CN103463307B - Composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and preparation method thereof - Google Patents
Composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses the composite chewable tablet of a kind of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), and its formula is: Ganoderma 10 ~ 25 parts; Fructus Lycii 10 ~ 15; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 2 ~ 6 parts; Fructus Momordicae 5 ~ 10 parts; Hydroxypropyl emthylcellulose 20 ~ 30 parts; Maltodextrin 5 ~ 15 parts; Lubricant 1 ~ 3.Its production method pulverized 500 mesh sieves separately by raw material to obtain superfine powder, then by recipe ratio combination, stir, adopt ethanol wet granulation, then at 60 ~ 80 DEG C, be dried to moisture weight content reach 4% ~ 6%, be cooled to room temperature, cross 60 mesh sieves, be mixed into tabletting after lubricant, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).Chewable tablet of the present invention has the health-care effects such as heat-clearing and toxic substances removing, liver protecting and nourishing, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing, defying age, replenishing vital essence to improve eyesight, life prolonging.
Description
Technical field
The present invention relates to composite chewable tablet of a kind of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and preparation method thereof.
Background technology
Ganoderma be Basidiomycetes Polyporaceae (
polyporaceae) Ganoderma (
ganodelma) fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. (
g.lucidumkarst).Wield research to show, the pharmaceutical component of Ganoderma is very abundant, and wherein effective ingredient can be divided into ten large classes, comprise ganoderan, Ganoderma polypeptide, triterpenes, 16 seed amino acids (being mainly Fumaric acid) and trace element every, ferrum, calcium, violent, zinc etc.Ganoderan is one of principle active component of Ganoderma, and it is the main component of Ganoderma strengthening the body resistance, strengthening by means of tonics, life lengthening.The effect of Ganoderma to human body is two-ways regulation, its power relates to each systems of human body such as cardiovascular and cerebrovascular vessel, digestion, breathing, endocrine, nerve, motion, and Ganoderma also has antitumor, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing and anti-aging effects.
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Classification system:
corydalissaxicolaBunting, belong to Papaverales Papaveraceae, another name: rock Hu, rock company, Radix corydalis pallidae, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), herbaceos perennial, high 15-40cm, main root is flourishing, is born in the border rock slot of mountain region, is distributed in the ground such as Gansu, Hubei, Guangxi, Sichuan, Guizhou, Yunnan.Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is also a kind of Chinese medicine, has the multiple curative effect such as heat-clearing and toxic substances removing, treatment hepatitis; Attending effectiveness: heat-clearing and toxic substances removing; Dampness removing; Analgesic hemostatic; Cure mainly hepatitis; Aphthous stomatitis; Acute catarrhal conjunctivitis; Cough, corneal nebula; Dysentery; Diarrhoea; Stomachache; Bleeding hemorrhoids, also has certain antitumaous effect.It is documented, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) contains multiple alkaloid.Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is owing to having above-mentioned heat-clearing and toxic substances removing, dampness removing, analgesic hemostatic function and chemical composition, it is found that it has special efficacy to liver disorders, the multi-efficiency that there is anti-hepatitis virus simultaneously and protect the liver, thus the treatment of hepatitis, liver cirrhosis, hepatocarcinoma is widely used in, and obtain beyond thought special effect, current Guangxi, some pharmaceutical factory Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae)s of Guizhou produce some for oral administration and ejection preparations, toxic and side effects is not found, so Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is as the important drugs for the treatment of hepatic disease through long-term taking and intravenous injection.
