CN104083727A - Traditional Chinese medicine composition for nourishing and protecting liver - Google Patents
Traditional Chinese medicine composition for nourishing and protecting liver Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for nourishing and protecting the liver. Pharmaceutically acceptable auxiliary materials or auxiliary components are added into the following components in parts by weight, i.e., 10 to 30 parts of kudzuvine root, 10 to 30 parts of salvia miltiorrhiza, 5 to 20 parts of lucid ganoderma, 5 to 20 parts of rhizoma curcumae longae and 5 to 15 parts of tea leaves, so as to be prepared into a clinically acceptable conventional oral preparation specified in the pharmaceutics according to a conventional medicine preparation method. The preparation can be of tablets, tea bags, granules, capsules, pills and oral liquids. The prepared traditional Chinese medicine composition is simple in formula and has the characteristics of being convenient to take and capable of enhancing body immunity and protecting the liver. According to the composition, the functions of enhancing the body immunity and protecting the liver are realized at the same time, thereby providing an ideal medicine or health-care product for people with liver injury and in sub-health. The traditional Chinese medicine composition is stable in preparation process, controllable in quality, good in repeatability and suitable for large-scale production.
Description
Technical field
the present invention relates to a kind of nourishing the liver hepatoprotective Chinese medicine composition that can be raw material for the Chinese herbal medicine of health food.
Background technology
liver is maximum, most important digestion body of gland in digestion, has important digestive function, is main metabolic organ and the defence organ of human body, and it implements its powerful defence function of detoxification to the external many harmful factors with metabolism generation of human body.Generally, liver has very strong biotransformation, function of detoxification to chemical toxicant.But modern society, due to environmental pollution (air, water, food), Drug abuse, the edible residual food that exceeds standard of agriculture, the factors such as bad alcohol drinking patterns have all increased the weight of digestion, metabolism, the detoxification ability of liver in human body, the defence function of detoxification of liver itself is reduced, and then cause chemical liver injury in various degree.Once liver damage will bring disaster to the other organs of human body in various degree.
theory of Chinese medical science is thought, liver controlling conveyance and dispersion, and property happiness bar reaches, taking blood as body, taking gas as use, if mechanism of qi discord, pent-up perverse and unreasonable manner, liver intrinsic heat, stagnation of liver-QI does not reach, and all easily fire-transformation, causes hepatopathy.Many chemical substances all can cause the infringement of hepatic parenchymal cells as industrial poison metal and compound thereof, carbon tetrachloride, chloroform, alcohol, ether, aldehyde, ketone, fat etc., and drink for a long time most of poisonous substances are had to potentiation." General Treatise on the Cause and Symptoms of Diseases is disliked wine and waited " said: " wine person, foodstuff essence also.Its gas boomerang is brave and very toxic, enters flatulence due to immoderate drinking QI rising in reverse order of stomach, and superinverse, in intrathoracic, smoked in liver and gall and caused a disease." recent studies proves, drinks in a large number or for a long time, really can cause inflammatory reaction in liver, hepatocellular degeneration, fatty infiltration, hepatic necrosis, hepatic fibrosis, even develop into liver cirrhosis, and there is jaundice in severe one, and even liver failure.Therefore the traditional Chinese medical science is focused on the aspect such as promoting digestion and invigorating the stomach, promoting diuresis to eliminate damp pathogen, activating blood circulation to dissipate blood stasis, removing liver heat and toxic substances, tonifying liver and strong liver to chemical liver injury and is started with.
in recent years, along with the fast development of work, agricultural, the grower of the food such as vegetable and fruit uses excessive fertilizer and pesticide in the process of plantation, pesticide residues cause toxicant constantly to be accumulated in human body, data shows, numerous disease has direct relation as liver cirrhosis, hepatocarcinoma etc. all enter health with the harmful substance such as pesticide residue.Under this large environmental background; add that people's dietary structure is unreasonable, rhythm of life is accelerated day by day, operating pressure is excessive, it is irregular to drink, live; do not focus on again self-protection; make most of crowd in sub-health state, the also increasing year by year of other chronic diseases that causes hepatic disease and hepatic injury to cause.Therefore, people, for preventing and therapeutical chemistry liver damage, improve body immunity, and the Chinese herb medicine health preserving having no side effect conditioning has very large demand.
