CN105770579A - Medicinal and edible homologous traditional Chinese medicine composition with liver-protecting effect - Google Patents
Medicinal and edible homologous traditional Chinese medicine composition with liver-protecting effect Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
The invention discloses a medicinal and edible homologous traditional Chinese medicine composition with a liver-protecting effect. The composition is prepared from the following components in parts by weight: 0.4-0.8 part of lotus leaves, 14-18 parts of flaxseeds, 8-12 parts of Chinese wolfberry fruits, 4-8 parts of radix fici simplicissimae, 6-10 parts of red dates, 8-12 parts of fingered citron, 0.2-0.6 part of peppermint, 18-22 parts of Chinese yam, 23-27 parts of oats, 2-3 parts of resistant dextrin and 1-2 parts of fructo-oligosaccharide. The preparation method comprises the steps of drying the raw materials, mixing, grinding into fine powder, and performing superfine grinding to obtain micro-powder. The medicinal materials are combined to achieve the effects of promoting liver tissue rehabilitation, enhancing toxin expelling and reinforcing liver tissue stability, and have a good liver-protecting effect.
Description
Technical field
The present invention relates to integration of edible and medicinal herbs Chinese medicine composition and preparation method thereof, especially, be a kind of Chinese medicine composition grounds travel with liver protection function and preparation method thereof.
Background technology
Liver is the parenchymatous organ that abdominal cavity is maximum, undertake human body important physiological function, not only secretion of bile participates in digestion activity, and the important skill such as nutritious substance metabolism, storage glycogen, removing toxic substances, phagocytosis defence, owing to liver is the most important removing toxic substances organ of human body, all entrance human bodies or in human body metabolism's process produced noxious substance all can aoxidize at liver, reduce, the chemical reaction such as hydrolysis, become nontoxic or that toxicity is less material.The excessive picked-up of ethanol, viral infection, unbalanced dietary habit, pressure and smoking, liver is extremely easily subject to the infringement of harmful substance, causes that the capillary permeability of liver increases, hepatocyte deformation swelling, liver internal hemorrhage, inflammatory cell infiltration, cause liver enlargement, normal function fails, and severe patient even develops into liver cirrhosis, hepatocarcinoma or liver failure.At present, various health product with liver function protecting on market and Chinese medicine preparation, adopt the extracts such as Cordyceps that economic worth is higher, Pollen Pini, Ganoderma, there is high cost and raw material supply is unstable, the shortcoming that output and quality controls difficulty.
Summary of the invention
It is an object of the invention to provide the Chinese medicine composition of the integration of edible and medicinal herbs of a kind of hepatoprotective, this Chinese medicine composition has remarkable result in hepatoprotective.
For achieving the above object, the technical solution used in the present invention is:
The compositions of the integration of edible and medicinal herbs of a kind of hepatoprotective, including the crude drug of following mass parts meter: 0.4～0.8 part of Folium Nelumbinis, Semen Lini 14～18 parts, Fructus Lycii 8～12 parts, Herba Fici Simplicissimae 4～8 parts, Fructus Jujubae 6～10 parts, Fructus Citri Sarcodactylis 8～12 parts, Herba Menthae 0.2～0.6 part, Rhizomadioscoreae 18～22 parts, Herba bromi japonici 23～27 parts, resistant dextrin 2～3 parts, oligofructose 1～2 part.
As preferred scheme, the present invention includes the crude drug of following mass parts meter, 0.6 part of Folium Nelumbinis, Semen Lini 16 parts, Fructus Lycii 10 parts, Herba Fici Simplicissimae 6 parts, Fructus Jujubae 8 parts, Fructus Citri Sarcodactylis 10 parts, Herba Menthae 0.4 part, Rhizomadioscoreae 20 parts, Herba bromi japonici 25 parts, resistant dextrin 3 parts, oligofructose 1 part.
