CN103720931B - A kind of Chinese medicine composition for the treatment of damp-heat accumulation type fatty liver - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of damp-heat accumulation type fatty liver. The interpretation of the cause, onset and process of an illness of fatty liver can be summarized as liver dysfunction, and the liver blood stasis of blood is stagnant; The dysfunction of the spleen in transport, damp evil is not changed, the turbid interior life of phlegm; Kidney qi mistakeization, the phlegm stasis of blood is detained etc. Damp-heat accumulation type fatty liver is because of damp-heat accumulation, and liver is lost bar and reaches due to catharsis dereliction of duty. For this reason, the present invention selects to have clearing heat and promoting diuresis, expectorant powder junction, Chinese medicine indian nightshade root, common butterbush root, Flabelate Maiden-hair Herb, white backleaf mallotus root, simon plum root or leaf, laxflower pottsia root, autumn cudweed herb, indian melothria root, little Jin cherry, Ophiorrhiza japonica, whiteflower cacalia seed, humid euphorbia promoting blood circulation and removing blood stasis, decocting becomes decoction, through my institute's clinical testing, total effective rate reaches 97.8%, obviously be better than 86.7% of control group, and in therapeutic process, treatment group patient do not have obvious adverse reaction.

Description

A kind of Chinese medicine composition for the treatment of damp-heat accumulation type fatty liver

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to one and treat damp-heat accumulation type fatThe Chinese medicine composition of fat liver.

Background technology

Fatty liver is a kind of comprehensive metabolic disease, is by intrahepatic fat oxidation reduction, fatFat acid is synthetic to be increased, and causes due to the interior fat accumulation of liver cell, is a kind of common disease, multipleSick. Because fatty liver is the disease that belongs to chronic process, if diagnose not in time and treat,Approximately there is 31% case can continue to develop into liver fibrosis and cirrhosis. Doctor trained in Western medicine is in treatment fatty liverAspect is that to remove the cause of disease and use lipid reducing and regulating medicine be main, but uses hypolipidemic to fatFat liver short term efficacy is not good, and long-term taking but has the potential problems that affect liver function, totally comesSay and still lack the desirable medicine for fatty liver treatment. By contrast, Chinese medicine is at treatment fatWhat liver aspect was brought into play is comprehensive therapeutic effect, and modern Chinese herbal medicine pharmacological research is found, plurality of Chinese instituteThe active component being rich in not only acts on lipometabolic different link, tune that more can many target spotsJoint physiological function, tends to balance body. In therapeutic process, use also body of drug for invigorating blood circulation and eliminating stasisReveal the thought that the traditional Chinese medical science " is preventiveed treatment of disease ", take precautions against state of an illness in-depth. And some Chinese medicine since ancient timesCan be used as exactly medicine, eat dual-purpose. Therefore treatment by Chinese herbs fatty liver is stable lasting with curative effect,Cheap without obvious toxic-side effects, medicine valency, the advantage such as can use for a long time.

Summary of the invention

The object of this invention is to provide a kind of Chinese traditional medicine composition for the treatment of damp-heat accumulation type fatty liverThing. It is liver addiction that the traditional Chinese medical science claims this sick, and the cause of disease of fatty liver, can think eating and drinking without temperance, has a liking forFood delicious food or on the scoop, interior duty in the dysfunction of the spleen in transport, liver dysfunction, damp and hotly accumulates long-pending spleenStomach, raw in phlegm turbid (wetting), qi depression to blood stasis, finally causes that the stagnation of the circulation of vital energy, phlegm are wet, hemostasis is tied mutually,Amass under the side of body, disease located in liver spleen, relevant with kidney. , hemostasis turbid, damp and hot with phlegm, stagnation of the circulation of vital energy etc.Pathological factor is relevant, wherein especially the most key with the phlegm stasis of blood. Visible, the generation of fatty liver is mainDuty dirty in liver spleen kidney three, its interpretation of the cause, onset and process of an illness can be summarized as liver dysfunction, and the liver blood stasis of blood is stagnant; Spleen loses strongFortune, damp evil is not changed, the turbid interior life of phlegm; Kidney qi mistakeization, the phlegm stasis of blood is detained etc. Therefore Chinese traditional treatmentThis disease should be distinguished the cause of disease, diagnosis and treatment based on an overall analysis of the illness and the patient's condition. Damp-heat accumulation type fatty liver is because of damp-heat accumulation,Liver is lost bar and reaches due to catharsis dereliction of duty, and principle of reatment is clearing heat and promoting diuresis, expectorant powder junction, invigorating blood circulationThe stasis of blood.

