine, can separate in the blood sugar poison, wherein the Rhizoma Coptidis heat clearing and damp drying is let out the fire detoxifcation, promptly is described as the panacea of controlling diabetes by Liu's interchannel period as far back as gold dollar; Radix Scutellariae can the lung heat clearing sthenia gastropyrexia.Radix Puerariae wherein, Rhizoma Coptidis, Radix Scutellariae confirm to have definite blood sugar reducing function through modern pharmacology, in clinical practice, the damp and hot tired spleen of type 2 diabetes mellitus are demonstrate,proved determined curative effect
[3]
Show in this research that each dose groups of GEGEN QINLIAN TANG all has blood sugar control effect in various degree; Analyze from overall glycemic control level angle, high dose group is blood sugar control preferably, and middle dose groups is taken second place; The low dose group effective percentage is lower, and three dose groups have tangible dose-effect relationship.More obvious to glycolated hemoglobin and fasting glucose actuating quantity effect relationship trend.Take all factors into consideration from safety and effectiveness, middle dose groups is preferred.
Test Example 2
Medicine composite for curing type 2 diabetes mellitus patient model case of the present invention
The Wang, man, 56 years old.Main suit: blood sugar increasing 6 years.The patient is health check-up inspection FBG:9mmol/l before June, is diagnosed as type 2 diabetes mellitus.Only diet motor control, not systematic treating.History of past illness: history of hypertension 2 years is surplus, does not use depressor.Slight fatty liver 1 year is surplus.Inscribe disease opinion: xerostomia, polydipsia, idol has asthenia, receive sleep can, big dry stool.Blood pressure: 130/100mmHg.Look into FBG:8.8mmol/L, TG:2.08mmol/L at present.Thick fur is rotten greasy, indentation is arranged, stringy pulse.Diagnosis: diabetes.Chinese medical discrimination is: damp and hot tired spleen, control with clearing away heat-damp and promoting diuresis.Prescription gives Radix Puerariae 72g Radix Scutellariae 27g Rhizoma Coptidis 27g and processs sweet 18g Rhizoma Zingiberis 4.5g Radix et Rhizoma Rhei (stir-fried with wine) 6g.The patient obeys 4 weeks of top.Xerostomia, polydipsia all alleviates to some extent, and is slightly weak, receive sleep can, fasting glucose is controlled between the 7-7.5mmol/L, looks into FBG:7.3mmol/L, TG:1.98mmol/L.The top adds Radix Panacis Quinquefolii 6g, and Monas cuspurpureus Went 9g continues 8 weeks of clothes, and fasting glucose is controlled at 6-7mmol/L, looks into FBG:6.4mmol/L, and blood fat is normal.Sight continues.
Test Example 3
Medicine composite for curing type 2 diabetes mellitus patient model case of the present invention
Lee, woman, 60 years old.Find that blood sugar increasing 1 year is surplus.Patient's health check-up before 1 year finds that blood glucose is higher, about fasting glucose 8mmol/L, gives diet, motor control, is interrupted and takes the bifilar 0.5mg of diformazan, and system does not take medicine.Inscribe disease: xerostomia is thirsty, polydipsia, food receive can, it is not smooth defecate, 2 days 1 row just glue.Urine can.History of past illness: hypertension finds that February is surplus, clothes irbesartan and metoprolol.Hyperlipidemia 1 year.Look into: HbA1c:7.3%, FBG:9.47mmol/L, ALT:55IU/L, LDL-C:3.67mmol/L is surplus normal.BP:130/80mmHg。Prescription: Radix Puerariae 72g Radix Scutellariae 27g Rhizoma Coptidis 27g Radix Glycyrrhizae Preparata 18g Rhizoma Zingiberis Recens 9g Rhizoma Anemarrhenae 30g Monas cuspurpureus Went 9g.Two examine and take medicine after 28 pairs, still have xerostomia thirsty, and stool is slightly sticking, and it is poor to sleep, FBG 7.5mmol/L, 2hPG:13mmol/L.The top adds Semen Ziziphi Spinosae (parched) 30g.Three examine and take medicine after 28 pairs, receive sleep can, xerostomia is defecated 1 time on the 1st.Look into FBG:7mmol/L; HbA1c:6.4%.Controlling of blood pressure is stable.
Description of drawings
Fig. 1: this pharmaceutical composition of various dose group blood glucose is totally controlled effective percentage
Fig. 2: this pharmaceutical composition of various dose group glycolated hemoglobin reduces amplitude
Fig. 3: this pharmaceutical composition of various dose group FBG, PBG reduce amplitude
Annotate: 1: fasting glucose reduces amplitude (mmol/L) 2: blood glucose reduced amplitude (mmol/L) in 2 hours after the meal
The specific embodiment
Through concrete embodiment application of the present invention is described further below, but not as limitation of the present invention.
Sequence number | Radix Puerariae | Radix Scutellariae | Rhizoma Coptidis | Radix Glycyrrhizae Preparata | Rhizoma Zingiberis/ |
1 | 57 | 14 | 14 | 8 | 7 |
2 | 59 | 15 | 7 | 14 | 5 |
3 | 5 | 29 | 29 | 30 | 7 |
4 | 5 | 31 | 31 | 32 | 1 |
5 | 7 | 44 | 44 | 4 | 1 |
6 | 12 | 7 | 72 | 7 | 2 |
7 | 12 | 72 | 7 | 7 | 2 |
8 | 23 | 14 | 14 | 14 | 35 |
9 | 47 | 18 | 18 | 12 | 5 |
10 | 48 | 24 | 3 | 24 | 1 |
11 | 51 | 19 | 19 | 4 | 7 |
12 | 55 | 14 | 20 | 5 | 6 |
13 | 55 | 21 | 7 | 14 | 3 |
14 | 55 | 14 | 14 | 14 | 3 |
15 | 55 | 21 | 7 | 14 | 3 |
16 | 55 | 14 | 14 | 14 | 3 |
17 | 56 | 21 | 14 | 5 | 4 |
18 | 56 | 21 | 14 | 5 | 4 |
19 | 57 | 21 | 7 | 7 | 8 |
20 | 59 | 22 | 7 | 5 | 7 |
21 | 59 | 22 | 7 | 7 | 5 |
22 | 59 | 15 | 15 | 7 | 4 |
23 | 59 | 15 | 7 | 15 | 4 |
24 | 66 | 16 | 8 | 5 | 5 |
[0080]?
