CN104337989A - Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout - Google Patents
Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout, which belongs to the technical field of medicines. The traditional Chinese medicine composition for treating gout is prepared from the following medicinal raw materials in parts by weight: 3 to 15 parts of scorpio, 3 to 15 parts of pangolin, 2 to 9 parts of centipeda minima, 1 to 5 parts of frankincense, 3 to 15 parts of tulipa edulis, 2 to 9 parts of buckwheat root and 1 to 6 parts of liquorice. According to the traditional Chinese medicine composition for treating gout, after the seven medicinal raw materials are proportionally combined, the traditional Chinese medicine composition for treating gout has a synergy function and has an obvious curative effect on treating gout, and obvious side effects and untoward effects are not found.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition containing the treatment gout of Herba Centipedae and Olibanum, belong to medical art.
Background technology
Gout is also known as hyperuricemia, and sickness rate is high, healing is difficult, recurrent exerbation, belongs to the metabolic disease that disorders of purine metabolism causes.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, the gouty acute arthritis recurrent exerbation that its clinical characters is hyperuricemia and causes thus, tophaceous deposition, tophaceous chronic arthritis and joint deformity etc., dumb for main clinical manifestation with redness and swelling of joints, burning pain, recurrent exerbation, joint motion.Often involving kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.Increase reason according to uric acid in blood and can be divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is caused by congenital purine metabolic disturbance, belongs to heritability.The cause of disease of secondary gout, can be caused by many reasons such as nephropathy, leukemia, medicine, foods, be apt to occur in male and menopausal woman.
The Western medicine being used for the treatment of gout at present mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only stablize the state of an illness mostly, gout can not be effected a radical cure; Serious side effect also can be caused to cause the infringement of hepatic and renal function; Even if Emergent therapy effectively can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.
In Chinese medicine, gout belongs to " arthromyodynia " category, " treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu say arthromyodynia ".Increasing expert thinks, from the organic conception of the traditional Chinese medical science, treats with Chinese medicine integral syndrome differentiation, the good footpath of another bar for the treatment of gout of can yet be regarded as; Not only the toxic and side effects of Chinese medicine itself is little, and can reduce Western medicine dose, overcomes the huge toxic and side effects taken merely Western medicine for a long time and bring.
Summary of the invention
To the object of the invention is to overcome in prior art existing Western medicine side effect large, treat halfway above-mentioned deficiency, a kind of Chinese medicine composition containing the treatment gout of Herba Centipedae and Olibanum is provided, this traditional Chinese medicine composition for treating gout good effect, instant effect, and little to patient body side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Contain a Chinese medicine composition for the treatment gout of Herba Centipedae and Olibanum, it is prepared from by the medicinal raw material of following weight proportion: Scorpio 3 ~ 15 parts, Squama Manis 3 ~ 15 parts, Herba Centipedae 2 ~ 9 parts, Olibanum 1 ~ 5 part, Tulipa edulis 3 ~ 15 parts, Semen Fagopyri Esculenti root 2 ~ 9 parts, 1 ~ 6 part, Radix Glycyrrhizae.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Scorpio is 6 ~ 12 parts.Preferred, part by weight shared by Scorpio is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Squama Manis is 6 ~ 12 parts.Preferred, part by weight shared by Squama Manis is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herba Centipedae is 4 ~ 8 parts.Preferred, part by weight shared by Herba Centipedae is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Olibanum is 2 ~ 4 parts.Preferred, part by weight shared by Olibanum is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Tulipa edulis is 6 ~ 12 parts.Preferred, part by weight shared by Tulipa edulis is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Semen Fagopyri Esculenti root is 4 ~ 8 parts.Preferred, part by weight shared by Semen Fagopyri Esculenti root is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.Preferred, part by weight shared by Radix Glycyrrhizae is 3 parts.
The Chinese medicine composition for the treatment of gout of the present invention, the active component of medicinal raw material can be extracted according to extracting method conventional on Chinese materia medica, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
The extracting method of Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of medicinal raw material of the present invention.
