CN1742939A - Medicine for treating pulmonary fibrosis and preparing method - Google Patents
Medicine for treating pulmonary fibrosis and preparing method Download PDFInfo
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- CN1742939A CN1742939A CN 200510044831 CN200510044831A CN1742939A CN 1742939 A CN1742939 A CN 1742939A CN 200510044831 CN200510044831 CN 200510044831 CN 200510044831 A CN200510044831 A CN 200510044831A CN 1742939 A CN1742939 A CN 1742939A
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Abstract
The present invention provides a Chinese medicine oral preparation for effectively curing pulmonary interstitial fibrosis and its preparation method. It is made up by using 8 Chinese medicinal materials of scutellaria root, lonicera flower, salvia root, astragalus root, Chinese angelica root and others. Said invention also provides the concrete steps of said preparation method.
Description
Technical field:
The present invention relates to medicine, especially a kind of is that raw material is treated the various interstitial pulmonary fibrosis medicine of (having another name called interstitial pneumonia) with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology:
Interstitial lung disease (ILD) has become the focus of world lung section research after proposing this disease name in the seminar of the U.S. in 1975 the 18 Aspen lung section, he is the not bright chronic interstitial lung disease (ILD) of a kind of cause of disease.The histology turns to feature with alveolitis and interstitial fibers, IPF invades alveolar wall, alveolar space, and then can develop into diffuse interstitial pulmonary fibrosis, clinical manifestation is a dyspnea, finally develop into respiratory failure and death, its definite sickness rate it be unclear that, sickness rate based on IPF, the rapid raising of disability rate and mortality rate, the current Therapeutic Method that does not have satisfaction again, its 5 years survival rates are lower than 50%, and prognosis can be comparable with cancer, thereby cause people's very big concern, particularly SRAS in 2003 popular after, pulmonary fibrosis has brought great misery after giving most of SRAS patient's rehabilitations.But unfortunately, up to the present, do not find a kind of Therapeutic Method and medicine yet,, promote the well-being of mankind so be badly in need of a kind of clinical effective medicine of development at this difficulty critical patient.
Goal of the invention:
One of purpose of the present invention provides and a kind ofly can play better treatment and medicine without any side effects to interstitial pulmonary fibrosis; Two of purpose provides a kind of preparation method of these oral drugs that one of achieve the goal.
One of purpose of the present invention can realize by following technical measures:
The medicine of this treatment interstitial pulmonary fibrosis is the medicament of being made by the herbal raw material of following weight parts proportioning:
Radix Scutellariae 3-15 Flos Lonicerae 6-30 Radix Salviae Miltiorrhizae 6-20 Radix Astragali 6-20
Radix Angelicae Sinensis 6-20 Rhizoma Chuanxiong 6-20 Bulbus Fritillariae Cirrhosae 3-10 Radix Glycyrrhizae 3-10.
The Radix Astragali (RADIX ASTRAGALI) nature and flavor are sweet, warm.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst.
Radix Salviae Miltiorrhizae (RADIX SALVIAE MILTIORRHIZAE) nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.
Radix Angelicae Sinensis (RADIX ANGELICAE SINENSIS) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Tool is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation." detailed outline " said: " control headache, all pains of trusted subordinate, intestine moistening stomach muscles and bones skin.Control carbuncle, evacuation of pus pain relieving and blood are enriched blood ".
Rhizoma Chuanxiong (RHIZOMA CHUANXIONG) nature and flavor suffering, temperature.Return liver, gallbladder, pericardium channel.Kind blood-activating and qi-promoting, wind-expelling pain-stopping." Japan hanako materia medica " carries: and " control a wind cutting, all gas, all strains, all blood are mended five kinds of over strain, and strengthening bone and muscle is transferred many arteries and veins, broken crux stagnated blood ... ".
