CN104337898B - A kind of Chinese medicine composition of the treatment gout containing Semen Pruni - Google Patents
A kind of Chinese medicine composition of the treatment gout containing Semen Pruni Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention relates to a kind of Chinese medicine composition, be specifically related to the Chinese medicine composition of a kind for the treatment of gout containing Semen Pruni, belong to pharmaceutical technology field.The medicament that the Chinese medicine composition of the treatment gout of the present invention is made up of the medicinal raw material of following weight proportion: Herba Lycopodii 4～20 parts, Fructus Choerospondiatis 3～15 parts, Herba Taraxaci 2～12 parts, Xi 2～11 parts, Nidus Vespae 2～11 parts, Semen Pruni 1～7 parts, Herb Gynostemmae Pentaphylli 1～7 parts.The present invention treats the Chinese medicine composition of gout, after 7 taste medicinal raw materials are combined by proportioning, has Synergistic function, is used for treating gout evident in efficacy, and does not finds obvious side effect and untoward reaction.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to the Chinese drug-treated group of a kind for the treatment of gout containing Semen Pruni
Compound, belongs to pharmaceutical technology field.
Background technology
Gout is also known as hyperuricemia, and sickness rate is high, cure difficult, recurrent exerbation, belongs to disorders of purine metabolism
The metabolic disease caused.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, and it is clinical special
Point is hyperuricemia and the gouty acute arthritis recurrent exerbation thus caused, tophaceous deposition, gout
Stone chronic arthritis and joint deformity etc., ineffective with redness and swelling of joints, burning pain, recurrent exerbation, joint motion
Live as main clinical manifestation.Often involving kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.According to
In blood, uric acid increases reason and can be divided into constitutional and the big class of Secondary cases two.The cause of disease of primary gout is due to elder generation
Caused by nature purine metabolic disturbance, belong to heritability.The cause of disease of secondary gout, can by nephropathy, leukemia,
The many reasons such as medicine, food causes, and is apt to occur in male and menopausal woman.
The Western medicine being currently used for treating gout mainly has: colchicine, Phenylbutazone or crovaril, antiinflammatory
Bitterly, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen
(naproxen congex), ACTH and prednisone etc..But said medicine can only stablize the state of an illness mostly, it is impossible to
Radical cure gout；Serious side effect also can be caused to cause the infringement of hepatic and renal function；Even if Emergent therapy is the most also
Can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, the heart
Dirty function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause diabetes etc.
Complication.
In Chinese medicine, gout belongs to " arthromyodynia " category, " treatise on blood trouble ": " gout, general numbness and hypoesthesia, extremity ache
Bitterly, modern name gout, Gu say arthromyodynia ".Increasing expert thinks, from the organic conception of the traditional Chinese medical science, uses
Chinese medicine integral syndrome differentiation treats, the good footpath of another bar for the treatment of gout of can yet be regarded as；The not only poison of Chinese medicine itself
Side effect is little, and can reduce Western medicine dose, overcomes and takes merely the huge poison pair that Western medicine is brought for a long time
Effect.
Summary of the invention
It is an object of the invention to overcome in the presence of prior art that Western medicine side effect is big, treat on halfway
State deficiency, it is provided that the Chinese medicine composition of a kind for the treatment of gout containing Semen Pruni, this traditional Chinese medicine composition for treating gout
Good effect, instant effect, and little to patient body side effect.
In order to realize foregoing invention purpose, the invention provides techniques below scheme:
The Chinese medicine composition of a kind for the treatment of gout containing Semen Pruni, it is by the medicinal raw material of following weight proportion
It is prepared from: Herba Lycopodii 4～20 parts, Fructus Choerospondiatis 3～15 parts, Herba Taraxaci 2～12 parts, Xi 2～11 parts,
Nidus Vespae 2～11 parts, Semen Pruni 1～7 parts, Herb Gynostemmae Pentaphylli 1～7 parts.Described various medicinal raw material is and meets
The Chinese crude drug that country or provincial standard specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herba Lycopodii is 8～16 parts.More preferably
, part by weight shared by Herba Lycopodii is 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Fructus Choerospondiatis is 5～12 parts.It is furthermore preferred that
Part by weight shared by Fructus Choerospondiatis is 8 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herba Taraxaci is 4～9 parts.It is furthermore preferred that
Part by weight shared by Herba Taraxaci is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Xi is 4～9 parts.It is furthermore preferred that
Part by weight shared by Xi is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Nidus Vespae is 4～8 parts.It is furthermore preferred that
Part by weight shared by Nidus Vespae is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Semen Pruni is 2～5 parts.It is furthermore preferred that
Part by weight shared by Semen Pruni is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Herb Gynostemmae Pentaphylli is 2～5 parts.It is furthermore preferred that
Part by weight shared by Herb Gynostemmae Pentaphylli is 3 parts.