chinese medicine has the feature of many target spots, too many levels comprehensive function, is having the advantage of self aspect therapeutical chemistry liver damage.This product is the Chinese medicine composition that chemical liver injury is had to assistant protection function that has by traditional Chinese medicine theory development.We have screened and have been widely used, used Radix Puerariae, Radix Salviae Miltiorrhizae, Ganoderma, the Rhizoma Curcumae Longae of safety, definite functions, have given full play to the synergism between each taste medicine.In side taking Radix Puerariae as primary raw material; and be aided with Radix Salviae Miltiorrhizae; assistant is with Ganoderma, Rhizoma Curcumae Longae; make this product pass through Multiple components combined effect; the effect of number of ways performance protection hepatic injury, effect is remarkable, but also can reduce by the effect of opposing free radical the increasing and the decline of stem cell DNA synthesis rate of NO content of hepatic tissue; thereby protection biomembrane avoids oxidative damage, further protects hepatic tissue.
at present, the medicine separately with blood fat reducing or therapeutical chemistry liver damage has a lot, but the medicine of the hepatoprotective of nourishing the liver is simultaneously little, and existing product more or less all exists following these problems: obvious effective rate is not high, and effect is unstable, and side effect is obvious etc.And as the medicine that needs long-term taking, effect, cost and side effect are the key factors that must consider.Wherein the Chinese medicine of the hepatoprotective of blood fat reducing is simultaneously all often large prescription, and complicated component, causes preparation technology also very complicated, as patent
the lowering fat to dredge vessels Chinese medicine of the middle treatment hyperlipidemia described in 200510012457.5 is by taking Fructus Crataegi, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Radix Polygoni Multiflori, Semen Cassiae, Radix Puerariae as medicine with sovereign right, is aided with Rhizoma Alismatis, Ganoderma, Rhizoma dioscoreae (parched), Rhizoma Chuanxiong, Radix Astragali composition.And for example the tune fat the liver benefiting medicine of CN200610048166.6 treatment fatty liver is taking prepared slices of Chinese crude drugs Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Fructus Crataegi, Herba Artemisiae Scopariae, Semen Cassiae, Rhizoma Curcumae Longae, processs Carapax Et Plastrum Testudinis as medicine with sovereign right; Be aided with radix curcumae, Ganoderma, Radix Polygoni Multiflori, Radix Puerariae, the Radix Paeoniae Alba, Rhizoma Polygonati composition.This based composition is claimed and can be improved respectively the symptom such as hyperlipidemia and fatty liver, act on relatively single-minded, simultaneously, the composition that these Chinese medicines contain nourishing toward contact, and these are all will absorb through liver to have an effect, these too much compositions tend to increase the weight of the burden of liver, are unfavorable on the contrary the recovery of liver function.
Summary of the invention
in order to overcome the above-mentioned deficiency of prior art, the invention provides a kind of component simple, active component is clear and definite, good stability, the Chinese medicine composition of quality controllable protecting and nourishing liver blood fat reducing.
for this reason, adopt following technical scheme:
a kind of nourishing the liver hepatoprotective Chinese medicine composition, by 10～30 parts of the component Radix Puerariaes of weight portion, 10～30 parts of Radix Salviae Miltiorrhizaes, 5～20 parts of Ganodermas, 5～20 parts, Rhizoma Curcumae Longae, 5～15 parts of Folium Camelliae sinensis, according to conventional pharmaceutical methods, add pharmaceutically acceptable adjuvant or complementary composition, make clinically said conventional oral preparations in acceptable, pharmaceutics.
further, preferred weight part of a kind of nourishing the liver hepatoprotective Chinese medicine composition formula is: 25 parts of Radix Puerariaes, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts of Ganodermas, 10 parts, Rhizoma Curcumae Longae, 8 parts of Folium Camelliae sinensis.
described Folium Camelliae sinensis is green tea.
described conventional oral preparations is tablet, teabag, granule, capsule, pill or oral liquid.
the present invention has hepatoprotective, effect of liver-smoothing, qi-regulating, heat-clearing and toxic substances removing, and A distinction should be made between what is primary and what is secondary in side, Each performs its own functions; Wherein, in crude drug of the present invention, monarch drug Radix Puerariae can improve hepatocellular regeneration capacity, recovers normal liver function, and ministerial drug Radix Salviae Miltiorrhizae improves microcirculation, blood fat reducing, prevents and treats atherosclerosis, liver is had to protective effect.Ganoderma the liver protecting, alleviates hepatic injury, promotes liver cell regeneration, strengthens hepatocellular function of detoxification.Assistant enters Liver Channel blood system with Rhizoma Curcumae Longae, the removing blood stasis treating blood disorders of holding concurrently, and the hepatic injury that exogenous poisonous substance causes has good protective effect.Make medicine green tea can alleviate hepatocellular degeneration, reduce serum transaminase vigor, improve glycogen and DNA content in hepatocyte, promote liver cell regeneration.