In above formula, Folium Nelumbinis nature and flavor are pained, flat, return liver, spleen, stomach, heart channel.There are the effects such as clearing away summer-heat and eliminating dampness, sending up the lucid YANG, cooling blood for hemostasis.Chinese medicine modern study is it is shown that Folium Nelumbinis has effect for reducing blood fat.Alkaloid in Folium Nelumbinis has effect for reducing blood fat, and is usually used in the treatment of obesity clinically.Having clinical data to report, Folium Nelumbinis has the effect of blood fat reducing, cholesterol reducing, and treatment hyperlipemia, atherosclerosis, coronary heart disease is effective；Containing materials such as a large amount of alpha-linolenic acids that human body is useful, linoleic acid, flax glue, lignans in Semen Lini, to preventing cardiovascular disease, reduce cancer incidence, prevent diabetes and arteriosclerosis, reduction cholesterol, promoting that the aspects such as growth all play an important role.Semen Lini oil therein can be used for treating viral hepatitis, liver cirrhosis disease and in regulating blood fat.Lignan in Semen Lini is used clinically for antitumor, prevents colon cancer, carcinoma of prostate, thymic carcinoma, diabetes, lupus nephritis, atherosclerosis, reduction acute coronary outbreak etc. auxiliary treatment；Fructus Lycii sweet in the mouth is put down, and returns liver, kidney channel, effect nourishing the liver and kidney, replenishing vital essence to improve eyesight.For the sweet flat matter profit of syndrome of yin deficiency of liver and kidney this product, flat invigorating the liver and kidney, having strengthening by means of tonics effect, all cards of all hepatic and renal YIN deficiency all can be applied.Modern study shows that it has and protects the liver function significantly, and hepatic injury is had repair by lycium barbarum polysaccharide, and its mechanism may be by stoping the damage of endoplasmic reticulum, promotes protein synthesis and Detoxication, recovers hepatocellular function, and promote hepatocellular regeneration；Herba Fici Simplicissimae acrid in the mouth, sweet, property is put down, and has effect of invigorating spleen to remove dampness, lung benefiting cough-relieving, channels sootheing and network vessel quickening, for diseases such as insufficiency of the spleen edema, lack of appetite unable, hepatitis, rheumatic arthralgia, pulmonary tuberculosis coughs.Modern study shows, Herba Fici Simplicissimae can make alanine transaminase, aspartate transaminase and the Dehydrogenase Content that cocaine exposed Mice raises be that dosage correlation reduces, hence it is evident that alleviate the pathological change of hepatic tissue, acute liver damage is had protective effect；Fructus Jujubae sweet in the mouth, warm in nature, can invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, be used for treating diseases such as " insufficiency of the spleen weak, anorexia and loose stool, deficiency of qi and blood "；Fructus Citri Sarcodactylis, nature and flavor are pungent, bitter, sweet, warm, nontoxic, are included into liver, spleen, stomach lung meridian.Effect dispersing the stagnated live-QI to relieve the stagnation of QI, regulate the flow of vital energy and in, drying dampness to eliminate phlegm.Can be used for distending pain in the chest and hypochondrium, stomachache due to hyperactive liver-QI attacking the stomach, stagnation of QI in spleen and stomach is demonstrate,proved, chronic cough abundant expectoration, hypochondriac pain uncomfortable in chest.Modern pharmacological research shows that it has significant liver protection function；The Herba Menthae property of medicine is pungent cool, returns lung Liver Channel.Effect dispelling wind and heat pathogens, the clear profit head, sore-throat relieving rash, dispersing the stagnated live-QI to relieve the stagnation of QI, ward off oxious gas.Modern pharmacological research shows that Herba Menthae has hepatoprotective effect, subcutaneous injection Herba Menthae injection, and the serum glutamic pyruvic transminase activity that the hepatic injury that carbon tetrachloride causes causes can be made substantially to reduce；Rhizoma Dioscoreae, the property of medicine is sweet flat, returns spleen lung kidney channel.There is supplementing QI and nourishing YIN, spleen reinforcing lung kidney, effect for the treatment of spontaneous emission and leukorrhagia.Modern study show its can kidney-tonifying health-care, build up resistance, it is possible to play good health care's effect；Not only rich in fat, protein and water soluble dietary fiber in Herba bromi japonici, it is often more important that containing the abundant polyphenol compound that human body is useful in Herba bromi japonici, such as cinnamic acid derivative, P-coumaric acid, P-hydroxybenzoic acid etc..These materials have good non-oxidizability, make Herba bromi japonici have the suppression important physiological function effect such as lipid oxidation, slow down aging；Resistant dextrin can conveniently be taken, and oligofructose is used for improving mouthfeel.All medicines share above, it is possible to reach hepatoprotective, the good effects of preventing liver injury.
