CN104127826A - Traditional Chinese medicine composition for treating chronic alcoholic liver disease - Google Patents
Traditional Chinese medicine composition for treating chronic alcoholic liver disease Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a chronic alcoholic liver disease and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the raw materials of white paeony root, rhizoma corydalis, hawthorn, rourstamen stephania root, tangerine peel, capillary artemisia, ligusticum wallichii, curcuma zedoaria, angelica sinensis, honeysuckle stem, flos sophorae, lotus aeedpod, tribulus terrestris, ligustrum lucidum, bupleurum, poria cocos, scutellaria baicalensis, cassia twig, jujube and glycyrrhiza. The traditional Chinese medicine composition has a very good therapeutic effect in the aspect of treating the chronic alcoholic liver disease and has remarkable clinic popularization value.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition and application thereof for the treatment of chronic alcoholism hepatopathy.
Background technology
Alcoholic liver disease (Alcoholic Hepatitis) is the hepatic disease causing due to long-term heavy drinking.Initial stage is usually expressed as fatty liver, and then can develop into alcoholic hepatitis, hepatic fibrosis and liver cirrhosis.Its main clinical characteristics is to feel sick, vomiting, jaundice, can have liver enlargement and tenderness.And can concurrent liver failure and upper gastrointestinal hemorrhage etc.During serious excessive drinking, can bring out extensive hepatic necrosis, even liver failure.Alcoholic liver disease is one of common hepatic disease of China, serious harm people ' s health.The ratio that alcoholic liver disease accounts for the hepatopathy inpatient same period is in recent years in continuous rising.
The Drug therapy of alcoholic liver disease has:
(1) glucocorticoid can improve serious symptom alcoholic hepatitis.
(2) metadoxine can be removed by acceleration of alcohol from serum, contributes to improve alcoholism symptom and dystropy.
(3) S mono-ademetionine treatment can improve clinical symptoms and the biochemical index of patients with alcoholic liver disease.Polyene phosphatidylcholine has the trend that prevents that histology from worsening to patients with alcoholic liver disease.Glycyrrhizic acid preparation, the medicines such as silymarin-group, polyene phosphatidylcholine and reduced glutathion have antioxidation in various degree, the effects such as antiinflammatory, protection liver plasma membrane and organelle, clinical practice can improve liver biochemical index.
Herbal treatment adopts dialectical therapy, is obtaining certain effect aspect the treatment of chronic alcoholic liver disease:
As CN103830337A discloses a kind of Chinese medicine composition for the treatment of chronic alcoholism hepatopathy, it comprises following raw material components: 10 parts of Rhizoma Corydalis, 15 parts of Radix Stephaniae Tetrandrae, 6 parts of Herba Artemisiae Scopariaes, 10 parts of Fructus Ligustri Lucidi, 10 parts of Rhizoma Chuanxiongs, 6 parts of Radix Angelicae Sinensis, 20 parts, Flos Sophorae, 20 parts of Fructus Atriplicis Sibiricaees, 10 parts of Radix Bupleuri, 12 parts of Radix Scutellariaes, 15 parts of Radix Scutellariaes, 30 parts of Ramulus Cinnamomi, 6 parts, Poria, 10 parts, Radix Glycyrrhizae.
CN103705731A discloses a kind of chronic alcoholism hepatopathy Chinese medicine composition for the treatment of, and it comprises following raw material components: 10 parts of Rhizoma Alismatis, 15 parts of Radix Stephaniae Tetrandrae, 6 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Polygoni Multiflori, 10 parts of Rhizoma Chuanxiongs, 6 parts of Radix Angelicae Sinensis, 20 parts of Fructus Aurantiis, 20 parts of Galla Chinensiss, 10 parts of Radix Bupleuri, 12 parts of Rhizoma Polygonatis, 15 parts of Radix Scutellariaes, 30 parts of Fructus Lyciis, 6 parts, Poria, 10 parts, Radix Glycyrrhizae.
CN103566123A discloses the pharmaceutical composition of a kind of prevention or treatment alcoholism and alcoholic liver injury, and this Chinese medicine is that raw material is prepared from by Fructus Crataegi, Rhizoma Dioscoreae, soybean lecithin, oligofructose.Can be clinical practice new selection is provided.