(cool in nature, sweet in the mouth, pungent, enters spleen, stomach warp to Radix Puerariae, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.This medicine begins to be loaded in Shennong's Herbal, is one of conventional Chinese medicine." medicine justice ": " Radix Puerariae because of its nature and flavor sweet cool, can inspire gastric qi, control asthenia gastropyrexia thirsty, alcoholism vomiting, stagnated fire in stomach "." property of medicine opinion ": " controlling the upper gas of day row, vomiting, whetting the appetite, principal solution alcoholism ".Modern medicine and pharmacology research shows: Radix Puerariae contains the important biomolecule active substances useful to human body such as abundant puerarin, this glucosides of puerarin, soybean isoflavone, daidzein, aminoacid, trace element, triterpene substance alkali.Can improve hepatocellular regeneration capacity, recover normal liver function, promote bile secretion, prevent that fat from piling up at liver.Enhance metabolism, strengthen liver detoxification function, prevent the damage of ethanol to liver.Strengthening liver and gall cell autoimmune function, opposing poisoning intrusion.There is nourishing the human Body, slow down aging, improve osteoporosis, regulate estrogen level, remove rubbish in body, and improve the plurality of health care functions such as circulation, blood fat reducing, adjusting blood pressure.
radix Salviae Miltiorrhizae: property mildly bitter flavor, be slightly cold, enter the heart, Liver Channel; There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clearing away heat and cooling blood, the effects such as relieving restlessness clear away heart-fire.Begin to be loaded in Shennong's Herbal, classify as top grade, claim its " main trusted subordinate's pathogen, broken loose except abdominal mass, only stuffy sensation with restlessness." modern study shows: Radix Salviae Miltiorrhizae has the microcirculation of improvement, blood fat reducing, prevents and treats atherosclerosis, myocardial cell and liver is had to the pharmacological actions such as protective effect, anti-gastric-ulcer, enhancing immunity.Can play hepatocellular degeneration when suppressing and alleviating acute and chronic liver injury, necrosis and inflammatory reaction, accelerating fibers is organized heavily and is absorbed, and has anti-hepatic fibrosis, improves the effect that liver blood circulates, prevents liver cirrhosis.Radix Salviae Miltiorrhizae has effect of blood circulation promoting and blood stasis dispelling nourishing blood to tranquillize the mind.Recent study discovery, Radix Salviae Miltiorrhizae can improve microcirculation in liver, reduces blood viscosity, reduces hepatic portal vein pressure, regulates immunologic function, promotion liver cell regeneration, anti-hepatic fibrosis liver fibrolysis and antineoplastic action that getting up early is formed.
ganoderma property is sweet, flat, GUIXIN, lung, liver, kidney channel.Having effect of strengthening the body resistance, strengthening by means of tonics, invigorating QI and tranquilization, is the treasure in motherland's pools of traditional Chinese medicine, have the reputation of " Herba mesonae chinensis ".Ganoderma has multiple hereditary active substance, contains triterpenes, Ganodenic acid, polysaccharide, ucleosides, enzyme, aminoacid, glycopeptide class, vitamins, carotene, sterols, alkaloids, fatty acid, lactone and inorganic ions class etc.Modern pharmacology through scientific research institution many decades studies confirm that, Ganoderma, for strengthening body immunity, regulates blood glucose, controls blood pressure, auxiliary tumor chemoradiotherapy, and hepatoprotective, the aspects such as hypnotic all have significant curative effect.The hepatic injury that Ganoderma causes multiple physics and chemistry and biological factor has protective effect.No matter before liver injury occurs or after occurring, taking Ganoderma all can the liver protecting, alleviates hepatic injury, and promotion liver cell regeneration, strengthens hepatocellular function of detoxification.Ganoderma can promote the metabolism of liver to medicine, poisonous substance, has definite curative effect for toxic hepatitis.Especially chronic hepatitis, Ganoderma can obviously be eliminated the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and can effectively improve liver function, makes indices be tending towards normal.
