CN104436017A - Traditional Chinese medicine composition containing caulis akebiae for treating gout - Google Patents
Traditional Chinese medicine composition containing caulis akebiae for treating gout Download PDFInfo
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- CN104436017A CN104436017A CN201410626057.2A CN201410626057A CN104436017A CN 104436017 A CN104436017 A CN 104436017A CN 201410626057 A CN201410626057 A CN 201410626057A CN 104436017 A CN104436017 A CN 104436017A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
The invention relates to a traditional Chinese medicine composition, particularly relates to a traditional Chinese medicine composition containing caulis akebiae for treating gout, and belongs to the technical field of medicines. The composition is a preparation prepared from the following medicinal raw materials in parts by weight: 5-20 parts of turmeric, 3-10 parts of caulis akebiae, 5-15 parts of ground beetle, 1-5 parts of scorpion and 0.02-0.15 part of borneol. The traditional Chinese medicine composition for treating gout is combined by five medicinal raw materials in a proportion, has the function of synergistic interaction and has a remarkable curative effect for treating gout. No remarkable side effect or adverse response is found.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment gout containing Caulis Akebiae, belong to medical art.
Background technology
Gout is also known as hyperuricemia, and sickness rate is high, healing is difficult, recurrent exerbation, belongs to the metabolic disease that disorders of purine metabolism causes.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, the gouty acute arthritis recurrent exerbation that its clinical characters is hyperuricemia and causes thus, tophaceous deposition, tophaceous chronic arthritis and joint deformity etc., dumb for main clinical manifestation with redness and swelling of joints, burning pain, recurrent exerbation, joint motion.Often involving kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.Increase reason according to uric acid in blood and can be divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is caused by congenital purine metabolic disturbance, belongs to heritability.The cause of disease of secondary gout, can be caused by many reasons such as nephropathy, leukemia, medicine, foods, be apt to occur in male and menopausal woman.
The Western medicine being used for the treatment of gout at present mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only stablize the state of an illness mostly, gout can not be effected a radical cure; Serious side effect also can be caused to cause the infringement of hepatic and renal function; Even if Emergent therapy effectively can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.
In Chinese medicine, gout belongs to " arthromyodynia " category, " treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu say arthromyodynia ".Increasing expert thinks, from the organic conception of the traditional Chinese medical science, treats with Chinese medicine integral syndrome differentiation, the good footpath of another bar for the treatment of gout of can yet be regarded as; Not only the toxic and side effects of Chinese medicine itself is little, and can reduce Western medicine dose, overcomes the huge toxic and side effects taken merely Western medicine for a long time and bring.
Summary of the invention
To the object of the invention is to overcome in prior art existing Western medicine side effect large, treat halfway above-mentioned deficiency, a kind of Chinese medicine composition of the treatment gout containing Caulis Akebiae is provided, this traditional Chinese medicine composition for treating gout good effect, instant effect, and little to patient body side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment gout of Caulis Akebiae, it is prepared from by the medicinal raw material of following weight proportion: 5 ~ 20 parts, Rhizoma Curcumae Longae, Caulis Akebiae 3 ~ 10 parts, Eupolyphaga Seu Steleophaga 5 ~ 15 parts, Scorpio 1 ~ 5 part, Borneolum Syntheticum 0.02 ~ 0.15 part.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Rhizoma Curcumae Longae is 8 ~ 15 parts.Preferred, part by weight shared by Rhizoma Curcumae Longae is 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Caulis Akebiae is 5 ~ 8 parts.Preferred, part by weight shared by Caulis Akebiae is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Eupolyphaga Seu Steleophaga is 7 ~ 12 parts.Preferred, part by weight shared by Eupolyphaga Seu Steleophaga is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Scorpio is 2 ~ 4 parts.Preferred, part by weight shared by Scorpio is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Borneolum Syntheticum is 0.05 ~ 0.12 part.Preferred, part by weight shared by Borneolum Syntheticum is 0.1 part.
The Chinese medicine composition for the treatment of gout of the present invention, the active component of medicinal raw material can be extracted according to extracting method conventional on Chinese materia medica, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
The extracting method of Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) get each medicinal raw material by formula proportion, except Borneolum Syntheticum, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of the medicinal raw material of the present invention except Borneolum Syntheticum.