25 | 86 | 4 | 4 | 4 | 2 |
26 | 5 | 27 | 27 | 27 | 14 |
27 | 6 | 4 | 36 | 36 | 18 |
28 | 6 | 36 | 36 | 4 | 18 |
29 | 7 | 4 | 40 | 40 | 9 |
30 | 7 | 40 | 4 | 40 | 9 |
31 | 7 | 40 | 40 | 4 | 9 |
32 | 7 | 4 | 44 | 44 | 1 |
33 | 7 | 44 | 4 | 44 | 1 |
34 | 9 | 54 | 5 | 5 | 27 |
35 | 34 | 20 | 20 | 20 | 6 |
36 | 38 | 19 | 19 | 19 | 5 |
37 | 43 | 2 | 22 | 22 | 11 |
38 | 43 | 22 | 2 | 22 | 11 |
39 | 43 | 22 | 22 | 2 | 11 |
40 | 46 | 2 | 23 | 23 | 6 |
41 | 46 | 23 | 2 | 23 | 6 |
42 | 46 | 23 | 23 | 2 | 6 |
43 | 48 | 18 | 18 | 12 | 4 |
44 | 48 | 24 | 24 | 2 | 2 |
45 | 50 | 19 | 19 | 6 | 6 |
46 | 50 | 19 | 13 | 13 | 5 |
47 | 50 | 13 | 19 | 13 | 5 |
48 | 51 | 13 | 19 | 13 | 4 |
49 | 51 | 19 | 13 | 13 | 4 |
50 | 51 | 13 | 19 | 13 | 4 |
51 | 52 | 19 | 19 | 6 | 4 |
52 | 52 | 19 | 13 | 13 | 3 |
53 | 52 | 13 | 19 | 13 | 3 |
54 | 53 | 20 | 20 | 4 | 3 |
55 | 53 | 13 | 13 | 13 | 8 |
56 | 54 | 3 | 3 | 27 | 13 |
57 | 55 | 20 | 7 | 14 | 4 |
58 | 55 | 14 | 14 | 14 | 3 |
59 | 55 | 20 | 14 | 7 | 4 |
60 | 55 | 20 | 7 | 14 | 5 |
61 | 55 | 14 | 14 | 14 | 3 |
62 | 55 | 21 | 14 | 7 | 3 |
63 | 55 | 21 | 7 | 14 | 3 |
64 | 55 | 14 | 21 | 7 | 3 |
65 | 56 | 14 | 21 | 5 | 4 |
66 | 58 | 3 | 3 | 29 | 7 |
67 | 59 | 15 | 7 | 15 | 4 |
68 | 60 | 15 | 15 | 5 | 5 |
[0081]?
69 | 61 | 23 | 8 | 5 | 3 |
70 | 61 | 15 | 15 | 5 | 4 |
71 | 62 | 3 | 3 | 31 | 1 |
72 | 62 | 31 | 3 | 3 | 1 |
73 | 64 | 16 | 8 | 8 | 4 |
74 | 71 | 4 | 4 | 3 | 18 |
75 | 78 | 4 | 4 | 4 | 10 |
76 | 6 | 36 | 4 | 36 | 18 |
77 | 10 | 6 | 62 | 6 | 16 |
78 | 10 | 62 | 6 | 6 | 16 |
79 | 36 | 18 | 18 | 18 | 10 |
80 | 48 | 2 | 24 | 25 | 1 |
81 | 48 | 18 | 18 | 12 | 4 |
82 | 53 | 13 | 20 | 7 | 7 |
83 | 54 | 3 | 27 | 2 | 14 |
84 | 54 | 27 | 3 | 2 | 14 |
85 | 58 | 3 | 29 | 3 | 7 |
86 | 58 | 29 | 3 | 3 | 7 |
Sequence number | Radix Puerariae | Radix Scutellariae | Rhizoma Coptidis | Radix Glycyrrhizae Preparata | Do/Rhizoma Zingiberis Recens | Radix et Rhizoma Rhei (stir-fried with wine) |
1 | 4 | 26 | 26 | 26 | 13 | 5 |
2 | 4 | 27 | 27 | 27 | 13 | 1 |
3 | 4 | 27 | 27 | 27 | 13 | 2 |
4 | 4 | 27 | 27 | 27 | 13 | 2 |
5 | 5 | 28 | 28 | 28 | 7 | 4 |
6 | 5 | 28 | 28 | 28 | 7 | 4 |
7 | 5 | 28 | 28 | 28 | 7 | 4 |
8 | 5 | 29 | 29 | 29 | 7 | 1 |
9 | 5 | 30 | 30 | 30 | 1 | 4 |
10 | 6 | 35 | 35 | 3 | 17 | 4 |
11 | 6 | 35 | 3 | 35 | 17 | 4 |
12 | 6 | 38 | 38 | 4 | 10 | 4 |
13 | 6 | 38 | 4 | 38 | 10 | 4 |
14 | 7 | 42 | 42 | 4 | 1 | 4 |
15 | 7 | 42 | 4 | 42 | 1 | 4 |
16 | 7 | 4 | 42 | 42 | 1 | 4 |
17 | 8 | 5 | 51 | 5 | 25 | 6 |
18 | 10 | 6 | 58 | 6 | 15 | 5 |
19 | 10 | 6 | 6 | 58 | 15 | 5 |
20 | 11 | 6 | 6 | 65 | 5 | 7 |
21 | 11 | 67 | 7 | 7 | 2 | 6 |
22 | 11 | 7 | 67 | 7 | 2 | 6 |
[0084]?