In addition, SAM treatment can improve alcohol fatty hepatopath's clinical symptoms and biochemical index.Polyene phosphatidylcholine has the trend that prevents that histology from worsening to alcohol fatty hepatopath.Glycyrrhizic acid preparation, the medicines such as silymarin-group, polyene phosphatidylcholine and reduced glutathion have antioxidation in various degree, the effects such as antiinflammatory, protection liver plasma membrane and organelle, clinical practice can improve liver biochemical index.But these medicines exist treatment target spot single in therapeutic process, long-term prescription easily occurs that the problems such as toleration are difficult to chronic alcoholism hepatopathy to reach comprehensive continued treatment effect, and therefore finding a kind of hepatosis treating medicine of chronic alcoholism safely and effectively has very important social meaning and economic implications.
Summary of the invention
For current chronic alcoholism hepatopathy, there is no Drug therapy very comprehensively and effectively, first object of the present invention is to provide a kind of Chinese medicine composition of chronic alcoholism hepatopathy, and this Chinese medicine composition has good active anticancer aspect the diseases such as the damage for the treatment of Alcoholic, alcoholic fatty liver.Chinese medicine composition of the present invention, according to parts by weight meter, by following raw material, made: Radix Paeoniae Alba 5-10 part, Rhizoma Corydalis 7-9 part, Fructus Crataegi 10-15 part, Radix Stephaniae Tetrandrae 10-12 part, Pericarpium Citri Reticulatae 2-7 part, Herba Artemisiae Scopariae 6-9 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Curcumae 3-5 part, Radix Angelicae Sinensis 6-8 part, Caulis Lonicerae 6-9 part, Flos Sophorae 15-20 part, Receptaculum Nelumbinis 5-7 part, Fructus Atriplicis Sibiricae 12-15 part, Fructus Ligustri Lucidi 10-12 part, Radix Bupleuri 8-10 part, Poria 5-10 part, Radix Scutellariae 10-15 part, Ramulus Cinnamomi 25-30 part, Fructus Jujubae 5-10 part, Radix Glycyrrhizae 10-15 part.
As a kind of embodiment preferred for this invention, above-mentioned Chinese medicine composition, according to components by weight percent meter, is made by following raw material: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Wherein, Receptaculum Nelumbinis is the dry holder of nymphaeaceae plant lotus Nelumbo nucifera Gaertn.Gather during fruit maturation autumn, removes fruit, dries.Nature and flavor are bitter, puckery, temperature.Return Liver Channel.Can removing stasis to stop bleeding.For metrorrhagia, hematuria, bleeding hemorrhoids, postpartum stagnation, lochiorrhea.
Rhizoma Curcumae is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.The latter practises title " warm Rhizoma Curcumae ".Winter, stem and leaf was excavated after withered, cleaned, and steamed or boiled to the saturating heart, dry or cold drying after remove fibrous root and impurity.Nature and flavor are pungent, bitter, temperature.Return liver, spleen channel.Energy circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For abdominal mass abdominal mass mass in the abdomen, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
Folium Eucommiae is Eucommiaceae plant Cortex Eucommiae Eucommz, the dried leaves of a ulmoides Oliv..Summer, autumn gathered when two seasons, branch and leaf were luxuriant, dried or oven drying at low temperature.Nature and flavor are micro-pungent, temperature.Return liver, kidney channel.Function invigorating the liver and kidney, bone and muscle strengthening.For deficiency of the liver and kindey, have a dizzy spell, soreness of waist and knee joint, muscles and bones flaccidity is soft.
As a kind of embodiment preferred for this invention, in above-mentioned Chinese medicine composition, can also further comprise 10 parts of 8 parts of Folium Eucommiaes and Radix Puerariaes.Two kinds of medicines and above-mentioned Chinese medicine composition coupling can further strengthen the metabolism ability of liver, and can reduce the drug toxicity of medicine to body.