(2) in above-mentioned extract, add pharmaceutic adjuvant and be mixed and made into acceptable various pharmaceutical dosage form on pharmaceutics.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of gout, be inventor based on the pathogenetic understanding of motherland's medical science to gout, according to oneself clinical experience for many years, first from numerous Chinese medicine, determine the effective Chinese medicine of a series for the treatment of gouts, repeatedly verify through clinical again, screen.Wherein, Scorpio is the dry body of Buthidae animal Scorpio; Acrid in the mouth, property is put down; Poisonous; Return Liver Channel; There is effect of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; , the disease such as hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula askew for infantile convulsion, tic spasm, middle air port.Squama Manis, another name armadillo scale, first sheet are the scute of Manidae animal Squama Manis; Salty, be slightly cold; Return liver, stomach warp; There is stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, effect of expel wind to dredge collateral; For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, the diseases such as numbness contracture.Herba Centipedae, another name myriogyne minuta, stone recklessly beach wormwood, Fructus Piperis, three tooth halberds; For the dry herb of feverfew Herba Centipedae; Pungent, temperature; Return lung, Liver Channel; There is clearing the nasal passage, effect of cough-relieving; For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, the diseases such as nasal sinusitis watery nasal discharge.Olibanum, another name drips Olibanum, smoked Lu Xiang; For the oleo-gum-resin that the trunk skin zone wounds such as Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii ooze out; Acrid in the mouth, hardship, warm in nature; There is effect of promoting blood circulation and stopping pain; For all pains of trusted subordinate, the contracture of muscle arteries and veins, traumatic injury, the diseases such as sore, carbuncle and painful swelling, external can also detumescence and promoting granulation.Tulipa edulis, is used as medicine with its bulb, has another name called Bulbus Tulipae.Sweet in the mouth, cold in nature, poisonous; Main eliminating stagnation, blood stasis dispelling; For laryngopharynx swelling and pain, scrofula, carbuncle, skin ulcer swells, disease such as the stasis of blood in puerperal stagnant grade.Semen Fagopyri Esculenti root, has effect of heat-clearing and toxic substances removing, eliminating evil QI invigorating.Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; There is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious disease such as pain, carbuncle sore tumefacting virus of extremity contraction.Above-mentioned 7 taste Chinese herbal medicine, flavour of a drug are few but function is complete, 7 taste medicinal raw materials are by after described proportioning combination, treatment gout has Synergistic function, and through clinical research test, Chinese medicine composition of the present invention is used for the treatment of gout short treating period, instant effect, administration is after 4 days, can take effect, and evident in efficacy, there is not obvious adverse reaction during patient consumes.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, and all technology realized based on content of the present invention all belong to scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, and the percentage composition of ethanol, if no special instructions, is volumn concentration.
Embodiment 1
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Scorpio 9g, Squama Manis 9g, Herba Centipedae 6g, Olibanum 3g, Tulipa edulis 9g, Semen Fagopyri Esculenti root 6g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is concentrated into relative density 1.20 (80 DEG C), obtain the extract of embodiment 1 medicinal raw material.
(2) in above-mentioned extract, add the soluble starch of extract weight 2 times of weight, granulate, dry, be distributed into bag, obtain granule.
Embodiment 2
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Scorpio 15g, Squama Manis 3g, Herba Centipedae 2g, Olibanum 5g, Tulipa edulis 8g, Semen Fagopyri Esculenti root 7g, Radix Glycyrrhizae 5g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 2 treats gout.
Embodiment 3
The Chinese medicine composition of the treatment gout of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Scorpio 6g, Squama Manis 12g, Herba Centipedae 8g, Olibanum 2g, Tulipa edulis 7g, Semen Fagopyri Esculenti root 5g, Radix Glycyrrhizae 4g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 3 treats gout.
Comparative example
The Chinese medicine composition of the treatment gout of this comparative example is prepared from by the medicinal raw material of following weight proportion: Scorpio 9g, Squama Manis 9g, Olibanum 3g, Tulipa edulis 9g, Semen Fagopyri Esculenti root 6g, Radix Glycyrrhizae 3g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition of comparative example treatment gout.
Pharmacodynamics and toxicity test:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to the Chinese medicine composition of embodiment 1 prepared by embodiment 1;
According to the Chinese medicine composition of comparative example prepared by comparative example;
Colchicine: be Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get Kunming mouse 50, male and female are use all, and body weight 18 ~ 22g is divided into five groups at random, often organize 10, first group is normal saline group, and second group is drug study group of the present invention (8g raw medicinal herbs/kg), 3rd group is positive controls, and the 4th group is matched group 1, and the 5th group is model group.