Flos Lonicerae (FLOS LONICERAE) nature and flavor are sweet, and are cold.Return lung, the heart, stomach warp.Kind heat-clearing and toxic substances removing, wind-heat dissipating.Be used for the carbuncle furuncle, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " all skin ulcers are separated in heat clearing away, carbuncle carbuncle on the back, red stream scrofula.”
Radix Scutellariae (RADIX SCUTELLARIAE) nature and flavor hardship, cold, return lung, gallbladder, Pi, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is spitted blood ugly, frequent fetal movement, carbuncle sore tumefacting virus.
Bulbus Fritillariae Cirrhosae (BULBUS FRITILLARIAE CIRRHOSAE) nature and flavor hardship, sweet, be slightly cold.Return lung, heart channel.Kind clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Radix Glycyrrhizae (RADIX GLYCYRRHIZAE) nature and flavor are sweet, and are flat.GUIXIN, lung, spleen, stomach warp.The tool invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used for shortness of breath and palpitation, cough with copious phlegm, epigastric pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
The Radix Astragali is a monarch drug, and property is sweet, warm, is used for the gas of tonification lung spleen.Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong are ministerial drug, and property suffering, temperature are used for blood circulation promoting and blood stasis dispelling, circulation of qi promoting.Bulbus Fritillariae Cirrhosae is an adjuvant drug, and property is sweet, cold, is used for nourishing the lung to arrest cough and reduces phlegm.Radix Glycyrrhizae is a messenger drug, and property is sweet, cough-relieving, coordinating the actions of various ingredients in a prescription.
Said medicament is a said oral agents on any pharmaceutics; Said oral agents is liquid agent, powder, tablet, capsule, granule, pill, drop pill.
Two of purpose of the present invention can realize by following technical measures:
The preparation method of medicine of the present invention is the ormal weight according to each component in one of above-mentioned purpose,
A, get the conventional volatile oil that extracts of Radix Angelicae Sinensis, Rhizoma Chuanxiong, collect distillate and distilled water, standby;
B, with the medicinal residues of a operation and Radix Scutellariae, Flos Lonicerae, Radix Salviae Miltiorrhizae, the Radix Astragali, Bulbus Fritillariae Cirrhosae, the conventional extracting in water of Radix Glycyrrhizae, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, concentrating the back, to add ethanol be 40～80% (weight) to containing amount of alcohol, left standstill 8～48 hours, filter and recovery ethanol, add the distillate of a operation again, in 0～10 ℃ of following cold preservation 8～36 hours, filter filtrate for later use;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2～6 times of amount dissolve with ethanols, be processed into oral agents then, encapsulation.
Extraction in the preparation method of medicine of the present invention comprises extracting method all in the pharmaceutical book, as backflow, extraction, percolation etc.
Active component of the present invention can add different auxiliary material according to the different dosage form of preparation, binding agent if necessary, disintegrating agent, lubricant, dispersant etc. are prepared into any peroral dosage form commonly used by the Chinese medicine preparation common method, as liquid agent, tablet, capsule, granule, pill, powder etc., also can utilize modern formulation method, add gelatin or other excipient and make soft capsule, drop pill or other modern peroral dosage form.
One, Pharmacodynamic test of active extract result
The animal experiment that causes the change of rat interstitial lung sexually transmitted disease (STD) through bleomycin proves that medicine pharmacological action of the present invention is as follows:
1, light microscopic histopathologic slide is observed, the heavy dose of group of medicine of the present invention (15g/Kg), small dose group (5g/Kg) have obvious therapeutic action to the alveolar septum broadening due to rat interstitial lung inflammatory cell quantity and the inflammatory cell infiltration, and it acts on significantly better than model group.And prolongation in time (28 days controlled observations than 14 days), the infiltration of inflammatory cell and alveole are every the improvement degree more obvious (P＜0.01) of broadening.
2, Electronic Speculum pathology section examination: euchromatin, heterochromatin distribute normal substantially in the interstitial lung nucleus of the large and small dosage group treatment of medicine of the present invention back, most mitochondrions are more complete, capillary endothelial cell matter is evenly distributed, thickness is unanimous on the whole, and II type i alveolar cell epithelial cell is normal substantially.These change significantly better than model group.