23 | 11 | 7 | 7 | 67 | 2 | 6 |
24 | 16 | 9 | 9 | 9 | 47 | 10 |
25 | 20 | 12 | 12 | 12 | 31 | 13 |
26 | 20 | 12 | 12 | 12 | 31 | 13 |
27 | 28 | 17 | 17 | 17 | 4 | 17 |
28 | 35 | 18 | 18 | 18 | 9 | 2 |
29 | 36 | 18 | 18 | 18 | 9 | 1 |
30 | 36 | 18 | 18 | 18 | 9 | 1 |
31 | 37 | 19 | 19 | 17 | 5 | 3 |
32 | 37 | 19 | 19 | 18 | 5 | 2 |
33 | 38 | 19 | 19 | 18 | 5 | 1 |
34 | 38 | 20 | 20 | 18 | 2 | 2 |
35 | 43 | 21 | 21 | 2 | 11 | 2 |
36 | 43 | 21 | 2 | 21 | 11 | 2 |
37 | 43 | 2 | 21 | 21 | 11 | 2 |
38 | 45 | 22 | 22 | 2 | 6 | 3 |
39 | 45 | 22 | 2 | 22 | 6 | 3 |
40 | 45 | 2 | 22 | 22 | 6 | 3 |
41 | 45 | 17 | 19 | 9 | 6 | 4 |
42 | 45 | 17 | 17 | 11 | 6 | 4 |
43 | 46 | 17 | 17 | 11 | 3 | 6 |
44 | 46 | 17 | 17 | 11 | 6 | 3 |
45 | 46 | 17 | 17 | 11 | 6 | 3 |
46 | 46 | 17 | 17 | 11 | 6 | 3 |
47 | 46 | 17 | 17 | 12 | 4 | 4 |
48 | 47 | 17 | 17 | 12 | 6 | 1 |
49 | 47 | 17 | 17 | 12 | 3 | 4 |
50 | 47 | 18 | 18 | 12 | 4 | 1 |
51 | 47 | 18 | 18 | 12 | 4 | 1 |
52 | 47 | 24 | 24 | 2 | 1 | 2 |
53 | 47 | 18 | 18 | 12 | 3 | 2 |
54 | 47 | 24 | 2 | 24 | 1 | 2 |
55 | 47 | 2 | 24 | 24 | 1 | 2 |
56 | 47 | 18 | 18 | 12 | 4 | 1 |
57 | 48 | 18 | 18 | 12 | 3 | 1 |
58 | 49 | 18 | 18 | 6 | 6 | 3 |
59 | 49 | 18 | 12 | 12 | 6 | 3 |
60 | 49 | 12 | 18 | 12 | 6 | 3 |
61 | 49 | 12 | 18 | 12 | 6 | 3 |
62 | 49 | 12 | 18 | 12 | 6 | 2 |
63 | 50 | 19 | 19 | 4 | 6 | 2 |
64 | 50 | 19 | 12 | 12 | 4 | 3 |
65 | 50 | 19 | 12 | 12 | 4 | 3 |
66 | 50 | 19 | 12 | 12 | 4 | 3 |
[0085]?
67 | 50 | 12 | 19 | 12 | 4 | 3 |
68 | 50 | 19 | 19 | 6 | 3 | 3 |
69 | 50 | 19 | 13 | 13 | 3 | 2 |
70 | 50 | 13 | 19 | 13 | 3 | 2 |
71 | 51 | 17 | 15 | 10 | 3 | 3 |
72 | 51 | 19 | 19 | 4 | 3 | 4 |
73 | 52 | 13 | 19 | 6 | 6 | 4 |
74 | 52 | 13 | 13 | 13 | 6 | 3 |
75 | 52 | 13 | 13 | 13 | 6 | 3 |
76 | 53 | 26 | 3 | 3 | 13 | 2 |
77 | 53 | 3 | 26 | 3 | 13 | 2 |
78 | 53 | 3 | 3 | 26 | 13 | 2 |
79 | 53 | 13 | 20 | 4 | 7 | 3 |
80 | 53 | 20 | 13 | 7 | 4 | 3 |
81 | 53 | 20 | 7 | 13 | 4 | 3 |
82 | 53 | 20 | 7 | 13 | 4 | 3 |
83 | 53 | 20 | 7 | 13 | 4 | 3 |
84 | 53 | 13 | 13 | 13 | 4 | 4 |
85 | 53 | 13 | 13 | 13 | 4 | 4 |
86 | 53 | 20 | 7 | 13 | 4 | 3 |
87 | 53 | 20 | 7 | 13 | 4 | 3 |
88 | 53 | 13 | 13 | 13 | 4 | 4 |
89 | 54 | 20 | 13 | 7 | 3 | 3 |
90 | 54 | 13 | 20 | 7 | 3 | 3 |
91 | 54 | 20 | 7 | 13 | 3 | 3 |
92 | 54 | 13 | 13 | 13 | 3 | 4 |
93 | 54 | 20 | 14 | 5 | 5 | 2 |
94 | 55 | 27 | 5 | 5 | 1 | 7 |
95 | 55 | 21 | 14 | 5 | 3 | 2 |
96 | 55 | 14 | 21 | 5 | 3 | 2 |
97 | 56 | 21 | 7 | 7 | 7 | 2 |
98 | 56 | 14 | 14 | 7 | 7 | 2 |
99 | 56 | 28 | 3 | 3 | 7 | 3 |
100 | 56 | 3 | 28 | 3 | 7 | 3 |
101 | 56 | 3 | 3 | 28 | 7 | 3 |
102 | 57 | 21 | 7 | 5 | 7 | 3 |
103 | 57 | 14 | 7 | 14 | 5 | 3 |
104 | 57 | 14 | 7 | 14 | 4 | 4 |
105 | 58 | 22 | 7 | 7 | 4 | 2 |
106 | 58 | 14 | 14 | 7 | 4 | 3 |
107 | 58 | 14 | 7 | 14 | 4 | 3 |
108 | 58 | 15 | 15 | 5 | 5 | 2 |
109 | 59 | 22 | 7 | 5 | 4 | 3 |
110 | 59 | 15 | 15 | 5 | 4 | 2 |
[0086]?