rhizoma Curcumae Longae: nature and flavor acrid, bitter, warm.Return spleen, Liver Channel.There is effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Partially enter Liver Channel blood system, the removing blood stasis stagnation of QI in treating blood disorders of holding concurrently.The blood stasis of kind broken liver spleen two warps is depressed.From ancient times as drug for invigorating blood circulation and eliminating stasis, can be used for the disease that treatment is relevant to stomachache, jaundice etc. in China." Newly Revised Canon of Materia Medica " said: " main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, and removing blood stasis, except wind heat, subduing inflammation." modern study shows Rhizoma Curcumae Longae extract, curcumin, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., has choleretic effect, generation and the secretion of bile can be increased, and gallbladder contraction can be promoted.Pharmacological research confirms that Rhizoma Curcumae Longae and main effective ingredient curcumin thereof have the multiple pharmacologically actives such as antitumor, antioxidation, atherosclerosis, the liver protecting, slow down aging; Rhizoma Curcumae Longae is widely used in clinical liver disease at present; the hepatic injury that exogenous poisonous substance causes has good protective effect, is a kind of very promising anti-liver injury medicament.
green tea: claim again azymic tea.Green tea is the tea of making without fermentation, therefore more reservation the natural materials of fresh leaf, the tea polyphenols containing, catechin, chlorophyll, caffeine, aminoacid, vitamins and other nutritious components is also more.These natural nutrition compositions in green tea, have special-effect to anti-aging, anti-cancer, anticancer, sterilization, antiinflammatory etc.Can alleviate hepatocellular degeneration and degree of necrosis, reduce serum transaminase vigor, improve glycogen and DNA content in hepatocyte, promote liver cell regeneration, hepatitis virus is had to inhibitory action.
the present invention is by traditional Chinese medical science compatibility theory; with reference to modern medicines achievement in research; screen through long-felt that the prescription that draws is simple, a kind of nourishing the liver hepatoprotective Chinese medicine composition of instant effect, all there is the definite efficacy effect that chemical liver injury is had to protection through modern medicine and pharmacological research proof.Each amounts of components all has good curative effect and without any side effects in described weight range.Above-mentioned all medicine combineds effect, have and have clearly benefit, take through long-term low dose, can improve liver microcirculation, promote the metabolism of liver to ethanol, medicine, poisonous substance, eliminate the symptoms such as the dizziness of overtime work person for staying up, weak, nauseating, uncomfortable liver area.
efficacy test of the present invention, toxicologic study and observation on Clinical Application
1 pair of chemical liver injury assistant protection function test.
1.1 test method
successfully setting up on the basis of alcoholic hepatic injury animal test model; respectively with 360,720, the compositions of the present invention of 1440mg/kg BW (being equivalent to 5,10,20 times of human body recommended amounts) dosage is to the continuous gavage of mice 30 days; in liver malonaldehyde (MDA) in the hepatic tissue of mice, three indexs of reduced glutathion (GSH) and triglyceride (TG), any two positives were both compared remarkable reduction in model control group, can judge that medicine of the present invention has alcoholic hepatic injury is had to auxiliary protection function.
1.2 result of the test
per os gives the mice various dose present composition 30 days, compared with alcoholic hepatic injury model control group, and the content (P ﹤ 0.05) of medicine of the present invention malonaldehyde in middle dosage group can reduce hepatic tissue; Triglyceride content (P ﹤ 0.05) in the content of malonaldehyde in high dose group can reduce hepatic tissue (P ﹤ 0.05), hepatic tissue.Experiment shows: this pharmaceutical composition can obviously alleviate liver tissues of rats steatosis degree, and body weight is had no significant effect.As can be seen here, the present composition has has assistant protection function effect to alcoholic liver injury.
2. toxicologic study
2.1 acute toxicity test conclusions: have no overt toxicity reaction.Odd-numbered day administration, is equivalent to recommend clinical application amount to amount to 150 times of crude drug amounts.
2.2 long term toxicity test conclusions: rat gives the present composition by high, medium and low dosage gavage, successive administration 3 months.According to rat body weight growth pattern, consumption appetite, hematology, blood biochemical, system postmortem, organ coefficient and histopathological examination interpretation of result, have no obvious toxic-side effects.Showing the present composition, is safe recommending use under clinical dosage.