(2) borneol and grinding is become powder, in above-mentioned extract, add borneol powder and mix, and then adding pharmaceutic adjuvant, be mixed and made into acceptable various pharmaceutical dosage form on pharmaceutics.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of gout, be inventor based on the pathogenetic understanding of motherland's medical science to gout, according to oneself clinical experience for many years, first from numerous Chinese medicine, determine the effective Chinese medicine of a series for the treatment of gouts, repeatedly verify through clinical again, screen.Wherein, Dioscorea zingiberensis, another name hair Rhizoma Curcumae Longae, tripod perfume, Radix Curcuma etc. are the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae; Pungent, bitter, temperature; Return spleen, Liver Channel.There is effect of removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia; Twinge for the breast side of body, the disease such as amenorrhea, WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.Caulis Akebiae, another name Medulla Tetrapanacis, attached (" herbal classic "), fourth father-in-law (" WU Pu Bencao ") etc. are the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae; Hardship, cool; Enter the heart, small intestinal, urinary bladder channel; There is effect of pathogenic fire purging row water, promoting blood circulation; For controlling hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, the diseases such as galactostasis.Eupolyphaga Seu Steleophaga is the female worm dry body of Corydiidae insecticide eupolyphoge sinensis or Ji eupolyphoge sinensis; Salty in the mouth, cold in nature; Slightly poisonous; Return Liver Channel; Main removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones; For diseases such as injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomens.Scorpio is the dry body of Buthidae animal Scorpio.Acrid in the mouth, property is put down; Poisonous; Return Liver Channel; There is effect of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; , the disease such as hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula askew for infantile convulsion, tic spasm, middle air port.Borneolum Syntheticum, another name borneolum syntheticum, borneol, Ai Fen, sheeting etc., acrid in the mouth, hardship, cold nature; GUIXIN, spleen, lung meridian; There is effect of refreshment of having one's ideas straightened out, clearing away heat to alleviate pain; Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, conjunctival congestion, aphtha, laryngopharynx swelling and pain, and auditory meatus such as to be suppurated the disease.Above-mentioned 5 taste Chinese herbal medicine, flavour of a drug are few but function is complete, 5 taste medicinal raw materials are by after described proportioning combination, treatment gout has Synergistic function, and through clinical research test, Chinese medicine composition of the present invention is used for the treatment of gout short treating period, instant effect, administration is after 5 days, can take effect, and evident in efficacy, there is not obvious adverse reaction during patient consumes.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, and all technology realized based on content of the present invention all belong to scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, and the percentage composition of ethanol, if no special instructions, is volumn concentration.
Embodiment 1
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Rhizoma Curcumae Longae 12g, Caulis Akebiae 6g, Eupolyphaga Seu Steleophaga 9g, Scorpio 3g, Borneolum Syntheticum 0.1g.
The extracting method of above-mentioned medicinal raw material:
(1) get each medicinal raw material by formula proportion, except Borneolum Syntheticum, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is concentrated into relative density 1.20 (80 DEG C), obtain the extract of the medicinal raw material of embodiment 1 except Borneolum Syntheticum.
(2) borneol and grinding is become powder, in above-mentioned extract, add borneol powder and mix, and then adding the soluble starch of extract weight 2 times of weight, granulate, dry, be distributed into bag, obtain granule.
Embodiment 2
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Rhizoma Curcumae Longae 20g, Caulis Akebiae 3g, Eupolyphaga Seu Steleophaga 15g, Scorpio 1g, Borneolum Syntheticum 0.1g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 2 treats gout.
Embodiment 3
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Rhizoma Curcumae Longae 13g, Caulis Akebiae 6g, Eupolyphaga Seu Steleophaga 8g, Scorpio 4g, Borneolum Syntheticum 0.08g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 3 treats gout.
Comparative example
The Chinese medicine composition of the treatment gout of this comparative example is be prepared from by the medicinal raw material of following weight proportion: Rhizoma Curcumae Longae 12g, Eupolyphaga Seu Steleophaga 9g, Scorpio 3g, Borneolum Syntheticum 0.1g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition of comparative example treatment gout.
Pharmacodynamics and toxicity test:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to the Chinese medicine composition of embodiment 1 prepared by embodiment 1;
According to the Chinese medicine composition of comparative example prepared by comparative example;
Colchicine: be Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get Kunming mouse 50, male and female are use all, and body weight 18 ~ 22g is divided into five groups at random, often organize 10, first group is normal saline group, and second group is drug study group of the present invention (8g raw medicinal herbs/kg), 3rd group is positive controls, and the 4th group is matched group 1, and the 5th group is model group.
Normal saline is gavaged by the dosage of 8g/kg to first group, second group gavages the Chinese medicine composition of the embodiment of the present invention 1 preparation by the dosage of 8g raw medicinal herbs/kg, 3rd group gavages colchicine by the drug dose of 0.1mg/kg, 4th group gavages Chinese medicine composition prepared by comparative example by the dosage of 8g raw medicinal herbs/kg, do not do any process for 5th group, every day 1 time, continuous 5 days.