Fructus Lycii, Classification system:
lycium, belong to Lycium, have a lot of call among the people Chinese Fructus Lycii, as red in Gou Qizi, Fructus Lycii real, Radix Betae is sub, FRUCTUS LYCII BARBARI, Canis familiaris L. milk, frame, red ear pendant, blood Fructus Lycii, Chinese holly ground bud, fructus lycii sinensis.This title of Fructus Lycii is first appeared in " Book of Songs " before China's two thousand years.The medicine scholar Li Shizhen (1518-1593 A.D.) cloud of the Ming Dynasty: " Fructus Lycii, two tree names.This thing sour jujube as the thorn of Chinese holly, stem as the bar of Qi, therefore hold concurrently name it ".Road book speech: thousand years Fructus Lyciis, its shape as dog, therefore obtains Chinese holly name.Song is said: Caulis Bambusae has three kinds: one to be Fructus Lycii; One is dish class, and leaf is like Herba Lactucae versicoloris; One be the darkish complexion person of withered bamboo pole also.Fructus Lycii has influence to function of exempting from service, and shows as nourishing the liver, nourishing kidney, lung moistening; Main component: lycium barbarum polysaccharide, wolfberry pigment, betanin (
betane), atropine (
atropine), hyoscyamine (
gyoscyamine).Fructus Lycii compares temperature compensation, and property is put down, sweet in the mouth, has the kidney invigorating nourishing the liver, replenishing vital essence to improve eyesight, strengthening bone and muscle, except lumbago, takes the functions such as energy life prolonging for a long time.Although but Fructus Lycii is that the excellent nourishing of a kind of drug effect is protected and built treasure, the effectiveness of its warm health is fairly obvious, for hyperpietic, irascible temperament person, or overnutrition person being not suitable for.
Fructus Momordicae, Classification system:
momordicagrosvenoriSwingle,for cucurbitaceous plant, Fructus Momordicae belongs to herbaceous perennial vine plant, the dry mature fruit of Fructus Momordicae.Fructus Momordicae is described as " angle fruit " by people.Mainly originating in the mountain area of Lingui district of Guangxi Zhuang Autonomous Region Guilin City and Yongfu county, is the famous and precious local and special products in Guilin.Fruits nutrition is worth very high, containing abundant vitamin C (containing 400 milligrams ~ 500 milligrams in every 100 grams of fresh fruits) and glucoside, fructose, glucose, protein, lipid etc.For a kind of conventional Chinese medicine, there is clearing away summer-heat, effect that lung moistening is quenched the thirst, also the various diseases such as hypertension, pulmonary tuberculosis, asthma, hepatitis, bronchitis and tonsillitis are had to effect for the treatment of.
Summary of the invention
The object of the invention is to the respective drug effect for Ganoderma, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Fructus Lycii, Fructus Momordicae, and a kind of simple formula combination is provided, allow its drug effect be improved and symphyogenetic a kind of chewable tablet.
The present invention is achieved in that
The composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), its composition comprises the raw material of following parts by weight:
Ganoderma 10 ~ 25 parts; Fructus Lycii 10 ~ 15; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 2-6 part; Fructus Momordicae 5 ~ 10 parts; Hydroxypropyl emthylcellulose 20 ~ 30 parts; Maltodextrin 5 ~ 15 parts; Lubricant 1 ~ 3.
Described Fructus Momordicae, English name: FructusMomordicae (drawing); The dry fruit of grosvenormomordicafruit cucurbitaceous plant Fructus Momordicae Siraitiagrosvenorii (Swingle) C.JeffreyexLuetZ.Y.Zhang.Fructus Momordicae sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, and effect of promoting the production of body fluid to quench thirst is applicable to lung-heat or xeropulmonary cough, pertussis and summer-heat impairment of body fluid thirsty etc., also have effect of loosening bowel to relieve constipation in addition.Fructus Momordicae contains the sweetener of a kind of sweeter than sucrose 300 times, but it does not produce heat, so be the desirable replacement beverage of the unsuitable sugar eater such as diabetes, obesity.
Described lubricant is the compositions of any one or they of Pulvis Talci, magnesium stearate, PEG4000 or PEG6000.
The preparation method of the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), first raw material Ganoderma, Fructus Lycii, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and Fructus Momordicae are carried out Feedstock treating respectively, then proportionally adjuvant is added, mix homogeneously, adopt ethanol wet granulation, after adding lubricant, make the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) with tabletting machine;
Described Ganoderma Feedstock treating is cleaned by Ganoderma clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Ganoderma superfine powder, package spare;
Described Fructus Lycii Feedstock treating is cleaned by Fructus Lycii clear water, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Lycii superfine powder, package spare;
Described Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) Feedstock treating is cleaned by Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, package spare;
Described Fructus Momordicae Feedstock treating is cleaned by Fructus Momordicae clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Momordicae superfine powder, package spare.
Described ethanol wet granulation, be various mixing of materials evenly after, add 60 ~ 85%(v/v) ethanol, mix homogeneously, the addition of ethanol is held agglomerating to material have gentle hands, looses one's grip and scatters; Make 20 object granules with screen cloth, then at 60 ~ 80 DEG C, dry moisture content processed is 4 ~ 6%; Be cooled to room temperature, cross 60 mesh sieves.