3. observation on Clinical Application
using present composition auxiliary treatment is alcoholic liver patient 46 examples after diagnosing, completes treatment in 2 months and follows up a case by regular visits to after January by research approach, and patient dependence is good.Observation item comprises: clinical symptoms before and after treatment: pain in the hepatic region, weak, abdominal distention, poor appetite, dyspepsia; Sign: hepatosplenomegaly is little.Liver function (ALT, γ-GT) before and after treatment, blood fat (TG, TC), A/G ratio; Before and after the super contrast therapy of B, hepatosplenomegaly is little.Curative effect determinate standard is effective: clinical symptom disappearance, and liver function, blood fat and B are super often to be checked again; Effective: clinical symptoms is clearly better, the super inspection of liver function, blood fat and B recovered the more than 50% of initial value; Invalid: to fail to reach above-mentioned standard.
Observed result shows: partner treatment can obviously improve patient's clinical symptoms in 2 months, and γ-GT, ALT, TG, A/G, TC total effective rate are respectively 88%, 94%, 92%, 88%, 88%.The present composition can effectively improve alcohol fatty hepatopath's clinical symptoms and liver function, can reduce blood fat, in clinical observation process, safety is better, do not find associated untoward reaction, routine blood test, routine urinalysis, stool routine examination, renal function and electrocardiogram to patient all have no adverse effects.
specific implementation method:
Embodiment 1
A kind of nourishing the liver hepatoprotective Chinese medicine composition, its component by following weight portion is made: 30 parts of Radix Puerariaes, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Ganodermas, 5 parts, Rhizoma Curcumae Longae, 10 parts of Folium Camelliae sinensis.
Embodiment 2
A kind of nourishing the liver hepatoprotective Chinese medicine composition, its component by following weight portion is made: 20 parts of Radix Puerariaes, 25 parts of Radix Salviae Miltiorrhizaes, 5 parts of Ganodermas, 20 parts, Rhizoma Curcumae Longae, 5 parts of Folium Camelliae sinensis.
Embodiment 3
A kind of nourishing the liver hepatoprotective Chinese medicine composition, its component by following weight portion is made: 10 parts of Radix Puerariaes, 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Ganodermas, 10 parts, Rhizoma Curcumae Longae, 15 parts of Folium Camelliae sinensis.
Embodiment 4
A kind of nourishing the liver hepatoprotective Chinese medicine composition, its component by following weight portion is made: 25 parts of Radix Puerariaes, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts of Ganodermas, 10 parts, Rhizoma Curcumae Longae, 8 parts of Folium Camelliae sinensis.
Preparation method of the present invention
Granule preparation: by after selected component medical material cleaning, use microwave auxiliary extraction technology to be extracted as extractum shape, add appropriate pharmaceutical excipient and mix, make every gram of product and be equivalent to the granule of 1 gram of primary crude drug and get final product.
Capsule preparation: by after selected component medical material cleaning, use the conventional extractive technique of Chinese medicine to be extracted as extractum shape, then use the dry or hypobaric drying method of spraying to be dried, to pulverize; Add appropriate pharmaceutical excipient and mix, make the microgranule that every gram of product is equivalent to primary crude drug 1g, filling is in edible capsule and get final product.
Tablet preparation: by after selected component medical material cleaning, use ultrasonic assisted Extraction Technology to be extracted as extractum shape, then use the dry or hypobaric drying method of spraying to be dried, to pulverize; Add appropriate pharmaceutical excipient and mix, make the granular that every gram of product is equivalent to primary crude drug 1g, be pressed into the tablet of predetermined weight and get final product.
Oral liquid preparation: by after selected component medical material cleaning, use biological enzymolysis technology to be extracted as every milliliter of medicinal liquid that is equivalent to primary crude drug 1g, prepare manufacturing technique requirent by oral liquid and carry out subpackage and get final product.
Teabag preparation: by after selected component medical material cleaning, use the conventional extractive technique of modern Chinese medicine to be extracted as extractum shape, then use the dry or hypobaric drying method of spraying to be dried, to pulverize; Ovendry power is broken into coarse powder, then mixs homogeneously with extract powder, packs among tea pouch and get final product.
The production technology of above-mentioned preparation method and various application forms all belongs to existing known technology.
Claims (4)
1. a nourishing the liver hepatoprotective Chinese medicine composition, it is characterized in that: by 10～30 parts of the component Radix Puerariaes of weight portion, 10～30 parts of Radix Salviae Miltiorrhizaes, 5～20 parts of Ganodermas, 5～20 parts, Rhizoma Curcumae Longae, 5～15 parts of Folium Camelliae sinensis, according to conventional pharmaceutical methods, add pharmaceutically acceptable adjuvant or complementary composition, make clinically said conventional oral preparations in acceptable, pharmaceutics.