3, Electronic Speculum and Electronic Speculum pathology are cut (sheet) observation: the large and small dosage group of medicine of the present invention interstitial tissue of lung fibrosis is light, arrangement of collagen fibers unanimity in the matter, and quantity is few, significantly better than model group.
4, the hydroxyproline in the lung tissue homogenate, lipid peroxide contents is starkly lower than model group, and SOD content is apparently higher than model group in the serum.
5, arterial blood gas analysis: the large and small dosage group of medicine of the present invention blood gas analysis PaO
2, apparently higher than model group, PaO
2, be starkly lower than model group.
6, cough-relieving, reduce phlegm, antiasthmatic effect: medicine of the present invention all has certain inhibitory action to physical stimulation and chemical stimulation are cough caused.Medicine of the present invention can the diastole tracheal smooth muscle, and the tracheal smooth muscle due to anti-acetylcholine and the histamine is shunk, and the guinea pig bronchial spasm that histamine is caused all has mitigation (P＞0.05).The logical oral liquid of lung can also increase the excretory function of respiratory mucus.
7, medicine of the present invention can obviously improve the phagocytic function of mouse monokaryon macrophage, and serum hemolysin is increased; Obviously promote the breeder reaction of mouse spleen lymphocyte.
Two, toxicological study:
The animal acute toxicity test result of medicine of the present invention shows, Kunming mouse gastric infusion 0.8ml/20g (3.0g/ml, by crude drug), 120g/Kg is equivalent to 168 times of clinical adult's consumption 0.712g/Kg, and mice activity after the administration, feed are not well seen the overt toxicity reaction, one week back execution mice, core, liver, spleen, lung, kidney main organs, perusal shows no obvious abnormalities reaction, illustrates that it is safe that medicine of the present invention is used for clinical.The long-term toxicity test for animals result of medicine of the present invention shows: the medication treated animal divides two groups, heavy dose of group 40g/Kg, small dose group 20g/Kg (be equivalent to respectively clinical adult's consumption 56,28), during administration generally in order, fur is glossy, defecation does not have obvious change, before each treated animal body weight and the administration increase is arranged more all.Two dosage groups are not seen the overt toxicity reaction at successive administration after 90 days, hematological examination and blood biochemical detect every index and the relatively more equal no significant difference (P＞0.05) of matched group.Histopathologic examination shows: two dosage groups and matched group relatively show no obvious abnormalities change.Medicine of the present invention can not cause the function and the organic change of body main organs in this test dose scope the rat long-term prescription.Infer that according to this experimental result it is safe that this medicine is used for clinical.
Three, clinical trial:
Medicine of the present invention carries out clinical trial in Hospital Attached to Shandong Chinese Medical Univ., accepts interstitial lung disease patient 30 examples altogether for medical treatment, age 32-79 year, male's 22 examples wherein, women's 8 examples.The adult takes oral liquid of the present invention, each 20-40 milliliter, every day 3 times; Take other oral agents of the present invention, each 15 grams, every day 3 times, taking 15 days continuously is a course of treatment.18 examples took for 4 courses of treatment, and 12 examples took for 2 courses of treatment, produce effects 9 examples, effective 17 examples, invalid 4 examples.Total effective rate 87%, obvious effective rate 30%.To clinical symptoms, sign, pulmonary function, blood gas analysis, the first quarter moon of taking medicine promptly has the improvement effect especially, long-term pill taker's lung sheet, and the CT sheet shows that the interstitial lung inflammation weakens, and part patient's fibrosis also has improvement in various degree, and the prompting said preparation has definite clinical efficacy.The improvement of X ray examination needs treatment cycle slightly long.