The method of preparing Chinese medicine composition of the present invention is as follows: get each medical material, add the water of 5-10 times of medical material gross weight, soak 10-60 minute, decoct 1-4 time, each 1-3 hour, filters, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.05-1.25, and this relative density is the testing result under 60 degrees Celsius, and adding ethanol is 60-90%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol to concentrated, obtain.The above-mentioned Chinese medicine composition of the present invention can further be prepared into conventional clinically pharmaceutical preparation, is preferably mixture, tablet, capsule.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, i.e. the purposes of above-mentioned Chinese medicine composition in preparation treatment or preventing chronic alcoholic-toxic liver disease drug.Wherein said chronic alcoholism hepatopathy is chronic alcoholism hepatopathy, alcoholic fatty liver, alcoholic hepatitis or the hepatic fibrosis being caused by chronic alcoholism hepatopathy or liver cirrhosis.The present invention tests the treatment of rat alcoholic fatty liver model by investigating Chinese medicine composition of the present invention, find that Chinese medicine composition provided by the invention can obviously reduce AST and the ALT of Rats with Fatty Liver model, TG, TC and the LDL-C of fatty rat model can be significantly reduced, and the liver index of rat model can be significantly reduced.This acts on comprehensively while showing Chinese medicine composition of the present invention to treatment or prevention fatty liver disease, has obvious synergism, has obtained unforeseeable curative effect of medication.Its therapeutic effect to fatty liver is better than existing medicine silibinin.
In a word, the present invention compared with prior art, has the activity of fine treatment fatty liver, and can the present invention be pure Chinese medicinal preparation, to human body particularly to liver avirulence.When the present invention uses as fatty liver medicine, drug effect is comprehensive, in dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating food stagnation removing, can also obtain the effect of activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness, and sb.'s illness took a favorable turn can to make rapidly Patients with Fatty Liver; And Chinese medicine composition preparation of the present invention is simple, and substantially nontoxic, raw material is easy to get, and is suitable for popular use, has good application prospect.
The specific embodiment
By the specific embodiment, further describe the present invention below, but the present invention is not limited only to following examples.Within the scope of the invention or within not departing from content of the present invention, spirit and scope, Chinese medicine composition of the present invention is suitably improved, replaces the component that effect is identical, within will become apparent to those skilled in the art that they are all deemed to be included in scope of the present invention.
First, the preparation of Chinese medicine composition of the present invention
Embodiment 1 Chinese medicine composition mixture of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of parts of Caulis Lonicerae, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 5 times of medical material gross weight, soak 30 minutes, decoct 2 times, each 2 hours, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.1, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 75%(v/v to containing alcohol amount), standing 24 hours, get supernatant, recovery ethanol is concentrated, adds water to 1000ml, stirs evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
Embodiment 2 Chinese medicine composition tablet of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 10 times of medical material gross weight, soak 60 minutes, decoct 1 time, each 1 hour, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.25, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 80%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulation, tabletting and get final product.
Embodiment 3 Chinese medicinal composition capsules of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 8 times of medical material gross weight, soak 45 minutes, decoct 4 times, each 1.5 hours, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.2, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 90%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulates, encapsulated and get final product.
Embodiment 4 Chinese medicine composition mixture of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 5 times of medical material gross weight, soak 30 minutes, decoct 2 times, each 2 hours, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.1, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 75%(v/v to containing alcohol amount), standing 24 hours, get supernatant, recovery ethanol is concentrated, adds water to 1000ml, stirs evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
Embodiment 5 Chinese medicine composition tablet of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 10 times of medical material gross weight, soak 60 minutes, decoct 1 time, each 1 hour, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.25, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 80%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulation, tabletting and get final product.
Embodiment 6 Chinese medicinal composition capsules of the present invention
Prescription: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
Preparation method: get each medical material of above-mentioned components by weight percent, add the water of 8 times of medical material gross weight, soak 45 minutes, decoct 4 times, each 1.5 hours, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.2, and this relative density is the testing result under 60 degrees Celsius, adding ethanol is 90%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulates, encapsulated and get final product.
Second portion, the pharmacodynamics of Chinese medicine composition of the present invention is investigated
The treatment of embodiment 7 Chinese medicine composition of the present invention to alcoholic fatty liver
The preparation of 1 alcoholic fatty liver model
The clean level healthy adult male SD rat that use body weight is 125-145g, freely drink the drinks beverage that 55 ° of strong, colourless liquor distilled from sorghum Chinese liquor are mixed with variable concentrations and contain 10% white sugar, its Chinese liquor degree increases progressively gradually according to 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% (V/V), each concentration continues 10 days, in the time of 40%, maintain 20 weeks, total 30 weeks modeling time, build alcoholic fatty liver pathology animal model.Each all gives ad lib full nutrition pellet during organizing rat experiment.