The pressure producing tablet machine during Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) composite chewable tablet is 2.5 ~ 4MPa
The invention has the beneficial effects as follows:
1., by the chewable tablet that combination four Chinese medicines are made, effectively solve the problem that single herbal medicine efficacy can not work completely.
2. the raw material such as Ganoderma, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), becomes superfine powder by superfine powder apparatus processing, directly uses, and its active ingredient fully can be absorbed by human body, play a role.
3. this chewable tablet have heat-clearing and toxic substances removing, liver protecting and nourishing, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing, defying age, replenishing vital essence to improve eyesight, strengthening bone and muscle, except the effect such as lumbago, life prolonging.
4, the present invention's preferred Ganoderma with health role, Fructus Lycii, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and Fructus Momordicae under guidance of traditional Chinese medicine theory is raw material, scientific compatibility, making in addition, each raw material is cooperatively interacted, learns from other's strong points to offset one's weaknesses, synergism, all medicines share, the deficiency of vital energy can be mended, and blood stasis can fall apart, and wind-phlegm can be dispelled, suppressing the hyperactive liver and subsiding YANG, plays benefiting QI for activating blood circulation, effect of the eliminating phlegm that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., disperse blood stasis and dredge collateral, treating both the principal and secondary aspects of a disease altogether.
5, experimental result confirms that the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is to rat CCl
4chronic hepatic injury has protective effect.The composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) can reduce serum alt, AST is active; Raise TP, ALB; Raise hepatic tissue SOD, GSH-px active, reduce Liver MDA; Improve hepatic tissue pathology change.With strong points, evident in efficacy.
6, the present invention also has functions such as reducing blood sugar concentration, and improve body immunity, effective two-ways regulation human immunity state, internal organs are strong, energetic, the resist the disease factor, prevents harmful levels of pathogens from invading human body.
7, raw material is easy to get, scientific formula, and production technology is advanced, workable, moderate product price, is applicable to suitability for industrialized production.
8, the result of product studies on acute toxicity of the present invention and long term toxicity research shows, uses product of the present invention to be safe the course for the treatment of by plan daily dose.
9, had Fructus Momordicae, no longer needed correctives, and Fructus Momordicae not only sweet taste is high, can also as diabetes or the crowd's food not needing sucrose.
Detailed description of the invention
Embodiment 1
Ganoderma 12 parts; Fructus Lycii 10; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 4 parts; Fructus Momordicae 6 parts; Hydroxypropyl emthylcellulose 30 parts; Maltodextrin 10 parts; Pulvis Talci 1 part.
Its preparation method is following steps:
(1) cleaned by Ganoderma clear water, be cut into 1 ~ 3cm fritter, 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Ganoderma superfine powder, package spare;
(2) cleaned by Fructus Lycii clear water, 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Lycii superfine powder, package spare;
(3) cleaned by Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) clear water, be cut into 1 ~ 3cm fritter, 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, package spare;
(4) cleaned by Fructus Momordicae clear water, be cut into 1 ~ 3cm fritter, 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Momordicae superfine powder, package spare;
(5) Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 60%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 60 DEG C, dry moisture content processed is 6%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 2.5Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Embodiment 2
Ganoderma 10 parts; Fructus Lycii 15; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 5 parts; Fructus Momordicae 8 parts; Hydroxypropyl emthylcellulose 25 parts; Maltodextrin 15 parts; Pulvis Talci 2 parts.
Its preparation method is:
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder and the preparation technology of Fructus Momordicae superfine powder and the identical of embodiment 1.
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, Fructus Momordicae fructoside, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 65%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 70 DEG C, dry moisture content processed is 5.6%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 2.8Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Embodiment 3
Ganoderma 20 parts; Fructus Lycii 10; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 6 parts; Fructus Momordicae 5 parts; Hydroxypropyl emthylcellulose 20 parts; Maltodextrin 15 parts; Magnesium stearate 2 parts.
Its preparation method is:
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder and the preparation technology of Fructus Momordicae superfine powder and the identical of embodiment 1.