111 | 60 | 30 | 3 | 3 | 1 | 3 |
112 | 60 | 3 | 30 | 3 | 1 | 3 |
113 | 60 | 3 | 3 | 30 | 1 | 3 |
114 | 62 | 16 | 8 | 8 | 4 | 2 |
115 | 64 | 16 | 8 | 5 | 4 | 3 |
116 | 66 | 3 | 16 | 5 | 5 | 5 |
117 | 69 | 3 | 3 | 3 | 17 | 5 |
118 | 75 | 4 | 4 | 4 | 9 | 4 |
Sequence number | Radix Puerariae | Radix Scutellariae | Rhizoma Coptidis | Radix Glycyrrhizae Preparata | Do/Rhizoma Zingiberis Recens | Radix et Rhizoma Rhei (stir-fried with wine) | Radix Panacis Quinquefolii | Monas cuspurpureus Went |
1 | 4 | 25 | 25 | 25 | 12 | 2 | 2 | 5 |
2 | 4 | 25 | 25 | 25 | 6 | 4 | 5 | 6 |
3 | 4 | 24 | 24 | 24 | 12 | 4 | 4 | 4 |
4 | 4 | 26 | 26 | 26 | 6 | 4 | 4 | 4 |
5 | 4 | 26 | 26 | 26 | 7 | 4 | 3 | 4 |
6 | 4 | 25 | 25 | 25 | 12 | 4 | 2 | 3 |
7 | 4 | 24 | 24 | 24 | 12 | 4 | 4 | 4 |
8 | 4 | 27 | 27 | 27 | 7 | 3 | 3 | 2 |
9 | 5 | 32 | 32 | 3 | 16 | 3 | 4 | 5 |
10 | 5 | 32 | 3 | 32 | 16 | 3 | 4 | 5 |
11 | 5 | 28 | 28 | 28 | 1 | 3 | 3 | 4 |
12 | 6 | 35 | 35 | 3 | 9 | 3 | 4 | 5 |
13 | 6 | 35 | 3 | 35 | 9 | 3 | 4 | 5 |
14 | 6 | 38 | 38 | 4 | 1 | 4 | 4 | 6 |
15 | 6 | 38 | 4 | 38 | 1 | 4 | 3 | 6 |
16 | 6 | 4 | 38 | 38 | 1 | 4 | 3 | 6 |
17 | 8 | 5 | 5 | 51 | 13 | 5 | 5 | 8 |
18 | 8 | 5 | 51 | 5 | 13 | 5 | 5 | 8 |
19 | 8 | 5 | 45 | 5 | 23 | 5 | 5 | 4 |
20 | 9 | 6 | 6 | 56 | 5 | 6 | 6 | 6 |
21 | 10 | 57 | 6 | 6 | 1 | 6 | 5 | 9 |
22 | 10 | 6 | 6 | 57 | 1 | 6 | 5 | 9 |
23 | 10 | 6 | 57 | 6 | 1 | 6 | 5 | 9 |
24 | 13 | 8 | 8 | 8 | 38 | 8 | 6 | 11 |
25 | 16 | 9 | 9 | 9 | 23 | 11 | 9 | 14 |
26 | 20 | 12 | 12 | 12 | 3 | 12 | 11 | 18 |
27 | 33 | 17 | 17 | 17 | 8 | 2 | 2 | 4 |
28 | 34 | 17 | 17 | 17 | 4 | 3 | 4 | 4 |
29 | 34 | 17 | 17 | 17 | 8 | 2 | 1 | 4 |
30 | 34 | 17 | 17 | 17 | 9 | 2 | 3 | 1 |
31 | 34 | 17 | 17 | 17 | 8 | 3 | 1 | 3 |
32 | 34 | 17 | 17 | 17 | 9 | 2 | 1 | 3 |
[0089]?