The processing of Chinese medicine whole part is taken, and dose is big, takes inconvenience.Treat in prescription Chinese medicine rapid processing dialectical, the application of super-micro wall-broken crushing technology, then can overcome disadvantage mentioned above.It is in the process of pulverizing Chinese medicine decoction pieces, makes the animal and plant cells wall overwhelming majority of the composition prepared slices of Chinese crude drugs crush, and cellular content is overflowed, and effective ingredient all directly can be absorbed with the form of approximate macromole by human body, reduces dose, improves curative effect.Due to " Baily " pulverizing mill solid emulsification in pulverizing so that it is carry out the operations such as emulsifying, dispersion, homogenizing, surface modification in fluidization solid phase.Meanwhile, temperature during pulverizing, the process of simulation decocting herb decoction pieces, it is possible to reduce temperature when pulverizing can be improved, preserve labile element.Also the prepared slices of Chinese crude drugs can be arranged to pulverize order, so as to meet decoction preparation is decocted first after the particular/special requirement such as enter.The superfine fibre in decoction pieces can also be utilized as supporting construction, form granule when being added without any adjuvant.Remain the preparation process of decoction, provide desirable raw material for being processed further the dosage form such as the watered pill, capsule simultaneously.
According to the conventional method of this area, the present composition can be ground to form fine powder and takes.Super-micro wall-broken is pulverized plurality of advantages, it is particularly possible to reduce dose, improves curative effect.Accordingly, as another preferred scheme, the preparation of the present invention is super-micro wall-broken micropowder.
The present invention also provides for the method preparing above-mentioned composition micropowder, including step: (1) weighs Chinese crude drug according to crude drug part by weight, cleans；(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become fine powder, standby；(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder.
Preferably, step (2), pulverizing medicinal materials is crossed 100～150 eye mesh screens and becomes fine powder.
Preferably, step (3), fine powder is carried out superfine grinding and crosses 300 eye mesh screens and become micropowder.
The instructions of taking of micropowder: warm water is taken after mixing it with water, each 20-30g, every day services once sooner or later, within 30th, is a course for the treatment of.Points for attention: greasy and maror of avoiding eating anything raw or cold during taking medicine.
Compositions of the present invention, has effect of hepatoprotective.The activity of superoxide dismutase can be strengthened, improve the vigor of scavenging free radicals, moreover it is possible to anti-oxidizing activities, accelerate the removing of free radical, reduce the generation of lipid peroxidation, thus stabilizing cell membrane structure, alleviate the hepatocellular detrimental effect of radical pair.All medicines use, can play promotion hepatocyte tissue rehabilitation, strengthen mediating of toxin, strengthen hepatic tissue stable, have the effect well protecting liver.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
Formula
0.4 part of Folium Nelumbinis, Semen Lini 18 parts, Fructus Lycii 12 parts, Herba Fici Simplicissimae 4 parts, Fructus Jujubae 6 parts, Fructus Citri Sarcodactylis 8 parts, Herba Menthae 0.6 part, Rhizomadioscoreae 22 parts, Herba bromi japonici 23 parts, resistant dextrin 2 parts, oligofructose 2 parts.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
Embodiment 2
Formula
0.5 part of Folium Nelumbinis, Semen Lini 17 parts, Fructus Lycii 11 parts, Herba Fici Simplicissimae 5 parts, Fructus Jujubae 7 parts, Fructus Citri Sarcodactylis 9 parts, Herba Menthae 0.5 part, Rhizomadioscoreae 21 parts, Herba bromi japonici 24 parts, resistant dextrin 3 parts, oligofructose 1 part.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
Embodiment 3
Formula
