CN104352672A - Tortoise plastron-containing traditional Chinese medicine composition for treating diabetes - Google Patents
Tortoise plastron-containing traditional Chinese medicine composition for treating diabetes Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, relates to traditional Chinese medicine compositions and particularly relates to a tortoise plastron-containing traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition for treating diabetes, disclosed by the invention, is prepared from the following medicinal raw materials in parts by weight: 5-13 parts of radix paeoniae rubra, 3-10 parts of saffron, 3-10 parts of tortoise plastron, 2-9 parts of fructus choerospondiatis, 3-10 parts of phellodendron bark and 1-5 parts of honeysuckle stem. According to the traditional Chinese medicine composition for treating diabetes, disclosed by the invention, the 6 kinds of medicinal raw materials are combined according to a proportioning ratio, so that the traditional Chinese medicine composition has a synergistic function during the treatment of diabetes and is remarkable in treatment effect and free from side effect on the body of a patient when the traditional Chinese medicine composition is used for treating diabetes.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment diabetes containing Carapax et Plastrum Testudinis.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature, is that China's sickness rate is high, endangers one of serious epidemic diseases.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, causes various diabetic complication.According to statistics, the mortality rate of diabetic complication is only second to cardiovascular diseases, cerebrovascular and tumor, occupies the 4th.Diabetes mellitus in China patient populations close to 4,000 ten thousand people, occupies third place in the world, compared with 0.7% of the eighties in 20th century, increases 5 times.Diabetes can be caused by h and E factor interaction, and common sympton has polydipsia, polyuria, polyphagia and becomes thin.Diabetes can cause the infringement of health multisystem; Absolute or the relative hyposecretion of insulin and target tissue cell is caused to reduce insulin sensitivity; Causing a series of metabolism disorder syndromes such as protein, fat, water and eletrolytes, is wherein outstanding feature with hyperglycemia.The medicine of current treatment diabetes is a lot, especially Western medicine, but side effect is large, and Chinese patent medicine effect is remarkable not.
Summary of the invention
Object of the present invention provides a kind of Chinese medicine composition of the treatment diabetes containing Carapax et Plastrum Testudinis, this Chinese medicine composition good effect, little to person side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment diabetes of Carapax et Plastrum Testudinis, be prepared from by the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 5 ~ 13 parts, Stigma Croci 3 ~ 10 parts, Carapax et Plastrum Testudinis 3 ~ 10 parts, Fructus Choerospondiatis 2 ~ 9 parts, Cortex Phellodendri 3 ~ 10 parts, Caulis Lonicerae 1 ~ 5 part.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Paeoniae Rubra is 7 ~ 11 parts.Preferred, part by weight shared by Radix Paeoniae Rubra is 9 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Stigma Croci is 4 ~ 8 parts.Preferred, part by weight shared by Stigma Croci is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Carapax et Plastrum Testudinis is 4 ~ 8 parts.Preferred, part by weight shared by Carapax et Plastrum Testudinis is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Fructus Choerospondiatis is 3 ~ 7 parts.Preferred, part by weight shared by Fructus Choerospondiatis is 5 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Cortex Phellodendri is 4 ~ 8 parts.Preferred, part by weight shared by Cortex Phellodendri is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Caulis Lonicerae is 2 ~ 4 parts.Preferred, part by weight shared by Caulis Lonicerae is 3 parts.
The Chinese medicine composition for the treatment of diabetes of the present invention, Traditional Chinese medicine extraction method conveniently can extract the active component of medicinal raw material, as decocted with water, or collects extracting solution and concentrated by the aqueous solution reflux, extract, of ethanol or ethanol; Add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of diabetes, that inventor is based on the pathogenetic understanding of motherland's medical science to diabetes, according to oneself clinical experience for many years, first determine a series of to the effective Chinese medicine for the treatment of diabetes from numerous Chinese medicine, then screen through clinical repeatedly checking.Wherein, Radix Paeoniae Rubra, another name mountain Radix Paeoniae, Paeonia obovata Maxim.; For the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra; Hardship, is slightly cold; Return Liver Channel; There is the effect of clearing away heat and cooling blood, eliminating stasis to stop pain; For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, the diseases such as carbuncle skin infection.Stigma Croci, another name Stigma Croci, Stigma Croci; For the dry stigma of Iridaceae crocus plant Stigma Croci; Sweet in the mouth, property is put down; GUIXIN, Liver Channel; There is blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, effect of resolving stagnation for tranquilization; For amenorrhea lump in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear such as to be gone mad the disease.Carapax et Plastrum Testudinis, another name Carapax et Plastrum Testudinis, Testudinis plate, Carapax et Plastrum Testudinis, blood plate, boiling hot plate, Carapax Et Plastrum Testudinis; For sternite and the carapace of Testudinidae animal; Salty, sweet, be slightly cold; Return liver, kidney, heart channel; There is effect of nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood; For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, forgetful disease such as grade of having a guilty conscience.Fructus Choerospondiatis is the dry mature fruit of Anacardiaceae plant Fructus Choerospondiatis; Sweet in the mouth, acid, property is put down; There is promoting flow of QI and blood, the effect of tranquilizing by nourishing the heart; For qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, the diseases such as irritability.Cortex Phellodendri, another name Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood; For the dry bark of rutaceae wampee or Cortex Phellodendri; Hardship, cold.Return kidney, urinary bladder channel; Have heat clearing and damp drying, pathogenic fire purging except steaming, effect of detoxification sore treatment; For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the diseases such as eczema pruritus.Caulis Lonicerae, another name Radix Ophiopogonis, Caulis Lonicerae, Caulis Lonicerae; For the dry stem branch of caprifoliaceae plant Radix Ophiopogonis; Sweet, cold; Attach to the lung and stomach meridians; There is effect of heat-clearing and toxic substances removing, dispelling wind dredging collateral; For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the diseases such as redness and swelling of joints burning pain.After above-mentioned 6 taste Chinese herbal medicine press formula proportion mixing, Traditional Chinese medicine extraction method conveniently obtains the Chinese medicine composition for the treatment of diabetes of the present invention after extracting the active component of medicinal raw material.After formula proportion combination pressed by 6 taste medicines wherein, treatment diabetes have the function of Synergistic, can significantly reduce blood glucose, serum lipid concentrations, improve blood flow and anti-oxidation efficacy, treat diabetes Be very effective and have no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 9g, Stigma Croci 6g, Carapax et Plastrum Testudinis 6g, Fructus Choerospondiatis 5g, Cortex Phellodendri 6g, Caulis Lonicerae 3g.
The extracting method of above-mentioned medicinal raw material: get medicinal raw material by formula proportion, 2 times are decocted with water in medicinal raw material, be followed successively by medicinal raw material volume by water volume 10 times and 8 times that decoct for 2 times, 2 times decocting time is followed successively by 1.5 hours and 1 hour, filters and collects filtrate after each decoction; Merge 2 filtrates, obtain the extracting solution of embodiment 1 medicinal raw material, the extracting solution of embodiment 1 medicinal raw material is concentrated into relative density 1.20 (80 DEG C), obtains the extract of embodiment 1.
In above-mentioned extract, add the soluble starch of extract 2 times of weight, granulation, drying, be distributed into bag, obtain the Chinese medicinal composition granules that embodiment 1 treats diabetes.
Embodiment 2
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 13g, Stigma Croci 10g, Carapax et Plastrum Testudinis 3g, Fructus Choerospondiatis 2g, Cortex Phellodendri 3g, Caulis Lonicerae 1g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Embodiment 3
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 8g, Stigma Croci 7g, Carapax et Plastrum Testudinis 5g, Fructus Choerospondiatis 7g, Cortex Phellodendri 7g, Caulis Lonicerae 4g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Comparative example
The Chinese medicine composition of the treatment diabetes of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 9g, Stigma Croci 6g, Fructus Choerospondiatis 5g, Cortex Phellodendri 6g, Caulis Lonicerae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Pharmacodynamics test proves:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to Chinese medicine composition of the present invention prepared by embodiment 1;
According to comparative example Chinese medicine composition prepared by comparative example;
Alloxan, SIGMA Co. produces;
Glucose estimation kit, is produced by Beijing Chemical Plant;
Insoral, commercially available.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
(3) instrument: VZS-723 spectrophotometer, electronic balance etc.
2, test method and result:
(1) medicine of the present invention is on the impact of alloxan diabetes mice hyperglycemia
(1) hyperglycemia model and grouping, is made
Get body weight 25 ± 1g Male Kunming strain mice 80, water is can't help in fasting.After 3 hours, tail vein injection alloxan normal saline solution 85mg/kg (0.5ml/ only) causes hyperglycemia model, separately by 15 body weight 25 ± 1g Male Kunming strain mice tail vein injection normal saline (0.5ml/ only), as Normal control animals.After 72 hours, above-mentioned mice fasting be can't help water 10 hours; Then get blood from its eye socket, glucose oxidase method surveys every mouse blood sugar concentration.
From the mice of 80 injection alloxan normal saline solutions, select blood glucose higher than 200mg/dL and close 60 of blood glucose value, be divided into 4 groups at random, i.e. model group, medicine group of the present invention, matched group 1 and insoral group, often organize 15.
(2), administration, survey blood sugar concentration
Five groups of mice difference gastric infusion and normal saline as follows: to the Chinese medicine composition of the medicine group gavage embodiment of the present invention 1 preparation of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To insoral group gavage insoral, medication accumulated dose: 80mg/kg; To Chinese medicine composition prepared by matched group 1 gavage comparative example of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To the normal saline of the solvent amounts such as model group gavages; The normal saline of the solvent amounts such as normal saline group gavages.