33 | 35 | 18 | 18 | 18 | 4 | 3 | 1 | 3 |
34 | 36 | 18 | 18 | 18 | 4 | 2 | 1 | 3 |
35 | 37 | 19 | 19 | 19 | 0 | 2 | 1 | 3 |
36 | 40 | 15 | 15 | 10 | 3 | 3 | 5 | 9 |
37 | 40 | 2 | 20 | 20 | 10 | 2 | 2 | 4 |
38 | 40 | 20 | 2 | 20 | 10 | 2 | 2 | 4 |
39 | 40 | 20 | 20 | 2 | 10 | 2 | 2 | 4 |
40 | 40 | 15 | 15 | 10 | 2 | 5 | 5 | 8 |
41 | 41 | 15 | 17 | 9 | 6 | 3 | 3 | 6 |
42 | 41 | 15 | 15 | 10 | 3 | 5 | 5 | 6 |
43 | 42 | 16 | 16 | 10 | 5 | 3 | 3 | 5 |
44 | 42 | 16 | 16 | 10 | 3 | 5 | 3 | 5 |
45 | 42 | 16 | 16 | 10 | 3 | 3 | 5 | 5 |
46 | 42 | 16 | 16 | 11 | 4 | 3 | 3 | 5 |
47 | 42 | 16 | 16 | 11 | 3 | 4 | 3 | 5 |
48 | 43 | 16 | 16 | 11 | 5 | 2 | 2 | 5 |
49 | 43 | 2 | 21 | 21 | 5 | 2 | 2 | 4 |
50 | 43 | 21 | 2 | 21 | 5 | 2 | 2 | 4 |
51 | 43 | 21 | 21 | 2 | 5 | 2 | 2 | 4 |
52 | 43 | 16 | 16 | 11 | 5 | 3 | 2 | 4 |
53 | 43 | 16 | 16 | 11 | 4 | 3 | 3 | 5 |
54 | 44 | 16 | 16 | 11 | 4 | 3 | 2 | 4 |
55 | 44 | 17 | 17 | 11 | 3 | 2 | 2 | 4 |
56 | 44 | 17 | 17 | 11 | 4 | 2 | 2 | 3 |
57 | 45 | 2 | 22 | 22 | 1 | 2 | 2 | 4 |
58 | 45 | 22 | 2 | 22 | 1 | 2 | 2 | 4 |
59 | 45 | 22 | 22 | 2 | 1 | 2 | 2 | 4 |
60 | 45 | 17 | 17 | 11 | 3 | 2 | 2 | 3 |
61 | 46 | 17 | 11 | 11 | 6 | 2 | 2 | 5 |
62 | 46 | 11 | 17 | 11 | 6 | 2 | 2 | 5 |
63 | 46 | 11 | 17 | 11 | 6 | 2 | 2 | 5 |
64 | 46 | 17 | 17 | 6 | 6 | 2 | 2 | 4 |
65 | 47 | 16 | 14 | 9 | 2 | 3 | 3 | 6 |
66 | 47 | 18 | 18 | 6 | 3 | 2 | 2 | 4 |
67 | 47 | 18 | 12 | 12 | 3 | 2 | 2 | 4 |
68 | 47 | 12 | 18 | 12 | 3 | 2 | 2 | 4 |
69 | 47 | 18 | 12 | 12 | 4 | 2 | 2 | 3 |
70 | 47 | 12 | 18 | 12 | 4 | 2 | 2 | 3 |
71 | 47 | 18 | 18 | 4 | 6 | 2 | 2 | 3 |
72 | 47 | 18 | 12 | 12 | 4 | 2 | 2 | 3 |
73 | 47 | 18 | 12 | 12 | 4 | 2 | 2 | 3 |
74 | 47 | 12 | 18 | 12 | 4 | 2 | 2 | 3 |
75 | 48 | 18 | 18 | 4 | 3 | 2 | 2 | 5 |
76 | 48 | 24 | 5 | 5 | 1 | 5 | 5 | 7 |
[0090]?
77 | 49 | 2 | 2 | 25 | 12 | 2 | 2 | 5 |
78 | 49 | 2 | 25 | 2 | 12 | 2 | 2 | 5 |
79 | 49 | 25 | 2 | 2 | 12 | 2 | 2 | 5 |
80 | 49 | 12 | 18 | 6 | 6 | 2 | 2 | 5 |
81 | 49 | 12 | 12 | 12 | 6 | 2 | 2 | 5 |
82 | 50 | 12 | 12 | 12 | 4 | 2 | 2 | 5 |
83 | 50 | 12 | 12 | 12 | 4 | 2 | 2 | 5 |
84 | 50 | 19 | 6 | 12 | 4 | 2 | 2 | 5 |
85 | 50 | 19 | 12 | 6 | 4 | 2 | 2 | 5 |
86 | 50 | 19 | 6 | 12 | 4 | 2 | 2 | 5 |
87 | 50 | 12 | 19 | 4 | 6 | 2 | 2 | 5 |
88 | 50 | 19 | 13 | 6 | 3 | 3 | 3 | 3 |
89 | 50 | 19 | 6 | 13 | 3 | 3 | 3 | 3 |
90 | 50 | 13 | 19 | 6 | 3 | 3 | 3 | 3 |
91 | 50 | 19 | 6 | 13 | 4 | 3 | 3 | 2 |
92 | 50 | 19 | 6 | 13 | 4 | 3 | 3 | 2 |
93 | 50 | 13 | 13 | 13 | 3 | 3 | 3 | 2 |
94 | 50 | 13 | 13 | 13 | 4 | 3 | 3 | 1 |
95 | 51 | 13 | 19 | 4 | 3 | 3 | 3 | 4 |
96 | 51 | 19 | 13 | 4 | 4 | 3 | 3 | 3 |
97 | 52 | 19 | 6 | 6 | 6 | 3 | 3 | 5 |
98 | 52 | 13 | 13 | 6 | 6 | 3 | 3 | 4 |