2. according to a kind of nourishing the liver hepatoprotective Chinese medicine composition described in claim 1, it is characterized in that: by 25 parts of the component Radix Puerariaes of weight portion, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts of Ganodermas, 10 parts, Rhizoma Curcumae Longae, 8 parts of Folium Camelliae sinensis, according to conventional pharmaceutical methods, add pharmaceutically acceptable adjuvant or complementary composition, make clinically said conventional oral preparations in acceptable, pharmaceutics.
3. according to a kind of nourishing the liver hepatoprotective Chinese medicine composition described in claim 1 or 2, it is characterized in that: described Folium Camelliae sinensis is green tea.
4. according to a kind of nourishing the liver hepatoprotective Chinese medicine composition described in claim 1 or 2, it is characterized in that: described conventional oral preparations is tablet, teabag, granule, capsule, pill or oral liquid.
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| CN104667195A (en) * | 2015-03-26 | 2015-06-03 | 江苏康缘药业股份有限公司 | Composition for protecting liver, preparation method thereof and traditional Chinese medicine preparation |
| CN104824639A (en) * | 2015-04-14 | 2015-08-12 | 贵阳德昌祥药业有限公司 | Liver protection health food and preparation method thereof |
| CN105053323A (en) * | 2015-07-16 | 2015-11-18 | 陆开云 | Traditional Chinese medicine health preserving tea |
| CN106666703A (en) * | 2016-07-11 | 2017-05-17 | 佛山市朗达信息科技有限公司 | Enzyme composition with liver-protecting function, as well as preparation and preparation method thereof |
| CN107468825A (en) * | 2017-08-25 | 2017-12-15 | 广州百翠原绿色农产品发展有限公司 | A kind of Chinese medicine composition of ganoderma lucidum protecting and nourishing liver and preparation method thereof |
| CN107536999A (en) * | 2017-09-08 | 2018-01-05 | 德兴市宋氏葛业有限公司 | A kind of root of kudzu vine Chinese medicine preparation and preparation method thereof |
| CN109512862A (en) * | 2018-12-11 | 2019-03-26 | 江苏康缘药业股份有限公司 | A kind of composition for protect liver and preparation method thereof and quality research |
| CN111493318A (en) * | 2020-04-26 | 2020-08-07 | 众生健康(广东)科技有限公司 | A composition containing curcumin for relieving hangover and protecting liver, and its preparation method |
| CN113318215A (en) * | 2021-06-16 | 2021-08-31 | 杨茂鑫 | Composition for improving hepatitis B, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104667195A (en) * | 2015-03-26 | 2015-06-03 | 江苏康缘药业股份有限公司 | Composition for protecting liver, preparation method thereof and traditional Chinese medicine preparation |
| CN104824639A (en) * | 2015-04-14 | 2015-08-12 | 贵阳德昌祥药业有限公司 | Liver protection health food and preparation method thereof |
| CN105053323A (en) * | 2015-07-16 | 2015-11-18 | 陆开云 | Traditional Chinese medicine health preserving tea |
| CN106666703A (en) * | 2016-07-11 | 2017-05-17 | 佛山市朗达信息科技有限公司 | Enzyme composition with liver-protecting function, as well as preparation and preparation method thereof |
| CN107468825A (en) * | 2017-08-25 | 2017-12-15 | 广州百翠原绿色农产品发展有限公司 | A kind of Chinese medicine composition of ganoderma lucidum protecting and nourishing liver and preparation method thereof |
| CN107536999A (en) * | 2017-09-08 | 2018-01-05 | 德兴市宋氏葛业有限公司 | A kind of root of kudzu vine Chinese medicine preparation and preparation method thereof |
| CN109512862A (en) * | 2018-12-11 | 2019-03-26 | 江苏康缘药业股份有限公司 | A kind of composition for protect liver and preparation method thereof and quality research |
| CN109512862B (en) * | 2018-12-11 | 2021-07-27 | 江苏康缘药业股份有限公司 | Composition for protecting liver and preparation method and quality research thereof |
| CN111493318A (en) * | 2020-04-26 | 2020-08-07 | 众生健康(广东)科技有限公司 | A composition containing curcumin for relieving hangover and protecting liver, and its preparation method |
| CN113318215A (en) * | 2021-06-16 | 2021-08-31 | 杨茂鑫 | Composition for improving hepatitis B, preparation method and application thereof |
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Application publication date: 20141008 |
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