2 grouping and administrations
Rat model adaptability was raised after 1 week, was divided at random normal group, model group and administration group, and specifically grouping situation sees the following form, 6 every group.Every afternoon is gavage medicine during 14:30, and dosage is as follows:
Normal group: gavage gives the distilled water of same volume;
Model control group: gavage gives the distilled water of same volume;
Low dose group: gavage gives the embodiment of the present invention 1 prepared Chinese medicine composition mixture, crude drug dosage 0.1g/(kg.d);
Middle dosage group: gavage gives the embodiment of the present invention 1 prepared Chinese medicine composition mixture, crude drug dosage 1g/(kg.d);
High dose group: gavage gives the embodiment of the present invention 1 prepared Chinese medicine composition mixture, crude drug dosage 10g/(kg.d);
Silibinin group: gavage gives 25mg/(kg.d) silibinin.
3 detect index
After last administration, pentobarbital sodium anesthetized rat, dissects, and abdomen cardinal vein is got hematometry biochemical indicator, gets liver and weighs.
3.1 blood fat
Result of the test shows (referring to table 1), the level of T-CHOL, triglyceride, HDL-C and the low-density lipoprotein cholesterol of each dosage group of compound recipe has been compared significant difference or utmost point significant difference with fatty liver model of rats group, compare with silibinin group and also there is significant difference or utmost point significant difference (except hdl level), Chinese medicine use in conjunction in this explanation Chinese medicine composition of the present invention, on fatty liver model of rats, on reduction TG, TC and LDL-C, obtained good synergism.
The impact of table 1 Chinese medicine composition of the present invention on rat model blood fat
With model group comparison,
*p < 0.05; With model group comparison,
*p < 0.01;
With the comparison of silibinin group,
#p < 0.05; With the comparison of silibinin group,
##p < 0.01.
3.2 liver function
Result of the test shows (referring to table 2), alcoholic fatty liver model group rat blood serum ALT, AST content are compared with normal group significantly and are raise, the rat blood serum ALT of each administration group, AST content are compared obvious decline with model group, especially, each dosage group of compound recipe is compared with model group has utmost point significant difference, compared utmost point significant difference with silibinin group, each Chinese medicine of this explanation Chinese medicine composition of the present invention has been obtained synergitic effect on to the prevention of rat fat liver or treatment.
The impact of table 2 Chinese medicine composition of the present invention on rat model liver function
With model group comparison,
*p < 0.05; With model group comparison,
*p < 0.01;
With the comparison of silibinin group,
#p < 0.05; With the comparison of silibinin group,
##p < 0.01.
3.3. liver index
Result of the test shows (referring to table 3), alcoholic fatty liver model group rats'liver index has been compared utmost point significant difference with normal group, the liver index of the rat of each administration group has been compared utmost point significant difference with model group, especially, each dosage group of compositions has been compared significant difference or utmost point significant difference with silibinin group, each Chinese medicine of this explanation Chinese medicine composition of the present invention, on fatty liver model of rats, has been obtained good synergism in this index of reduction liver index.
The impact of table 3 Chinese medicine composition of the present invention on Rats Organs and Tissues index
With normal group comparison,
$ p < 0.05; With normal group comparison,
$$ p < 0.01;
With model group comparison,
*p < 0.05; With model group comparison,
*p < 0.01;
With the comparison of silibinin group,
#p < 0.05; With the comparison of silibinin group,
##p < 0.01.