Normal saline is gavaged by the dosage of 8g/kg to first group, second group gavages the Chinese medicine composition of the embodiment of the present invention 1 preparation by the dosage of 8g raw medicinal herbs/kg, 3rd group gavages colchicine by the drug dose of 0.1mg/kg, 4th group gavages Chinese medicine composition prepared by comparative example by the dosage of 8g raw medicinal herbs/kg, do not do any process for 5th group, every day 1 time, continuous 4 days.
After last administration 1h, except normal saline group, all the other each group, namely second group to the 5th group, animal Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, and normal saline group presses 1mg/kg injecting normal saline.0.5h after injection, plucks eyeball to each treated animal and gets blood, and the blood obtained after centrifugal 15min, is got serum and surveyed Level of Serum Uric Acid under the speed conditions of 3000r/min.Table 1 be each experimental group and matched group after treatment, the statistical result of blood uric acid measured value.
Table 1
Note: compare with model group:
*p<0.01; Compare with matched group 1:
▲ ▲p<0.01.
In table 1, it is 171 ± 33umol/l that drug study group of the present invention records Level of Serum Uric Acid: close with the Level of Serum Uric Acid 135 ± 27umol/l of normal saline group and the Level of Serum Uric Acid 154 ± 24umol/l of positive controls; Level of Serum Uric Acid 753 ± 112umol/l that relative model group records reduces about 580umol/l, and the statistical result of drug study group of the present invention is relative to model group P<0.01, has significant difference; The traditional Chinese medicine composition for treating gout that the present invention treats gout has good curative effect.
And in table 1, it is 246 ± 35umol/l that matched group 1 records Level of Serum Uric Acid, relative drug study group of the present invention records Level of Serum Uric Acid 171 ± 33umol/l and exceeds about 75umol/l.And the blood uric acid measured value of drug study group of the present invention is compared with the blood uric acid measured value P < 0.01 of matched group 1, has significant difference.Learn thus, 7 taste medicinal raw materials are by after described weight proportion combination, and have Synergistic function, can significantly improve the curative effect of Chinese medicine composition, lack any component, the curative effect of Chinese medicine composition all significantly declines.
In sum, the present invention treats the Chinese medicine composition of gout, and the short treating period for the treatment of gout, instant effect, administration can take effect for 4 days, evident in efficacy.Administration injected hypoxanthine after 4 days, and the blood uric acid measured value of drug study group of the present invention all can not occur significantly to raise phenomenon; 7 taste medicinal raw materials, by after described weight proportion combination, have Synergistic function, can significantly improve the curative effect of Chinese medicine composition.Lack any component, its curative effect all significantly declines, and as matched group 1, after injection hypoxanthine, the blood uric acid measured value recording the relative drug study group of the present invention of Level of Serum Uric Acid exceeds about 75umol/l.
Claims (10)
1. contain a Chinese medicine composition for the treatment gout of Herba Centipedae and Olibanum, it is characterized in that: it is prepared from by the medicinal raw material of following weight proportion: Scorpio 3 ~ 15 parts, Squama Manis 3 ~ 15 parts, Herba Centipedae 2 ~ 9 parts, Olibanum 1 ~ 5 part, Tulipa edulis 3 ~ 15 parts, Semen Fagopyri Esculenti root 2 ~ 9 parts, 1 ~ 6 part, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Scorpio is 6 ~ 12 parts.
3. the Chinese medicine composition for the treatment of gout according to claim 2, is characterized in that: part by weight shared by Scorpio is 9 parts.
4. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Squama Manis is 6 ~ 12 parts.
5. the Chinese medicine composition for the treatment of gout according to claim 4, is characterized in that: part by weight shared by Squama Manis is 9 parts.
6. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Herba Centipedae is 4 ~ 8 parts.
7. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Olibanum is 2 ~ 4 parts.
8. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Tulipa edulis is 6 ~ 12 parts.
9. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Semen Fagopyri Esculenti root is 4 ~ 8 parts.
10. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.
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| CN107875266A (en) * | 2017-11-28 | 2018-04-06 | 高大朋 | For treating the oral traditional Chinese medicine of gout and tophus |
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