The object of the invention is to be achieved through the following technical solutions this treatment damp-heat accumulation typeThe Chinese medicine composition of fatty liver is made up of the Chinese medicine of following weight portion: indian nightshade root 6-15 part, windCase tree root 30-60 part, Flabelate Maiden-hair Herb 20-25 part, white backleaf mallotus root 18-24 part, simon plum root or leaf 25-35Part, laxflower pottsia root 15-25 part, autumn cudweed herb 15-25 part, indian melothria root 25-45 part, littleGold cherry 20-40 part, Ophiorrhiza japonica 15-25 part, whiteflower cacalia seed 6-9 part, humid euphorbia 10-15 part.

Preferred: 10 parts of indian nightshade roots, 45 parts of common butterbush roots, 23 parts of Flabelate Maiden-hair Herbs, Whitebackleaf Mallotus Root21 parts of roots, 30 parts of simon plum root or leafs, 20 parts of laxflower pottsia roots, 20 parts of autumn cudweed herbs, indian melothria root35 parts, 30 parts, little Jin cherry, 20 parts of Ophiorrhiza japonicas, 7 parts of whiteflower cacalia seeds, 13 parts of humid euphorbias.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: indian nightshade root, common butterbush root, Flabelate Maiden-hair Herb removing damp-heat, eliminating stasis to resolve swelling; The white back of the bodyBlade root clearing heat and promoting diuresis, the solid de-stasis of blood that disappears; The simon plum root or leaf promoting flow of qi and blood circulation; The active promoting circulation of blood of laxflower pottsia root,Wind is removed in dehumidifying; Autumn cudweed herb dispels the wind, and ventilatings the lung and resolving phlegm; Indian melothria root clearing heat and eliminating phlegm, dampness removing is looseKnot detumescence; The removing toxic substances of little Jin cherry eliminating stasis to subdue swelling; Ophiorrhiza japonica promoting blood circulation to remove blood stasis; Whiteflower cacalia seed blood stasis removing analgesic,Clearing heat and expelling damp; Humid euphorbia promoting blood circulation and stopping pain is dispeled the wind.

Clinical data

1. physical data is chosen Patients with Fatty Liver totally 90 examples of my Out-patient Department treatment, with 2002The diagnostic criteria that hepatology branch of year Chinese Medical Association fatty liver disease group is worked out is facedBed diagnosis, adopts ultrasound diagnosis method to carry out clinical scale, is divided at random two groups: treatment group45 examples, male 30 examples, female's 15 examples, the age: 20～65 years old, average 38 years old; Fatty liverClinical scale: slight 15 examples, moderate 17 examples, severe 13 examples, low alcohol consumption history person 6 examples.Control group 45 examples, male 31 examples, female's 14 examples, the age: 22～63 years old, average 37 years old;Fatty liver clinical scale: slight 14 examples, moderate 18 examples, severe 13 examples, low alcohol consumption historyPerson's 5 examples. Poor without conspicuousness at aspects such as sex, age and clinical manifestations before 2 groups of patient treatmentsDifferent (P > 0.05), there is comparativity.

2. diagnostic criteria (1) is without history of drinking history or drink and amount to the amount of alcohol male sex 140 grams weekly,70 grams of women; (2) get rid of virus hepatitis, DILD, total parenteral nutrition, liverLenticular degenerations etc. can cause the specified disease of fatty liver. (3) except primary disease clinical manifestationThere are nonspecific symptom and the bodies such as weak, indigestion, dull pain in liver, hepatosplenomegaly outward,Levy. (4) can have that overweight/Abdominal obesity, fasting blood-glucose increase, blood fat disorder, hypertensionDeng metabolic syndrome. (5) serum transaminase and glutamyl transpeptidase level can be by mild to moderateIncrease (being less than 5 times of Upper Limit of Normal Values), conventionally (pass by popular with ALTClaim " GPT ") raise be main. (6) tcm diagnosis standard: right flank shouting pain, swollen under right flankPiece, what push away does not move, local tenderness, fat abdominal distension, tongue purple or spottiness, stringy and hesitant pulse.

3. the oral Silybin capsule that fatty liver is had to clear and definite curative effect of methods for the treatment of control group(main component is legalon, 0.35g/ grain, the production of Tianjin Tian Shili company, the accurate word of traditional Chinese medicinesH20040299), 4 tablets/time, 3 times/d, oral. Treatment group take of the present invention inMedicine preparation, take indian nightshade root 10g, common butterbush root 45g, Flabelate Maiden-hair Herb 23g, white backleaf mallotus root 21g,Simon plum root or leaf 30g, laxflower pottsia root 20g, autumn cudweed herb 20g, indian melothria root 35g, little Jin cherry 30g,Ophiorrhiza japonica 20g, whiteflower cacalia seed 7g, humid euphorbia 13g. Decocting becomes decoction, every order potion, point morning and eveningTake for 2 times, be 3 months two groups of courses for the treatment of. During two groups of treatments, formulate individuation diet meterDraw and suitable exercise scheme, control body weight, do not apply the medicines such as other protect the liver, lipopenicillinase.