The specific embodiment:
Embodiment 1:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 6 weight portions, 20 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 3 weight portions, 30 weight portions, 6 weight portions, 20 weight portions, 3 weight portions, 10 weight portions three times, 1 hour for the first time, 2 hours for the second time, 0.5 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.10 (60 ℃ time) back, to add ethanol be 40% (weight) to containing amount of alcohol, left standstill 48 hours, filter and reclaim ethanol, the distillate that adds a operation again in 0 ℃ of following cold preservation 36 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 1% (weight) to containing the benzoic acid amount, transfer PH=7.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 2:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 20 weight portions, 6 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 15 weight portions, 6 weight portions, 20 weight portions, 6 weight portions, 10 weight portions, 3 weight portions three times, 3 hours for the first time, 0.5 hour for the second time, 1 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.20 (60 ℃ time) back, to add ethanol be 80% (weight) to containing amount of alcohol, left standstill 8 hours, filter and reclaim ethanol, the distillate that adds a operation again in 10 ℃ of following cold preservations 8 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 6 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 3% (weight) to containing the benzoic acid amount, transfer PH=4.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 3:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 20 weight portions, 20 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 3 weight portions, 30 weight portions, 6 weight portions, 20 weight portions, 3 weight portions, 10 weight portions three times, 1 hour for the first time, 2 hours for the second time, 0.5 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.10 (60 ℃ time) back, to add ethanol be 40% (weight) to containing amount of alcohol, left standstill 48 hours, filter and reclaim ethanol, the distillate that adds a operation again in 0 ℃ of following cold preservation 36 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 1% (weight) to containing the benzoic acid amount, transfer PH=7.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 4:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 6 weight portions, 6 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 15 weight portions, 6 weight portions, 20 weight portions, 6 weight portions, 10 weight portions, 3 weight portions three times, 3 hours for the first time, 0.5 hour for the second time, 1 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.20 (60 ℃ time) back, to add ethanol be 80% (weight) to containing amount of alcohol, left standstill 8 hours, filter and reclaim ethanol, the distillate that adds a operation again in 10 ℃ of following cold preservations 8 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 6 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 3% (weight) to containing the benzoic acid amount, transfer PH=4.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 5:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 20 weight portions, 20 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 15 weight portions, 30 weight portions, 20 weight portions, 20 weight portions, 10 weight portions, 10 weight portions three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.20 (60 ℃ time) back, to add ethanol be 70% (weight) to containing amount of alcohol, left standstill 20 hours, filter and reclaim ethanol, the distillate that adds a operation again in 10 ℃ of following cold preservations 36 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 6 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 3% (weight) to containing the benzoic acid amount, transfer PH=7.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 6:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 6 weight portions, 6 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 3 weight portions, 6 weight portions, 6 weight portions, 6 weight portions, 3 weight portions, 3 weight portions three times, 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.10 (60 ℃ time) back, to add ethanol be 45% (weight) to containing amount of alcohol, quiet 30 hours, filter and reclaim ethanol, the distillate that adds a operation again in 0 ℃ of following cold preservation 8 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 1% (weight) to containing the benzoic acid amount, transfer PH=4.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 7:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 10 weight portions, 10 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 10 weight portions, 20 weight portions, 15 weight portions, 15 weight portions, 7 weight portions, 7 weight portions three times, 2 hours for the first time, 1.2 hours for the second time, 0.7 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.15 (60 ℃ time) back, to add ethanol be 65% (weight) to containing amount of alcohol, left standstill 24 hours, filter and reclaim ethanol, the distillate that adds a operation again in 5 ℃ of following cold preservations 24 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 4 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 2% (weight) to containing the benzoic acid amount, transfer PH=6.