0.6 part of Folium Nelumbinis, Semen Lini 16 parts, Fructus Lycii 10 parts, Herba Fici Simplicissimae 6 parts, Fructus Jujubae 8 parts, Fructus Citri Sarcodactylis 10 parts, Herba Menthae 0.4 part, Rhizomadioscoreae 20 parts, Herba bromi japonici 25 parts, resistant dextrin 2 parts, oligofructose 2 parts.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
Embodiment 4
Formula
0.7 part of Folium Nelumbinis, Semen Lini 15 parts, Fructus Lycii 9 parts, Herba Fici Simplicissimae 7 parts, Fructus Jujubae 9 parts, Fructus Citri Sarcodactylis 11 parts, Herba Menthae 0.3 part, Rhizomadioscoreae 19 parts, Herba bromi japonici 26 parts, resistant dextrin 2 parts, oligofructose 2 parts.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
Embodiment 5
Formula
0.8 part of Folium Nelumbinis, Semen Lini 14 parts, Fructus Lycii 8 parts, Herba Fici Simplicissimae 8 parts, Fructus Jujubae 10 parts, Fructus Citri Sarcodactylis 12 parts, Herba Menthae 0.2 part, Rhizomadioscoreae 18 parts, Herba bromi japonici 27 parts, resistant dextrin 3 parts, oligofructose 1 part.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
Embodiment 6
Formula
0.6 part of Folium Nelumbinis, Semen Lini 16 parts, Fructus Lycii 10 parts, Herba Fici Simplicissimae 6 parts, Fructus Jujubae 8 parts, Fructus Citri Sarcodactylis 10 parts, Herba Menthae 0.4 part, Rhizomadioscoreae 20 parts, Herba bromi japonici 25 parts, resistant dextrin 3 parts, oligofructose 1 part.
Preparation method
(1) weigh Chinese crude drug according to crude drug part by weight, clean.(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become 100～150 order fine powders, standby.(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder and cross 300 orders and get final product.
For proving the effect of present invention Chinese medicine composition recklessly, carry out tests below:
1, medicine:
Mix medical material in the ratio of embodiment 3-6 weight portion respectively, add the water boiling and extraction twice of 10 times amount, merge Aqueous extracts, concentration, dry, pulverize, respectively extract dry extract (be designated as respectively BGF-3, BGF-4, BGF-5, BGF-6).
2, test method:
Select healthy Kunming mouse 60, male and female half and half, body weight 18～22g, be randomly divided into 6 groups, be negative control group, blank group, experimental group 1～4 respectively；Being made into 0.1% carbon tetrachloride solution with Oleum Arachidis hypogaeae semen, experimental group 1～4 gives the medicine described in embodiment 1～4 by 0.6g/kg gavage respectively；Negative control group and blank group gavage give 20mL/kg normal saline, and once a day, continuous 7 days, 1h after last administration, except giving the 0.1%CCl of 20mL/kg to all the other equal gavages of each group except blank group4Oleum Arachidis hypogaeae semen, after gavage, water is can't help in the equal fasting of each treated animal, 16h with after through venous blood sampling, separate serum, measure glutamate pyruvate transaminase (ALT) in serum, glutamic oxaloacetic transaminase, GOT (AST), Serum MDA (MDA) content.
After taking blood, mice is put to death with cervical dislocation, solution takes its complete liver, is placed in 4% formalin, murine liver tissue is fixed, after dehydration, do paraffin section, HE (Hematoxylin-eosin) dye, with observation by light microscope and record hepatocyte deformation, necrosis, the Pathological morphologic change such as inflammatory reaction situation.
3, result of the test
3.1 each treated animal glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), Serum MDA (MDA) assay result is in Table 1:
Table 1
Note: compare with negative control group, * P < 0.05, * * P < 0.01.
3.2 level of fibrosis observed results
Blank group murine liver tissue clear in structure.Negative control group mouse liver cell obvious tumefaction deforms, hepatocyte arrangement disorder, visible point-like hepatic necrosis in lobule, and erythrocyte boundary is unclear, has balloon sample to attenuate born of the same parents, and a large amount of inflammatory cell infiltration occurs.Experimental group 1～4 mouse liver cell degeneration, downright bad, inflammatory reaction substantially alleviates, and hepatocyte arrangement is relatively regular.Wherein, experimental group 4 mouse liver cell swelling and degeneration, downright bad and inflammatory reaction improves best results.