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, Fructus Momordicae fructoside, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 70%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 75 DEG C, dry moisture content processed is 5.2%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 3.0Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Embodiment 4
Ganoderma 25 parts; Fructus Lycii 12; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 2 parts; Fructus Momordicae 10 parts; Hydroxypropyl emthylcellulose 24 parts; Maltodextrin 13 parts; Magnesium stearate 2.
Its preparation method is:
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder and the preparation technology of Fructus Momordicae superfine powder and the identical of embodiment 1.
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, Fructus Momordicae fructoside, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 80%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 70 DEG C, dry moisture content processed is 5%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 3.5Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Embodiment 5
Ganoderma 16 parts; Fructus Lycii 14; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 4 parts; Fructus Momordicae 7 parts; Hydroxypropyl emthylcellulose 26 parts; Maltodextrin 12 parts; PEG40002.5 part.
Its preparation method is:
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder and the preparation technology of Fructus Momordicae superfine powder and the identical of embodiment 1.
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, Fructus Momordicae fructoside, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 85%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 80 DEG C, dry moisture content processed is 4%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 4Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Embodiment 6
Ganoderma 22 parts; Fructus Lycii 11; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 3 parts; Fructus Momordicae 8 parts; Hydroxypropyl emthylcellulose 28 parts; Maltodextrin 10 parts; PEG60001.5 part.
Its preparation method is:
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder and the preparation technology of Fructus Momordicae superfine powder and the identical of embodiment 1.
Ganoderma superfine powder, Fructus Lycii superfine powder, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, Fructus Momordicae superfine powder, Fructus Momordicae fructoside, hydroxypropyl emthylcellulose and maltodextrin proportionally put into V-Mixer, after mix homogeneously, add 70%(V/V under stirring) ethanol, hold agglomerating to material have gentle hands, loose one's grip till scattering, make 20 object granules with screen cloth, then at 70 DEG C, dry moisture content processed is 5.2%; Be cooled to room temperature, cross 60 mesh sieves, after even with mix lubricant, with tablet machine at 3.2Mpa lower sheeting, obtain the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
The composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) of above-mentioned 6 embodiments prepared has multiple biological activity, find that there is protect the liver, antiinflammatory, raising body immunity and anti-hepatic fibrosis, the effect of anti-apoptotic.The present invention observes its protective effect to the rat chronic hepatic injury that CCl4 causes, and its mechanism of action of Primary Study.
1 material
1.1 medicines and reagent:
The composite formula of chewable tablets of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae): the present inventor embodiment 1-6(Ganoderma; Fructus Lycii; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae); Fructus Momordicae water extraction, per kilogram adds water 5-8 kilogram and extracts 2 times, concentrated, removes slag into thick paste, called after LHYL); Bifendate drop pill: Beijing consonance pharmaceutical factory, CCl4(analytical pure): Shanghai Changjiang River chemical plant produces; ALT, AST measure test kit: Bioengineering Research Institute is built up in Nanjing; TP, ALB measure test kit: Bioengineering Research Institute is built up in Nanjing, and SOD, MDA measure test kit: Bioengineering Research Institute is built up in Nanjing; GSH-px measures test kit: Bioengineering Research Institute is built up in Nanjing.
1.2 animals:
Cleaning grade Wistar rat, male and female dual-purpose, body weight 200 ± 20g, Guangxi university Experimental Animal Center provides.
2 methods
2.1 animal grouping and process:
Rat is divided into 6 groups at random: the high, medium and low dosage group of Normal group, model control group, positive controls, LHYL.Experimental session is except Normal group, and each group rat presses 3ml/kg (first 5ml/kg) body weight dorsal sc injection 40%CCl4 peanut oil solution, and weekly twice, continuous 8 weeks, cause rat chronic hepatic injury.Weigh weekly twice, and adjust the dosage of medicine and CCl4 successively.Normal group, model control group gavage deionized water; The other gavage LHYL0.8g/kg of the high, medium and low dosage component of LHYL, 0.4g/kg, 0.2g/kg, positive controls gavage 0.1g/kg bifendate drop pill, administration two is 10ml/kg.
2.2 sample receptions:
After last administration 24h, frog board fixes rat, femoral artery sacrificed by exsanguination, and before getting blood, water is can't help in 12h fasting.Separation of serum, cryopreservation; Get the homogenate that same position hepatic tissue makes 10%; Get hepatomegaly leaf 10% formaldehyde to fix.