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 8:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 6 weight portions, 20 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 15 weight portions, 30 weight portions, 20 weight portions, 20 weight portions, 10 weight portions, 10 weight portions three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.20 (60 ℃ time) back, to add ethanol be 70% (weight) to containing amount of alcohol, left standstill 30 hours, filter and reclaim ethanol, the distillate that adds a operation again in 10 ℃ of following cold preservations 36 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 6 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 3% (weight) to containing the benzoic acid amount, transfer PH=7.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Embodiment 9:
The conventional volatile oil that extracts of the Rhizoma Chuanxiong of a, the Radix Angelicae Sinensis of getting 20 weight portions, 6 weight portions is collected distillate, and the distilled water after distillation device is in addition collected, and is standby;
B, with the conventional extracting in water of Radix Glycyrrhizae of the Bulbus Fritillariae Cirrhosae of the Radix Astragali of the Radix Salviae Miltiorrhizae of the Flos Lonicerae of the Radix Scutellariae of the medicinal residues of a operation and 3 weight portions, 6 weight portions, 6 weight portions, 6 weight portions, 3 weight portions, 3 weight portions three times, 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the third time, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, being evaporated to relative density d=1.10 (60 ℃ time) back, to add ethanol be 45% (weight) to containing amount of alcohol, left standstill 20 hours, filter and reclaim ethanol, the distillate that adds a operation again in 0 ℃ of following cold preservation 8 hours, filters, the syrup that filtrate and sucrose are made merges, and is standby;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2 times of amount dissolve with ethanols, and then to add benzoic acid in filtrate be 3% (weight) to containing the benzoic acid amount, transfer PH=4.0 at last, filter, add water, fill, sterilization, liquid agent; Perhaps, make fine powder with this filtrate concentrate drying after reclaiming ethanol.According to conventional method, make powder when directly packing; Gelatine capsule is made hard capsule when packing into; When making granule with marumerization or two step granulations; Further be pressed into tablet; The tablet of making can sugar coating or film-coat; Be pressed into soft capsule when adding gelatin or arabic gum glycerol etc.; Melt mixing altogether when adding proper auxiliary materials, drip and make drop pill; When making watered pill with water pill.Perhaps filtrate is concentrated into the thick paste shape after reclaiming ethanol, adds the soluble starch dextrin at last, conventional method is made the relevant oral solid formulation of describing in the pharmaceuticss such as powder, tablet, capsule, granule, pill, drop pill.
Claims (4)
1, a kind of medicine for the treatment of interstitial pulmonary fibrosis is characterized in that it is the medicament of being made by the herbal raw material of following weight parts proportioning:
Radix Scutellariae 3-15 Flos Lonicerae 6-30 Radix Salviae Miltiorrhizae 6-20 Radix Astragali 6-20
Radix Angelicae Sinensis 6-20 Rhizoma Chuanxiong 6-20 Bulbus Fritillariae Cirrhosae 3-10 Radix Glycyrrhizae 3-10.
2, a kind of medicine for the treatment of interstitial pulmonary fibrosis according to claim 1 is characterized in that said medicament is a said oral agents on any pharmaceutics.
3, a kind of medicine for the treatment of interstitial pulmonary fibrosis according to claim 2 is characterized in that said oral agents is liquid agent, powder, tablet, capsule, granule, pill, drop pill.
4, a kind of preparation method for the treatment of the medicine of interstitial pulmonary fibrosis is characterized in that: according to the ormal weight of each component in the claim 1,
A, get the conventional volatile oil that extracts of Radix Angelicae Sinensis, Rhizoma Chuanxiong, collect distillate and distilled water, standby;
B, with the medicinal residues of a operation and Radix Scutellariae, Flos Lonicerae, Radix Salviae Miltiorrhizae, the Radix Astragali, Bulbus Fritillariae Cirrhosae, the conventional extracting in water of Radix Glycyrrhizae, extracting solution merges, and is standby;
C, the distilled water of the extracting solution of b operation and a operation is merged, concentrating the back, to add ethanol be 40～80% (weight) to containing amount of alcohol, left standstill 8～48 hours, filter and recovery ethanol, add the distillate of a operation again, in 0～10 ℃ of following cold preservation 8～36 hours, filter filtrate for later use;
D, the volatile oil of a operation is added in the filtrate of C operation after with 2～6 times of amount dissolve with ethanols, be processed into oral agents then, encapsulation.
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