99 | 53 | 3 | 3 | 26 | 7 | 3 | 3 | 2 |
100 | 53 | 3 | 26 | 3 | 7 | 3 | 3 | 2 |
101 | 53 | 26 | 3 | 3 | 7 | 3 | 3 | 2 |
102 | 53 | 13 | 7 | 13 | 4 | 3 | 3 | 4 |
103 | 53 | 20 | 7 | 4 | 7 | 3 | 3 | 3 |
104 | 54 | 20 | 7 | 7 | 3 | 3 | 3 | 3 |
105 | 54 | 13 | 13 | 7 | 3 | 3 | 3 | 4 |
106 | 54 | 13 | 7 | 13 | 3 | 3 | 3 | 4 |
107 | 54 | 14 | 14 | 5 | 5 | 3 | 3 | 2 |
108 | 55 | 21 | 7 | 5 | 3 | 3 | 3 | 3 |
109 | 55 | 14 | 14 | 5 | 3 | 3 | 3 | 3 |
110 | 56 | 3 | 3 | 28 | 1 | 3 | 3 | 3 |
111 | 56 | 3 | 28 | 3 | 1 | 3 | 3 | 3 |
112 | 56 | 28 | 3 | 3 | 1 | 3 | 3 | 3 |
113 | 58 | 14 | 7 | 7 | 4 | 3 | 3 | 4 |
114 | 59 | 15 | 7 | 5 | 4 | 3 | 3 | 4 |
115 | 61 | 3 | 15 | 5 | 5 | 3 | 3 | 5 |
116 | 63 | 3 | 3 | 3 | 16 | 3 | 3 | 6 |
117 | 69 | 3 | 3 | 3 | 9 | 3 | 3 | 7 |
Sequence number | Radix Puerariae | Radix Scutellariae | Rhizoma Coptidis | Radix Glycyrrhizae Preparata | Do/Rhizoma Zingiberis Recens | Radix et Rhizoma Rhei (stir-fried with wine) | The Rhizoma Anemarrhenae | Monas cuspurpureus Went |
1 | 4 | 22 | 22 | 22 | 11 | 3 | 11 | 5 |
2 | 4 | 23 | 23 | 23 | 11 | 2 | 11 | 3 |
3 | 4 | 23 | 23 | 23 | 11 | 3 | 11 | 2 |
4 | 4 | 23 | 23 | 23 | 6 | 3 | 12 | 6 |
5 | 4 | 24 | 24 | 24 | 6 | 4 | 12 | 4 |
6 | 4 | 24 | 24 | 24 | 6 | 2 | 12 | 4 |
7 | 4 | 24 | 24 | 24 | 6 | 4 | 12 | 2 |
8 | 4 | 25 | 25 | 25 | 12 | 4 | 4 | 1 |
9 | 4 | 25 | 25 | 25 | 1 | 3 | 13 | 4 |
10 | 4 | 26 | 26 | 26 | 7 | 4 | 6 | 1 |
11 | 5 | 28 | 28 | 3 | 14 | 3 | 14 | 5 |
12 | 5 | 28 | 3 | 28 | 14 | 3 | 14 | 5 |
13 | 5 | 31 | 31 | 3 | 8 | 3 | 15 | 4 |
14 | 5 | 31 | 3 | 31 | 8 | 3 | 15 | 4 |
15 | 5 | 33 | 33 | 3 | 1 | 3 | 16 | 6 |
16 | 5 | 33 | 3 | 33 | 1 | 3 | 16 | 6 |
17 | 5 | 3 | 33 | 33 | 1 | 3 | 16 | 6 |
18 | 6 | 4 | 38 | 4 | 19 | 4 | 19 | 6 |
19 | 7 | 4 | 4 | 42 | 11 | 4 | 21 | 77 |
20 | 7 | 4 | 42 | 4 | 11 | 4 | 21 | 7 |
21 | 8 | 5 | 5 | 45 | 4 | 5 | 23 | 5 |
22 | 8 | 47 | 5 | 5 | 1 | 5 | 23 | 6 |
23 | 8 | 5 | 5 | 47 | 1 | 5 | 23 | 6 |
24 | 8 | 5 | 47 | 5 | 1 | 5 | 23 | 6 |
25 | 10 | 6 | 6 | 6 | 29 | 6 | 29 | 8 |
26 | 11 | 7 | 7 | 7 | 17 | 7 | 34 | 10 |
27 | 13 | 8 | 8 | 8 | 2 | 9 | 40 | 12 |
28 | 31 | 16 | 16 | 16 | 8 | 2 | 8 | 3 |
29 | 32 | 16 | 16 | 16 | 8 | 2 | 8 | 2 |
30 | 33 | 16 | 16 | 16 | 4 | 2 | 8 | 5 |
31 | 33 | 17 | 17 | 17 | 4 | 2 | 8 | 2 |
32 | 33 | 17 | 17 | 17 | 8 | 2 | 4 | 5 |
33 | 34 | 17 | 17 | 17 | 4 | 3 | 7 | 1 |
34 | 34 | 17 | 17 | 17 | 9 | 3 | 1 | 2 |
35 | 34 | 17 | 17 | 17 | 4 | 3 | 4 | 4 |
36 | 35 | 17 | 17 | 17 | 4 | 2 | 4 | 4 |
37 | 36 | 13 | 13 | 9 | 2 | 4 | 15 | 8 |
38 | 36 | 18 | 18 | 18 | 4 | 3 | 2 | 1 |
39 | 36 | 14 | 14 | 9 | 2 | 3 | 15 | 7 |
40 | 36 | 14 | 15 | 8 | 5 | 3 | 15 | 4 |
41 | 36 | 18 | 18 | 18 | 0 | 2 | 5 | 3 |
42 | 37 | 14 | 14 | 9 | 2 | 5 | 15 | 4 |
[0093]?