Successive administration 10 days, during administration and the ingesting of the mice respectively organized of fore-and-aft observing, movable and excretion situation situation all without exception occur.In administration in the 10th day after 1 hour, eye socket gets blood, surveys fasting plasma glucose concentration (fasting can't help water 10 hours, and method is with aforementioned).Between comparative control group 1 and model group, difference between each administration group, the results are shown in Table 1.
Table 1
Note: in table 1, compares with model group:
▲ ▲ ▲p < 0.001,
▲ ▲p < 0.05,
▲p > 0.05.
In table 1, experimental result shows: mouse mainline alloxan is after 72 hours, and mice hyperglycemia modeling success, its blood sugar concentration is significantly higher than normal saline group.With medicine group successive administration of the present invention after 10 days, mouse blood sugar concentration reduces to 386.3 ± 31.1mg/dL, about 62mg/dL lower than the mouse blood sugar concentration 448.5 ± 44.3mg/dL of model group.And the statistical result of medicine group of the present invention relative to model group statistical result P < 0.05, have significant difference, the blood sugar lowering therapeutic effect of medicine group of the present invention to alloxan diabetes mice hyperglycemia is good; And during mice administration and front and back have no adverse reaction, the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
And matched group 1 successive administration is after 10 days, mouse blood sugar concentration is 419.2 ± 87.4mg/dL, about 29mg/dL lower than the mouse blood sugar concentration 448.5 ± 44.3mg/dL of model group; Than statistical value 386.3 ± 31.1mg/dL height about 33mg/dL of medicine group mouse blood sugar concentration of the present invention; And the statistical result of matched group 1 is relative to the statistical result P > 0.05 of model group, there was no significant difference.Therefore learn, the blood sugar lowering therapeutic effect of Chinese medicine composition to alloxan diabetes mice hyperglycemia prepared by comparative example is poor.
To sum up, the present invention treats the Chinese medicine composition of diabetes, good, the instant effect for the treatment of diabetes curative effect and having no side effect to health, and 6 taste medicinal raw materials press after formula proportion combines, and have Synergistic function; Lack any component, the curative effect of traditional Chinese medicine composition for treating diabetes all can obviously reduce, as in above-mentioned pharmacodynamics test, the therapeutic effect of matched group 1 obviously reduces relative to the curative effect of medicine group of the present invention, and the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
Claims (10)
1., containing a Chinese medicine composition for the treatment diabetes of Carapax et Plastrum Testudinis, it is characterized in that: it is made up of the medicinal raw material of following weight proportion: Radix Paeoniae Rubra 5 ~ 13 parts, Stigma Croci 3 ~ 10 parts, Carapax et Plastrum Testudinis 3 ~ 10 parts, Fructus Choerospondiatis 2 ~ 9 parts, Cortex Phellodendri 3 ~ 10 parts, Caulis Lonicerae 1 ~ 5 part.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Radix Paeoniae Rubra is 7 ~ 11 parts.
3. the Chinese medicine composition for the treatment of diabetes according to claim 2, is characterized in that: part by weight shared by Radix Paeoniae Rubra is 9 parts.
4. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Stigma Croci is 4 ~ 8 parts.
5. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Carapax et Plastrum Testudinis is 4 ~ 8 parts.
6. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Carapax et Plastrum Testudinis is 6 parts.
7. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Fructus Choerospondiatis is 3 ~ 7 parts.
8. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Cortex Phellodendri is 4 ~ 8 parts.
9. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Caulis Lonicerae is 2 ~ 4 parts.
10. the Chinese medicine composition for the treatment of diabetes according to claim 9, is characterized in that: part by weight shared by Caulis Lonicerae is 3 parts.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743783A (en) * | 2018-08-29 | 2018-11-06 | 齐爱萍 | A kind of Chinese medicine for treating diabetes |
| CN111110781A (en) * | 2020-01-17 | 2020-05-08 | 北京汉典制药有限公司 | Traditional Chinese medicine composition for treating diabetes, preparation and preparation method thereof |
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| CN1390577A (en) * | 2002-07-22 | 2003-01-15 | 段仕敏 | Pill of tortoise plastron and turtle shell |
| CN102940693A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating diabetic foot |
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2014
- 2014-11-11 CN CN201410633319.8A patent/CN104352672A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1390577A (en) * | 2002-07-22 | 2003-01-15 | 段仕敏 | Pill of tortoise plastron and turtle shell |
| CN102940693A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating diabetic foot |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743783A (en) * | 2018-08-29 | 2018-11-06 | 齐爱萍 | A kind of Chinese medicine for treating diabetes |
| CN111110781A (en) * | 2020-01-17 | 2020-05-08 | 北京汉典制药有限公司 | Traditional Chinese medicine composition for treating diabetes, preparation and preparation method thereof |
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Application publication date: 20150218 |