Claims (6)
1. treat a Chinese medicine composition for chronic alcoholism hepatopathy, it is characterized in that being made by the raw material of following weight portion: Radix Paeoniae Alba 7-10 part, Rhizoma Corydalis 7-9 part, Fructus Crataegi 10-15 part, Radix Stephaniae Tetrandrae 10-12 part, Pericarpium Citri Reticulatae 5-7 part, Herba Artemisiae Scopariae 6-9 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Curcumae 3-5 part, Radix Angelicae Sinensis 6-8 part, Caulis Lonicerae 6-9 part, Flos Sophorae 15-20 part, Receptaculum Nelumbinis 5-7 part, Fructus Atriplicis Sibiricae 12-15 part, Fructus Ligustri Lucidi 10-12 part, Radix Bupleuri 8-10 part, Poria 5-10 part, Radix Scutellariae 10-15 part, Ramulus Cinnamomi 25-30 part, Fructus Jujubae 5-10 part, Radix Glycyrrhizae 10-15 part.
2. treat as claimed in claim 1 the Chinese medicine composition of chronic alcoholism hepatopathy, it is characterized in that being made by the raw material of following weight portion: 7 parts of the Radix Paeoniae Albas, 9 parts of Rhizoma Corydalis, 10 parts of Fructus Crataegis, 10 parts of Radix Stephaniae Tetrandrae, 5 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Artemisiae Scopariaes, 5 parts of Rhizoma Chuanxiongs, 5 parts of Rhizoma Curcumae, 6 parts of Radix Angelicae Sinensis, 9 parts of Caulis Loniceraes, 15 parts, Flos Sophorae, 7 parts of Receptaculum Nelumbiniss, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Ligustri Lucidi, 8 parts of Radix Bupleuri, 7 parts, Poria, 10 parts of Radix Scutellariaes, 25 parts of Ramulus Cinnamomi, 5 parts, Fructus Jujubae, 10 parts, Radix Glycyrrhizae.
3. treat as claimed in claim 1 the Chinese medicine composition of chronic alcoholism hepatopathy, it is characterized in that: the raw material of described Chinese medicine composition also contains 10 parts of 8 parts of Folium Eucommiaes and Radix Puerariaes.
4. as described in claim 1,2 or 3, treat the Chinese medicine composition of chronic alcoholism hepatopathy, it is characterized in that: described Chinese medicine composition is mixture, tablet or capsule.
5. prepare the method for the treatment of the Chinese medicine composition of chronic alcoholism hepatopathy as described in claim 1,2 or 3 for one kind, it is characterized in that comprising the following steps: get each medical material, the water of 5-10 times that adds medical material gross weight, soak 10-60 minute, decoct 1-4 time, each 1-3 hour, filter, merging filtrate, filtrate decompression is concentrated into the extractum of relative density 1.05-1.25, this relative density is the testing result under 60 degrees Celsius, add ethanol to being 60-90%v/v containing alcohol amount, standing 24 hours, get supernatant, reclaim ethanol to concentrated, obtain.
6. the purposes of the Chinese medicine composition for the treatment of chronic alcoholism hepatopathy as described in claim 1,2 or 3 in preparation treatment or preventing chronic alcoholic-toxic liver disease drug.
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| CN106109731A (en) * | 2016-07-15 | 2016-11-16 | 赵玮 | A kind of Chinese medicine composition treating chronic hepatopathy and preparation method thereof |
| CN113398225A (en) * | 2021-07-12 | 2021-09-17 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for alcoholic hepatic fibrosis |
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| CN102669667A (en) * | 2012-05-25 | 2012-09-19 | 北京三奇本草医药技术有限公司 | Health food with dual functions of protecting liver and adjusting blood fat and preparation method thereof |
| CN102920975A (en) * | 2012-09-13 | 2013-02-13 | 魏喜成 | Traditional Chinese medicine for treating gastropathy and preparation method thereof |
| CN103301412A (en) * | 2013-07-07 | 2013-09-18 | 崔新明 | Traditional Chinese medicine composition for treating alcoholic liver |
| CN103705731A (en) * | 2014-01-02 | 2014-04-09 | 王雪雁 | Traditional Chinese medicine composition for treating chronic alcoholic toxic liver disease |
| CN103830337A (en) * | 2014-03-25 | 2014-06-04 | 崔新明 | Chinese medicinal composition for treating chronic alcoholic toxic liver disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109731A (en) * | 2016-07-15 | 2016-11-16 | 赵玮 | A kind of Chinese medicine composition treating chronic hepatopathy and preparation method thereof |
| CN113398225A (en) * | 2021-07-12 | 2021-09-17 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for alcoholic hepatic fibrosis |
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