43 | 37 | 14 | 14 | 9 | 2 | 3 | 16 | 5 |
44 | 38 | 14 | 14 | 9 | 2 | 5 | 16 | 2 |
45 | 38 | 14 | 14 | 10 | 2 | 3 | 16 | 3 |
46 | 39 | 15 | 15 | 10 | 5 | 3 | 10 | 3 |
47 | 39 | 2 | 20 | 20 | 10 | 2 | 5 | 2 |
48 | 39 | 20 | 2 | 20 | 10 | 2 | 5 | 2 |
49 | 39 | 20 | 20 | 2 | 10 | 2 | 5 | 2 |
50 | 39 | 15 | 15 | 10 | 3 | 3 | 10 | 5 |
51 | 40 | 15 | 15 | 10 | 5 | 2 | 10 | 3 |
52 | 40 | 15 | 15 | 10 | 3 | 3 | 10 | 4 |
53 | 40 | 20 | 4 | 4 | 1 | 4 | 20 | 7 |
54 | 40 | 15 | 15 | 10 | 5 | 3 | 11 | 1 |
55 | 41 | 15 | 15 | 10 | 3 | 2 | 10 | 4 |
56 | 41 | 2 | 21 | 21 | 1 | 2 | 10 | 2 |
57 | 41 | 21 | 2 | 21 | 1 | 2 | 10 | 2 |
58 | 41 | 21 | 21 | 2 | 1 | 2 | 10 | 2 |
59 | 41 | 15 | 15 | 10 | 3 | 2 | 10 | 4 |
60 | 41 | 2 | 21 | 21 | 5 | 2 | 5 | 3 |
61 | 41 | 21 | 2 | 21 | 5 | 2 | 5 | 3 |
62 | 41 | 21 | 21 | 2 | 5 | 2 | 5 | 3 |
63 | 42 | 16 | 16 | 10 | 5 | 3 | 5 | 3 |
64 | 42 | 14 | 13 | 8 | 2 | 3 | 14 | 4 |
65 | 42 | 16 | 16 | 5 | 5 | 2 | 11 | 3 |
66 | 42 | 16 | 11 | 11 | 5 | 2 | 11 | 2 |
67 | 42 | 11 | 16 | 11 | 5 | 2 | 11 | 2 |
68 | 42 | 11 | 16 | 11 | 5 | 2 | 11 | 2 |
69 | 42 | 11 | 16 | 11 | 5 | 2 | 11 | 2 |
70 | 42 | 16 | 16 | 11 | 3 | 5 | 6 | 1 |
71 | 42 | 16 | 16 | 11 | 4 | 3 | 5 | 3 |
72 | 43 | 16 | 16 | 4 | 5 | 2 | 11 | 3 |
73 | 43 | 16 | 16 | 11 | 3 | 4 | 6 | 1 |
74 | 43 | 16 | 11 | 11 | 3 | 2 | 11 | 3 |
75 | 43 | 11 | 16 | 11 | 3 | 2 | 11 | 3 |
76 | 43 | 16 | 16 | 5 | 3 | 2 | 11 | 4 |
77 | 43 | 16 | 16 | 11 | 5 | 3 | 5 | 1 |
78 | 44 | 17 | 17 | 4 | 3 | 2 | 11 | 2 |
79 | 44 | 17 | 17 | 11 | 4 | 3 | 3 | 1 |
80 | 44 | 11 | 17 | 6 | 6 | 2 | 11 | 3 |
81 | 44 | 11 | 11 | 11 | 6 | 2 | 11 | 4 |
82 | 45 | 2 | 2 | 22 | 11 | 2 | 11 | 5 |
83 | 45 | 2 | 22 | 2 | 11 | 2 | 11 | 5 |
84 | 45 | 22 | 2 | 2 | 11 | 2 | 11 | 5 |
85 | 45 | 17 | 6 | 11 | 4 | 2 | 11 | 4 |
86 | 45 | 11 | 11 | 11 | 4 | 2 | 11 | 5 |
Embodiment 5
Radix Puerariae 480g, Radix Scutellariae 120g, Rhizoma Coptidis 120g, Radix Glycyrrhizae Preparata 90g, Rhizoma Zingiberis 40g
5 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 6
Radix Puerariae 480g, Radix Scutellariae 120g, Rhizoma Coptidis 120g, Radix Glycyrrhizae Preparata 90g, Rhizoma Zingiberis Recens 80g
5 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 7
Radix Puerariae 600g, Radix Scutellariae 200g, Rhizoma Coptidis 200g, Radix Glycyrrhizae Preparata 100g, Rhizoma Zingiberis 60g, Radix et Rhizoma Rhei (stir-fried with wine) 60g
6 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 8
Radix Puerariae 600g, Radix Scutellariae 300g, Rhizoma Coptidis 300g, Radix Glycyrrhizae Preparata 150g, Rhizoma Zingiberis Recens 50g, Radix et Rhizoma Rhei (stir-fried with wine) 60g
7 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 9
Radix Puerariae 600g, Radix Scutellariae 400g, Rhizoma Coptidis 400g, Radix Glycyrrhizae Preparata 100g, Rhizoma Zingiberis Recens 1500g, Radix et Rhizoma Rhei (stir-fried with wine) 60g, Radix Panacis Quinquefolii 90g, Monas cuspurpureus Went 90g
7 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Radix Puerariae 600g, Radix Scutellariae 300g, Rhizoma Coptidis 300g, Radix Glycyrrhizae Preparata 150g, Rhizoma Zingiberis 100g, Radix et Rhizoma Rhei (stir-fried with wine) 60g, Radix Panacis Quinquefolii 30g, Monas cuspurpureus Went 30g
9 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 11
Radix Puerariae 300g, Radix Scutellariae 600g, Rhizoma Coptidis 600g, Radix Glycyrrhizae Preparata 90g, Rhizoma Zingiberis Recens 200g, Radix et Rhizoma Rhei (stir-fried with wine) 90g, Rhizoma Anemarrhenae 60g, Monas cuspurpureus Went 90g
9 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Embodiment 12
Radix Puerariae 200g, Radix Scutellariae 300g, Rhizoma Coptidis 300g, Radix Glycyrrhizae Preparata 100g, Rhizoma Zingiberis 100g, Radix et Rhizoma Rhei (stir-fried with wine) 90g, Rhizoma Anemarrhenae 60g, Monas cuspurpureus Went 60g
9 flavor medical materials are ground into powder No. 7, are made as the watered pill.
Embodiment 13
Radix Puerariae 300g, Radix Scutellariae 120g, Rhizoma Coptidis 120g, Radix Glycyrrhizae Preparata 90g, Rhizoma Zingiberis 40g
5 flavor medical materials are crushed into powder, take after mixing it with water.