Claims (6)
1. the Chinese medicine composition of an integration of edible and medicinal herbs with liver protection function, it is characterised in that: the crude drug including following mass parts meter is made: 0.4～0.8 part of Folium Nelumbinis, Semen Lini 14～18 parts, Fructus Lycii 8～12 parts, Herba Fici Simplicissimae 4～8 parts, Fructus Jujubae 6～10 parts, Fructus Citri Sarcodactylis 8～12 parts, Herba Menthae 0.2～0.6 part, Rhizomadioscoreae 18～22 parts, Herba bromi japonici 23～27 parts, resistant dextrin 2～3 parts, oligofructose 1～2 part.
2. the Chinese medicine composition of the integration of edible and medicinal herbs with liver protection function according to claim 1, it is characterised in that: mainly it is made up of the raw material of following mass parts: 0.6 part of Folium Nelumbinis, Semen Lini 16 parts, Fructus Lycii 10 parts, Herba Fici Simplicissimae 6 parts, Fructus Jujubae 8 parts, Fructus Citri Sarcodactylis 10 parts, Herba Menthae 0.4 part, Rhizomadioscoreae 20 parts, Herba bromi japonici 25 parts, resistant dextrin 3 parts, oligofructose 1 part.
3. the compositions with liver protection function according to claim 1 and 2, it is characterised in that: described compositions is wall-broken micro powder.
4. the preparation method preparing compositions as claimed in claim 3, it is characterised in that include step:
(1) weigh Chinese crude drug according to crude drug part by weight, clean；
(2) respectively medicinal material drying to moisture is about 6%, mixing, pulverizing medicinal materials is become fine powder, standby.
(3) fine medicinal material powder is added in material bin, use " Baily " pulverizing mill to carry out super-micro wall-broken pulverizing, collect super-micro wall-broken micropowder.
5. method according to claim 4, it is characterised in that: step (2), pulverizing medicinal materials is crossed 100～150 eye mesh screens and becomes fine powder.
6. method according to claim 4, it is characterised in that: step (3), fine powder is carried out superfine grinding and crosses 300 eye mesh screens and become micropowder.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107692217A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with anti-alcohol function and preparation method thereof |
| CN107692199A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with Soboring-up liver-protecting function and preparation method thereof |
| CN107692218A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with liver-protecting function and preparation method thereof |
Citations (3)
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| US20060045929A1 (en) * | 2004-09-01 | 2006-03-02 | Lee Haeng W | Functional food composition having effects of relieving alcohol-induced hangover symptoms and improving liver function |
| CN103734710A (en) * | 2013-11-26 | 2014-04-23 | 威海纽麦斯保健品有限责任公司 | Functional food able to supplement qi and blood and preparation method thereof |
| CN104398694A (en) * | 2014-11-28 | 2015-03-11 | 桂林市和胤祥新型材料有限公司 | Traditional Chinese medicine composition with effect of protecting liver |
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| US20060045929A1 (en) * | 2004-09-01 | 2006-03-02 | Lee Haeng W | Functional food composition having effects of relieving alcohol-induced hangover symptoms and improving liver function |
| CN103734710A (en) * | 2013-11-26 | 2014-04-23 | 威海纽麦斯保健品有限责任公司 | Functional food able to supplement qi and blood and preparation method thereof |
| CN104398694A (en) * | 2014-11-28 | 2015-03-11 | 桂林市和胤祥新型材料有限公司 | Traditional Chinese medicine composition with effect of protecting liver |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107692217A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with anti-alcohol function and preparation method thereof |
| CN107692199A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with Soboring-up liver-protecting function and preparation method thereof |
| CN107692218A (en) * | 2017-09-14 | 2018-02-16 | 柳州衍生科技有限公司 | A kind of health care broken wall Ultramicro-powder with liver-protecting function and preparation method thereof |
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