2.3 Indexs measure:
All detections all detect with U.S. Agilent8543 ultraviolet-uisible spectrophotometer; Detection all illustrates by test kit to be carried out.
2.4 liver histopathology procuratorial work:
Paraffin embedding, section, HE dyes, and light Microscopic observation hepatic tissue pathology changes.Undertaken mark [6,7] by following standard
(-) 1 point: lobules of liver structural integrity, hepatocyte is neat, without exception.
(+) 2 points: hepatocyte limitation degeneration, slight fibrosis, hepatocyte focal necrosis, has a small amount of cell infiltration.
(++) 3 points: the degeneration of hepatocyte diffusivity, necrosis, fibrosis, lobules of liver structural change, hepatocyte limitation is downright bad, has more cell infiltration.
(+++) 4 points: the degeneration of hepatocyte diffusivity, necrosis, fibrosis is heavier, the heavy damage of lobules of liver structure, a large amount of cell infiltration.
2.5 statistical procedures:
Data with
represent, between two groups, mean difference t checks.
3 results
3.1LHYL is on the impact of rat CCl4 chronic hepatic injury serum alt, AST:
CCl4 chronic hepatic injury rat blood serum ALT, AST level obviously raises.The horizontal compared with normal matched group of model control group rat blood serum Serum ALT, AST obviously raises, P<0.01.Compare with model group, the high, medium and low dosage group of positive controls, LHYL four medication groups all significantly can reduce CCl4 chronic hepatic injury rat blood serum ALT, AST level, P<0.01 or P<0.05.The results are shown in Table 1
Table 1LHYL is to rat CCl
4the impact of chronic hepatic injury serum alt, AST
* P<0.05 is compared with model control group; * compares P<0.01 with model control group
3.2LHYL is to rat CCl
4the impact of ALB, TP, A/G in chronic hepatic injury serum:
Compare with Normal group, model control group serum ALB, TP content significantly reduces, and A/G value also significantly reduces, P<0.01.Positive controls serum ALB, TP content, A/G value have remarkable rising effect, P<0.01.Compare LHYL each dosage group with model control group and have obvious rising effect P<0.01 or P<0.05 to ALB, TP content.The results are shown in Table 2
Table 2LHYL is to rat CCl
4in chronic hepatic injury serum ALB, TP, A/G impact (
, n=12)
* P<0.05 is compared with model control group; * compares P<0.01 with model control group
3.3LHYL is to rat CCl
4the impact of chronic hepatic injury liver histopathology:
Model group rats hepatic tissue normal configuration is destroyed, and collagen contents increases, and has obvious fiber every formation, and liver rope arrangement disorder, lobules of liver structure is obviously destroyed.Compare positive controls with model group, LHYL each dosage group pathological tissue has clear improvement, in table 4.
Table 3LHYL is to CCl
4the pathological impact of chronic hepatic injury liver tissues of rats (
, n=10)
* P<0.05 is compared with model group; * compares P<0.01 with model group
4. discuss:
We carry out LHYL to rat CCl
4the experimentation of chronic hepatic injury protective effect, experimental result confirms that LHYL is to rat CCl
4chronic hepatic injury has protective effect.LHYL can reduce serum alt, AST is active; Raise TP, ALB; Raise hepatic tissue SOD, GSH-px active, reduce Liver MDA; Improve hepatic tissue pathology change.Its mechanism may with Ganoderma; Fructus Lycii; Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae); The lipotropism matter that Fructus Momordicae has, peroxidating are relevant, and concrete mechanism needs research further.
Case 1, Wei ××, man, 45 years old, Nanning Enterprise Staff, found abdominal pain in 2013, all day flatulence pain, and the soreness of waist, does not feel like eating, and survey report is (TBIL18.21, TP65.26, ALT192, AST58).Be diagnosed as Type B viral hepatitis, adopt the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) of the embodiment of the present invention 1, every day 3 grams, continuous 30 days, abdominal pain, the symptom of flatulence disappeared substantially, then takes medicine 30 days with consolidate curative effect, can go to work at present.
Case 2, deep ××, female, nineteen fifty-nine is raw, Liuzhou technical school teacher, and in December, 2008 is to hospital outpatient, readme hepatalgia, skin light yellow complexion, is diagnosed as Type B viral hepatitis through inspection (HBV-DNA3.82 × 104, TBIL21.82, AST128).Open the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) of inventive embodiments 3, every sheet 1 gram, three times on the one, hepatalgia transference cure after taking medicine 20 days, face starts to occur ruddy.
The composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) of the present invention can also prevent the health preparation of hyperlipidemia, blood sugar lowering, antioxidation, blood fat reducing as middle age, it takes case history:
Case 3, Liu's ××, birth in 1966, civil servant, in the past due to work busy all the year round, have no time to attend to and take good care of one's health so that fall sick from overwork, immunity degradation, feel physical tiredness, sit down and just do not remember, inefficiency, energy do not pant plentifully, upstairs unable, easy catching a cold, hypomnesis, distraction, face gloomy unglazed, be full of wrinkles, that skin does rough, vexed meaning is dry, and suffers from hyperglycemia, hyperlipidemia, easily rush down again, cold perspiration, a large amount of alopecia, poliosis, endure serious illness puzzlement to the fullest extent, live the painful date.After alleviating a period of time by rest and western medical treatment at that time, the busy old complaint that is not careful in one's diet of work one can recur again, causes other state of an illness sometimes, permanent hospital, have an injection to take medicine and just control table and do not control root, live low quality life, upon somebody's introduction, take the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) of the present invention, every day 3-4 sheet, every sheet 1 gram, after 2 months, skin starts to become smooth high resilience! Not alopecia, the blackening of poliosis part, sleep improvement, memory improves, and original disease disappears automatically, and whole people is full of youthful vigor, produces huge energy in body, and upper 6 floor ladders do not think tired without a break, got back to again 10 in vigorous health several years ago time.
Claims (5)
1. the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), is characterized in that: with Ganoderma, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Fructus Lycii and Fructus Momordicae for main component, adds pharmaceutical grade adjuvant, and adopt ethanol wet granulation, after adding lubricant, tabletting is made;
The parts by weight of raw material are as follows:
Ganoderma 10 ~ 25 parts;
Fructus Lycii 10 ~ 15 parts;
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 2-6 part;
Fructus Momordicae 5 ~ 10 parts;
Hydroxypropyl emthylcellulose 20 ~ 30 parts;
Maltodextrin 5 ~ 15 parts;
Lubricant 1 ~ 3 part.
2. the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) as claimed in claim 1, is characterized in that, described lubricant is the compositions of any one or they of Pulvis Talci, magnesium stearate, PEG4000 or PEG6000.
3. the preparation method of the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) as claimed in claim 1, it is characterized in that, first raw material Ganoderma, Fructus Lycii, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and Fructus Momordicae are carried out Feedstock treating respectively, then proportionally adjuvant is added, mix homogeneously, adopt ethanol wet granulation, after adding lubricant, make the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) with tabletting machine;
Described Ganoderma Feedstock treating is cleaned by Ganoderma clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Ganoderma superfine powder, package spare;
Described Fructus Lycii Feedstock treating is cleaned by Fructus Lycii clear water, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Lycii superfine powder, package spare;
Described Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) Feedstock treating is cleaned by Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) superfine powder, package spare;
Described Fructus Momordicae Feedstock treating is cleaned by Fructus Momordicae clear water, is cut into 1 ~ 3cm fritter, and 100 ~ 120 DEG C of hot-air seasonings, are pulverized with super micron mill to moisture lower than 5%, cross 500 mesh sieves, obtain Fructus Momordicae superfine powder, package spare.
4. the preparation method of the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) according to claim 3, is characterized in that, described ethanol wet granulation, be various mixing of materials evenly after, add the ethanol that volume fraction is 60 ~ 85%, mix homogeneously, the addition of ethanol is held agglomerating to material have gentle hands, looses one's grip and scatters; Make 20 object granules with screen cloth, then at 60 ~ 80 DEG C, dry moisture content processed is 4 ~ 6%; Be cooled to room temperature, cross 60 mesh sieves.
5. the preparation method of the composite chewable tablet of Ganoderma Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) according to claim 3, is characterized in that, the pressure of tabletting machine is 2.5 ~ 4MPa.
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| CN105746817A (en) * | 2016-05-16 | 2016-07-13 | 董珉 | Corydalis saxicola Bunting health tea capable of clearing heat and lowering ministerial fire and preparation method thereof |
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