The Chinese medicine composition of the treatment gout of the present invention, can extract according to extracting method conventional on Chinese materia medica
The active component of medicinal raw material, adds pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin,
Microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl
Methylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make medicament
Dosage form suitable on, such as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill
Deng.
The extracting method of Chinese medicine composition of the present invention can use but be not limited to following methods:
(1) take each medicinal raw material by formula proportion, in medicinal raw material, add medicinal raw material volume 8～10 times
60～80% ethanol or water；Reflux, extract, 2～3 times；Extraction time is respectively 1～2h；Collection merging carries
Take liquid, and extracting solution is condensed into extractum, be dried, obtain the extract of the medicinal raw material of the present invention.
(2) in above-mentioned extract, add pharmaceutic adjuvant and be mixed and made into acceptable various medicine agent on pharmaceutics
Type.
According to preparing the needs of various drug form, it is suitable that medicine of the present invention also can add in preparation process
Pharmaceutic adjuvant such as filler, disintegrating agent, binding agent, lubricant, preservative etc..
Compared with prior art, beneficial effects of the present invention:
The present invention treats the Chinese medicine composition of gout, is inventor based on motherland's medical science pathogeny to gout
Understanding, according to oneself clinical experience for many years, first from numerous Chinese medicines, determine that a series for the treatment of gout is effective
Chinese medicine, more repeatedly verify through clinic, and screen.Wherein, Herba Lycopodii, another name Lycopodium clavatum, lion tail,
Lion hair careless, green stretches muscle etc., for the dry herb of lycopsid Lycopodium clavatum；Mildly bitter flavor, pungent, warm in nature；Return
Liver,spleen,kidney warp；There is effect of expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral；For joint aches, joint stuffiness etc.
Disease.Fructus Choerospondiatis, for the dry mature fruit of Anacardiaceae plant Fructus Choerospondiatis；Sweet in the mouth, acid, property is put down；There is circulation of qi promoting
Invigorate blood circulation, tranquilizing by nourishing the heart, resist myocardial ischemia and the effect such as cardiac function protecting, be mainly used in qi depression to blood stasis, the thoracic obstruction
Have a pain, the disease such as shortness of breath and palpitation, irritability.Herba Taraxaci, calls Herba crotalariae albidae, Po Poding, feverfew Pu
Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together；Bitter, sweet, cold；Return liver, stomach warp；Tool
There are heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome；For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion,
Pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the disease such as puckery pain of pyretic stranguria.Xi, calls Herba Patriniae, Thalaspi arvense L.；
For Cruciferae Xi platymiscium Xi herb；Bitter in the mouth, sweet, property is put down；Return liver, kidney channel；There is heat clearing away solution
Poison, inducing diuresis and reducing edema, and the effect of middle appetizing；For appendicitis, lung abscess, carbuncle furuncle and phyma poison, erysipelas, son
The diseases such as Endometrium is scorching, leucorrhea, nephritis, cirrhotic ascites, infantile dyspepsia.Nidus Vespae, Nidus Vespae, another name
Nidus Vespae, hornet's nest, Nidus Vespae, wild bee nest, hornet's nest, hundred nests etc. worn；For Vespidae insecticide fruit hornet,
The long foot wasp of Japan or the nest of different abdomen wasp；Sweet, flat；Return stomach warp；Have dispel the wind, merit poison, parasite killing, only
Effect of pain；For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, the disease such as fungal infection of hand and foot.