After last administration 1h, except normal saline group, all the other each group, namely second group to the 5th group, animal Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, and normal saline group presses 1mg/kg injecting normal saline.0.5h after injection, plucks eyeball to each treated animal and gets blood, and the blood obtained after centrifugal 15min, is got serum and surveyed Level of Serum Uric Acid under the speed conditions of 3000r/min.Table 1 be each experimental group and matched group after treatment, the statistical result of blood uric acid measured value.
Table 1
Note: compare with model group:
*p<0.01; Compare with matched group 1:
▲ ▲p<0.01.
In table 1, it is 171 ± 34umol/l that drug study group of the present invention records Level of Serum Uric Acid: close with the Level of Serum Uric Acid 133 ± 26umol/l of normal saline group and the Level of Serum Uric Acid 157 ± 22umol/l of positive controls; Level of Serum Uric Acid 751 ± 105umol/l that relative model group records reduces about 580umol/l, and the statistical result of drug study group of the present invention is relative to model group P<0.01, has significant difference; The traditional Chinese medicine composition for treating gout that the present invention treats gout has good curative effect.
And in table 1, it is 247 ± 43umol/l that matched group 1 records Level of Serum Uric Acid, relative drug study group of the present invention records Level of Serum Uric Acid 171 ± 34umol/l and exceeds about 80umol/l.And the blood uric acid measured value of drug study group of the present invention is compared with the blood uric acid measured value P < 0.01 of matched group 1, has significant difference.Learn thus, 5 taste medicinal raw materials are by after described weight proportion combination, and have Synergistic function, can significantly improve the curative effect of Chinese medicine composition, lack any component, the curative effect of Chinese medicine composition all significantly declines.
In sum, the present invention treats the Chinese medicine composition of gout, and the short treating period for the treatment of gout, instant effect, administration can take effect for 5 days, evident in efficacy.Administration injected hypoxanthine after 5 days, and the blood uric acid measured value of drug study group of the present invention all can not occur significantly to raise phenomenon; 5 taste medicinal raw materials, by after described weight proportion combination, have Synergistic function, can significantly improve the curative effect of Chinese medicine composition.Lack any component, its curative effect all significantly declines, and as matched group 1, after injection hypoxanthine, the blood uric acid measured value recording the relative drug study group of the present invention of Level of Serum Uric Acid raises about 80umol/l.
Claims (10)
1., containing a Chinese medicine composition for the treatment gout of Caulis Akebiae, it is characterized in that: it is prepared from by the medicinal raw material of following weight proportion: 5 ~ 20 parts, Rhizoma Curcumae Longae, Caulis Akebiae 3 ~ 10 parts, Eupolyphaga Seu Steleophaga 5 ~ 15 parts, Scorpio 1 ~ 5 part, Borneolum Syntheticum 0.02 ~ 0.15 part.
2. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Rhizoma Curcumae Longae is 8 ~ 15 parts.
3. the Chinese medicine composition for the treatment of gout according to claim 2, is characterized in that: part by weight shared by Rhizoma Curcumae Longae is 12 parts.
4. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Caulis Akebiae is 5 ~ 8 parts.
5. the Chinese medicine composition for the treatment of gout according to claim 4, is characterized in that: part by weight shared by Caulis Akebiae is 6 parts.
6. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Eupolyphaga Seu Steleophaga is 7 ~ 12 parts.
7. the Chinese medicine composition for the treatment of gout according to claim 6, is characterized in that: part by weight shared by Eupolyphaga Seu Steleophaga is 9 parts.
8. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Scorpio is 2 ~ 4 parts.
9. the Chinese medicine composition for the treatment of gout according to claim 8, is characterized in that: part by weight shared by Scorpio is 3 parts.
10. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Borneolum Syntheticum is 0.05 ~ 0.12 part.
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| CN201410626057.2A CN104436017A (en) | 2014-11-07 | 2014-11-07 | Traditional Chinese medicine composition containing caulis akebiae for treating gout |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105456537A (en) * | 2016-01-27 | 2016-04-06 | 李纪美 | External medicine for treating gouty arthritis |
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| CN102940850A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating gout |
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2014
- 2014-11-07 CN CN201410626057.2A patent/CN104436017A/en active Pending
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| JP2011236133A (en) * | 2010-05-06 | 2011-11-24 | Nippon Tablet Kk | XANTHINE OXIDASE INHIBITOR, ENZYME INHIBITOR HAVING XANTHINE OXIDASE INHIBITION ACTIVITY AND 5α-REDUCTASE INHIBITION ACTIVITY, AND FOOD AND DRINK, COSMETIC COMPOSITION AND PHARMACEUTICAL COMPOSITION CONTAINING THE ENZYME INHIBITOR |
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| CN105456537A (en) * | 2016-01-27 | 2016-04-06 | 李纪美 | External medicine for treating gouty arthritis |
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Application publication date: 20150325 |