Embodiment 14
Radix Puerariae 300g, Radix Scutellariae 600g, Rhizoma Coptidis 600g, Radix Glycyrrhizae Preparata 90g, Rhizoma Zingiberis Recens 200g, Radix et Rhizoma Rhei (stir-fried with wine) 90g, Rhizoma Anemarrhenae 90g, Monas cuspurpureus Went 90g
9 flavor medical materials, it is heavy to add 10 times of medicines of water, soaks 60 minutes.Decocted 50 minutes, drainage screen filters (aperture is less than 0.5mm), gets filtrating, and the concentrating under reduced pressure medicinal liquid becomes cream.
Claims (13)
1. a Chinese medicine composition that is used for the diabetics glycemic control is characterized in that, contains: Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae Preparata and Rhizoma Zingiberis or Rhizoma Zingiberis Recens, and wherein, the weight ratio of each crude drug is:
Radix Puerariae 5-86 part, Radix Scutellariae 2-72 part, Rhizoma Coptidis 2-72 part, Radix Glycyrrhizae Preparata 2-44 part, Rhizoma Zingiberis 1-35 part.
Radix Puerariae 5-86 part, Radix Scutellariae 2-72 part, Rhizoma Coptidis 2-72 part, Radix Glycyrrhizae Preparata 2-44 part, Rhizoma Zingiberis Recens 1-35 part.
2. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 1 is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss.
3. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 1 is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens.
4. Chinese medicine composition that is used for the diabetics glycemic control; It is characterized in that; Contain: Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis or Rhizoma Zingiberis Recens; Also have Radix et Rhizoma Rhei (stir-fried with wine), wherein, the weight ratio of each crude drug is: Radix Puerariae 4-75 part, Radix Scutellariae 1-67 part, Rhizoma Coptidis 1-67 part, Radix Glycyrrhizae Preparata 2-67 part, Rhizoma Zingiberis or Rhizoma Zingiberis Recens 1-47 part, Radix et Rhizoma Rhei (stir-fried with wine) 1-17 part.
5. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 4 is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine).
6. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 4 is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine).
7. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 4 is characterized in that, in said Chinese medicine composition, also has Radix Panacis Quinquefolii 1-12 part, Monas cuspurpureus Went 1-18 part.
8. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 7; It is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 6 parts of Radix Panacis Quinquefoliis, 9 parts in Monas cuspurpureus Went.
9. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 7; It is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 6 parts of Radix Panacis Quinquefoliis, 9 parts in Monas cuspurpureus Went.
10. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 4 is characterized in that, in said Chinese medicine composition, also has Rhizoma Anemarrhenae 3-40 part, Monas cuspurpureus Went 1-12 part.
11. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 10; It is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 4.5 parts of Rhizoma Zingiberiss, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 30 parts of the Rhizoma Anemarrhenaes, 9 parts in Monas cuspurpureus Went.
12. a kind of Chinese medicine composition that is used for the diabetics glycemic control according to claim 10; It is characterized in that the preferred weight ratio of each crude drug is: 72 parts of Radix Puerariaes, 27 parts of Radix Scutellariaes, 27 parts of Rhizoma Coptidis, 18 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 6 parts of Radix et Rhizoma Rhei (stir-fried with wine), 30 parts of the Rhizoma Anemarrhenaes, 9 parts in Monas cuspurpureus Went.
13. according to the described pharmaceutical composition of claim 1 to 12, it is characterized in that: the dosage form of said medicine is decoction, granule, powder or pill.
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105497051A (en) * | 2015-12-09 | 2016-04-20 | 陕西中医药大学 | Pharmaceutical formula capable of lowering blood glucose and experiment method of pharmaceutical formula |
CN107095092A (en) * | 2017-05-11 | 2017-08-29 | 王长山 | A kind of wintercherry fruit or calyx health drink and preparation method thereof |
CN107115515A (en) * | 2017-05-15 | 2017-09-01 | 张苏锋 | A kind of Hyperglycemic health care Chinese medicine composition and preparation method thereof |
CN107184923A (en) * | 2017-01-13 | 2017-09-22 | 李欣 | The Chinese medicinal liquor of Long Drinks hypoglycemic |
CN111759999A (en) * | 2020-07-01 | 2020-10-13 | 李赛美 | Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and/or treating diabetes |
CN112741872A (en) * | 2019-10-29 | 2021-05-04 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition and preparation method and application thereof |
-
2010
- 2010-11-17 CN CN2010105474260A patent/CN102462834A/en active Pending
Non-Patent Citations (3)
Title |
---|
刘霞,等: "仝小林教授治疗糖尿病常用药对选析", 《第十次全国中医糖尿病大会论文集》 * |
叶晓峰,等: "葛根芩连加味汤对糖尿病大鼠视网膜病变的防治作用", 《中国中医眼科杂志》 * |
潘竞锵,等: "葛根芩连汤降血糖作用的实验研究", 《中国新药杂志》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105497051A (en) * | 2015-12-09 | 2016-04-20 | 陕西中医药大学 | Pharmaceutical formula capable of lowering blood glucose and experiment method of pharmaceutical formula |
CN105497051B (en) * | 2015-12-09 | 2018-07-17 | 陕西中医药大学 | A kind of hypoglycemic pharmaceutical formulation and its experimental method |
CN107184923A (en) * | 2017-01-13 | 2017-09-22 | 李欣 | The Chinese medicinal liquor of Long Drinks hypoglycemic |
CN107095092A (en) * | 2017-05-11 | 2017-08-29 | 王长山 | A kind of wintercherry fruit or calyx health drink and preparation method thereof |
CN107115515A (en) * | 2017-05-15 | 2017-09-01 | 张苏锋 | A kind of Hyperglycemic health care Chinese medicine composition and preparation method thereof |
CN112741872A (en) * | 2019-10-29 | 2021-05-04 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition and preparation method and application thereof |
CN112741872B (en) * | 2019-10-29 | 2022-04-26 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition and preparation method and application thereof |
CN111759999A (en) * | 2020-07-01 | 2020-10-13 | 李赛美 | Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and/or treating diabetes |
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Application publication date: 20120523 |