Semen Pruni, calls semen pruni humilidis et japonicae, semen pruni tomentosae et trilobae；(red for rosaceous plant Prunus humilis (acid fourth, Xiao Li red), strongly fragrant Lee
Fructus Pruni salicinae) or the dry mature seed of Prunus pedunculata Maxim.；Acrid in the mouth, hardship, sweet, property is put down；Return spleen, large intestine, small intestinal
Warp；Have and moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, effect of diuretic；For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation,
Edema, tinea pedis, the disease such as dysuria.Herb Gynostemmae Pentaphylli, calls Herba Gynostemmatis, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, calabash
The root stock of section gynostemma plant Herb Gynostemmae Pentaphylli；Hardship, cold；Return lung, spleen, kidney channel；Have heat-clearing and toxic substances removing,
Effect of eliminating phlegm and stopping cough；For chronic bronchitis, infectious hepatitis, nephritis, gastroenteritis.Above-mentioned 7 tastes
Chinese herbal medicine, flavour of a drug are few but function is complete, and after 7 taste medicinal raw materials are combined by described proportioning, treatment gout has
Synergistic function, tests through clinical research, the Chinese medicine composition of the present invention be used for treating gout short treating period,
Instant effect, after being administered 4 days, can take effect, and evident in efficacy, and patient does not occurs the worst during taking medicine
Reaction.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail, but should be by
This is interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to below example, all real based on present invention institute
Existing technology belongs to the scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, the percentage composition of ethanol,
If no special instructions, it is volumn concentration.
Embodiment 1
The Chinese medicine composition of the treatment gout of the present embodiment, is by the medicinal raw material preparation of following weight proportion
Become: Herba Lycopodii 12g, Fructus Choerospondiatis 8g, Herba Taraxaci 6g, Xi 6g, Nidus Vespae 6g, Semen Pruni 3g, Herb Gynostemmae Pentaphylli
3g。
The extracting method of above-mentioned medicinal raw material:
(1) take each medicinal raw material by formula proportion, in medicinal raw material, add medicinal raw material volume 8～10 times
60～80% ethanol or water；Reflux, extract, 2～3 times；Extraction time is respectively 1～2h；Collection merging carries
Take liquid, and extracting solution is concentrated into relative density 1.20 (80 DEG C), obtain the extraction of embodiment 1 medicinal raw material
Thing.
(2) in above-mentioned extract, add the soluble starch of 2 times of weight of extract weight, pelletize, be dried,
It is distributed into bag, obtains granule.
Embodiment 2
The Chinese medicine composition of the treatment gout of the present embodiment, is by the medicinal raw material preparation of following weight proportion
Become: Herba Lycopodii 20g, Fructus Choerospondiatis 11g, Herba Taraxaci 2g, Xi 2g, Nidus Vespae 9g, Semen Pruni 1g, strand
The blue 7g of stock.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain embodiment 2
The Chinese medicine composition for the treatment of gout.
Embodiment 3
The Chinese medicine composition of the treatment gout of the present embodiment, is by the medicinal raw material preparation of following weight proportion
Become: Herba Lycopodii 15g, Fructus Choerospondiatis 10g, Herba Taraxaci 8g, Xi 7g, Nidus Vespae 5g, Semen Pruni 4g, strand
The blue 5g of stock.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain embodiment 3
The Chinese medicine composition for the treatment of gout.
Comparative example
The Chinese medicine composition of the treatment gout of this comparative example, is by the medicinal raw material preparation of following weight proportion
Become: Herba Lycopodii 12g, Fructus Choerospondiatis 8g, Herba Taraxaci 6g, Xi 6g, Nidus Vespae 6g, Herb Gynostemmae Pentaphylli 3g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain comparative example and control
Treat the Chinese medicine composition of gout.
Pharmacodynamics and toxicity test:
In order to confirm the efficacy and saferry of medicine of the present invention, inventor has carried out pharmacodynamics and toxicity test is examined
Examine.The research method and the result of the test that are used are as follows:
1, test material
(1) medicine and reagent:
The Chinese medicine composition of the embodiment 1 according to embodiment 1 preparation；
Chinese medicine composition according to comparative example prepared by comparative example；
Colchicine: for Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
2, test method and result
(1) impact on hyperuricemia Mouse Blood uric acid level
Take Kunming mouse 50, male and female all use, body weight 18～22g, be randomly divided into five groups, often group 10,
First group is normal saline group, and second group is drug study group of the present invention (8g raw medicinal herbs/kg), and the 3rd group is
Positive controls, the 4th group is matched group 1, and the 5th group is model group.