4. criterion of therapeutical effect clinical cure: symptom, sign disappear, and liver function recovery is normal,B ultrasonic shows that fatty liver acoustic image is normal, and TC, TG recover normal level; Effective: symptom,Sign disappears, and liver function recovery is normal, and B ultrasonic shows that fatty liver acoustic image recovers normally substantially,TC, TG treat front decline > 50%; Effective: symptom, sign obviously alleviate, B ultrasonic showsFatty liver acoustic image makes moderate progress before treating but is not obvious; ALT declines more than 50%, TGDecline more than 20%, TC declines more than 10%; Invalid: after medication symptom, sign without improvement,Before and after treatment, B ultrasonic is unchanged, or has symptom, sign to increase the weight of, and ALT, TC, TG decline respectively< 50%, < 20% and < 10%.

5. result for the treatment of treatment was carried out effect assessment after 3 months, and treatment group is cured 25 examples(55.6%), effective 13 examples (28.9%), effective 6 examples (13.3%), invalid 1 example (2.2%),Total effective rate 97.8%. Control group is cured 9 examples (20%), and effective 13 examples (28.9%), haveImitate 17 examples (37.8%), invalid 6 examples (13.3%), total effective rate 86.7%. Two groups of comparisons,Treatment group cure rate, total effective rate are obviously better than control group, have comparativity (P < 0.05).In therapeutic process, treatment group patient does not have obvious adverse reaction, and control group has 6 examples (13.3%)There is slight gastrointestinal symptom (feel sick, hiccup) and uncomfortable in chest etc. in patient.

Detailed description of the invention

Embodiment mono-: take indian nightshade root 10g, common butterbush root 45g, Flabelate Maiden-hair Herb 23g, carry on the back in vainBlade root 21g, simon plum root or leaf 30g, laxflower pottsia root 20g, autumn cudweed herb 20g, indian melothria root 35g,Little Jin cherry 30g, Ophiorrhiza japonica 20g, whiteflower cacalia seed 7g, humid euphorbia 13g, above-mentioned Chinese medicine decocting becomes soupAgent.

Embodiment bis-: take indian nightshade root 15g, common butterbush root 30g, Flabelate Maiden-hair Herb 25g, carry on the back in vainBlade root 18g, simon plum root or leaf 25g, laxflower pottsia root 15g, autumn cudweed herb 25g, indian melothria root 25g,Little Jin cherry 40g, Ophiorrhiza japonica 15g, whiteflower cacalia seed 9g, humid euphorbia 10g, become above-mentioned Chinese medicine decoctingDecoction.

Embodiment tri-: take indian nightshade root 6g, common butterbush root 60g, Flabelate Maiden-hair Herb 20g, Whitebackleaf Mallotus RootRoot 24g, simon plum root or leaf 35g, laxflower pottsia root 25g, autumn cudweed herb 15g, indian melothria root 45g, littleGold cherry 20g, Ophiorrhiza japonica 25g, whiteflower cacalia seed 6g, humid euphorbia 15g, become soup by above-mentioned Chinese medicine decoctingAgent.

Claims (2)

1. a Chinese medicine composition for the treatment of damp-heat accumulation type fatty liver, is characterized in that in thisDrug composition is made up of the Chinese medicine of following weight portion: indian nightshade root 6-15 part, common butterbush root 30-60Part, Flabelate Maiden-hair Herb 20-25 part, white backleaf mallotus root 18-24 part, simon plum root or leaf 25-35 part, flower turnRattan root 15-25 part, autumn cudweed herb 15-25 part, indian melothria root 25-45 part, little Jin cherry 20-40Part, Ophiorrhiza japonica 15-25 part, whiteflower cacalia seed 6-9 part, humid euphorbia 10-15 part.

2. a kind of Chinese drug-treated group for the treatment of damp-heat accumulation type fatty liver according to claim 1Compound, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: indian nightshade root10 parts, 45 parts of common butterbush roots, 23 parts of Flabelate Maiden-hair Herbs, 21 parts of white backleaf mallotus roots, simon plum root or leaf 30Part, 20 parts of laxflower pottsia roots, 20 parts of autumn cudweed herbs, 35 parts of indian melothria roots, 30 parts, little Jin cherry,20 parts of Ophiorrhiza japonicas, 7 parts of whiteflower cacalia seeds, 13 parts of humid euphorbias.