Gavaging normal saline to first group by the dosage of 8g/kg, second group of dosage pressing 8g raw medicinal herbs/kg fills
Taking the Chinese medicine composition of the embodiment of the present invention 1 preparation, the 3rd group gavages autumn waters--limid eyes by the drug dose of 0.1mg/kg
Celestial alkali, the 4th group gavages Chinese medicine composition prepared by comparative example by the dosage of 8g raw medicinal herbs/kg, and the 5th group is not
Make any process, every day 1 time, continuous 4 days.
After last is administered 1h, in addition to normal saline group, remaining each group, i.e. second group to the 5th group, animal
Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, normal saline group to press 1mg/kg injection raw
Reason saline.0.5h after injection, plucks eyeball to each treated animal and takes blood, by the blood of acquirement at 3000r/min
Speed conditions under after centrifugal 15min, take serum and survey Level of Serum Uric Acid.Table 1 is each experimental group and matched group warp
After process, the statistical result of blood uric acid measured value.
Table 1
Note: compare with model group:**P<0.01；Compare with matched group 1:▲▲P<0.01。
In table 1, it is 169 ± 36umol/l that drug study group of the present invention records Level of Serum Uric Acid: with normal saline group
Level of Serum Uric Acid 125 ± 26umol/l and the Level of Serum Uric Acid 146 ± 43umol/l of positive controls close；Phase
Level of Serum Uric Acid 742 ± the 104umol/l recording model group reduces about 570umol/l, and medicine of the present invention
The statistical result of thing experimental group relative to model group P < 0.01, there is significant difference；The present invention treats gout
Traditional Chinese medicine composition for treating gout there is good curative effect.
And in table 1, it is 232 ± 41umol/l that matched group 1 records Level of Serum Uric Acid, relative drug study of the present invention
Group records Level of Serum Uric Acid 169 ± 36umol/l and exceeds about 63umol/l.And the blood of drug study group of the present invention
Uric acid measurement value, compared with the blood uric acid measured value P ＜ 0.01 of matched group 1, has significant difference.It follows that
After 7 taste medicinal raw materials are combined by described weight proportion, there is Synergistic function, Chinese medicine composition can be significantly improved
The curative effect of thing, lacks any component, and the curative effect of Chinese medicine composition is all remarkably decreased.
In sum, the present invention treats the Chinese medicine composition of gout, the short treating period for the treatment of gout, instant effect,
It is administered and can take effect for 4 days, evident in efficacy.Hypoxanthine, drug study group of the present invention is injected after being administered 4 days
Blood uric acid measured value all will not occur significantly to raise phenomenon；7 taste medicinal raw materials are combined by described weight proportion
After, there is Synergistic function, the curative effect of Chinese medicine composition can be significantly improved.Lacking any component, it is treated
Effect is all remarkably decreased, and such as matched group 1, after injection hypoxanthine, records Level of Serum Uric Acid real relative to medicine of the present invention
The blood uric acid measured value testing group exceeds about 63umol/l.
Claims (10)
1. the Chinese medicine composition of the treatment gout containing Semen Pruni, it is characterised in that: it is to be prepared from by the medicinal raw material of following weight proportion: Herba Lycopodii 4～20 parts, Fructus Choerospondiatis 3～15 parts, Herba Taraxaci 2～12 parts, Xi 2～11 parts, Nidus Vespae 2～11 parts, Semen Pruni 1～7 parts, Herb Gynostemmae Pentaphylli 1～7 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Herba Lycopodii is 8～16 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 2, it is characterised in that: part by weight shared by Herba Lycopodii is 12 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Fructus Choerospondiatis is 5～12 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Herba Taraxaci is 4～9 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Xi is 4～9 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 6, it is characterised in that: part by weight shared by Xi is 6 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Nidus Vespae is 4～8 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Semen Pruni is 2～5 parts.
The Chinese medicine composition for the treatment of gout the most according to claim 1, it is characterised in that: part by weight shared by Herb Gynostemmae Pentaphylli is 2～5 parts.
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Address after: 610041, No. 12, 9, 911, 88 South Garden Road, Chengdu hi tech Zone, Sichuan, China Patentee after: Chengdu medical road Kang Huaxi medical science and Technology Co Ltd Address before: 610000, No. 12, 9, 911, 88 South Garden Road, Chengdu hi tech Zone, Sichuan, China Patentee before: CHENGDU HUAXI TECHNOLOGY CO., LTD. |